메뉴 건너뛰기




Volumn 1370, Issue 1, 2016, Pages 5-14

Molecular landscapes of human hematopoietic stem cells in health and leukemia

Author keywords

acute myeloid leukemia; epigenetics; hematopoietic stem cells; transcriptomics

Indexed keywords

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; CANCER PROGNOSIS; CELL DIFFERENTIATION; DNA MODIFICATION; EPIGENETICS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; HUMAN; NONHUMAN; PLURIPOTENT STEM CELL; PROGENY; SINGLE CELL ANALYSIS; TISSUE ENGINEERING; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS;

EID: 84976619586     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12981     Document Type: Article
Times cited : (23)

References (78)
  • 1
    • 56549128268 scopus 로고    scopus 로고
    • Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    • Wilson, A, E. Laurenti, G. Oser, et al. 2008. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135: 1118–1129.
    • (2008) Cell , vol.135 , pp. 1118-1129
    • Wilson, A.1    Laurenti, E.2    Oser, G.3
  • 2
    • 60149104597 scopus 로고    scopus 로고
    • Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells
    • Foudi, A, K. Hochedlinger, D. Van Buren, et al. 2009. Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat. Biotechnol. 27: 84–90.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 84-90
    • Foudi, A.1    Hochedlinger, K.2    Van Buren, D.3
  • 3
    • 79951698622 scopus 로고    scopus 로고
    • Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation
    • Takizawa, H, R.R. Regoes, C.S. Boddupalli, et al. 2011. Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation. J. Exp. Med. 208: 273–284.
    • (2011) J. Exp. Med. , vol.208 , pp. 273-284
    • Takizawa, H.1    Regoes, R.R.2    Boddupalli, C.S.3
  • 4
    • 84919360111 scopus 로고    scopus 로고
    • The analysis, roles and regulation of quiescence in hematopoietic stem cells
    • Nakamura-Ishizu, A, H. Takizawa & T. Suda . 2014. The analysis, roles and regulation of quiescence in hematopoietic stem cells. Development 141: 4656–4666.
    • (2014) Development , vol.141 , pp. 4656-4666
    • Nakamura-Ishizu, A.1    Takizawa, H.2    Suda, T.3
  • 5
    • 84896929687 scopus 로고    scopus 로고
    • Metabolic requirements for the maintenance of self-renewing stem cells
    • Ito, K. & T. Suda . 2014. Metabolic requirements for the maintenance of self-renewing stem cells. Nat. Rev. Mol. Cell Biol. 15: 243–256.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 243-256
    • Ito, K.1    Suda, T.2
  • 6
    • 84928923099 scopus 로고    scopus 로고
    • Making sense of hematopoietic stem cell niches
    • Boulais, P.E. & P.S. Frenette . 2015. Making sense of hematopoietic stem cell niches. Blood 125: 2621–2629.
    • (2015) Blood , vol.125 , pp. 2621-2629
    • Boulais, P.E.1    Frenette, P.S.2
  • 7
    • 84856738988 scopus 로고    scopus 로고
    • Hematopoiesis: a human perspective
    • Doulatov, S, F. Notta, E. Laurenti, et al. 2012. Hematopoiesis: a human perspective. Cell Stem Cell 10: 120–136.
    • (2012) Cell Stem Cell , vol.10 , pp. 120-136
    • Doulatov, S.1    Notta, F.2    Laurenti, E.3
  • 8
    • 36749098400 scopus 로고    scopus 로고
    • Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood
    • Majeti, R, C.Y. Park & I.L. Weissman . 2007. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1: 635–645.
    • (2007) Cell Stem Cell , vol.1 , pp. 635-645
    • Majeti, R.1    Park, C.Y.2    Weissman, I.L.3
  • 9
    • 77953754015 scopus 로고    scopus 로고
    • Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development
    • Doulatov, S, F. Notta, K. Eppert, et al. 2010. Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nat. Immunol. 11: 585–593.
    • (2010) Nat. Immunol. , vol.11 , pp. 585-593
    • Doulatov, S.1    Notta, F.2    Eppert, K.3
  • 10
    • 78651416188 scopus 로고    scopus 로고
    • Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia
    • Goardon, N, E. Marchi, A. Atzberger, et al. 2011. Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia. Cancer Cell 19: 138–152.
    • (2011) Cancer Cell , vol.19 , pp. 138-152
    • Goardon, N.1    Marchi, E.2    Atzberger, A.3
  • 11
    • 84866565243 scopus 로고    scopus 로고
    • Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin
    • Kohn, L.A, Q.-L. Hao, R. Sasidharan, et al. 2012. Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. Nat. Immunol. 13: 963–971.
    • (2012) Nat. Immunol. , vol.13 , pp. 963-971
    • Kohn, L.A.1    Hao, Q.-L.2    Sasidharan, R.3
  • 12
    • 79960106880 scopus 로고    scopus 로고
    • Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment
    • Notta, F, S. Doulatov, E. Laurenti, et al. 2011. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 333: 218–221.
    • (2011) Science , vol.333 , pp. 218-221
    • Notta, F.1    Doulatov, S.2    Laurenti, E.3
  • 13
    • 78651486442 scopus 로고    scopus 로고
    • Densely interconnected transcriptional circuits control cell states in human hematopoiesis
    • Novershtern, N, A. Subramanian, L.N. Lawton, et al. 2011. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell 144: 296–309.
    • (2011) Cell , vol.144 , pp. 296-309
    • Novershtern, N.1    Subramanian, A.2    Lawton, L.N.3
  • 14
    • 78650444882 scopus 로고    scopus 로고
    • Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia
    • Gentles, A.J, S.K. Plevritis, R. Majeti & A.A. Alizadeh . Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA 304: 2706–2715.
    • JAMA , vol.304 , pp. 2706-2715
    • Gentles, A.J.1    Plevritis, S.K.2    Majeti, R.3    Alizadeh, A.A.4
  • 15
    • 84879421185 scopus 로고    scopus 로고
    • The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment
    • Laurenti, E, S. Doulatov, S. Zandi, et al. 2013. The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment. Nat. Immunol. 14: 756–763.
    • (2013) Nat. Immunol. , vol.14 , pp. 756-763
    • Laurenti, E.1    Doulatov, S.2    Zandi, S.3
  • 16
    • 84907916620 scopus 로고    scopus 로고
    • Transcriptional diversity during lineage commitment of human blood progenitors
    • Chen, L, M. Kostadima, J.H.A. Martens, et al. 2014. Transcriptional diversity during lineage commitment of human blood progenitors. Science 345: 1251033.
    • (2014) Science , vol.345 , pp. 1251033
    • Chen, L.1    Kostadima, M.2    Martens, J.H.A.3
  • 17
    • 35848943273 scopus 로고    scopus 로고
    • Hematopoietic fingerprints: an expression database of stem cells and their progeny
    • Chambers, S.M, N.C. Boles, K.-Y.K. Lin, et al. 2007. Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell 1: 578–591.
    • (2007) Cell Stem Cell , vol.1 , pp. 578-591
    • Chambers, S.M.1    Boles, N.C.2    Lin, K.-Y.K.3
  • 18
    • 84883894867 scopus 로고    scopus 로고
    • Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells
    • Gazit, R, B.S. Garrison, T.N. Rao, et al. 2013. Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells. Stem Cell Rep. 1: 266–280.
    • (2013) Stem Cell Rep , vol.1 , pp. 266-280
    • Gazit, R.1    Garrison, B.S.2    Rao, T.N.3
  • 19
    • 77956233247 scopus 로고    scopus 로고
    • A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal
    • Milyavsky, M, O.I. Gan, M. Trottier, et al. 2010. A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell 7: 186–197.
    • (2010) Cell Stem Cell , vol.7 , pp. 186-197
    • Milyavsky, M.1    Gan, O.I.2    Trottier, M.3
  • 20
    • 77956251480 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
    • Mohrin, M, E. Bourke, D. Alexander, et al. 2010. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell 7: 174–185.
    • (2010) Cell Stem Cell , vol.7 , pp. 174-185
    • Mohrin, M.1    Bourke, E.2    Alexander, D.3
  • 21
    • 84902343044 scopus 로고    scopus 로고
    • The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress
    • van Galen, P, A. Kreso, N. Mbong, et al. 2014. The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress. Nature 510: 268–272.
    • (2014) Nature , vol.510 , pp. 268-272
    • van Galen, P.1    Kreso, A.2    Mbong, N.3
  • 22
    • 84902343965 scopus 로고    scopus 로고
    • Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress
    • Miharada, K, V. Sigurdsson & S. Karlsson . 2014. Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress. Cell Rep. 7: 1381–1392.
    • (2014) Cell Rep , vol.7 , pp. 1381-1392
    • Miharada, K.1    Sigurdsson, V.2    Karlsson, S.3
  • 23
    • 77958542905 scopus 로고    scopus 로고
    • Load and lock: the molecular mechanisms of B-lymphocyte commitment
    • Zandi, S, D. Bryder & M. Sigvardsson . 2010. Load and lock: the molecular mechanisms of B-lymphocyte commitment. Immunol. Rev. 238: 47–62.
    • (2010) Immunol. Rev. , vol.238 , pp. 47-62
    • Zandi, S.1    Bryder, D.2    Sigvardsson, M.3
  • 24
    • 84891687999 scopus 로고    scopus 로고
    • Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion
    • van Galen, P, A. Kreso, E. Wienholds, et al. 2014. Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion. Cell Stem Cell 14: 94–106.
    • (2014) Cell Stem Cell , vol.14 , pp. 94-106
    • van Galen, P.1    Kreso, A.2    Wienholds, E.3
  • 25
    • 84922605057 scopus 로고    scopus 로고
    • A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells
    • Beer, P.A, D.J.H.F. Knapp, N. Kannan, et al. A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells. Stem Cell Rep. 3: 841–857.
    • Stem Cell Rep , vol.3 , pp. 841-857
    • Beer, P.A.1    Knapp, D.J.H.F.2    Kannan, N.3
  • 26
    • 84922541996 scopus 로고    scopus 로고
    • Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis
    • Cabezas-Wallscheid, N, D. Klimmeck, J. Hansson, et al. 2014. Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis. Cell Stem Cell 15: 507–522.
    • (2014) Cell Stem Cell , vol.15 , pp. 507-522
    • Cabezas-Wallscheid, N.1    Klimmeck, D.2    Hansson, J.3
  • 27
    • 84924284076 scopus 로고    scopus 로고
    • CDK6 levels regulate quiescence exit in human hematopoietic stem cells
    • Laurenti, E, C. Frelin, S. Xie, et al. 2015. CDK6 levels regulate quiescence exit in human hematopoietic stem cells. Cell Stem Cell 16: 302–313.
    • (2015) Cell Stem Cell , vol.16 , pp. 302-313
    • Laurenti, E.1    Frelin, C.2    Xie, S.3
  • 28
    • 84940446838 scopus 로고    scopus 로고
    • Combined single-cell functional and gene expression analysis resolves heterogeneity within stem cell populations
    • Wilson, N.K, D.G. Kent, F. Buettner, et al. 2015. Combined single-cell functional and gene expression analysis resolves heterogeneity within stem cell populations. Cell Stem Cell 16: 712–724.
    • (2015) Cell Stem Cell , vol.16 , pp. 712-724
    • Wilson, N.K.1    Kent, D.G.2    Buettner, F.3
  • 29
    • 84956599311 scopus 로고    scopus 로고
    • Single cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells
    • Kowalczyk, M.S, I. Tirosh, D. Heckl, et al. 2015. Single cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells. Genome Res. doi:10.1101/gr.192237.115
    • (2015) Genome Res
    • Kowalczyk, M.S.1    Tirosh, I.2    Heckl, D.3
  • 30
    • 84941929935 scopus 로고    scopus 로고
    • Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells
    • Tsang, J.C, Y. Yu, S. Burke, et al. 2015. Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells. Genome Biol. 16: 178.
    • (2015) Genome Biol , vol.16 , pp. 178
    • Tsang, J.C.1    Yu, Y.2    Burke, S.3
  • 31
    • 84905815023 scopus 로고    scopus 로고
    • Kit regulates HSC engraftment across the human-mouse species barrier
    • Cosgun, K.N, S. Rahmig, N. Mende, et al. 2014. Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell 15: 227–238.
    • (2014) Cell Stem Cell , vol.15 , pp. 227-238
    • Cosgun, K.N.1    Rahmig, S.2    Mende, N.3
  • 32
    • 84926260800 scopus 로고    scopus 로고
    • Long non-coding RNAs control hematopoietic stem cell function
    • Luo, M, M. Jeong, D. Sun, et al. 2015. Long non-coding RNAs control hematopoietic stem cell function. Cell Stem Cell 16: 426–438.
    • (2015) Cell Stem Cell , vol.16 , pp. 426-438
    • Luo, M.1    Jeong, M.2    Sun, D.3
  • 33
    • 84926163086 scopus 로고    scopus 로고
    • The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells
    • Ramos, A.D, R.E. Andersen, S.J. Liu, et al. 2015. The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells. Cell Stem Cell 16: 439–447.
    • (2015) Cell Stem Cell , vol.16 , pp. 439-447
    • Ramos, A.D.1    Andersen, R.E.2    Liu, S.J.3
  • 34
    • 84920730997 scopus 로고    scopus 로고
    • Single-cell transcriptome analysis reveals dynamic changes in lncRNA expression during reprogramming
    • Kim, D.H, G.K. Marinov, S. Pepke, et al. 2015. Single-cell transcriptome analysis reveals dynamic changes in lncRNA expression during reprogramming. Cell Stem Cell 16: 88–101.
    • (2015) Cell Stem Cell , vol.16 , pp. 88-101
    • Kim, D.H.1    Marinov, G.K.2    Pepke, S.3
  • 35
    • 80052223272 scopus 로고    scopus 로고
    • An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming
    • Gabut, M, P. Samavarchi-Tehrani, X. Wang, et al. 2011. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell 147: 132–146.
    • (2011) Cell , vol.147 , pp. 132-146
    • Gabut, M.1    Samavarchi-Tehrani, P.2    Wang, X.3
  • 36
    • 84884682635 scopus 로고    scopus 로고
    • Modeling human hematopoietic stem cell biology in the mouse
    • Sykes, S.M. & D.T. Scadden . 2013. Modeling human hematopoietic stem cell biology in the mouse. Semin. Hematol. 50: 92–100.
    • (2013) Semin. Hematol. , vol.50 , pp. 92-100
    • Sykes, S.M.1    Scadden, D.T.2
  • 37
    • 84874235360 scopus 로고    scopus 로고
    • Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes
    • Pang, W.W, J.V. Pluvinage, E.A. Price, et al. 2013. Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes. Proc. Natl. Acad. Sci. U.S.A. 110: 3011–3016.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 3011-3016
    • Pang, W.W.1    Pluvinage, J.V.2    Price, E.A.3
  • 38
    • 84876909069 scopus 로고    scopus 로고
    • The ageing haematopoietic stem cell compartment
    • Geiger, H, G. de Haan & M.C. Florian . 2013. The ageing haematopoietic stem cell compartment. Nat. Rev. Immunol. 13: 376–389.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 376-389
    • Geiger, H.1    de Haan, G.2    Florian, M.C.3
  • 39
    • 84906254220 scopus 로고    scopus 로고
    • Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
    • Flach, J, S.T. Bakker, M. Mohrin, et al. 2014. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature 512: 198–202.
    • (2014) Nature , vol.512 , pp. 198-202
    • Flach, J.1    Bakker, S.T.2    Mohrin, M.3
  • 40
    • 84875965163 scopus 로고    scopus 로고
    • Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    • Beerman, I, C. Bock, B.S. Garrison, et al. 2013. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell 12: 413–425.
    • (2013) Cell Stem Cell , vol.12 , pp. 413-425
    • Beerman, I.1    Bock, C.2    Garrison, B.S.3
  • 41
    • 21544467270 scopus 로고    scopus 로고
    • Cell intrinsic alterations underlie hematopoietic stem cell aging
    • Rossi, D.J, D. Bryder, J.M. Zahn, et al. 2005. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc. Natl. Acad. Sci. U. S. A. 102: 9194–9199.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 9194-9199
    • Rossi, D.J.1    Bryder, D.2    Zahn, J.M.3
  • 42
    • 84865369147 scopus 로고    scopus 로고
    • DNA methylation dynamics during in vivo differentiation of blood and skin stem cells
    • Bock, C, I. Beerman, W.-H. Lien, et al. 2012. DNA methylation dynamics during in vivo differentiation of blood and skin stem cells. Mol. Cell 47: 633–647.
    • (2012) Mol. Cell , vol.47 , pp. 633-647
    • Bock, C.1    Beerman, I.2    Lien, W.-H.3
  • 43
    • 79955970344 scopus 로고    scopus 로고
    • Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging
    • Bocker, M.T, I. Hellwig, A. Breiling, et al. 2011. Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging. Blood 117: e182–e189.
    • (2011) Blood , vol.117 , pp. e182-e189
    • Bocker, M.T.1    Hellwig, I.2    Breiling, A.3
  • 44
    • 84899768899 scopus 로고    scopus 로고
    • Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal
    • Sun, D, M. Luo, M. Jeong, et al. 2014. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell 14: 673–688.
    • (2014) Cell Stem Cell , vol.14 , pp. 673-688
    • Sun, D.1    Luo, M.2    Jeong, M.3
  • 45
    • 58049191558 scopus 로고    scopus 로고
    • Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
    • Cui, K, C. Zang, T.-Y. Roh, et al. 2009. Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell 4: 80–93.
    • (2009) Cell Stem Cell , vol.4 , pp. 80-93
    • Cui, K.1    Zang, C.2    Roh, T.-Y.3
  • 46
    • 75649147458 scopus 로고    scopus 로고
    • Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells
    • Weishaupt, H, M. Sigvardsson & J.L. Attema . 2010. Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells. Blood 115: 247–256.
    • (2010) Blood , vol.115 , pp. 247-256
    • Weishaupt, H.1    Sigvardsson, M.2    Attema, J.L.3
  • 47
    • 84907419194 scopus 로고    scopus 로고
    • Chromatin state dynamics during blood formation
    • Lara-Astiaso, D, A. Weiner, E. Lorenzo-Vivas, et al. 2014. Chromatin state dynamics during blood formation. Science 345: 943–949.
    • (2014) Science , vol.345 , pp. 943-949
    • Lara-Astiaso, D.1    Weiner, A.2    Lorenzo-Vivas, E.3
  • 48
    • 83855163414 scopus 로고    scopus 로고
    • Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence
    • Wittkopp, P.J. & G. Kalay . 2012. Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence. Nat. Rev. Genet. 13: 59–69.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 59-69
    • Wittkopp, P.J.1    Kalay, G.2
  • 49
    • 84920053873 scopus 로고    scopus 로고
    • Age-related clonal hematopoiesis associated with adverse outcomes
    • Jaiswal, S, P. Fontanillas, J. Flannick, et al. 2014. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371: 2488–2498.
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2488-2498
    • Jaiswal, S.1    Fontanillas, P.2    Flannick, J.3
  • 50
    • 84868208186 scopus 로고    scopus 로고
    • Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
    • Busque, L, J.P. Patel, M.E. Figueroa, et al. 2012. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat. Genet. 44: 1179–1181.
    • (2012) Nat. Genet. , vol.44 , pp. 1179-1181
    • Busque, L.1    Patel, J.P.2    Figueroa, M.E.3
  • 51
    • 84920024296 scopus 로고    scopus 로고
    • Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
    • Genovese, G, A.K. Kähler, R.E. Handsaker, et al. 2014. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N. Engl. J. Med. 371: 2477–2487.
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2477-2487
    • Genovese, G.1    Kähler, A.K.2    Handsaker, R.E.3
  • 52
    • 84930003179 scopus 로고    scopus 로고
    • Age-related mutations associated with clonal hematopoietic expansion and malignancies
    • Xie, M, C. Lu, J. Wang, et al. 2014. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat. Med. 20: 1472–1478.
    • (2014) Nat. Med. , vol.20 , pp. 1472-1478
    • Xie, M.1    Lu, C.2    Wang, J.3
  • 53
    • 84924620531 scopus 로고    scopus 로고
    • Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis
    • McKerrell, T, N. Park, T. Moreno, et al. 2015. Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis. Cell Rep. 10: 1239–1245.
    • (2015) Cell Rep , vol.10 , pp. 1239-1245
    • McKerrell, T.1    Park, N.2    Moreno, T.3
  • 54
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick, J.E. 2008. Stem cell concepts renew cancer research. Blood 112: 4793–4807.
    • (2008) Blood , vol.112 , pp. 4793-4807
    • Dick, J.E.1
  • 55
    • 78751676408 scopus 로고    scopus 로고
    • Cells of origin in cancer
    • Visvader, J.E. 2011. Cells of origin in cancer. Nature 469: 314–322.
    • (2011) Nature , vol.469 , pp. 314-322
    • Visvader, J.E.1
  • 56
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • Kreso, A. & J.E. Dick . 2014. Evolution of the cancer stem cell model. Cell Stem Cell 14: 275–291.
    • (2014) Cell Stem Cell , vol.14 , pp. 275-291
    • Kreso, A.1    Dick, J.E.2
  • 57
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet, D. & J.E. Dick . 1997. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3: 730–737.
    • (1997) Nat. Med. , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 59
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot, T, C. Sirard, J. Vormoor, et al. 1994. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367: 645–648.
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 60
    • 80052468964 scopus 로고    scopus 로고
    • Stem cell gene expression programs influence clinical outcome in human leukemia
    • Eppert, K, K. Takenaka, E.R. Lechman, et al. 2011. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat. Med. 17: 1086–1093.
    • (2011) Nat. Med. , vol.17 , pp. 1086-1093
    • Eppert, K.1    Takenaka, K.2    Lechman, E.R.3
  • 61
    • 77957995156 scopus 로고    scopus 로고
    • + cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice
    • + cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice. Blood 116: 3907–3922.
    • (2010) Blood , vol.116 , pp. 3907-3922
    • Martelli, M.P.1    Pettirossi, V.2    Thiede, C.3
  • 62
    • 50949090415 scopus 로고    scopus 로고
    • Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells
    • Taussig, D.C, F. Miraki-Moud, F. Anjos-Afonso, et al. 2008. Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. Blood 112: 568–575.
    • (2008) Blood , vol.112 , pp. 568-575
    • Taussig, D.C.1    Miraki-Moud, F.2    Anjos-Afonso, F.3
  • 63
    • 78650950098 scopus 로고    scopus 로고
    • Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL-2Rγc-deficient mice
    • Sarry, J.-E, K. Murphy, R. Perry, et al. 2011. Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL-2Rγc-deficient mice. J. Clin. Invest. 121: 384–395.
    • (2011) J. Clin. Invest. , vol.121 , pp. 384-395
    • Sarry, J.-E.1    Murphy, K.2    Perry, R.3
  • 64
    • 62549160065 scopus 로고    scopus 로고
    • Dysregulated gene expression networks in human acute myelogenous leukemia stem cells
    • Majeti, R, M.W. Becker, Q. Tian, et al. 2009. Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc. Natl. Acad. Sci. U.S.A. 106: 3396–3401.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 3396-3401
    • Majeti, R.1    Becker, M.W.2    Tian, Q.3
  • 65
    • 77749294821 scopus 로고    scopus 로고
    • Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells
    • Saito, Y, H. Kitamura, A. Hijikata, et al. 2010. Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Sci. Transl. Med. 2: 17ra9.
    • (2010) Sci. Transl. Med. , vol.2 , pp. 17
    • Saito, Y.1    Kitamura, H.2    Hijikata, A.3
  • 66
    • 84865183566 scopus 로고    scopus 로고
    • Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS
    • Barreyro, L, B. Will, B. Bartholdy, et al. 2012. Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. Blood 120: 1290–1298.
    • (2012) Blood , vol.120 , pp. 1290-1298
    • Barreyro, L.1    Will, B.2    Bartholdy, B.3
  • 67
    • 33749440584 scopus 로고    scopus 로고
    • Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
    • Somervaille, T.C.P. & M.L. Cleary . 2006. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 10: 257–268.
    • (2006) Cancer Cell , vol.10 , pp. 257-268
    • Somervaille, T.C.P.1    Cleary, M.L.2
  • 68
    • 84939463901 scopus 로고    scopus 로고
    • The H3K4-methyl epigenome regulates leukemia stem cell oncogenic potential
    • Wong, S.H.K, D.L. Goode, M. Iwasaki, et al. 2015. The H3K4-methyl epigenome regulates leukemia stem cell oncogenic potential. Cancer Cell 28: 198–209.
    • (2015) Cancer Cell , vol.28 , pp. 198-209
    • Wong, S.H.K.1    Goode, D.L.2    Iwasaki, M.3
  • 69
    • 84934442835 scopus 로고    scopus 로고
    • Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis
    • Levine, J.H, E.F. Simonds, S.C. Bendall, et al. 2015. Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis. Cell 162: 184–197.
    • (2015) Cell , vol.162 , pp. 184-197
    • Levine, J.H.1    Simonds, E.F.2    Bendall, S.C.3
  • 70
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov, L.B, S. Nik-Zainal, D.C. Wedge, et al. 2013. Signatures of mutational processes in human cancer. Nature 500: 415–421.
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1    Nik-Zainal, S.2    Wedge, D.C.3
  • 71
    • 77957348625 scopus 로고    scopus 로고
    • Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators
    • Wilson, N.K, S.D. Foster, X. Wang, et al. 2010. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell 7: 532–544.
    • (2010) Cell Stem Cell , vol.7 , pp. 532-544
    • Wilson, N.K.1    Foster, S.D.2    Wang, X.3
  • 72
    • 84877930760 scopus 로고    scopus 로고
    • Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia
    • Diffner, E, D. Beck, E. Gudgin, et al. 2013. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia. Blood 121: 2289–2300.
    • (2013) Blood , vol.121 , pp. 2289-2300
    • Diffner, E.1    Beck, D.2    Gudgin, E.3
  • 73
    • 78149356747 scopus 로고    scopus 로고
    • Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia
    • Müller-Tidow, C, H.-U. Klein, A. Hascher, et al. 2010. Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia. Blood 116: 3564–3571.
    • (2010) Blood , vol.116 , pp. 3564-3571
    • Müller-Tidow, C.1    Klein, H.-U.2    Hascher, A.3
  • 74
    • 84899780589 scopus 로고    scopus 로고
    • Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin
    • Moti, N, T. Malcolm, R. Hamoudi, et al. 2014. Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin. Oncogene 34: 1843–1852.
    • (2014) Oncogene , vol.34 , pp. 1843-1852
    • Moti, N.1    Malcolm, T.2    Hamoudi, R.3
  • 75
    • 84862907593 scopus 로고    scopus 로고
    • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
    • Zhang, J, L. Ding, L. Holmfeldt, et al. 2012. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481: 157–163.
    • (2012) Nature , vol.481 , pp. 157-163
    • Zhang, J.1    Ding, L.2    Holmfeldt, L.3
  • 76
    • 84875548150 scopus 로고    scopus 로고
    • Human hemato-lymphoid system mice: current use and future potential for medicine
    • Rongvaux, A, H. Takizawa, T. Strowig, et al. 2013. Human hemato-lymphoid system mice: current use and future potential for medicine. Annu. Rev. Immunol. 31: 635–674.
    • (2013) Annu. Rev. Immunol. , vol.31 , pp. 635-674
    • Rongvaux, A.1    Takizawa, H.2    Strowig, T.3
  • 77
    • 84928524428 scopus 로고    scopus 로고
    • Xenograft models for normal and malignant stem cells
    • Goyama, S, M. Wunderlich & J.C. Mulloy . 2015. Xenograft models for normal and malignant stem cells. Blood 125: 2630–2640.
    • (2015) Blood , vol.125 , pp. 2630-2640
    • Goyama, S.1    Wunderlich, M.2    Mulloy, J.C.3
  • 78
    • 84928910821 scopus 로고    scopus 로고
    • De novo generation of HSCs from somatic and pluripotent stem cell sources
    • Vo, L.T. & G.Q. Daley . 2015. De novo generation of HSCs from somatic and pluripotent stem cell sources. Blood 125: 2641–2648.
    • (2015) Blood , vol.125 , pp. 2641-2648
    • Vo, L.T.1    Daley, G.Q.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.