Structures of Pseudomonas aeruginosa LpxA Reveal the Basis for Its Substrate Selectivity

Biochemistry

Volumn 54, Issue 38, 2015, Pages 5937-5948

  Smith, Emmanuel W ^a   Zhang, XiuJun ^a   Behzadi, Cyrus ^a   Andrews, Logan D ^b   Cohen, Frederick ^b   Chen, Yu ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b Achaogen Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYSIS; CHAINS; ESCHERICHIA COLI; PROTEINS; SUBSTRATES;

ACYL CARRIER PROTEINS; CONFORMATIONAL CHANGE; CRITICAL DETERMINANT; GRAM-NEGATIVE BACTERIA; NUCLEOPHILIC ATTACK; PSEUDOMONAS AERUGINOSA; SUBSTRATE SELECTIVITY; SUBSTRATE SPECIFICITY;

BACTERIA;

ACYL CARRIER PROTEIN; BACTERIAL ENZYME; HYDROCARBON; HYDROXYL GROUP; LIPID A; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE ACYLTRANSFERASE; ACYL-(ACYL-CARRIER-PROTEIN)-UDP-N-ACETYLGLUCOSAMINE ACYLTRANSFERASE; ACYLTRANSFERASE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; ESCHERICHIA COLI; LEPTOSPIRA INTERROGANS; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PSEUDOMONAS INFECTION; X RAY CRYSTALLOGRAPHY;

ACYLTRANSFERASES; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SUBSTRATE SPECIFICITY; URIDINE DIPHOSPHATE N-ACETYLGLUCOSAMINE;

EID: 84942595722     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00720     Document Type: Article

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