Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 8, 2013, Pages 2426-2431

  Barker, Courtney A ^a   Allison, Sarah E ^a   Zlitni, Soumaya ^a   Nguyen, Nick Duc ^a   Das, Rahul ^a   Melacini, Giuseppe ^a   Capretta, Alfredo A ^a   Brown, Eric D ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Chemical biology; Chemical genetic interactions; Lipoprotein trafficking; LolA; MreB; Structure activity relationship

Indexed keywords

ACTIN; ANTIINFECTIVE AGENT; CHAPERONE; LIPOPROTEIN; MAC 13243; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG DEGRADATION; GENE DOSAGE; NONHUMAN; PROTEIN TARGETING;

ANTI-BACTERIAL AGENTS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; LIPOPROTEINS; MOLECULAR CHAPERONES; PERIPLASMIC BINDING PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

BACTERIA (MICROORGANISMS); LOLA;

EID: 84875471476     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.005     Document Type: Article

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