Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO-B Inhibitors

ChemMedChem

Volumn , Issue , 2016, Pages 1161-1171

  Mathew, Bijo ^a   Haridas, Abitha ^b   Uçar, Gülberk ^c   Baysal, Ipek ^c   Joy, Monu ^d   Mathew, Githa E ^b   Lakshmanan, Baskar ^b   Jayaprakash, Venkatesan ^e  

^a Department of Pharmaceutical Chemistry   (India)

^b Grace College of Pharmacy   (India)

^c HACETTEPE UNIVERSITY   (Turkey)

^d MAHATMA GANDHI UNIVERSITY   (India)

^e BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

chalcones; cytotoxicity; molecular docking; monoamine oxidases

Indexed keywords

1 (5 BROMOTHIOPHEN 2 YL) 3 (4 CHLOROPHENYL)PROP 2 EN 1 ONE; 1 (5 BROMOTHIOPHEN 2 YL) 3 (4 ETHYLPHENYL)PROP 2 EN 1 ONE; 1 (5 BROMOTHIOPHEN 2 YL) 3 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 1 (5 BROMOTHIOPHEN 2 YL) 3 (4 HYDROXYPHENYL)PROP 2 EN 1 ONE; 1 (5 BROMOTHIOPHEN 2 YL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (5 BROMOTHIOPHEN 2 YL) 3 (4 METHYLPHENYL)PROP 2 EN 1 ONE; 1 (5 BROMOTHIOPHEN 2 YL) 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 (5 BROMOTHIOPHEN 2 YL) 3 PHENYLPROP 2 EN 1 ONE; 1 (5 BROMOTHIOPHEN 2 YL) 3 [4 (DIMETHYLAMINO)PROP] 2 EN 1 ONE; 1 (5 BROMOTHIOPHEN 2 YL) 3 [4 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 3 (4 BROMOPHENYL) 1 (5 BROMOTHIOPHEN 2 YL)PROP 2 EN 1 ONE; CHALCONE DERIVATIVE; CORTICOSTERONE; DOPAMINE; ESTRADIOL; HYDROCORTISONE; LAZABEMIDE; LOMEFLOXACIN; MOCLOBEMIDE; MONOAMINE OXIDASE B INHIBITOR; PIROXICAM; PROGESTERONE; SELEGILINE; TESTOSTERONE; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; BLOOD BRAIN BARRIER; BROMINATION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE PERMEABILITY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

EID: 84973622864     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201600122     Document Type: Article

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