-
1
-
-
0034093374
-
Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme a reductase: The concept of cholesterol buffering capacity
-
G.C. Ness, and C.M. Chambers Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: the concept of cholesterol buffering capacity Proc. Soc. Exp. Biol. Med. 224 2000 8 19
-
(2000)
Proc. Soc. Exp. Biol. Med.
, vol.224
, pp. 8-19
-
-
Ness, G.C.1
Chambers, C.M.2
-
2
-
-
0034680918
-
The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl coenzyme a reductase
-
T. Ravid, R. Doolman, R. Avner, D. Harats, and J. Roitelman The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase J. Biol. Chem. 275 2000 35840 35847
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35840-35847
-
-
Ravid, T.1
Doolman, R.2
Avner, R.3
Harats, D.4
Roitelman, J.5
-
3
-
-
0021856440
-
Membrane-bound domain of HMG-CoA reductase is required for sterol-enhanced degradation of the enzyme
-
G. Gil, J.R. Faust, D.J. Chin, J.L. Goldstein, and M.S. Brown Membrane-bound domain of HMG-CoA reductase is required for sterol-enhanced degradation of the enzyme Cell 41 1985 249 258
-
(1985)
Cell
, vol.41
, pp. 249-258
-
-
Gil, G.1
Faust, J.R.2
Chin, D.J.3
Goldstein, J.L.4
Brown, M.S.5
-
4
-
-
0024287649
-
The membrane domain of 3-hydroxy-3-methylglutaryl coenzyme a reductase confers endoplasmic reticulum localization and sterol-regulated degradation onto beta-galactosidase
-
D.G. Skalnik, H. Narita, C. Kent, and R.D. Simoni The membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase confers endoplasmic reticulum localization and sterol-regulated degradation onto beta-galactosidase J. Biol. Chem. 263 1988 6836 6841
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 6836-6841
-
-
Skalnik, D.G.1
Narita, H.2
Kent, C.3
Simoni, R.D.4
-
5
-
-
0026742974
-
The role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase
-
K.T. Chun, and R.D. Simoni The role of the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase J. Biol. Chem. 267 1992 4236 4246
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 4236-4246
-
-
Chun, K.T.1
Simoni, R.D.2
-
6
-
-
0029045589
-
Molecular dissection of the role of the membrane domain in regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase
-
H. Kumagai, K.T. Chun, and R.D. Simoni Molecular dissection of the role of the membrane domain in regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase J. Biol. Chem. 270 1995 19107 19113
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 19107-19113
-
-
Kumagai, H.1
Chun, K.T.2
Simoni, R.D.3
-
7
-
-
0032555650
-
Degradation of HMG-CoA reductase in vitro: Cleavage in the membrane domain by a membrane-bound cysteine protease
-
T. Moriyama, S.K. Sather, T.P. McGee, and R.D. Simoni Degradation of HMG-CoA reductase in vitro: cleavage in the membrane domain by a membrane-bound cysteine protease J. Biol. Chem. 273 1998 22037 22043
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 22037-22043
-
-
Moriyama, T.1
Sather, S.K.2
McGee, T.P.3
Simoni, R.D.4
-
8
-
-
0023902411
-
Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme a reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme
-
M. Nakanishi, J.L. Goldstein, and M.S. Brown Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme J. Biol. Chem. 263 1988 8929 8937
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 8929-8937
-
-
Nakanishi, M.1
Goldstein, J.L.2
Brown, M.S.3
-
9
-
-
0026461126
-
Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl CoA reductase
-
J. Roitelman, and R.D. Simoni Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl CoA reductase J. Biol. Chem. 267 1992 25264 25273
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 25264-25273
-
-
Roitelman, J.1
Simoni, R.D.2
-
10
-
-
0029969302
-
Regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo
-
T.E. Meigs, D.S. Roseman, and R.D. Simoni Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo J. Biol. Chem. 271 1996 7916 7922
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7916-7922
-
-
Meigs, T.E.1
Roseman, D.S.2
Simoni, R.D.3
-
11
-
-
0031239831
-
Farnesol as a regulator of HMG-CoA reductase degradation: Characterization and role of farnesyl pyrophosphate
-
T.E. Meigs, and R.D. Simoni Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphate Arch. Biochem. Biophys. 345 1997 1 9
-
(1997)
Arch. Biochem. Biophys.
, vol.345
, pp. 1-9
-
-
Meigs, T.E.1
Simoni, R.D.2
-
12
-
-
0033546303
-
Oligomerization state influences the degradation rate of 3-hydroxy-3-methylglutaryl CoA reductase
-
H.H. Cheng, L. Xu, H. Kumagai, and R.D. Simoni Oligomerization state influences the degradation rate of 3-hydroxy-3-methylglutaryl CoA reductase J. Biol. Chem. 274 1999 17171 17178
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17171-17178
-
-
Cheng, H.H.1
Xu, L.2
Kumagai, H.3
Simoni, R.D.4
-
13
-
-
0028307290
-
Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase
-
C.C. Correll, L. Ng, and P.A. Edwards Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase J. Biol. Chem. 269 1994 17390 17393
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 17390-17393
-
-
Correll, C.C.1
Ng, L.2
Edwards, P.A.3
-
14
-
-
0028157541
-
Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase in vivo and in vitro
-
C.C. Correll, and P.A. Edwards Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vivo and in vitro J. Biol. Chem. 269 1994 633 638
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 633-638
-
-
Correll, C.C.1
Edwards, P.A.2
-
15
-
-
1542379024
-
Membrane topology of human insig-1, a protein regulator of lipid synthesis
-
J.D. Feramisco, J.L. Goldstein, and M.S. Brown Membrane topology of human insig-1, a protein regulator of lipid synthesis J. Biol. Chem. 279 2004 8487 8496
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 8487-8496
-
-
Feramisco, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
16
-
-
0029837381
-
Degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis
-
T.P. McGee, H.H. Cheng, H. Kumagai, S. Omura, and R.D. Simoni Degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis J. Biol. Chem. 271 1996 25630 25638
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 25630-25638
-
-
McGee, T.P.1
Cheng, H.H.2
Kumagai, H.3
Omura, S.4
Simoni, R.D.5
-
17
-
-
5644244825
-
Isolation of mutant cells lacking insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase
-
N. Sever, P.C.W. Lee, B.-L. Song, R.B. Rawson, and R.A. DeBose-Boyd Isolation of mutant cells lacking insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase J. Biol. Chem. 279 2004 43136 43147
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 43136-43147
-
-
Sever, N.1
Lee, P.C.W.2
Song, B.-L.3
Rawson, R.B.4
Debose-Boyd, R.A.5
-
18
-
-
0346101770
-
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol
-
N. Sever, B.-L. Song, D. Yabe, J.L. Goldstein, M.S. Brown, and R.A. DeBose-Boyd Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol J. Biol. Chem. 278 2003 52479 52490
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52479-52490
-
-
Sever, N.1
Song, B.-L.2
Yabe, D.3
Goldstein, J.L.4
Brown, M.S.5
Debose-Boyd, R.A.6
-
19
-
-
0035890127
-
Regulation of hepatic lanosterol 14α-demethylase gene expression by dietary cholesterol and cholesterol-lowering agents
-
G.C. Ness, K.R. Gertz, and R.C. Holland Regulation of hepatic lanosterol 14α-demethylase gene expression by dietary cholesterol and cholesterol-lowering agents Arch. Biochem. Biophys. 395 2001 233 238
-
(2001)
Arch. Biochem. Biophys.
, vol.395
, pp. 233-238
-
-
Ness, G.C.1
Gertz, K.R.2
Holland, R.C.3
-
20
-
-
0032526825
-
Dietary cholesterol regulates hepatic 3-hydroxy-3-methylglutaryl coenzyme a reductase gene expression in rats primarily at the level of translation
-
C.M. Chambers, and G.C. Ness Dietary cholesterol regulates hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in rats primarily at the level of translation Arch. Biochem. Biophys. 354 1998 317 322
-
(1998)
Arch. Biochem. Biophys.
, vol.354
, pp. 317-322
-
-
Chambers, C.M.1
Ness, G.C.2
-
21
-
-
0032530606
-
Effects of 15 oxa-32-vinyl-lanost-8-ene-3β, 32 diol on the expression of HMG-CoA reductase and LDL receptor in rat liver
-
G.C. Ness, D. Lopez, C.M. Chambers, Z. Zhao, D.L. Beach, S.S. Ko, and J.M. Trzaskos Effects of 15 oxa-32-vinyl-lanost-8-ene-3β, 32 diol on the expression of HMG-CoA reductase and LDL receptor in rat liver Arch. Biochem. Biophys. 357 1998 259 264
-
(1998)
Arch. Biochem. Biophys.
, vol.357
, pp. 259-264
-
-
Ness, G.C.1
Lopez, D.2
Chambers, C.M.3
Zhao, Z.4
Beach, D.L.5
Ko, S.S.6
Trzaskos, J.M.7
-
22
-
-
0022516611
-
Characteristics of rat liver microsomal 3-hydroxy-3-methylglutaryl coenzyme a reductase
-
G.C. Ness, C.E. Sample, M. Smith, L.C. Pendleton, and D.C. Eichler Characteristics of rat liver microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase Biochem. J. 233 1986 167 172
-
(1986)
Biochem. J.
, vol.233
, pp. 167-172
-
-
Ness, G.C.1
Sample, C.E.2
Smith, M.3
Pendleton, L.C.4
Eichler, D.C.5
-
23
-
-
2142808829
-
Increased sensitivity to dietary cholesterol in diabetic and hypothyroid rats associated with low levels of hepatic HMG-CoA reductase expression
-
G.C. Ness, and K.R. Gertz Increased sensitivity to dietary cholesterol in diabetic and hypothyroid rats associated with low levels of hepatic HMG-CoA reductase expression Exp. Biol. Med. 229 2004 407 411
-
(2004)
Exp. Biol. Med.
, vol.229
, pp. 407-411
-
-
Ness, G.C.1
Gertz, K.R.2
-
24
-
-
0037470787
-
Association of the low-density lipoprotein receptor with caveolae in hamster and rat liver
-
G.C. Ness, N. Kohlruss, and K.R. Gertz Association of the low-density lipoprotein receptor with caveolae in hamster and rat liver Biochem. Biophys. Res. Commun. 303 2003 177 181
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.303
, pp. 177-181
-
-
Ness, G.C.1
Kohlruss, N.2
Gertz, K.R.3
-
25
-
-
0018427864
-
Perinatal development of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in rat lung, liver and brain
-
G.C. Ness, J.P. Miller, M.H. Moffler, L.S. Woods, and H.B. Harris Perinatal development of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in rat lung, liver and brain Lipids 14 1979 447 450
-
(1979)
Lipids
, vol.14
, pp. 447-450
-
-
Ness, G.C.1
Miller, J.P.2
Moffler, M.H.3
Woods, L.S.4
Harris, H.B.5
-
26
-
-
0020571671
-
Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase by mevinolin
-
M. Sinensky, and J. Logel Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevinolin J. Biol. Chem. 258 1983 8547 8549
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 8547-8549
-
-
Sinensky, M.1
Logel, J.2
-
27
-
-
4644243461
-
Ubiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme a reductase
-
R. Doolman, G.S. Leichner, R. Avner, and J. Roitelman Ubiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase J. Biol. Chem. 279 2004 38184 38193
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38184-38193
-
-
Doolman, R.1
Leichner, G.S.2
Avner, R.3
Roitelman, J.4
-
28
-
-
0036437316
-
Proteolysis and sterol regulation
-
R.Y. Hampton Proteolysis and sterol regulation Annu. Rev. Cell Dev. Biol. 18 2002 345 378
-
(2002)
Annu. Rev. Cell Dev. Biol.
, vol.18
, pp. 345-378
-
-
Hampton, R.Y.1
-
29
-
-
0037245750
-
Accelerated degradation of HMG-CoA reductase mediated by binding of insig-1 to its sterol-sensing domain
-
N. Sever, T. Yang, M.S. Brown, J.L. Goldstein, and R.A. DeBose-Boyd Accelerated degradation of HMG-CoA reductase mediated by binding of insig-1 to its sterol-sensing domain Mol. Cell. 11 2003 25 33
-
(2003)
Mol. Cell.
, vol.11
, pp. 25-33
-
-
Sever, N.1
Yang, T.2
Brown, M.S.3
Goldstein, J.L.4
Debose-Boyd, R.A.5
-
30
-
-
9144239817
-
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
-
M. Kikkert, R. Doolman, M. Dai, R. Avner, G. Hassink, S. van Voorden, S. Thanedar, J. Roitelman, V. Chau, and E. Wiertz Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum J. Biol. Chem. 279 2004 3525 3534
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 3525-3534
-
-
Kikkert, M.1
Doolman, R.2
Dai, M.3
Avner, R.4
Hassink, G.5
Van Voorden, S.6
Thanedar, S.7
Roitelman, J.8
Chau, V.9
Wiertz, E.10
-
31
-
-
3142654791
-
Ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme a reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase
-
B.-L. Song, and R.A. DeBose-Boyd Ubiquitination of 3-hydroxy-3- methylglutaryl coenzyme A reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase J. Biol. Chem. 279 2004 28798 28806
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 28798-28806
-
-
Song, B.-L.1
Debose-Boyd, R.A.2
-
32
-
-
0031575766
-
Translational regulation of hepatic HMG-CoA reductase by dietary cholesterol
-
C.M. Chambers, and G.C. Ness Translational regulation of hepatic HMG-CoA reductase by dietary cholesterol Biochem. Biophys. Res. Commun. 232 1997 278 281
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.232
, pp. 278-281
-
-
Chambers, C.M.1
Ness, G.C.2
-
33
-
-
0015015553
-
Loss of feedback control of hydroxymethylglutaryl coenzyme a reductase in hepatomas
-
M.D. Siperstein, A.M. Gyde, and H.P. Morris Loss of feedback control of hydroxymethylglutaryl coenzyme A reductase in hepatomas Proc. Natl. Acad. Sci. USA 68 1971 315 317
-
(1971)
Proc. Natl. Acad. Sci. USA
, vol.68
, pp. 315-317
-
-
Siperstein, M.D.1
Gyde, A.M.2
Morris, H.P.3
-
34
-
-
0015181972
-
The regulation of β-hydroxy-β-methylglutaryl coenzyme a reductase in Morris Hepatomas 5123C, 7800 and 9618A
-
S. Goldfarb, and H.C. Pitot The regulation of β-hydroxy-β- methylglutaryl coenzyme A reductase in Morris Hepatomas 5123C, 7800 and 9618A Cancer Res. 31 1971 1879 1882
-
(1971)
Cancer Res.
, vol.31
, pp. 1879-1882
-
-
Goldfarb, S.1
Pitot, H.C.2
-
35
-
-
0015764584
-
Regulation of cholesterol synthesis in normal and malignant tissue
-
M.S. Brown, J.L. Goldstein, and M.D. Siperstein Regulation of cholesterol synthesis in normal and malignant tissue Fed. Proc. 32 1973 2168 2173
-
(1973)
Fed. Proc.
, vol.32
, pp. 2168-2173
-
-
Brown, M.S.1
Goldstein, J.L.2
Siperstein, M.D.3
-
36
-
-
0018182731
-
Partial "feedback Control" of β-hydroxy-β- methylglutaryl coenzyme a reductase activity in primary hepatocellular carcinomas
-
A.D. Mitchell, T.D. Pugh, and S. Goldfarb Partial "Feedback Control" of β-hydroxy-β-methylglutaryl coenzyme A reductase activity in primary hepatocellular carcinomas Cancer Res. 38 1978 4474 4477
-
(1978)
Cancer Res.
, vol.38
, pp. 4474-4477
-
-
Mitchell, A.D.1
Pugh, T.D.2
Goldfarb, S.3
-
37
-
-
0002498245
-
Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat
-
J.M. Dietschy, and M.D. Siperstein Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat J. Lipid Res. 8 1967 97 104
-
(1967)
J. Lipid Res.
, vol.8
, pp. 97-104
-
-
Dietschy, J.M.1
Siperstein, M.D.2
-
38
-
-
0029937677
-
Mechanistic studies on the inactivation of the proteasome by lactacystin: A central role for clastolactacystin beta-lactone
-
L.R. Dick, A.A. Cruikshank, L. Grenier, F.D. Melandri, S.L. Nunes, and R.L. Stein Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clastolactacystin beta-lactone J. Biol. Chem. 271 1996 7273 7276
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7273-7276
-
-
Dick, L.R.1
Cruikshank, A.A.2
Grenier, L.3
Melandri, F.D.4
Nunes, S.L.5
Stein, R.L.6
-
39
-
-
0022383292
-
Sulfhydryl-disulfide forms of rat liver 3-hydroxy-3-methylglutaryl coenzyme a reductase
-
G.C. Ness, M.J. McCreery, C.E. Sample, M. Smith, and L.C. Pendleton Sulfhydryl-disulfide forms of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase J. Biol. Chem. 260 1985 16395 16399
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 16395-16399
-
-
Ness, G.C.1
McCreery, M.J.2
Sample, C.E.3
Smith, M.4
Pendleton, L.C.5
-
40
-
-
0024285947
-
In situ determination of the functional size of hepatic HMG-CoA reductase by radiation inactivation analysis
-
G.C. Ness, L.C. Pendleton, and M.J. McCreery In situ determination of the functional size of hepatic HMG-CoA reductase by radiation inactivation analysis Biochim. Biophys. Acta 953 1988 361 364
-
(1988)
Biochim. Biophys. Acta
, vol.953
, pp. 361-364
-
-
Ness, G.C.1
Pendleton, L.C.2
McCreery, M.J.3
-
41
-
-
18544378347
-
Insig-mediated degradation of HMG-CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol
-
B.-L. Song, N.B. Javitt, and R.A. DeBose-Boyd Insig-mediated degradation of HMG-CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol Cell Met. 1 2005 179 189
-
(2005)
Cell Met.
, vol.1
, pp. 179-189
-
-
Song, B.-L.1
Javitt, N.B.2
Debose-Boyd, R.A.3
|