Site-specific phosphorylation of synapsin I by Ca2+/calmodulin- dependent protein kinase II in pancreatic βTC3 cells: Synapsin I is not associated with insulin secretory granules

Diabetes

Volumn 48, Issue 3, 1999, Pages 499-506

  Krueger, Kimberly A ^a   Ings, Emma I ^a   Brun, Anne Marie ^a   Landt, Michael ^b   Easom, Richard A ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROTEIN KINASE (CALCIUM,CALMODULIN) II; SYNAPSIN I;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; EXOCYTOSIS; IMMUNOBLOTTING; INSULIN RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; TRANSPORT KINETICS;

EID: 0032972673     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.3.499     Document Type: Article

References (52)

1. Harrison DE, Ashcroft SJ, Christie MR, Lord JM: Protein phosphorylation in the pancreatic β-cell. Experientia 40:1075-1084, 1984
2. Ammala C, Eliasson L, Bokvist K, Berggren PO, Honkanen RE, Sjoholm A, Rorsman P: Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic β-cells. Proc Natl Acad Sci U S A 91:4343-4347, 1994
3. Ashcroft SJ: Protein phosphorylation and β-cell function. Diabetologia 37 (Suppl. 2):S21-S29, 1994
4. 2+/calmodulin-dependent protein kinase in rat pancreatic islets. Biochem J 289:795-800, 1993
5. 2+/calmodulin-dependent myosin light-chain phosphorylating activity in insulin-secreting tissues. FEBS Lett 139:4-8, 1982
6. 2+-dependent translocation of protein kinase C and glucose-induced insulin release. J Biol Chem 271:18154-18160, 1996
7. Gagliardino JJ, Krinks MH, Gagliardino EE: Identification of the calmodulin-regulated protein phosphatase, ralcineurin, in rat pancreatic islets. Biochim Biophys Acta 1091:370-373, 1991
8. 2+/calmodulin-dependent protein kinase II in isolated rat pancreatic islets. J Biol Chem 269:4947-4952, 1994
9. 2+/calmodulin-dependent protein kinase II with the initiation of insulin secretion from perifused pancreatic islets. Endocrinology 138:2359-2364, 1997
10. 2+/calmodulin-dependent protein kinase II in pancreatic islets: temporal dissociation of kinase activation and insulin secretion. Biochem J 317:167-172, 1996
11. Sudhof TC: The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 375:645-653, 1995
12. Hirling H, Scheller RH: Phosphorylation of synaptic vesicle proteins: modulation of the α-SNAP interaction with the core complex. Proc Natl Acad Sci U S A 93:11945-11949, 1996
13. Greengard P, Valtorta F, Czernik AJ, Benfenati F: Synaptic vesicle phosphoproteins and regulation of synaptic function. Science 259:780-785, 1993
14. Nielander HB, Onofri F, Valtorta F, Schiavo G, Montecucco C, Greengard P, Benfenati F: Phosphorylation of VAMP/synaptobrevin in synaptic vesicles by endogenous protein kinases. J Neurochem 65:1712-1720, 1995
15. 2+/calmodulin protein kinase II in synaptic vesicles. FEBS Lett 317:85-88, 1993
16. 2+/calmodulin-dependent protein kinase II is a binding protein for synapsin I. Nature 359:417-420, 1992
17. Huttner WB, Schiebler W, Greengard P, De Camilli P: Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J Cell Biol 96:1374-1388, 1983
18. Ceccaldi PE, Grohovaz F, Benfenati F, Chieregatti E, Greengard P, Valtorta F: Dephosphorylated synapsin I anchors synaptic vesicles to actin cytoskeleton: an analysis by videomicroscopy. J Cell Biol 128:905-912, 1995
19. Valtorta F, Greengard P, Fesce R, Chieregatti E, Benfenati F: Effects of the neuronal phosphoprotein synapsin I on actin polymerization. I. Evidence for a phosphorylation-dependent nucleating effect. J Biol Chem 267:11281-11288, 1992
20. Thomas-Reetz A, De Camilli P: A role for synaptic vesicles in non-neuronal cells: clues from pancreatic β-cells and from chromaffin cells. FASEB J 8:209-216, 1994
21. Rothman JE, Warren G: Implications of the SNARE hypothesis for intracellular membrane topology and dynamics. Curr Biol 4:220-233, 1994
22. Ferro-Novick S, Jahn R: Vesicle fusion from yeast to man. Nature 370:191-193, 1994
23. Wheeler MB, Sheu L, Ghai M, Bouquillon A, Grondin G, Weller U, Beaudoin AR, Bennett MK, Trimble WS, Gaisano HY: Characterization of SNARE protein expression in β-cell lines and pancreatic islets. Endocrinology 137:1340-1348, 1996
24. Jacobsson G, Bean AJ, Scheller RH, Juntti-Berggren L, Deeney JT, Berggren PO, Meister B: Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells. Proc Natl Acad Sci U S A 91:12487-12491, 1994
25. 2+/calmodulin-dependent kinase II. J Biol Chem 272:27464-27469, 1997
26. Maccioni RB, Cambiazo V: Role of microtubule-associated proteins in the control of microtubule assembly. Physiol Rev 75:835-864, 1995
27. 2+/calmodulin-dependent protein kinase II and synapsin I-like protein in mouse insulinoma MIN6 cells. Endocrinology 136:3784-3793, 1995
28. Bennett MK, Erondu NE, Kennedy MB: Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain. J Biol Chem 258:12735-12744, 1983
29. Bers DM: A simple method for the accurate determination of free [Ca] in Ca-EGTA solutions. Am J Physiol 242:C404-C408, 1982
30. Huttner WB, Greengard P: Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium. Proc Natl Acad Sci U S A 76:5402-5406, 1979
31. van der Geer P, Luo K, Sefton BM, Hunter T: Phosphopeptide mapping and phosphoamino analysis on cellulose thin-layer plates. In Cell Biology: A Laboratory Handbook. Vol. 3. Celic JE, Ed. San Diego, Academic Press, 1994, p. 422-448
32. Weaver CD, Yao TL, Powers AC, Verdoorn TA: Differential expression of glutamate receptor subtypes in rat pancreatic islets. J Biol Chem 271: 12977-12984, 1996
33. Lenormand P, Sardet C, Pages G, L'Allemain G, Brunet A, Pouyssegur J: Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts. J Cell Biol 122:1079-1088, 1993
34. Chick WL, Warren S, Chute RN, Like AA, Lauris V, Kitchen KC: A transplantable insulinoma in the rat. Proc Natl Acad Sci U S A 74:628-632, 1977
35. Czernik AJ, Pang DT, Greengard P: Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I. Proc Natl Acad Sci U S A 84:7518-7522, 1987
36. Jovanovic JN, Benfenati F, Siow YL, Sihra TS, Sanghera JS, Pelech SL, Greengard P, Czernik AJ: Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. Proc Natl Acad Sci U S A 93:3679-3683, 1996
37. Teitelman G: Insulin cells of pancreas extend neurites but do not arise from the neuroectoderm. Dev Biol 142:368-379, 1990
38. Darchen F, Zahraoui A, Hammel F, Monteils MP, Tavitian A, Scherman D: Association of the GTP-binding protein Rab3A with bovine adrenal chromaffin granules. Proc Natl Acad Sci U S A 87:5692-5696, 1990
39. 2+)-dependent and-independent activities of neural and non-neural synaptotagmins. Nature 375:594-599, 1995
40. Schmidle T, Weiler R, Desnos C, Scherman D, Fischer-Colbrie R, Floor E, Winkler H: Synaptin/synaptophysin, p65 and SV2: their presence in adrenal chromaffin granules and sympathetic large dense core vesicles. Biochim Biophys Acta 1060:251-256, 1991
41. Sudhof TC: The structure of the human synapsin I gene and protein. J Biol Chem 265:7849-7852, 1990
42. Puitout V, Olson LK, Rohertson RP: Insulin-secreting cell lines: classification, characteristics, and potential applications. Diabetes Metab 22:7-14, 1996
43. Thomas-Reetz A, Hell JW, During MJ, Walch-Solimena C, Jahn R, De Camilli P: A γ-aminobutyric acid transporter driven by a proton pump is present in synaptic-like microvesicles of pancreatic β-cells. Proc Natl Acad Sci U S A 90:5317-5321, 1993
44. 2+- and okadaic acid-sensitive protein phosphatases. Biochem J 329: 283-288, 1998
45. Sharp GW: The adenylate cyclase-cyclic AMP system in islets of Langerhans and its role in the control of insulin release. Diabetologia 16:287-296, 1979
46. Ammala C, Ashcroft FM, Rorsman P: Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells. Nature 363:356-358, 1993
47. Reetz A, Solimena M, Matteoli M, Folli F, Takei K, De Camilli P: GABA and pancreatic β-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion. Embo J 10:1275-1284, 1991
48. Gaskins HR, Baldeon ME, Selassie L, Beverly JL: Glucose modulates γ-aminobutyric acid release from the pancreatic βTC6 cell line. J Biol Chem 270:30286-30289, 1995
49. Rosahl TW, Spillane D, Missler M, Herz J, Selig DK, Wolff JR, Hammer RE, Malenka RC, Sudhof TC: Essential functions of synapsins I and II in synaptic vesicle regulation [see comments]. Nature 375:488-493, 1995
50. 2+ oscillations [see comments]. Science 279:227-230, 1998
51. Esser L, Wang CR, Hosaka M, Smagula CS, Sudhof TC, Deisenhofer J: Synapsin I is structurally similar to ATP-utilizing enzymes. EMBO J 17:977-984, 1998
52. 2+ regulation. J Biol Chem 273:1425-1429, 1998