Synthesis, biological evaluation, and molecular simulation of chalcones and aurones as selective MAO-B inhibitors

Chemical Biology and Drug Design

Volumn 85, Issue 6, 2015, Pages 685-695

  Morales Camilo, Nicole ^a   Salas, Cristian O ^a   Sanhueza, Claudia ^b   Espinosa Bustos, Christian ^a   Sepúlveda Boza, Silvia ^b   Reyes Parada, Miguel ^b,c   Gonzalez Nilo, Fernando ^d   Caroli Rezende, Marcos ^b   Fierro, Angélica ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

^c UNIVERSIDAD AUTÓNOMA DE CHILE   (Chile)

^d UNIVERSIDAD ANDRÉS BELLO   (Chile)

Author keywords

aurones; chalcones; molecular modeling; monoamine oxidase inhibitors; QSAR

Indexed keywords

1 (2 HYDROXY 5 METHOXYPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (2 HYDROXY 6 METHOXYPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 2 (2,3 DIMETHOXYBENZYLIDENE) 4 METHOXYBENZOFURAN 3(2H) ONE; 2 (2,3 DIMETHOXYBENZYLIDENE) 5 METHOXYBENZOFURAN 3(2H) ONE; 2 (2,4,5 TRIMETHOXYBENZYLIDENE) 4 METHOXYBENZOFURAN 3(2H) ONE; 2 (2,4,5 TRIMETHOXYBENZYLIDENE) 5 METHOXYBENZOFURAN 3(2H) ONE; 2 (2,5 DIMETHOXYBENZYLIDENE) 4 METHOXYBENZOFURAN 3(2H) ONE; 2 (2,5 DIMETHOXYBENZYLIDENE) 5 METHOXYBENZOFURAN 3(2H) ONE; 2 (4 BROMO 2,5 DIMETHOXYBENZYLIDENE) 4 METHOXYBENZOFURAN 3(2H) ONE; 2 (4 BROMO 2,5 DIMETHOXYBENZYLIDENE) 5 METHOXYBENZOFURAN 3(2H) ONE; 3 (2,3 DIMETHOXYPHENYL) 1 (2 HYDROXY 5 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 (2,3 DIMETHOXYPHENYL) 1 (2 HYDROXY 6 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 (2,5 DIMETHOXYPHENYL) 1 (2 HYDROXY 5 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 (2,5 DIMETHOXYPHENYL) 1 (2 HYDROXY 6 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 (4 BROMO 2,5 DIMETHOXYPHENYL) 1 (2 HYDROXY 5 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 (4 BROMO 2,5 DIMETHOXYPHENYL) 1 (2 HYDROXY 6 METHOXYPHENYL)PROP 2 EN 1 ONE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AURONE DERIVATIVE; CHALCONE DERIVATIVE; MONOAMINE OXIDASE B INHIBITOR; NATURAL PRODUCTS AND THEIR SYNTHETIC DERIVATIVES; UNCLASSIFIED DRUG; AMINE OXIDASE (FLAVIN CONTAINING); AURONE; BENZOFURAN DERIVATIVE; MONOAMINE OXIDASE INHIBITOR;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; CHEMISTRY; METABOLISM; SYNTHESIS;

BENZOFURANS; CHALCONES; HUMANS; MOLECULAR DOCKING SIMULATION; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84929310167     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12458     Document Type: Article

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