Crystallographic and biophysical analysis of a bacterial signal peptidase in complex with a lipopeptide-based inhibitor

Journal of Biological Chemistry

Volumn 279, Issue 29, 2004, Pages 30781-30790

  Paetzel, Mark ^a   Goodall, Jonathon J ^b   Kania, Malgosia ^b   Dalbey, Ross E ^c   Page, Malcolm G P ^b  

^a SIMON FRASER UNIVERSITY   (Canada)

^b BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CATALYSIS; CELLS; CRYSTALLOGRAPHY; ENZYMES; ESCHERICHIA COLI;

BIOPHYSICAL ANALYSIS; BOUND INHIBITORS;

BIOCHEMICAL ENGINEERING;

ANTIBIOTIC AGENT; ARYLOMYCIN A2; ENZYME INHIBITOR; LIPOPEPTIDE; LYSINE; SERINE; SIGNAL PEPTIDASE; UNCLASSIFIED DRUG;

ARTICLE; BETA SHEET; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTALLOGRAPHY; DRUG DEVELOPMENT; ENZYME ANALYSIS; ENZYME KINETICS; ESCHERICHIA COLI; FLUORESCENCE SPECTROSCOPY; HYDROGEN BOND; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL;

BACTERIAL OUTER MEMBRANE PROTEINS; BINDING SITES; CALORIMETRY; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; KINETICS; LIGANDS; LIPOPROTEINS; MEMBRANE PROTEINS; MODELS, CHEMICAL; MODELS, MOLECULAR; OLIGOPEPTIDES; OXYGEN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SERINE ENDOPEPTIDASES; SPECTROMETRY, FLUORESCENCE; TEMPERATURE; TIME FACTORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 3142715940     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401686200     Document Type: Article

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