Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

Blood

Volumn 121, Issue 12, 2013, Pages 2289-2300

  Diffner, Eva ^a   Beck, Dominik ^a   Gudgin, Emma ^b   Thoms, Julie A I ^a   Knezevic, Kathy ^a   Pridans, Clare ^b   Foster, Sam ^b   Goode, Debbie ^b   Lim, Weng Khong ^c,d   Boelen, Lies ^a   Metzeler, Klaus H ^e   Micklem, Gos ^c,d   Bohlander, Stefan K ^e,f   Buske, Christian ^g   Burnett, Alan ^d   Ottersbach, Katrin ^b,h   Vassiliou, George S ⁱ   Olivier, Jake ^a   Wong, Jason W H ^a   Göttgens, Berthold ^b,h   Huntly, Brian J ^b,h   Pimanda, John E ^a   more..

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^f UNIVERSITY HOSPITAL ULM   (Germany)

^g CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^h PHILIPPS UNIVERSITY MARBURG   (Germany)

ⁱ WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ERG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ERG PROTEIN, HUMAN; FLI1 PROTEIN, HUMAN; GATA2 PROTEIN, HUMAN; LIM PROTEIN; LMO2 PROTEIN, HUMAN; LYL1 PROTEIN, HUMAN; ONCOPROTEIN; RUNX1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TAL1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR FLI 1; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR RUNX1; TUMOR PROTEIN;

ACUTE MYELOID LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL OUTCOME; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION; GENE MUTATION; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SOMATIC MUTATION; STEM CELL; TRANSCRIPTION REGULATION; ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL; CANCER STEM CELL; CELL CULTURE; CELL STRAIN K 562; GENE EXPRESSION REGULATION; GENETICS; HEMATOPOIETIC STEM CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 2 SUBUNIT; ENHANCER ELEMENTS, GENETIC; GATA2 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, LEUKEMIC; HEMATOPOIETIC STEM CELLS; HUMANS; K562 CELLS; LEUKEMIA, MYELOID, ACUTE; LIM DOMAIN PROTEINS; MICE; MICE, TRANSGENIC; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; PROGNOSIS; PROTO-ONCOGENE PROTEIN C-FLI-1; PROTO-ONCOGENE PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

MLCS; MLOWN;

EID: 84877930760     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-07-446120     Document Type: Article

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