Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells

Genome Biology

Volumn 16, Issue 1, 2015, Pages

  Tsang, Jason C H ^a   Yu, Yong ^a   Burke, Shannon ^a   Buettner, Florian ^c,e   Wang, Cui ^a   Kolodziejczyk, Aleksandra A ^a,c   Teichmann, Sarah A ^a,c   Lu, Liming ^a,d   Liu, Pentao ^a,b  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BCL 11A; TRANSCRIPTOME; UNCLASSIFIED DRUG; BCL11A PROTEIN, MOUSE; CARRIER PROTEIN; NUCLEAR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL COMPARTMENTALIZATION; CELL CYCLE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL LINEAGE; CELL RENEWAL; CELL SUBPOPULATION; COMPUTER MODEL; CONTROLLED STUDY; ERYTHROID CELL; GENE DELETION; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PHENOTYPE; PURIFICATION; RNA SEQUENCE; SINGLE CELL ANALYSIS; TRANSCRIPTOMICS; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; GENETICS; LYMPHOPOIESIS; METABOLISM;

ANIMALS; CARRIER PROTEINS; CELL CYCLE; CELL LINEAGE; CELL PROLIFERATION; CELLS, CULTURED; HEMATOPOIETIC STEM CELLS; LYMPHOPOIESIS; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; PHENOTYPE; SINGLE-CELL ANALYSIS; TRANSCRIPTOME;

EID: 84941929935     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-015-0739-5     Document Type: Article

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