-
1
-
-
56549128268
-
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
-
Wilson, A, E. Laurenti, G. Oser, et al. 2008. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135: 1118–1129.
-
(2008)
Cell
, vol.135
, pp. 1118-1129
-
-
Wilson, A.1
Laurenti, E.2
Oser, G.3
-
2
-
-
60149104597
-
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells
-
Foudi, A, K. Hochedlinger, D. Van Buren, et al. 2009. Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat. Biotechnol. 27: 84–90.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 84-90
-
-
Foudi, A.1
Hochedlinger, K.2
Van Buren, D.3
-
3
-
-
79951698622
-
Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation
-
Takizawa, H, R.R. Regoes, C.S. Boddupalli, et al. 2011. Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation. J. Exp. Med. 208: 273–284.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 273-284
-
-
Takizawa, H.1
Regoes, R.R.2
Boddupalli, C.S.3
-
4
-
-
84919360111
-
The analysis, roles and regulation of quiescence in hematopoietic stem cells
-
Nakamura-Ishizu, A, H. Takizawa & T. Suda . 2014. The analysis, roles and regulation of quiescence in hematopoietic stem cells. Development 141: 4656–4666.
-
(2014)
Development
, vol.141
, pp. 4656-4666
-
-
Nakamura-Ishizu, A.1
Takizawa, H.2
Suda, T.3
-
5
-
-
84896929687
-
Metabolic requirements for the maintenance of self-renewing stem cells
-
Ito, K. & T. Suda . 2014. Metabolic requirements for the maintenance of self-renewing stem cells. Nat. Rev. Mol. Cell Biol. 15: 243–256.
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 243-256
-
-
Ito, K.1
Suda, T.2
-
6
-
-
84928923099
-
Making sense of hematopoietic stem cell niches
-
Boulais, P.E. & P.S. Frenette . 2015. Making sense of hematopoietic stem cell niches. Blood 125: 2621–2629.
-
(2015)
Blood
, vol.125
, pp. 2621-2629
-
-
Boulais, P.E.1
Frenette, P.S.2
-
8
-
-
36749098400
-
Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood
-
Majeti, R, C.Y. Park & I.L. Weissman . 2007. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1: 635–645.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 635-645
-
-
Majeti, R.1
Park, C.Y.2
Weissman, I.L.3
-
9
-
-
77953754015
-
Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development
-
Doulatov, S, F. Notta, K. Eppert, et al. 2010. Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nat. Immunol. 11: 585–593.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 585-593
-
-
Doulatov, S.1
Notta, F.2
Eppert, K.3
-
10
-
-
78651416188
-
Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia
-
Goardon, N, E. Marchi, A. Atzberger, et al. 2011. Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia. Cancer Cell 19: 138–152.
-
(2011)
Cancer Cell
, vol.19
, pp. 138-152
-
-
Goardon, N.1
Marchi, E.2
Atzberger, A.3
-
11
-
-
84866565243
-
Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin
-
Kohn, L.A, Q.-L. Hao, R. Sasidharan, et al. 2012. Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. Nat. Immunol. 13: 963–971.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 963-971
-
-
Kohn, L.A.1
Hao, Q.-L.2
Sasidharan, R.3
-
12
-
-
79960106880
-
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment
-
Notta, F, S. Doulatov, E. Laurenti, et al. 2011. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 333: 218–221.
-
(2011)
Science
, vol.333
, pp. 218-221
-
-
Notta, F.1
Doulatov, S.2
Laurenti, E.3
-
13
-
-
78651486442
-
Densely interconnected transcriptional circuits control cell states in human hematopoiesis
-
Novershtern, N, A. Subramanian, L.N. Lawton, et al. 2011. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell 144: 296–309.
-
(2011)
Cell
, vol.144
, pp. 296-309
-
-
Novershtern, N.1
Subramanian, A.2
Lawton, L.N.3
-
14
-
-
78650444882
-
Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia
-
Gentles, A.J, S.K. Plevritis, R. Majeti & A.A. Alizadeh . Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA 304: 2706–2715.
-
JAMA
, vol.304
, pp. 2706-2715
-
-
Gentles, A.J.1
Plevritis, S.K.2
Majeti, R.3
Alizadeh, A.A.4
-
15
-
-
84879421185
-
The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment
-
Laurenti, E, S. Doulatov, S. Zandi, et al. 2013. The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment. Nat. Immunol. 14: 756–763.
-
(2013)
Nat. Immunol.
, vol.14
, pp. 756-763
-
-
Laurenti, E.1
Doulatov, S.2
Zandi, S.3
-
16
-
-
84907916620
-
Transcriptional diversity during lineage commitment of human blood progenitors
-
Chen, L, M. Kostadima, J.H.A. Martens, et al. 2014. Transcriptional diversity during lineage commitment of human blood progenitors. Science 345: 1251033.
-
(2014)
Science
, vol.345
, pp. 1251033
-
-
Chen, L.1
Kostadima, M.2
Martens, J.H.A.3
-
17
-
-
35848943273
-
Hematopoietic fingerprints: an expression database of stem cells and their progeny
-
Chambers, S.M, N.C. Boles, K.-Y.K. Lin, et al. 2007. Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell 1: 578–591.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 578-591
-
-
Chambers, S.M.1
Boles, N.C.2
Lin, K.-Y.K.3
-
18
-
-
84883894867
-
Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells
-
Gazit, R, B.S. Garrison, T.N. Rao, et al. 2013. Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells. Stem Cell Rep. 1: 266–280.
-
(2013)
Stem Cell Rep
, vol.1
, pp. 266-280
-
-
Gazit, R.1
Garrison, B.S.2
Rao, T.N.3
-
19
-
-
77956233247
-
A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal
-
Milyavsky, M, O.I. Gan, M. Trottier, et al. 2010. A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell 7: 186–197.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 186-197
-
-
Milyavsky, M.1
Gan, O.I.2
Trottier, M.3
-
20
-
-
77956251480
-
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
-
Mohrin, M, E. Bourke, D. Alexander, et al. 2010. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell 7: 174–185.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 174-185
-
-
Mohrin, M.1
Bourke, E.2
Alexander, D.3
-
21
-
-
84902343044
-
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress
-
van Galen, P, A. Kreso, N. Mbong, et al. 2014. The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress. Nature 510: 268–272.
-
(2014)
Nature
, vol.510
, pp. 268-272
-
-
van Galen, P.1
Kreso, A.2
Mbong, N.3
-
22
-
-
84902343965
-
Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress
-
Miharada, K, V. Sigurdsson & S. Karlsson . 2014. Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress. Cell Rep. 7: 1381–1392.
-
(2014)
Cell Rep
, vol.7
, pp. 1381-1392
-
-
Miharada, K.1
Sigurdsson, V.2
Karlsson, S.3
-
23
-
-
77958542905
-
Load and lock: the molecular mechanisms of B-lymphocyte commitment
-
Zandi, S, D. Bryder & M. Sigvardsson . 2010. Load and lock: the molecular mechanisms of B-lymphocyte commitment. Immunol. Rev. 238: 47–62.
-
(2010)
Immunol. Rev.
, vol.238
, pp. 47-62
-
-
Zandi, S.1
Bryder, D.2
Sigvardsson, M.3
-
24
-
-
84891687999
-
Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion
-
van Galen, P, A. Kreso, E. Wienholds, et al. 2014. Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion. Cell Stem Cell 14: 94–106.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 94-106
-
-
van Galen, P.1
Kreso, A.2
Wienholds, E.3
-
25
-
-
84922605057
-
A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells
-
Beer, P.A, D.J.H.F. Knapp, N. Kannan, et al. A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells. Stem Cell Rep. 3: 841–857.
-
Stem Cell Rep
, vol.3
, pp. 841-857
-
-
Beer, P.A.1
Knapp, D.J.H.F.2
Kannan, N.3
-
26
-
-
84922541996
-
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis
-
Cabezas-Wallscheid, N, D. Klimmeck, J. Hansson, et al. 2014. Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis. Cell Stem Cell 15: 507–522.
-
(2014)
Cell Stem Cell
, vol.15
, pp. 507-522
-
-
Cabezas-Wallscheid, N.1
Klimmeck, D.2
Hansson, J.3
-
27
-
-
84924284076
-
CDK6 levels regulate quiescence exit in human hematopoietic stem cells
-
Laurenti, E, C. Frelin, S. Xie, et al. 2015. CDK6 levels regulate quiescence exit in human hematopoietic stem cells. Cell Stem Cell 16: 302–313.
-
(2015)
Cell Stem Cell
, vol.16
, pp. 302-313
-
-
Laurenti, E.1
Frelin, C.2
Xie, S.3
-
28
-
-
84940446838
-
Combined single-cell functional and gene expression analysis resolves heterogeneity within stem cell populations
-
Wilson, N.K, D.G. Kent, F. Buettner, et al. 2015. Combined single-cell functional and gene expression analysis resolves heterogeneity within stem cell populations. Cell Stem Cell 16: 712–724.
-
(2015)
Cell Stem Cell
, vol.16
, pp. 712-724
-
-
Wilson, N.K.1
Kent, D.G.2
Buettner, F.3
-
29
-
-
84956599311
-
Single cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells
-
Kowalczyk, M.S, I. Tirosh, D. Heckl, et al. 2015. Single cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells. Genome Res. doi:10.1101/gr.192237.115
-
(2015)
Genome Res
-
-
Kowalczyk, M.S.1
Tirosh, I.2
Heckl, D.3
-
30
-
-
84941929935
-
Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells
-
Tsang, J.C, Y. Yu, S. Burke, et al. 2015. Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells. Genome Biol. 16: 178.
-
(2015)
Genome Biol
, vol.16
, pp. 178
-
-
Tsang, J.C.1
Yu, Y.2
Burke, S.3
-
31
-
-
84905815023
-
Kit regulates HSC engraftment across the human-mouse species barrier
-
Cosgun, K.N, S. Rahmig, N. Mende, et al. 2014. Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell 15: 227–238.
-
(2014)
Cell Stem Cell
, vol.15
, pp. 227-238
-
-
Cosgun, K.N.1
Rahmig, S.2
Mende, N.3
-
32
-
-
84926260800
-
Long non-coding RNAs control hematopoietic stem cell function
-
Luo, M, M. Jeong, D. Sun, et al. 2015. Long non-coding RNAs control hematopoietic stem cell function. Cell Stem Cell 16: 426–438.
-
(2015)
Cell Stem Cell
, vol.16
, pp. 426-438
-
-
Luo, M.1
Jeong, M.2
Sun, D.3
-
33
-
-
84926163086
-
The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells
-
Ramos, A.D, R.E. Andersen, S.J. Liu, et al. 2015. The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells. Cell Stem Cell 16: 439–447.
-
(2015)
Cell Stem Cell
, vol.16
, pp. 439-447
-
-
Ramos, A.D.1
Andersen, R.E.2
Liu, S.J.3
-
34
-
-
84920730997
-
Single-cell transcriptome analysis reveals dynamic changes in lncRNA expression during reprogramming
-
Kim, D.H, G.K. Marinov, S. Pepke, et al. 2015. Single-cell transcriptome analysis reveals dynamic changes in lncRNA expression during reprogramming. Cell Stem Cell 16: 88–101.
-
(2015)
Cell Stem Cell
, vol.16
, pp. 88-101
-
-
Kim, D.H.1
Marinov, G.K.2
Pepke, S.3
-
35
-
-
80052223272
-
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming
-
Gabut, M, P. Samavarchi-Tehrani, X. Wang, et al. 2011. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell 147: 132–146.
-
(2011)
Cell
, vol.147
, pp. 132-146
-
-
Gabut, M.1
Samavarchi-Tehrani, P.2
Wang, X.3
-
36
-
-
84884682635
-
Modeling human hematopoietic stem cell biology in the mouse
-
Sykes, S.M. & D.T. Scadden . 2013. Modeling human hematopoietic stem cell biology in the mouse. Semin. Hematol. 50: 92–100.
-
(2013)
Semin. Hematol.
, vol.50
, pp. 92-100
-
-
Sykes, S.M.1
Scadden, D.T.2
-
37
-
-
84874235360
-
Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes
-
Pang, W.W, J.V. Pluvinage, E.A. Price, et al. 2013. Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes. Proc. Natl. Acad. Sci. U.S.A. 110: 3011–3016.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 3011-3016
-
-
Pang, W.W.1
Pluvinage, J.V.2
Price, E.A.3
-
39
-
-
84906254220
-
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
-
Flach, J, S.T. Bakker, M. Mohrin, et al. 2014. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature 512: 198–202.
-
(2014)
Nature
, vol.512
, pp. 198-202
-
-
Flach, J.1
Bakker, S.T.2
Mohrin, M.3
-
40
-
-
84875965163
-
Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
-
Beerman, I, C. Bock, B.S. Garrison, et al. 2013. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell 12: 413–425.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 413-425
-
-
Beerman, I.1
Bock, C.2
Garrison, B.S.3
-
41
-
-
21544467270
-
Cell intrinsic alterations underlie hematopoietic stem cell aging
-
Rossi, D.J, D. Bryder, J.M. Zahn, et al. 2005. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc. Natl. Acad. Sci. U. S. A. 102: 9194–9199.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 9194-9199
-
-
Rossi, D.J.1
Bryder, D.2
Zahn, J.M.3
-
42
-
-
84865369147
-
DNA methylation dynamics during in vivo differentiation of blood and skin stem cells
-
Bock, C, I. Beerman, W.-H. Lien, et al. 2012. DNA methylation dynamics during in vivo differentiation of blood and skin stem cells. Mol. Cell 47: 633–647.
-
(2012)
Mol. Cell
, vol.47
, pp. 633-647
-
-
Bock, C.1
Beerman, I.2
Lien, W.-H.3
-
43
-
-
79955970344
-
Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging
-
Bocker, M.T, I. Hellwig, A. Breiling, et al. 2011. Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging. Blood 117: e182–e189.
-
(2011)
Blood
, vol.117
, pp. e182-e189
-
-
Bocker, M.T.1
Hellwig, I.2
Breiling, A.3
-
44
-
-
84899768899
-
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal
-
Sun, D, M. Luo, M. Jeong, et al. 2014. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell 14: 673–688.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 673-688
-
-
Sun, D.1
Luo, M.2
Jeong, M.3
-
45
-
-
58049191558
-
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
-
Cui, K, C. Zang, T.-Y. Roh, et al. 2009. Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell 4: 80–93.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 80-93
-
-
Cui, K.1
Zang, C.2
Roh, T.-Y.3
-
46
-
-
75649147458
-
Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells
-
Weishaupt, H, M. Sigvardsson & J.L. Attema . 2010. Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells. Blood 115: 247–256.
-
(2010)
Blood
, vol.115
, pp. 247-256
-
-
Weishaupt, H.1
Sigvardsson, M.2
Attema, J.L.3
-
47
-
-
84907419194
-
Chromatin state dynamics during blood formation
-
Lara-Astiaso, D, A. Weiner, E. Lorenzo-Vivas, et al. 2014. Chromatin state dynamics during blood formation. Science 345: 943–949.
-
(2014)
Science
, vol.345
, pp. 943-949
-
-
Lara-Astiaso, D.1
Weiner, A.2
Lorenzo-Vivas, E.3
-
48
-
-
83855163414
-
Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence
-
Wittkopp, P.J. & G. Kalay . 2012. Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence. Nat. Rev. Genet. 13: 59–69.
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 59-69
-
-
Wittkopp, P.J.1
Kalay, G.2
-
49
-
-
84920053873
-
Age-related clonal hematopoiesis associated with adverse outcomes
-
Jaiswal, S, P. Fontanillas, J. Flannick, et al. 2014. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371: 2488–2498.
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 2488-2498
-
-
Jaiswal, S.1
Fontanillas, P.2
Flannick, J.3
-
50
-
-
84868208186
-
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
-
Busque, L, J.P. Patel, M.E. Figueroa, et al. 2012. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat. Genet. 44: 1179–1181.
-
(2012)
Nat. Genet.
, vol.44
, pp. 1179-1181
-
-
Busque, L.1
Patel, J.P.2
Figueroa, M.E.3
-
51
-
-
84920024296
-
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
-
Genovese, G, A.K. Kähler, R.E. Handsaker, et al. 2014. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N. Engl. J. Med. 371: 2477–2487.
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 2477-2487
-
-
Genovese, G.1
Kähler, A.K.2
Handsaker, R.E.3
-
52
-
-
84930003179
-
Age-related mutations associated with clonal hematopoietic expansion and malignancies
-
Xie, M, C. Lu, J. Wang, et al. 2014. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat. Med. 20: 1472–1478.
-
(2014)
Nat. Med.
, vol.20
, pp. 1472-1478
-
-
Xie, M.1
Lu, C.2
Wang, J.3
-
53
-
-
84924620531
-
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis
-
McKerrell, T, N. Park, T. Moreno, et al. 2015. Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis. Cell Rep. 10: 1239–1245.
-
(2015)
Cell Rep
, vol.10
, pp. 1239-1245
-
-
McKerrell, T.1
Park, N.2
Moreno, T.3
-
54
-
-
58149380742
-
Stem cell concepts renew cancer research
-
Dick, J.E. 2008. Stem cell concepts renew cancer research. Blood 112: 4793–4807.
-
(2008)
Blood
, vol.112
, pp. 4793-4807
-
-
Dick, J.E.1
-
55
-
-
78751676408
-
Cells of origin in cancer
-
Visvader, J.E. 2011. Cells of origin in cancer. Nature 469: 314–322.
-
(2011)
Nature
, vol.469
, pp. 314-322
-
-
Visvader, J.E.1
-
56
-
-
84896125494
-
Evolution of the cancer stem cell model
-
Kreso, A. & J.E. Dick . 2014. Evolution of the cancer stem cell model. Cell Stem Cell 14: 275–291.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 275-291
-
-
Kreso, A.1
Dick, J.E.2
-
57
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet, D. & J.E. Dick . 1997. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3: 730–737.
-
(1997)
Nat. Med.
, vol.3
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
59
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot, T, C. Sirard, J. Vormoor, et al. 1994. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367: 645–648.
-
(1994)
Nature
, vol.367
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
-
60
-
-
80052468964
-
Stem cell gene expression programs influence clinical outcome in human leukemia
-
Eppert, K, K. Takenaka, E.R. Lechman, et al. 2011. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat. Med. 17: 1086–1093.
-
(2011)
Nat. Med.
, vol.17
, pp. 1086-1093
-
-
Eppert, K.1
Takenaka, K.2
Lechman, E.R.3
-
61
-
-
77957995156
-
+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice
-
+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice. Blood 116: 3907–3922.
-
(2010)
Blood
, vol.116
, pp. 3907-3922
-
-
Martelli, M.P.1
Pettirossi, V.2
Thiede, C.3
-
62
-
-
50949090415
-
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells
-
Taussig, D.C, F. Miraki-Moud, F. Anjos-Afonso, et al. 2008. Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. Blood 112: 568–575.
-
(2008)
Blood
, vol.112
, pp. 568-575
-
-
Taussig, D.C.1
Miraki-Moud, F.2
Anjos-Afonso, F.3
-
63
-
-
78650950098
-
Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL-2Rγc-deficient mice
-
Sarry, J.-E, K. Murphy, R. Perry, et al. 2011. Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL-2Rγc-deficient mice. J. Clin. Invest. 121: 384–395.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 384-395
-
-
Sarry, J.-E.1
Murphy, K.2
Perry, R.3
-
64
-
-
62549160065
-
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells
-
Majeti, R, M.W. Becker, Q. Tian, et al. 2009. Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc. Natl. Acad. Sci. U.S.A. 106: 3396–3401.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 3396-3401
-
-
Majeti, R.1
Becker, M.W.2
Tian, Q.3
-
65
-
-
77749294821
-
Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells
-
Saito, Y, H. Kitamura, A. Hijikata, et al. 2010. Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Sci. Transl. Med. 2: 17ra9.
-
(2010)
Sci. Transl. Med.
, vol.2
, pp. 17
-
-
Saito, Y.1
Kitamura, H.2
Hijikata, A.3
-
66
-
-
84865183566
-
Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS
-
Barreyro, L, B. Will, B. Bartholdy, et al. 2012. Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. Blood 120: 1290–1298.
-
(2012)
Blood
, vol.120
, pp. 1290-1298
-
-
Barreyro, L.1
Will, B.2
Bartholdy, B.3
-
67
-
-
33749440584
-
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
-
Somervaille, T.C.P. & M.L. Cleary . 2006. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 10: 257–268.
-
(2006)
Cancer Cell
, vol.10
, pp. 257-268
-
-
Somervaille, T.C.P.1
Cleary, M.L.2
-
68
-
-
84939463901
-
The H3K4-methyl epigenome regulates leukemia stem cell oncogenic potential
-
Wong, S.H.K, D.L. Goode, M. Iwasaki, et al. 2015. The H3K4-methyl epigenome regulates leukemia stem cell oncogenic potential. Cancer Cell 28: 198–209.
-
(2015)
Cancer Cell
, vol.28
, pp. 198-209
-
-
Wong, S.H.K.1
Goode, D.L.2
Iwasaki, M.3
-
69
-
-
84934442835
-
Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis
-
Levine, J.H, E.F. Simonds, S.C. Bendall, et al. 2015. Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis. Cell 162: 184–197.
-
(2015)
Cell
, vol.162
, pp. 184-197
-
-
Levine, J.H.1
Simonds, E.F.2
Bendall, S.C.3
-
70
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov, L.B, S. Nik-Zainal, D.C. Wedge, et al. 2013. Signatures of mutational processes in human cancer. Nature 500: 415–421.
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
-
71
-
-
77957348625
-
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators
-
Wilson, N.K, S.D. Foster, X. Wang, et al. 2010. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell 7: 532–544.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 532-544
-
-
Wilson, N.K.1
Foster, S.D.2
Wang, X.3
-
72
-
-
84877930760
-
Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia
-
Diffner, E, D. Beck, E. Gudgin, et al. 2013. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia. Blood 121: 2289–2300.
-
(2013)
Blood
, vol.121
, pp. 2289-2300
-
-
Diffner, E.1
Beck, D.2
Gudgin, E.3
-
73
-
-
78149356747
-
Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia
-
Müller-Tidow, C, H.-U. Klein, A. Hascher, et al. 2010. Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia. Blood 116: 3564–3571.
-
(2010)
Blood
, vol.116
, pp. 3564-3571
-
-
Müller-Tidow, C.1
Klein, H.-U.2
Hascher, A.3
-
74
-
-
84899780589
-
Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin
-
Moti, N, T. Malcolm, R. Hamoudi, et al. 2014. Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin. Oncogene 34: 1843–1852.
-
(2014)
Oncogene
, vol.34
, pp. 1843-1852
-
-
Moti, N.1
Malcolm, T.2
Hamoudi, R.3
-
75
-
-
84862907593
-
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
-
Zhang, J, L. Ding, L. Holmfeldt, et al. 2012. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481: 157–163.
-
(2012)
Nature
, vol.481
, pp. 157-163
-
-
Zhang, J.1
Ding, L.2
Holmfeldt, L.3
-
76
-
-
84875548150
-
Human hemato-lymphoid system mice: current use and future potential for medicine
-
Rongvaux, A, H. Takizawa, T. Strowig, et al. 2013. Human hemato-lymphoid system mice: current use and future potential for medicine. Annu. Rev. Immunol. 31: 635–674.
-
(2013)
Annu. Rev. Immunol.
, vol.31
, pp. 635-674
-
-
Rongvaux, A.1
Takizawa, H.2
Strowig, T.3
-
77
-
-
84928524428
-
Xenograft models for normal and malignant stem cells
-
Goyama, S, M. Wunderlich & J.C. Mulloy . 2015. Xenograft models for normal and malignant stem cells. Blood 125: 2630–2640.
-
(2015)
Blood
, vol.125
, pp. 2630-2640
-
-
Goyama, S.1
Wunderlich, M.2
Mulloy, J.C.3
-
78
-
-
84928910821
-
De novo generation of HSCs from somatic and pluripotent stem cell sources
-
Vo, L.T. & G.Q. Daley . 2015. De novo generation of HSCs from somatic and pluripotent stem cell sources. Blood 125: 2641–2648.
-
(2015)
Blood
, vol.125
, pp. 2641-2648
-
-
Vo, L.T.1
Daley, G.Q.2
|