Exploration of chlorinated thienyl chalcones: A new class of monoamine oxidase-B inhibitors

International Journal of Biological Macromolecules

Volumn 91, Issue , 2016, Pages 680-695

  Mathew, Bijo ^a   Haridas, Abitha ^b   Uçar, Gülberk ^c   Baysal, Ipek ^c   Adeniyi, Adebayo A ^d   Soliman, Mahmoud E S ^d   Joy, Monu ^e   Mathew, Githa Elizabeth ^b   Lakshmanan, Baskar ^b   Jayaprakash, Venkatesan ^f  

^a Department of Pharmaceutical Chemistry   (India)

^b Grace College of Pharmacy   (India)

^c HACETTEPE UNIVERSITY   (Turkey)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e MAHATMA GANDHI UNIVERSITY   (India)

^f BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Human monoamine oxidase; Molecular docking; Molecular dynamics; Thienyl chalcones

Indexed keywords

1 (4 CHLOROCYCLOPENTA 1,3 DIEN 1 YL) 3 (4 CHLOROPHENYL)PROP 2 EN 1 ONE; 1 (4 CHLOROCYCLOPENTA 1,3 DIEN 1 YL) 3 (4 ETHYLPHENYL)PROP 2 EN 1 ONE; 1 (4 CHLOROCYCLOPENTA 1,3 DIEN 1 YL) 3 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 1 (4 CHLOROCYCLOPENTA 1,3 DIEN 1 YL) 3 (4 HYDROXYPHENYL)PROP 2 EN 1 ONE; 1 (4 CHLOROCYCLOPENTA 1,3 DIEN 1 YL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4 CHLOROCYCLOPENTA 1,3 DIEN 1 YL) 3 (4 METHYLPHENYL)PROP 2 EN 1 ONE; 1 (4 CHLOROCYCLOPENTA 1,3 DIEN 1 YL) 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 (4 CHLOROCYCLOPENTA 1,3 DIEN 1 YL) 3 PHENYLPROP 2 EN 1 ONE; 1 (4 CHLOROCYCLOPENTA 1,3 DIEN 1 YL) 3 [4 (DIMETHYLAMINO)PHENYL]PROP 2 EN 1 ONE; 1 (4 CHLOROCYCLOPENTA 1,3 DIEN 1 YL) 3 [4 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 3 (4 BROMOPHENYL) 1 (4 CHLOROCYCLOPENTA 1,3 DIEN 1 YL)PROP 2 EN 1 ONE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CHALCONE DERIVATIVE; LAZABEMIDE; MOCLOBEMIDE; MONOAMINE OXIDASE B INHIBITOR; SELEGILINE; UNCLASSIFIED DRUG; AMINE OXIDASE (FLAVIN CONTAINING); ISOENZYME; LIGAND; MONOAMINE OXIDASE INHIBITOR;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER CELL; MOLECULAR DOCKING; MOLECULAR DYNAMICS; CELL DEATH; CHEMISTRY; CONFORMATION; DRUG EFFECTS; ENZYME ACTIVE SITE; HALOGENATION; HEP-G2 CELL LINE; KINETICS; METABOLISM; PRINCIPAL COMPONENT ANALYSIS; THERMODYNAMICS;

CATALYTIC DOMAIN; CELL DEATH; CHALCONES; HALOGENATION; HEP G2 CELLS; HUMANS; ISOENZYMES; KINETICS; LIGANDS; MOLECULAR CONFORMATION; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PRINCIPAL COMPONENT ANALYSIS; THERMODYNAMICS;

EID: 84974851890     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2016.05.110     Document Type: Article

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