Population-based genetic screening for the estimation of Type 1 diabetes mellitus risk in Finland: Selective genotyping of markers in the HLA-DQB1, HLA-DQA1 and HLA-DRB1 loci

Diabetic Medicine

Volumn 16, Issue 12, 1999, Pages 985-992

  Nejentsev, Sergei ^a   Sjoroos M ^a   Soukka, T ^a   Knip, M ^b,c   Simell, O ^a   Lovgren T ^a   Ilonen, J ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Genetic screening; HLA; Prediction; Type 1 diabetes mellitus

Indexed keywords

HLA DQ ANTIGEN; HLA DR ANTIGEN;

ARTICLE; CONTROLLED STUDY; FINLAND; GENETIC RISK; GENETIC SCREENING; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY;

BIOLOGICAL MARKERS; CHILD; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; DNA PROBES; FINLAND; GENETIC SCREENING; GENOTYPE; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; INFANT, NEWBORN; NUCLEIC ACID HYBRIDIZATION; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; RISK FACTORS; SENSITIVITY AND SPECIFICITY;

EID: 0033401173     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-5491.1999.00186.x     Document Type: Article

References (30)

1. 1 Gale EA. Theory and practice of nicotinamide trials in pre-type 1 diabetes. J Pediatr Endocrinol Metab 1996; 9: 375-379.
2. 2 Knip M. IDDM prevention trials in progress - a critical assessment. J Pediatr Endocrinol Metab 1998; 11: 371-377.
3. 3 Slover RH, Eisenbarth GS. Prevention of type I diabetes and recurrent beta-cell destruction of transplanted islets. Endocr Rev 1997; 18: 241-58.
4. 4 Dahlquist G, Blom L, Holmgren G, Hagglof B, Larsson Y, Sterky G et al. The epidemiology of diabetes in Swedish children 0-14 years - a six-year prospective study. Diabetologia 1985; 28: 802-808.
5. 5 Tuomilehto J, Lounamaa R, Tuomilehto-Wolf E, Reunanen A, Virtala E, Kaprio EA et al. Epidemiology of childhood diabetes mellitus in Finland - background of a nationwide study of type 1 (insulin-dependent) diabetes mellitus. The Childhood Diabetes in Finland (DiMe) Study Group. Diabetologia 1992; 35: 70-76.
6. 6 Pociot F, Norgaard K, Hobolth N, Andersen O, Nerup J. A nationwide population-based study of the familial aggregation of type 1 (insulin-dependent) diabetes mellitus in Denmark. Danish Study Group of Diabetes in Childhood. Diabetologia 1993; 36: 870-875.
7. 7 Wagener DK, Sacks JM, LaPorte RE, Macgregor JM. The Pittsburgh study of insulin-dependent diabetes mellitus. Risk for diabetes among relatives of IDDM. Diabetes 1982; 31: 136-144.
8. 8 Hahl J, Simell T, Ilonen J, Knip M, Simell O. Costs of predicting IDDM. Diabetologia 1998; 41: 79-85.
9. 9 Sjöroos M, Iitiä A, Ilonen J, Reijonen H, Lövgren T. Triple-label hybridization assay for type-1 diabetes-related HLA alleles. Biotechniques 1995; 18: 870-877.
10. 10 Ilonen J, Reijonen H, Herva E, Sjöroos M, Iitia A, Lövgren T et al. Rapid HLA-DQB1 genotyping for four alleles in the assessment of risk for IDDM in the Finnish population. Diabetes Care 1996; 19: 795-800.
11. 11 Nejentsev S, Koskinen S, Sjöroos M, Reijonen H, Schwartz EI, Kovalchuk L et al. Distribution of IDDM-related HLA alleles correlates with differece in IDDM incidence in four populations of eastern Baltic region. Tissue Antigens 1998; 52: 473-477.
12. 12 She JX. Susceptibility to type I diabetes: HLA-DQ and DR revisited. Immunol Today 1996; 17: 323-329.
13. 13 Reijonen H, Nejentsev S, Tuokko J, Koskinen S, Tuomilehto-Wolf E, Åkernblom HK et al. HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. Eur J Immunogenet 1997; 24: 357-363.
14. 14 Sjöroos M, Ilonen J, Reijonen H, Lövgren T. Time-resolved fluorometry based sandwich hybridization assay for HLA-DQA1 typing. Dis Markers 1998; 14: 9-19.
15. 15 Olerup O, Zetterquist H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 1992; 39: 225-235.
16. 16 Nejentsev S, Reijonen H, Adojaan B, Kovalchuk L, Sochnevs A, Schwartz EI et al. The effect of HLA-B allele on the IDDM risk defined by DRB1*04 subtypes and DQBI*0302. Diabetes 1997; 46: 1888-1892.
17. 17 Altman D. Practical Statistics for Medical Research. London: Chapman & Hall, 1996: 416.
18. 18 Ronningen KS, Spurkland A, Iwe T, Vartdal F, Thorsby E. Distribution of HLA-DRB1-DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus. Tissue Antigens 1991; 37: 105-111.
19. 19 Kockum I, Sanjeevi CB, Eastman S, Landin Olsson M, Dahlquist G, Lernmark A. Population analysis of protection by HLA-DR and DQ genes from insulin-dependent diabetes mellitus in Swedish children with insulin-dependent diabetes and controls. Eur J Immunogenet 1995; 22: 443-465.
20. 20 Chauffert M, Cisse A, Chevenne D, Parfait B, Michel S, Trivin F. HLA-DQ beta 1 typing and non-Asp57 alleles in the aborigine population of Senegal. Diabetes Care 1995; 18: 677-680.
21. 21 Mijovic CH, Jenkins D, Jacobs KH, Penny MA, Fletcher JA, Barnett AH. HLA-DQA1 and -DQB1 alleles associated with genetic susceptibility to IDDM in a black population. Diabetes 1991; 40: 748-53.
22. 22 Buyse I, Sandkuyl LA, Zamani-Ghabanbasani M, Gu XX, Bouillion R, Bex M et al. Association of particular HLA class II alleles, haplotypes and genotypes with susceptibility to IDDM in the Belgian population. Diabetologia 1994; 37: 808-817.
23. 23 Balducci-Silano PL, Layrisse Z, Domingnez E, Amaro R, Gunczler P, Lanes R et al. HLA-DQA1 and DQB1 allele and genotype contribution to IDDM susceptibility in an ethnically mixed population. Eur J Immunogenet 1994; 21: 405-414.
24. 24 Marsh SGE. HLA class II region sequences. 1998 Tissue Antigens 1998; 51: 467-507.
25. 25 Cucca F, Goy JV, Kawaguchi Y, Esposito L, Merriman ME, Wilson AJ et al. A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients. Nat Genet 1998; 19:301-302.
26. 26 Todd JA. Genetic analysis of type 1 diabetes using whole genome approaches. Proc Natl Acad Sci USA 1995; 92: 8560-8565.
27. 27 Thomson G, Robinson WP, Kuhner MK, Joe S, MacDonald MJ, Gottschall JL et al. Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus. Am J Hum Genet 1988; 43: 799-816.
28. 28 Cucca F, Muntoni F, Lampis R, Frau F, Argiolas L, Silvetti M et al. Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia. Hum Immunol 1993; 37: 85-94.
29. 29 Cucca F, Todd JA. HLA susceptibility to type 1 diabetes: methods and mechanisms. In Browning MJ, McMichael AJ. eds. HLA and MHC Genes, Molecules and Functions. Oxford: BIOS Scientific Publishers Ltd, 1996: 383-406.
30. 30 Hanifi Moghaddam P, De Knijf P, Roep BO, Van der Auwera B, Naipal A, Gorus F et al. Generic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry. Diabetes 1998; 47: 263-269.