Drug discovery strategies to outer membrane targets in Gram-negative pathogens

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 24, 2016, Pages 6320-6331

  Brown, Dean G ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Antibacterial; Gram negative; Lipid A; Lipopolysaccharide; Outer membrane

Indexed keywords

ARYLOMYCIN; ARYLOMYCIN D; BACTERIAL PROTEIN; BETA BARREL PROTEIN; CB 102 804; CCT 00431; CCT 00432; COLISTIN; GLOBOMYCIN; JB 95; KRISYNOMYCIN; LIPOPROTEIN; LOLA INHIBITOR; LOLCDE INHIBITOR; LPXA INHIBITOR; LPXC INHIBITOR; MREB INHIBITOR; MUREPAVADIN; MYXOVIRESCIN; NAB 739; NAB 741; POLYMYXIN B; POLYMYXIN DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; SIGNAL PEPTIDASE I; SIGNAL PEPTIDASE II; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; OUTER MEMBRANE PROTEIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL OUTER MEMBRANE; CYTOTOXICITY; GRAM NEGATIVE BACTERIUM; HUMAN; LIPOPROTEIN SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN ASSEMBLY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST;

ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; DRUG DISCOVERY; GRAM-NEGATIVE BACTERIA; MICROBIAL SENSITIVITY TESTS;

EID: 84975125270     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.05.004     Document Type: Article

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