Contribution of accelerated degradation to feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol metabolism in the liver

Journal of Biological Chemistry

Volumn 291, Issue 26, 2016, Pages 13479-13494

  Hwang, Seonghwan ^a   Hartman, Isamu Z ^a   Calhoun, Leona N ^a   Garland, Kristina ^a   Young, Gennipher A ^a   Mitsche, Matthew A ^a   McDonald, Jeffrey ^a   Xu, Fang ^a   Engelking, Luke ^a   DeBose Boyd, Russell A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CHOLESTEROL; COENZYMES; DISEASES; FEEDBACK; MAMMALS; METABOLISM; PHYSIOLOGY;

3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; ACCELERATED DEGRADATION; CARDIO-VASCULAR DISEASE; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; ENDOPLASMIC RETICULUM MEMBRANES; FEEDBACK REGULATION; THERAPEUTIC TARGETS;

ALCOHOLS;

GENOMIC DNA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MESSENGER RNA; CHOLESTEROL; MEVINOLIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CHOLESTEROL LIVER LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME DEGRADATION; ENZYME REGULATION; FATTY ACID SYNTHESIS; FEMALE; IN VIVO STUDY; LIVER; MALE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; TRANSGENIC MOUSE; UBIQUITINATION; ANIMAL; ATHEROSCLEROSIS; CELL CULTURE; GENETICS; KNOCKOUT MOUSE; METABOLISM; PROTEIN DEGRADATION; PROTEIN TERTIARY STRUCTURE;

ANIMALS; ATHEROSCLEROSIS; CELLS, CULTURED; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIVER; LOVASTATIN; MICE; MICE, KNOCKOUT; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS;

EID: 84976430986     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.728469     Document Type: Article

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