Baclofen and other GABAB receptor agents are allosteric modulators of the CXCL12 chemokine receptor CXCR4

Journal of Neuroscience

Volumn 33, Issue 28, 2013, Pages 11643-11654

  Guyon, Alice ^a   Kussrow, Amanda ^b   Roys Olmsted, Ian ^c   Sandoz, Guillaume ^d   Bornhop, Darryl J ^e   Nahon, Jean Louis ^f  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

^b CNRS   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Laboratory of Excellence Ion Channel Science and Therapeutics   (France)

^f Station de Primatologie UPS 846 Centre CNRS ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; BACLOFEN; BENZYL [3 [[1 (3, 4 DICHLOROPHENYL) ETHYL] AMINO] 2 HYDROXYPROPYL] PHOSPHINIC ACID; CHEMOKINE RECEPTOR CXCR4; DOPAMINE; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; CXCL12 PROTEIN, RAT; CXCR4 PROTEIN, RAT; GABAERGIC RECEPTOR AFFECTING AGENT;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; EVOKED RESPONSE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INTERFEROMETRY; MALE; MEMBRANE POTENTIAL; MOLECULAR BIOLOGY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBSTANTIA NIGRA; XENOPUS; ALLOSTERISM; ANIMAL; CELL STRAIN HEK293; DRUG EFFECT; FEMALE; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PROTEIN BINDING; TUMOR CELL LINE; WISTAR RAT; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; ANIMALS; BACLOFEN; CELL LINE, TUMOR; CHEMOKINE CXCL12; FEMALE; GABA AGENTS; GABA-B RECEPTOR AGONISTS; HEK293 CELLS; HUMANS; MALE; ORGAN CULTURE TECHNIQUES; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, CXCR4; XENOPUS LAEVIS;

EID: 84880416279     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6070-11.2013     Document Type: Article

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