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Volumn 304, Issue 24, 2010, Pages 2706-2715

Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CELL MARKER;

EID: 78650444882     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2010.1862     Document Type: Article
Times cited : (325)

References (55)
  • 1
    • 33751267902 scopus 로고    scopus 로고
    • Acute myeloid leukaemia
    • Estey E, Döhner H. Acute myeloid leukaemia. Lancet. 2006;368(9550):1894-1907.
    • (2006) Lancet , vol.368 , Issue.9550 , pp. 1894-1907
    • Estey, E.1    Döhner, H.2
  • 3
    • 0037114753 scopus 로고    scopus 로고
    • Cancer and Leukemia Group B (CALGB 8461). Pretreatment cytogenetic abnormalities are predictive of induction success cumulative incidence of relapse and overall survival in adult patients with de novo acute myeloid leukemia
    • Byrd JC, Mrózek K, Dodge RK, et al; Cancer and Leukemia Group B (CALGB 8461). Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia. Blood. 2002;100(13):4325-4336.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4325-4336
    • Byrd, J.C.1    Mrózek, K.2    Dodge, R.K.3
  • 4
    • 0032188805 scopus 로고    scopus 로고
    • Medical research council adult and children's leukaemia working parties. The importance of diagnostic cytogenetics on outcome in AML
    • Grimwade D, Walker H, Oliver F, et al; Medical Research Council Adult and Children's Leukaemia Working Parties. The importance of diagnostic cytogenetics on outcome in AML. Blood. 1998;92(7): 2322-2333.
    • (1998) Blood , vol.92 , Issue.7 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 5
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics
    • Mrózek K, Marcucci G, Paschka P, et al. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics. Blood. 2007;109(2):431-448.
    • (2007) Blood , vol.109 , Issue.2 , pp. 431-448
    • Mrózek, K.1    Marcucci, G.2    Paschka, P.3
  • 6
    • 42949142189 scopus 로고    scopus 로고
    • German- Austrian Acute Myeloid Leukemia Study Group. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    • Schlenk RF, Döhner K, Krauter J, et al; German- Austrian Acute Myeloid Leukemia Study Group. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med. 2008; 358(18):1909-1918.
    • (2008) N Engl J Med , vol.358 , Issue.18 , pp. 1909-1918
    • Schlenk, R.F.1    Döhner, K.2    Krauter, J.3
  • 8
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya T, Morrison SJ, Clarke MF,Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001; 414(6859):105-111.
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke Mfweissman, I.L.3
  • 9
    • 25144455560 scopus 로고    scopus 로고
    • Stem cell research
    • Weissman I. Stem cell research. JAMA. 2005; 294(11):1359-1366.
    • (2005) JAMA , vol.294 , Issue.11 , pp. 1359-1366
    • Weissman, I.1
  • 10
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick JE. Stem cell concepts renew cancer research. Blood. 2008;112(13):4793-4807.
    • (2008) Blood , vol.112 , Issue.13 , pp. 4793-4807
    • Dick, J.E.1
  • 11
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3 (7):730-737.
    • (1997) Nat Med , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 12
    • 62549160065 scopus 로고    scopus 로고
    • Dysregulated gene expression networks in human acute myelogenous leukemia stem cells
    • Majeti R, Becker MW, Tian Q, et al. Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A. 2009;106(9):3396-3401.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.9 , pp. 3396-3401
    • Majeti, R.1    Becker, M.W.2    Tian, Q.3
  • 13
    • 35948984135 scopus 로고    scopus 로고
    • Chemotherapy- resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
    • Ishikawa F, Yoshida S, Saito Y, et al. Chemotherapy- resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol. 2007;25(11):1315-1321.
    • (2007) Nat Biotechnol , vol.25 , Issue.11 , pp. 1315-1321
    • Ishikawa, F.1    Yoshida, S.2    Saito, Y.3
  • 14
    • 0038054341 scopus 로고    scopus 로고
    • PGC- 1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha VK, Lindgren CM, Eriksson KF, et al. PGC- 1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003;34(3):267-273.
    • (2003) Nat Genet , vol.34 , Issue.3 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3
  • 15
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A. 2001;98(9): 5116-5121.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.9 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 16
    • 57449103508 scopus 로고    scopus 로고
    • Cancer and Leukemia Group B; German AML Cooperative Group. An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia
    • Metzeler KH, Hummel M, Bloomfield CD, et al; Cancer and Leukemia Group B; German AML Cooperative Group. An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia. Blood. 2008;112(10):4193-4201.
    • (2008) Blood , vol.112 , Issue.10 , pp. 4193-4201
    • Metzeler, K.H.1    Hummel, M.2    Bloomfield, C.D.3
  • 17
    • 47149087181 scopus 로고    scopus 로고
    • Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia
    • Tomasson MH, Xiang Z, Walgren R, et al. Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood. 2008;111 (9):4797-4808.
    • (2008) Blood , vol.111 , Issue.9 , pp. 4797-4808
    • Tomasson, M.H.1    Xiang, Z.2    Walgren, R.3
  • 18
    • 33745957993 scopus 로고    scopus 로고
    • Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction
    • Wilson CS, Davidson GS, Martin SB, et al. Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood. 2006;108(2):685-696.
    • (2006) Blood , vol.108 , Issue.2 , pp. 685-696
    • Wilson, C.S.1    Davidson, G.S.2    Martin, S.B.3
  • 19
    • 63849241865 scopus 로고    scopus 로고
    • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
    • Wouters BJ, Löwenberg B, Erpelinck-Verschueren CA, et al. Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood. 2009;113(13):3088-3091.
    • (2009) Blood , vol.113 , Issue.13 , pp. 3088-3091
    • Wouters, B.J.1    Löwenberg, B.2    Erpelinck-Verschueren, C.A.3
  • 20
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009;361(11):1058- 1066.
    • (2009) N Engl J Med , vol.361 , Issue.11 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 21
    • 16844363378 scopus 로고    scopus 로고
    • The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
    • Guzman ML, Rossi RM, Karnischky L, et al. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood. 2005;105(11):4163-4169.
    • (2005) Blood , vol.105 , Issue.11 , pp. 4163-4169
    • Guzman, M.L.1    Rossi, R.M.2    Karnischky, L.3
  • 22
    • 77449159028 scopus 로고    scopus 로고
    • European LeukemiaNet. Diagnosis and management of acute myeloid leukemia in adults
    • Döhner H, Estey EH, Amadori S, et al; European LeukemiaNet. Diagnosis and management of acute myeloid leukemia in adults. Blood. 2010;115(3): 453-474.
    • (2010) Blood , vol.115 , Issue.3 , pp. 453-474
    • Döhner, H.1    Estey, E.H.2    Amadori, S.3
  • 24
    • 0033936550 scopus 로고    scopus 로고
    • Timedependent ROC curves for censored survival data and a diagnostic marker
    • Heagerty PJ, Lumley T, Pepe MS. Timedependent ROC curves for censored survival data and a diagnostic marker. Biometrics. 2000;56(2):337-344.
    • (2000) Biometrics , vol.56 , Issue.2 , pp. 337-344
    • Heagerty, P.J.1    Lumley, T.2    Pepe, M.S.3
  • 25
    • 45949110015 scopus 로고    scopus 로고
    • Cancer and Leukemia Group B (CALGB). High BAALC expression associates with other molecular prognostic markers poor outcome and a distinct geneexpression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia
    • Langer C, Radmacher MD, Ruppert AS, et al; Cancer and Leukemia Group B (CALGB). High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct geneexpression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia. Blood. 2008;111(11):5371-5379.
    • (2008) Blood , vol.111 , Issue.11 , pp. 5371-5379
    • Langer, C.1    Radmacher, M.D.2    Ruppert, A.S.3
  • 26
    • 11144358111 scopus 로고    scopus 로고
    • Prognostically useful gene-expression profiles in acute myeloid leukemia
    • Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med. 2004;350(16):1617-1628.
    • (2004) N Engl J Med , vol.350 , Issue.16 , pp. 1617-1628
    • Valk, P.J.1    Verhaak, R.G.2    Beijen, M.A.3
  • 27
    • 77449146413 scopus 로고    scopus 로고
    • Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome
    • Dufour A, Schneider F, Metzeler KH, et al. Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome. J Clin Oncol. 2010;28(4):570-577.
    • (2010) J Clin Oncol , vol.28 , Issue.4 , pp. 570-577
    • Dufour, A.1    Schneider, F.2    Metzeler, K.H.3
  • 28
    • 0023580075 scopus 로고
    • Minimally differentiated acute nonlymphocytic leukemia
    • Lee EJ, Pollak A, Leavitt RD, et al. Minimally differentiated acute nonlymphocytic leukemia. Blood. 1987;70(5):1400-1406.
    • (1987) Blood , vol.70 , Issue.5 , pp. 1400-1406
    • Lee, E.J.1    Pollak, A.2    Leavitt, R.D.3
  • 29
    • 0032865742 scopus 로고    scopus 로고
    • The immunophenotype of minimally differentiated acute myeloid leukemia (AML-M0)
    • Costello R, Mallet F, Chambost H, et al. The immunophenotype of minimally differentiated acute myeloid leukemia (AML-M0). Leukemia. 1999;13 (10):1513-1518.
    • (1999) Leukemia , vol.13 , Issue.10 , pp. 1513-1518
    • Costello, R.1    Mallet, F.2    Chambost, H.3
  • 30
    • 71749121612 scopus 로고    scopus 로고
    • Regulating the leukaemia stem cell
    • Cleary ML. Regulating the leukaemia stem cell. Best Pract Res Clin Haematol. 2009;22(4):483-487.
    • (2009) Best Pract Res Clin Haematol , vol.22 , Issue.4 , pp. 483-487
    • Cleary, M.L.1
  • 31
    • 77950451485 scopus 로고    scopus 로고
    • Leukemia- initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction
    • Taussig DC, Vargaftig J, Miraki-Moud F, et al. Leukemia- initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction. Blood. 2010;115(10):1976- 1984.
    • (2010) Blood , vol.115 , Issue.10 , pp. 1976-1984
    • Taussig, D.C.1    Vargaftig, J.2    Miraki-Moud, F.3
  • 32
    • 50949090415 scopus 로고    scopus 로고
    • Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemiainitiating cells
    • Taussig DC, Miraki-Moud F, Anjos-Afonso F, et al. Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemiainitiating cells. Blood. 2008;112(3):568-575.
    • (2008) Blood , vol.112 , Issue.3 , pp. 568-575
    • Taussig, D.C.1    Miraki-Moud, F.2    Anjos-Afonso, F.3
  • 33
    • 25144433295 scopus 로고    scopus 로고
    • High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival
    • van Rhenen A, Feller N, Kelder A, et al. High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival. Clin Cancer Res. 2005;11(18):6520-6527.
    • (2005) Clin Cancer Res , vol.11 , Issue.18 , pp. 6520-6527
    • Van Rhenen, A.1    Feller, N.2    Kelder, A.3
  • 34
    • 31544436322 scopus 로고    scopus 로고
    • AML engraftment in the NOD/SCID assay reflects the outcome of AML
    • Pearce DJ, Taussig D, Zibara K, et al. AML engraftment in the NOD/SCID assay reflects the outcome of AML. Blood. 2006;107(3):1166-1173.
    • (2006) Blood , vol.107 , Issue.3 , pp. 1166-1173
    • Pearce, D.J.1    Taussig, D.2    Zibara, K.3
  • 35
    • 67649200331 scopus 로고    scopus 로고
    • Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells
    • Jin L, Lee EM, Ramshaw HS, et al. Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell. 2009;5(1):31-42.
    • (2009) Cell Stem Cell , vol.5 , Issue.1 , pp. 31-42
    • Jin, L.1    Lee, E.M.2    Ramshaw, H.S.3
  • 36
    • 67650632683 scopus 로고    scopus 로고
    • CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    • Majeti R, Chao MP, Alizadeh AA, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. 2009;138(2):286-299.
    • (2009) Cell , vol.138 , Issue.2 , pp. 286-299
    • Majeti, R.1    Chao, M.P.2    Alizadeh, A.A.3
  • 37
    • 34948839959 scopus 로고    scopus 로고
    • The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells
    • van Rhenen A, van Dongen GA, Kelder A, et al. The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. Blood. 2007;110(7):2659-2666.
    • (2007) Blood , vol.110 , Issue.7 , pp. 2659-2666
    • Van Rhenen, A.1    Van Dongen, G.A.2    Kelder, A.3
  • 38
    • 16544369516 scopus 로고    scopus 로고
    • Use of geneexpression profiling to identify prognostic subclasses in adult acute myeloid leukemia
    • Bullinger L, Döhner K, Bair E, et al. Use of geneexpression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med. 2004; 350(16):1605-1616.
    • (2004) N Engl J Med , vol.350 , Issue.16 , pp. 1605-1616
    • Bullinger, L.1    Döhner, K.2    Bair, E.3
  • 39
    • 33846645383 scopus 로고    scopus 로고
    • The lymphocyte guard-IANs
    • Nitta T, Takahama Y. The lymphocyte guard-IANs. Trends Immunol. 2007;28(2):58-65.
    • (2007) Trends Immunol , vol.28 , Issue.2 , pp. 58-65
    • Nitta, T.1    Takahama, Y.2
  • 40
    • 34447098370 scopus 로고    scopus 로고
    • A chromatin landmark and transcription initiation at most promoters in human cells
    • Guenther MG, Levine SS, Boyer LA, et al. A chromatin landmark and transcription initiation at most promoters in human cells. Cell. 2007;130(1):77-88.
    • (2007) Cell , vol.130 , Issue.1 , pp. 77-88
    • Guenther, M.G.1    Levine, S.S.2    Boyer, L.A.3
  • 41
    • 85047694248 scopus 로고    scopus 로고
    • Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop
    • Kook H, Lepore JJ, Gitler AD, et al. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J Clin Invest. 2003;112 (6):863-871.
    • (2003) J Clin Invest , vol.112 , Issue.6 , pp. 863-871
    • Kook, H.1    Lepore, J.J.2    Gitler, A.D.3
  • 42
    • 51649126841 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma
    • Ellis L, Pan Y, Smyth GK, et al. Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. Clin Cancer Res. 2008;14(14):4500-4510.
    • (2008) Clin Cancer Res , vol.14 , Issue.14 , pp. 4500-4510
    • Ellis, L.1    Pan, Y.2    Smyth, G.K.3
  • 43
    • 0036897350 scopus 로고    scopus 로고
    • Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner
    • Lodygin D, Menssen A, Hermeking H. Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner. J Clin Invest. 2002;110(11):1717-1727.
    • (2002) J Clin Invest , vol.110 , Issue.11 , pp. 1717-1727
    • Lodygin, D.1    Menssen, A.2    Hermeking, H.3
  • 44
    • 0017333990 scopus 로고
    • CGMP stimulation of stem cell proliferation
    • Oshita AK, Rothstein G, Lonngi G. cGMP stimulation of stem cell proliferation. Blood. 1977;49 (4):585-591.
    • (1977) Blood , vol.49 , Issue.4 , pp. 585-591
    • Oshita, A.K.1    Rothstein, G.2    Lonngi, G.3
  • 45
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breastcancer cells
    • Liu R, Wang X, Chen GY, et al. The prognostic role of a gene signature from tumorigenic breastcancer cells. N Engl J Med. 2007;356(3):217-226.
    • (2007) N Engl J Med , vol.356 , Issue.3 , pp. 217-226
    • Liu, R.1    Wang, X.2    Chen, G.Y.3
  • 46
    • 70350447494 scopus 로고    scopus 로고
    • A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients
    • Gentles AJ, Alizadeh AA, Lee SI, et al. A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients. Blood. 2009;114(15):3158-3166.
    • (2009) Blood , vol.114 , Issue.15 , pp. 3158-3166
    • Gentles, A.J.1    Alizadeh, A.A.2    Lee, S.I.3
  • 47
    • 41449118521 scopus 로고    scopus 로고
    • Module map of stem cell genes guides creation of epithelial cancer stem cells
    • Wong DJ, Liu H, Ridky TW, et al. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell. 2008;2(4):333-344.
    • (2008) Cell Stem Cell , vol.2 , Issue.4 , pp. 333-344
    • Wong, D.J.1    Liu, H.2    Ridky, T.W.3
  • 48
    • 33746498580 scopus 로고    scopus 로고
    • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
    • Krivtsov AV, Twomey D, Feng Z, et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature. 2006;442(7104): 818-822.
    • (2006) Nature , vol.442 , Issue.7104 , pp. 818-822
    • Krivtsov, A.V.1    Twomey, D.2    Feng, Z.3
  • 49
    • 75649084233 scopus 로고    scopus 로고
    • A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib
    • McWeeney SK, Pemberton LC, Loriaux MM, et al. A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib. Blood. 2010;115(2):315-325.
    • (2010) Blood , vol.115 , Issue.2 , pp. 315-325
    • McWeeney, S.K.1    Pemberton, L.C.2    Loriaux, M.M.3
  • 50
    • 39649085170 scopus 로고    scopus 로고
    • Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4- thiadiazolidine, 3,5 dione (TDZD-8)
    • Guzman ML, Li X, Corbett CA, et al. Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4- thiadiazolidine, 3,5 dione (TDZD-8). Blood. 2007; 110(13):4436-4444.
    • (2007) Blood , vol.110 , Issue.13 , pp. 4436-4444
    • Guzman, M.L.1    Li, X.2    Corbett, C.A.3
  • 51
    • 70349445412 scopus 로고    scopus 로고
    • Proteomic and genetic approaches identify Syk as an AML target
    • Hahn CK, Berchuck JE, Ross KN, et al. Proteomic and genetic approaches identify Syk as an AML target. Cancer Cell. 2009;16(4):281-294.
    • (2009) Cancer Cell , vol.16 , Issue.4 , pp. 281-294
    • Hahn, C.K.1    Berchuck, J.E.2    Ross, K.N.3
  • 52
    • 47049105891 scopus 로고    scopus 로고
    • Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data
    • Hassane DC, Guzman ML, Corbett C, et al. Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data. Blood. 2008;111(12):5654-5662.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5654-5662
    • Hassane, D.C.1    Guzman, M.L.2    Corbett, C.3
  • 53
    • 33749515476 scopus 로고    scopus 로고
    • Targeting of CD44 eradicates human acute myeloid leukemic stem cells
    • Jin L, Hope KJ, Zhai Q, et al. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med. 2006;12(10):1167-1174.
    • (2006) Nat Med , vol.12 , Issue.10 , pp. 1167-1174
    • Jin, L.1    Hope, K.J.2    Zhai, Q.3
  • 54
    • 77953004083 scopus 로고    scopus 로고
    • Why most gene expression signatures of tumors have not been useful in the clinic
    • Koscielny S. Why most gene expression signatures of tumors have not been useful in the clinic. Sci Transl Med. 2010;2(14):14ps12.
    • (2010) Sci Transl Med , vol.2 , Issue.14
    • Koscielny, S.1
  • 55
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, nodenegative breast cancer
    • Paik S, Shak S, Tang G, et al. A multigene assay to predict recurrence of tamoxifen-treated, nodenegative breast cancer. N Engl J Med. 2004;351 (27):2817-2826.
    • (2004) N Engl J Med , vol.351 , Issue.27 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3


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