Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase

Journal of the American Chemical Society

Volumn 133, Issue 44, 2011, Pages 17869-17877

  Liu, Jian ^a   Luo, Chuanyun ^b   Smith, Peter A ^a   Chin, Jodie K ^a   Page, Malcolm G P ^c   Paetzel, Mark ^b   Romesberg, Floyd E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SIMON FRASER UNIVERSITY   (Canada)

^c BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ABSOLUTE STEREOCHEMISTRY; ANTI-BACTERIAL ACTIVITY; B-SERIES; BIOLOGICAL EVALUATION; CRYSTALLOGRAPHIC ANALYSIS; DRUG CANDIDATES; GLYCOSYLATED; LIPOGLYCOPEPTIDE; LIPOPEPTIDES; MACROCYCLES; NATURAL PRODUCTS; PROTEIN BINDING; SIGNAL PEPTIDASE; STRUCTURAL STUDIES; TOTAL SYNTHESIS;

ESTERIFICATION; GLYCOSYLATION; SCAFFOLDS (BIOLOGY); SOLUBILITY; STEREOCHEMISTRY; SUGARS;

ANTIBIOTICS;

ANTIBIOTIC AGENT; ARYLOMYCIN LIPOGLYCOPEPTIDE ANTIBIOTIC; MACROCYCLIC COMPOUND; MANNOSE; SIGNAL PEPTIDASE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING SITE; CRYSTALLOGRAPHY; DRUG HYDROXYLATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; GLYCOSYLATION; MOLECULAR INTERACTION; NONHUMAN; PROTEIN BINDING; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; GLYCOPEPTIDES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDE HYDROLASES; STEREOISOMERISM;

EID: 80455129410     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja207318n     Document Type: Article

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