The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells

International Journal of Antimicrobial Agents

Volumn 41, Issue 3, 2013, Pages 292-293

  Vaara, Martti ^a,b   Vaara, Timo ^a  

^a Technopolis   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

COLISTIN; NAB 739; POLYMYXIN B; POLYMYXIN DERIVATIVE; UNCLASSIFIED DRUG;

CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LETTER; PRIORITY JOURNAL;

CELL LINE; CELL SURVIVAL; COLISTIN; HUMANS; KIDNEY TUBULES, PROXIMAL; POLYMYXIN B; POLYMYXINS;

EID: 84872945726     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2012.10.005     Document Type: Letter

References (3)

1. M. Vaara, J. Fox, G. Loidl, O. Siikanen, J. Apajalahti, and F. Hansen Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents Antimicrob Agents Chemother 52 2008 3229 3236
2. M. Vaara Polymyxins and their novel derivatives Curr Opin Microbiol 13 2010 574 581
3. M.P. Mingeot-Leclercq, P.M. Tulkens, S. Denamur, T. Vaara, and M. Vaara Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells Peptides 35 2012 248 252