The structure and mechanism of bacterial type I signal peptidases: A novel antibiotic target

Pharmacology and Therapeutics

Volumn 87, Issue 1, 2000, Pages 27-49

  Paetzel, Mark ^a   Dalbey, Ross E ^b   Strynadka, Natalie C J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Antibiotic target; Leader peptidase; Protein translocation: Serine protease; Signal peptidase; Signal peptide

Indexed keywords

BETA LACTAM ANTIBIOTIC; SERINE PROTEINASE; SIGNAL PEPTIDASE; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; BACTERIAL MEMBRANE; BINDING SITE; CELL SURFACE; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; MEMBRANE STRUCTURE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; REVIEW; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS;

EID: 0033866745     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(00)00064-4     Document Type: Review

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