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Volumn 4, Issue JUNE 2015, 2015, Pages 1-21

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Author keywords

[No Author keywords available]

Indexed keywords

24 DEHYDROCHOLESTEROL REDUCTASE; 7 DEHYDROCHOLESTEROL; CALNEXIN; CHOLESTEROL; DESMOSTEROL; DEUTERIUM OXIDE; DIHYDROLANOSTEROL; LANOSTEROL; OXIDOREDUCTASE; UNCLASSIFIED DRUG; ZYMOSTEROL;

EID: 84937410008     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.07999.001     Document Type: Article
Times cited : (143)

References (40)
  • 1
    • 0030858044 scopus 로고    scopus 로고
    • Cholesterol biosynthesis from lanosterol: Development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase
    • Bae SH, Paik YK. 1997. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. The Biochemical Journal 326:609–616.
    • (1997) The Biochemical Journal , vol.326 , pp. 609-616
    • Bae, S.H.1    Paik, Y.K.2
  • 3
    • 0002380192 scopus 로고
    • The biological synthesis of cholesterol
    • Bloch K. 1965. The biological synthesis of cholesterol. Science 150:19–28. doi: 10.1126/science.150.3692.19.
    • (1965) Science , vol.150 , pp. 19-28
    • Bloch, K.1
  • 4
    • 0036671360 scopus 로고    scopus 로고
    • Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism
    • Brown AJ, Sun L, Feramisco JD, Brown MS, Goldstein JL. 2002. Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. Molecular Cell 10: 237–245. doi: 10.1016/S1097-2765(02)00591-9.
    • (2002) Molecular Cell , vol.10 , pp. 237-245
    • Brown, A.J.1    Sun, L.2    Feramisco, J.D.3    Brown, M.S.4    Goldstein, J.L.5
  • 6
    • 52649174229 scopus 로고    scopus 로고
    • Evolution of our understanding of vitamin D
    • DeLuca HF. 2008. Evolution of our understanding of vitamin D. Nutrition Reviews 66:S73–S87. doi: 10.1111/j.1753-4887.2008.00105.x.
    • (2008) Nutrition Reviews , vol.66
    • Deluca, H.F.1
  • 7
    • 0021676528 scopus 로고
    • Measurement of rates of cholesterol synthesis using tritiated water
    • Dietschy JM, Spady DK. 1984. Measurement of rates of cholesterol synthesis using tritiated water. Journal of Lipid Research 25:1469–1476.
    • (1984) Journal of Lipid Research , vol.25 , pp. 1469-1476
    • Dietschy, J.M.1    Spady, D.K.2
  • 8
    • 0037040184 scopus 로고    scopus 로고
    • Control of cholesterol turnover in the mouse
    • Dietschy JM, Turley SD. 2002. Control of cholesterol turnover in the mouse. The Journal of Biological Chemistry 277:3801–3804. doi: 10.1074/jbc.R100057200.
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 3801-3804
    • Dietschy, J.M.1    Turley, S.D.2
  • 9
    • 0014264541 scopus 로고
    • The plasma lecithin: Cholesterol acyltransferease reaction
    • Glomset JA. 1968. The plasma lecithin: cholesterol acyltransferease reaction. Journal of Lipid Research 9:155–167.
    • (1968) Journal of Lipid Research , vol.9 , pp. 155-167
    • Glomset, J.A.1
  • 10
    • 0017710978 scopus 로고
    • Characteristics of a human cell line transformed by DNA from human adenovirus type 5
    • Graham FL, Smiley J, Russell WC, Nairn R. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. The Journal of General Virology 36:59–74. doi: 10.1099/0022-1317-36-1-59.
    • (1977) The Journal of General Virology , vol.36 , pp. 59-74
    • Graham, F.L.1    Smiley, J.2    Russell, W.C.3    Nairn, R.4
  • 11
    • 84893013430 scopus 로고    scopus 로고
    • Reverse cholesterol transport fluxes
    • Hellerstein M, Turner S. 2014. Reverse cholesterol transport fluxes. Current Opinion in Lipidology 25:40–47. doi: 10.1097/MOL.0000000000000050.
    • (2014) Current Opinion in Lipidology , vol.25 , pp. 40-47
    • Hellerstein, M.1    Turner, S.2
  • 12
    • 0026448766 scopus 로고
    • Mass isotopomer distribution analysis: A technique for measuring biosynthesis and turnover of polymers
    • Hellerstein MK, Neese RA. 1992. Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers. The American Journal of Physiology 263:E988–E1001.
    • (1992) The American Journal of Physiology , vol.263
    • Hellerstein, M.K.1    Neese, R.A.2
  • 13
    • 0033038503 scopus 로고    scopus 로고
    • Mass isotopomer distribution analysis at eight years: Theoretical, analytic, and experimental considerations
    • Hellerstein MK, Neese RA. 1999. Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations. The American Journal of Physiology 276:E1146–E1170.
    • (1999) The American Journal of Physiology , vol.276
    • Hellerstein, M.K.1    Neese, R.A.2
  • 15
    • 0005702297 scopus 로고
    • Preputial gland tumor sterols. 2. The identification of 4 alpha-methyl-Delta 8-cholesten-3 beta-ol
    • Kandutsch AA, Russell AE. 1960a. Preputial gland tumor sterols. 2. The identification of 4 alpha-methyl-Delta 8-cholesten-3 beta-ol. The Journal of Biological Chemistry 235:2253–2255.
    • (1960) The Journal of Biological Chemistry , vol.235 , pp. 2253-2255
    • Kandutsch, A.A.1    Russell, A.E.2
  • 16
    • 0001415416 scopus 로고
    • Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol
    • Kandutsch AA, Russell AE. 1960b. Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol. The Journal of Biological Chemistry 235:2256–2261.
    • (1960) The Journal of Biological Chemistry , vol.235 , pp. 2256-2261
    • Kandutsch, A.A.1    Russell, A.E.2
  • 17
    • 84877880864 scopus 로고    scopus 로고
    • Male germ cell-specific knockout of cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51)
    • Keber R, Acimovic J, Majdic G, Motaln H, Rozman D, Horvat S. 2013. Male germ cell-specific knockout of cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51). Journal of Lipid Research 54: 1653–1661. doi: 10.1194/jlr.M035717.
    • (2013) Journal of Lipid Research , vol.54 , pp. 1653-1661
    • Keber, R.1    Acimovic, J.2    Majdic, G.3    Motaln, H.4    Rozman, D.5    Horvat, S.6
  • 18
    • 0026522051 scopus 로고
    • Model equations for condensation biosynthesis using stable isotopes and radioisotopes
    • Kelleher JK, Masterson TM. 1992. Model equations for condensation biosynthesis using stable isotopes and radioisotopes. The American Journal of Physiology 262:E118–E125.
    • (1992) The American Journal of Physiology , vol.262
    • Kelleher, J.K.1    Masterson, T.M.2
  • 19
    • 38349112601 scopus 로고    scopus 로고
    • Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase
    • Lange Y, Ory DS, Ye J, Lanier MH, Hsu FF, Steck TL. 2008. Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. The Journal of Biological Chemistry 283:1445–1455. doi: 10.1074/jbc.M706967200.
    • (2008) The Journal of Biological Chemistry , vol.283 , pp. 1445-1455
    • Lange, Y.1    Ory, D.S.2    Ye, J.3    Lanier, M.H.4    Hsu, F.F.5    Steck, T.L.6
  • 22
    • 0038265008 scopus 로고    scopus 로고
    • Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
    • Lund EG, Xie C, Kotti T, Turley SD, Dietschy JM, Russell DW. 2003. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. The Journal of Biological Chemistry 278: 22980–22988. doi: 10.1074/jbc.M303415200.
    • (2003) The Journal of Biological Chemistry , vol.278 , pp. 22980-22988
    • Lund, E.G.1    Xie, C.2    Kotti, T.3    Turley, S.D.4    Dietschy, J.M.5    Russell, D.W.6
  • 24
    • 84927555904 scopus 로고    scopus 로고
    • The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7 interact physically and functionally
    • Luu W, Hart-Smith G, Sharpe LJ, Brown AJ. 2015. The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7 interact physically and functionally. Journal of Lipid Research 56:888–897. doi: 10.1194/jlr.M056986.
    • (2015) Journal of Lipid Research , vol.56 , pp. 888-897
    • Luu, W.1    Hart-Smith, G.2    Sharpe, L.J.3    Brown, A.J.4
  • 25
    • 28444479505 scopus 로고    scopus 로고
    • Role of cholesterol and lipid organization in disease
    • Maxfield FR, Tabas I. 2005. Role of cholesterol and lipid organization in disease. Nature 438:612–621. doi: 10.1038/nature04399.
    • (2005) Nature , vol.438 , pp. 612-621
    • Maxfield, F.R.1    Tabas, I.2
  • 26
    • 84862339778 scopus 로고    scopus 로고
    • A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma
    • McDonald JG, Smith DD, Stiles AR, Russell DW. 2012. A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. Journal of Lipid Research 53:1399–1409. doi: 10.1194/jlr.D022285.
    • (2012) Journal of Lipid Research , vol.53 , pp. 1399-1409
    • McDonald, J.G.1    Smith, D.D.2    Stiles, A.R.3    Russell, D.W.4
  • 27
    • 0021347915 scopus 로고
    • Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium
    • Nakabayashi H, Taketa K, Yamane T, Miyazaki M, Miyano K, Sato J. 1984. Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium. Gan 75:151–158.
    • (1984) Gan , vol.75 , pp. 151-158
    • Nakabayashi, H.1    Taketa, K.2    Yamane, T.3    Miyazaki, M.4    Miyano, K.5    Sato, J.6
  • 28
    • 80054063178 scopus 로고    scopus 로고
    • Biosynthesis of cholesterol and other sterols
    • Nes WD. 2011. Biosynthesis of cholesterol and other sterols. Chemical Reviews 111:6423–6451. doi: 10.1021/cr200021m.
    • (2011) Chemical Reviews , vol.111 , pp. 6423-6451
    • Nes, W.D.1
  • 29
    • 0028929262 scopus 로고
    • Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse
    • Osono Y, Woollett LA, Herz J, Dietschy JM. 1995. Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse. The Journal of Clinical Investigation 95: 1124–1132. doi: 10.1172/JCI117760.
    • (1995) The Journal of Clinical Investigation , vol.95 , pp. 1124-1132
    • Osono, Y.1    Woollett, L.A.2    Herz, J.3    Dietschy, J.M.4
  • 30
    • 0033215204 scopus 로고    scopus 로고
    • Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein
    • Rawson RB, DeBose-Boyd R, Goldstein JL, Brown MS. 1999. Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein. The Journal of Biological Chemistry 274:28549–28556. doi: 10.1074/jbc.274.40.28549.
    • (1999) The Journal of Biological Chemistry , vol.274 , pp. 28549-28556
    • Rawson, R.B.1    Debose-Boyd, R.2    Goldstein, J.L.3    Brown, M.S.4
  • 31
    • 66349134159 scopus 로고    scopus 로고
    • Fifty years of advances in bile acid synthesis and metabolism
    • Russell DW. 2009. Fifty years of advances in bile acid synthesis and metabolism. Journal of Lipid Research 50 (Suppl):S120–S125. doi: 10.1194/jlr.R800026-JLR200.
    • (2009) Journal of Lipid Research , vol.50
    • Russell, D.W.1
  • 32
    • 0020015472 scopus 로고
    • Sterol biosynthesis
    • Schroepfer GJ Jr. 1982. Sterol biosynthesis. Annual Review of Biochemistry 51:555–585. doi: 10.1146/annurev.bi.51.070182.003011.
    • (1982) Annual Review of Biochemistry , vol.51 , pp. 555-585
    • Schroepfer, G.J.1
  • 34
    • 18544378347 scopus 로고    scopus 로고
    • Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol
    • Song BL, Javitt NB, DeBose-Boyd RA. 2005. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. Cell Metabolism 1:179–189. doi: 10.1016/j.cmet.2005.01.001.
    • (2005) Cell Metabolism , vol.1 , pp. 179-189
    • Song, B.L.1    Javitt, N.B.2    Debose-Boyd, R.A.3
  • 36
    • 33746095457 scopus 로고    scopus 로고
    • The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols
    • Tint GS, Yu H, Shang Q, Xu G, Patel SB. 2006. The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols. Journal of Lipid Research 47:1535–1541. doi: 10.1194/jlr.M600141-JLR200.
    • (2006) Journal of Lipid Research , vol.47 , pp. 1535-1541
    • Tint, G.S.1    Yu, H.2    Shang, Q.3    Xu, G.4    Patel, S.B.5
  • 37
    • 0019779236 scopus 로고
    • Association of a 68,000-dalton protein with adrenocorticotropin-sensitive adenylate cyclase activity in Y1 adrenocortical tumor cells
    • Watt VM, Schimmer BP. 1981. Association of a 68,000-dalton protein with adrenocorticotropin-sensitive adenylate cyclase activity in Y1 adrenocortical tumor cells. The Journal of Biological Chemistry 256:11365–11371.
    • (1981) The Journal of Biological Chemistry , vol.256 , pp. 11365-11371
    • Watt, V.M.1    Schimmer, B.P.2
  • 40
    • 53149086305 scopus 로고    scopus 로고
    • Sex-and gonad-affecting scent compounds and 3 male pheromones in the rat
    • Zhang JX, Sun L, Zhang JH, Feng ZY. 2008. Sex-and gonad-affecting scent compounds and 3 male pheromones in the rat. Chemical Senses 33:611–621. doi: 10.1093/chemse/bjn028.
    • (2008) Chemical Senses , vol.33 , pp. 611-621
    • Zhang, J.X.1    Sun, L.2    Zhang, J.H.3    Feng, Z.Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.