GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus

Neuropharmacology

Volumn 48, Issue 7, 2005, Pages 956-964

  Helm, K A ^a   Haberman, R P ^a   Dean, S L ^a   Hoyt, E C ^b   Melcher, T ^c   Lund, P K ^b   Gallagher, M ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c Saegis Pharmaceutical Inc   (United States)

Author keywords

Cognition; CREB2; Long term memory; Memory suppressor; Radial arm maze

Indexed keywords

3 AMINOPROPYLBUTYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; BACLOFEN; CHOLINESTERASE INHIBITOR; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DONEPEZIL; NOOTROPIC AGENT; PROTEIN ANTIBODY; (3 AMINOPROPYL)(N BUTYL)PHOSPHINIC ACID; (3-AMINOPROPYL)(N-BUTYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; CREBBP PROTEIN, RAT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; NUCLEAR PROTEIN; ORGANOPHOSPHORUS COMPOUND; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; GENETICS; HIPPOCAMPUS; LONG TERM MEMORY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SPATIAL MEMORY; ANIMAL; BEHAVIOR; COMPARATIVE STUDY; DNA RESPONSIVE ELEMENT; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; MAZE TEST; MEMORY; METABOLISM; PHYSIOLOGY;

ANIMALS; CREB-BINDING PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA ANTAGONISTS; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY; NUCLEAR PROTEINS; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN BINDING; RATS; RECEPTORS, GABA-B; RESPONSE ELEMENTS; SPATIAL BEHAVIOR; TRANS-ACTIVATORS;

EID: 18044396542     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.01.019     Document Type: Article

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