Monoamine oxidase: From genes to behavior

Annual Review of Neuroscience

Volumn 22, Issue , 1999, Pages 197-217

  Shih, J C ^a   Chen, K ^a   Ridd, M J ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Aggression; Characterization; Cloning; Knock out mice; Neurotransmitter

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CLORGYLINE; COMPLEMENTARY DNA; DOPAMINE; NORADRENALIN; SELEGILINE; SEROTONIN;

AGGRESSION; ALCOHOL CONSUMPTION; CIGARETTE SMOKING; DEGENERATIVE DISEASE; ENZYME ACTIVITY; HUMAN; KNOCKOUT MOUSE; MENTAL DISEASE; MONOAMINE METABOLISM; NEUROLOGIC DISEASE; NEUROTRANSMISSION; NONHUMAN; PANIC; PARKINSON DISEASE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOSIS; REVIEW; X CHROMOSOME;

ALCOHOLISM; ANIMALS; BEHAVIOR; BEHAVIOR, ANIMAL; HUMANS; MICE; MICE, KNOCKOUT; MONOAMINE OXIDASE; PARKINSON DISEASE; SMOKING; STRESS;

EID: 0032914318     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.neuro.22.1.197     Document Type: Review

References (130)

1. Achee FM, Gabay S. 1977. Studies of monoamine oxidases. Inhibition of bovine brain MAO in intact mitochondria by selective inhibitors. Biochem. Pharmacol. 26(17):1637-44
2. Bach AW, Lan NC, Johnson DL, Abell CW, Bembenek ME, et al. 1988. cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc. Natl. Acad. Sci. USA 85:4934-38
3. Berlin I, Said S, Spreux-Varoquaux O, Olivares R, Launay JM, et al. 1995. Monoamine oxidase A and B activities in heavy smokers. Biol. Psychiatr. 38(11):756-61
4. Berry MD, Scarr E, Zhu MY, Paterson IA, Juorio AV. 1994. The effects of administration of monoamine oxidase-B inhibitors on rat striatal neurone responses to dopamine. Br. J. Pharmacol. 113(4):1159-66
5. Blier P, De Montigny C, Azzaro AJ. 1986. Modification of serotonergic and noradrenergic neurotransmissions by repeated administration of monoamine oxidase inhibitors: electrophysiological studies in the rat central nervous system. J. Pharmacol. Exp. Ther. 237(3):987-94
6. Boulton AA, Yu PH, Tipton KF, 1988. Biogenic amine adducts, monoamine oxidase inhibitors, and smoking. Lancet 1(8577):114-15 (Letter)
7. Brunner HG. 1995. Monoamine oxidase and behavior. Ann. Med. 27(4):431-32 (Editorial)
8. Brunner HG, Nelen M, Breakefield XO, Ropers HH, Van Oost BA, 1993a. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262:578-80
9. Brunner HG, Nelen MR, Van Zandvoort P, Abeling NGGM, Van Gennip AH, et al. 1993b. X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism. Am. J. Hum. Genet. 52:1032-39
10. Carr LA, Basham JK. 1991. Effects of tobacco smoke constituents on MPTP-induced toxicity and monoamine oxidase activity in the mouse brain. Life Sci. 48(12):1173-77
11. Carr LA, Rowell PP. 1990. Attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity by tobacco smoke. Neuropharmacology 29(3):311-14
12. Cases O, Seif I, Grimsby J, Gaspar P, Chen K, et al. 1995. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAO A. Science 268(5218):1763-66
13. Cases O, Vitalis T, Seif I, De Maeyer E, Sotelo C, et al. 1996. Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: role of a serotonin excess during the critical period. Neuron 16:297-307
14. Cesura AM, Gottowik J, Lahm HW, Lang G, Imhof R, et al. 1996. Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis. Eur. J. Biochem. 236(3):996-1002
15. 2 cells. Presented at 26th Annu. Meet. Neurosci., Washington, DC
16. Chen K, Wu HF, Grimsby J, Shih JC. 1994. Cloning of a novel monoamine oxidase cDNA from trout liver. Mol. Pharmacol. 46(6):1226-33
17. Chen K, Wu HF, Shih JC. 1996b. Influence of C terminus on monoamine oxidase A and B catalytic activity. J. Neurochem. 66(2):797-803
18. Cohen G. 1990. Monoamine oxidase and oxidative stress at dopaminergic synapses. J. Neural Transm. 32(Suppl.):229-38
19. Collins FA, Murphy DL, Reiss AL, Sims KB, Lewis JG, et al. 1992. Clinical, biochemical, and neuropsychiatric evaluation of a patient with a contiguous gene syndrome due to a microdeletion Xp 11.3 including the Norrie disease locus and monoamine oxidase (MAO A and MAO B) genes. Am. J. Med. Genet. 42(1):127-34
20. Denney RM, Fritz RR, Patel NT, Abell CW. 1982. Human liver MAO-A and MAO-B separated by immunoaffinity chromatography with MAO-B specific monoclonal antibody. Science 215:1400-3
21. Denney RM, Sharma A, Dave SK, Waguespack A. 1994. A new look at the promoter of the human monoamine oxidase A gene: mapping transcription initiation sites and capacity to drive luciferase expression. J. Neurochem. 63:843-56
22. Derry JM, Lan NC, Shih JC, Barnard EA, Barnard PJ. 1989. Localization of monoamine oxidase A and B genes on the mouse X chromosome. Nucleic Acids Res. 17:8403
23. Devor EJ, Cloninger CR, Hoffman PL, Tabakoff B. 1993. Association of monoamine oxidase (MAO) activity with alcoholism and alcoholic subjects. Am. J. Med. Genet. 48:209-13
24. Diez JA, Maderdrut JL. 1977. Development of multiple forms of mouse brain monoamine oxidase in vivo and in vitro. Brain Res. 128(1):187-92
25. Doyle A, Hucklebridge F, Evans P, Clow A. 1996. Salivary monoamine oxidase A and B inhibitory activities correlate with stress. Life Sci. 59(16):1357-62
26. Dyck LE, Durden DA, Boulton AA. 1993. Effects of monoamine oxidase inhibitors on the acid metabolites of some trace amines and of dopamine in the rat striatum. Biochem. Pharmacol. 45(6):1317-22
27. Ekstedt B, Oreland L. 1976. Heterogeneity of pig liver and pig brain mitochondrial monoamine oxidase. Arch. Int. Pharmacodyn. Ther. 222(1):157-65
28. Erwin VG, Hellerman L. 1967. Mitochondrial monoamine oxidase I. Purification and characterization of the bovine kidney enzyme. J. Biol. Chem. 242:4230-38
29. Faraj BA, Davis DC, Camp VM, Mooney AJ, Holloway T, et al. 1994. Platelet monoamine oxidase activity in alcoholics, alcoholics with drug dependence, and cocaine addicts. Alcohol Clin. Exp. Res. 18:1114-20
30. Fowler CJ, Mantle TJ, Tipton KF. 1982. The nature of the inhibition of rat liver monoamine oxidase types A and B by the acetylenic inhibitors clorgyline, l-deprenyl and pargyline. Biochem. Pharmacol. 31:3555-61
31. Fowler CJ, Wiberg A, Oreland L, Marcusson J, Winblad B. 1980. The effect of age on the activity and molecular properties of human brain monoamine oxidase. J. Neural Transm. 49(1-2):1-20
32. Fowler JS, Volkow ND, Wang GJ, Pappas N, Logan J, et al. 1996a. Inhibition of monoamine oxidase B in the brains of smokers. Nature 379(6567):733-36
33. Fowler JS, Volkow ND, Wang GJ, Pappas N, Logan J, et al. 1996b. Brain monoamine oxidase A inhibition in cigarette smokers. Proc. Natl. Acad. Sci. USA 93(24):14065-69
34. Fuller RW, Hemrick-Luecke SK. 1984. Deprenyl protection against striatal dopamine depletion by 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine in mice. Res. Commun. Subst. Abuse 5:241-46
35. Gerlach M, Riederer P, Youdim MBH. 1996a. Molecular mechanisms for neurodegeneration: synergism between reactive oxygen species, calcium and excitotoxic amino acids. Adv. Neurol. 69:177-94
36. Gerlach M, Youdim MBH, Riederer P. 1996b. Pharmacology of selegiline. Neurology 47(3):S137-45
37. Glover V, Sandler M, Owen F, Riley GJ. 1977. Dopamine is a monoamine oxidase B substrate in man. Nature 265(5589):80-81
38. Gottowik J, Malherbe P, Jang G, Da Prada M, Cesura AM. 1995. Structure/function relationships of mitochondrial monoamine oxidase A and B chimeric forms. Eur J. Biochem. 230:934-42
39. Green AR, Youdim MBH, 1975. Effects of monoamine oxidase inhibition by clorgyline, deprenyl or tranycypromine on 5-hydroxytryptamine concentrations in rat brain and hyperactivity following subsequent tryptophan administration. Br. J. Pharmacol. 55:415-22
40. Grimsby J, Chen K, Devor EJ, Cloninger CR, Shih JC. 1992. Dinucleotide repeat (TG)23 polymorphism in the MAO B gene. Nucleic Acids Res. 20(4):924
41. Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC. 1991. Human monoamine oxidase A and B genes exhibit identical exon-intron organization. Proc. Natl. Acad. Sci. USA 88(9):3637-41
42. Grimsby J, Toth M, Chen K, Kumazawa T, Klaidman L, et al. 1997. Increased stress response and β-phenylethylamine in MAO B-deficient mice. Nature Genet. 17:1-5
43. Grimsby J, Zentner M, Shih JC. 1996. Identification of a region important for human monoamine oxidase B substrate and inhibitor selectivity. Life Sci. 58(9):777-87
44. Haney M, Noda K, Kream R, Miczek KA. 1990. Regional serotonin and dopamine activity: sensitivity to amphetamine and aggressive behavior in mice. Aggress. Behav. 16:259-70
45. Hauptmann N, Grimsby J, Shih JC, Cadenas E. 1996. The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA. Arch. Biochem. Biophys. 335(2):295-304
46. Heikkila RE, Manzino L, Cabbat FS, Duvoisin RC. 1984. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature 311(5985):467-69
47. Hiro I, Tsugeno Y, Hirashiki I, Ogata F, Ito A. 1996. Characterization of wild-type and mutant forms of human monoamine oxidase A and B expressed in a mammalian cell line. J. Biochem. 124(4):759-65
48. Hotamisligil GS, Girmen AS, Fink JS, Tivol E, Shalish C, et al. 1994. Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease. Mov. Disord. 9(3):305-10
49. Hough LB, Domino EF. 1979. Tele-methylhistamine oxidation by type B monoamine oxidase. J. Pharmacol. Exp. Ther. 208:422-28
50. Hsu MC, Shih JC. 1988. Photoaffinity labeling of human placenta monoamine oxidase A by 4-fluoro-3-nitrophenylazide. Mol. Pharmacol. 33:237-41
51. Hsu YP, Weyler W, Chen S, Sims KB, Rinehart WB, et al. 1988. Structural features of human monoamine oxidase A elucidated from cDNA and peptide sequences. J. Neurochem. 51(4):1321-24
52. Hsu Y-PP, Loh EW, Chen WJ, Chen C-C, Yu J-M, et al. 1996. Association of monoamine oxidase A alleles with alcoholism among male Chinese in Taiwan. Am. J. Psychiatr. 153:1209-11
53. Ito A, Kuwahara T, Inadome S, Sagara Y. 1988. Molecular cloning of a cDNA for rat liver monoamine oxidase B. Biochem. Biophys. Res. Commun. 157:970-76
54. Jahng JW, Houpt TA, Wessel TC, Chen K, Shih JC, et al. 1997. Localization of monoamine oxidase A and B mRNA in the rat brain by in situ hybridization. Synapse 25(1):30-36
55. Johnston JP. 1968. Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochem. Pharmacol. 17(7):1285-97
56. Juorio AV, Greenshaw AJ, Wishart TB. 1988. Reciprocal changes in striatal dopamine and β-phenylethylamine induced by reserpine in the presence of monoamine oxidase inhibitors. Naunyn-Schmiedeberg's Arch. Pharmacol. 338(6):644-48
57. Kearney EB, Salach JL, Walker WH, Seng RL, Singer TP. 1971. The covalently bound flavin of hepatic monoamine oxidase. I. Isolation and sequence of a flavin peptide and evidence for binding at the 8a position. Eur. J. Biochem. 24:321-27
58. Kim JJ, Shih JC, Chen K, Chen L, Bao S, et al. 1997. Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice. Proc. Natl. Acad. Sci. USA 94:5929-33
59. Knoll J. 1988. Extension of life span of rats by long-term (-)deprenyl treatment. Mt. Sinai J. Med 55(1):67-74
60. Knoll J. 1989. The pharamcology of selegiline ((-)deprenyl). New aspects. Acta Neurol. Scand. Suppl. 126:83-91
61. Knoll J, Magyar K. 1972. Some puzzling pharmacological effects of monoamine oxidase inhibitors. Adv. Biochem. Psychopharmacol. 5:393-408
62. Kochersperger LM, Parker EL, Siciliano M, Darlington GJ, Denney RM. 1986. Assignment of genes for human monoamine oxidases A and B to the X chromosome. J. Neurosci. Res. 16:601-16
63. n repeat sequence in intron 11 of the human MAO B gene. Genomics 12(1):176-77
64. 1A receptor expression in forebrain regions of aggressive house mice. Brain Res. 736(1-2):338-43
65. Kurth JH, Kurth MC, Poduslo SE, Schwankhaus JD. 1993. Association of a monoamine oxidase B allele with Parkinson's disease. Ann. Neurol. 33:368-72
66. Kuwahara T, Takamoto S, Ito A. 1990. Primary structure of rat monoamine oxidase A deduced from cDNA and its expression in rat tissues. Agric. Biol. Chem. (54):253-57
67. Kwan SW, Lewis DA, Zhou BP, Abell CW. 1995. Characterization of a dinucleotide-binding site in monoamine oxidase B by site-directed mutagenesis. Arch. Biochem. Biophys. 316(1):385-91
68. Lan NC, Chen CH, Shih JC. 1989a. Expression of functional human monoamine oxidase A and B cDNAs in mammalian cells. J. Neurochem. 52:1652-54
69. Lan NC, Heinzmann C, Gal A, Klisak I, Orth U, et al. 1989b. Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease. Genomics 4(4):552-59
70. Langston JW, Forno LS, Rebert CS, Irwin I. 1984. Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the squirrel monkey. Brain Res. 292:390-94
71. Levitt P, Pintar JE, Breakefield XO. 1982. Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons. Proc. Natl. Acad. Sci. USA 79(20):6385-89
72. Levy ER, Powell JF, Buckle VJ, Hsu YP, Breakefield XO, et al. 1989. Localization of human monoamine oxidase-A gene to Xp 11.23-11.4 by in situ hybridization: implications for Norrie disease. Genomics 5:368-70
73. Lewinsohn R, Glover V, Sandler M. 1980. Development of benzylamine oxidase and monoamine oxidase A and B in man. Biochem. Pharmacol. 29(9):1221-30
74. Liebowitz MR, Hollander E, Schneier F, Campeas K, Welkowitz L, et al. 1990. Reversible and irreversible monoamine oxidase inhibitors in other psychiatric disorders. Acta Psychiatr. Scand. Suppl. 360:29-34
75. Luque JM, Kwan S-W, Abell CW, Da Prada M, Richards GJ. 1995. Cellular expression of mRNAs encoding monoamine oxidases A and B in the rat central nervous system. J. Comp. Neurol. 363:665-80
76. Masini-Repiso AM, Cabanillas AM, Andrada MC, Coleoni AH. 1986. Monoamine oxidase in bovine thyroid tissue. Horm. Metabol. Res. 18:750-53
77. Minamiura N, Yasunobu KT. 1978. Bovine liver monoamine oxidase. A modified purification procedure and preliminary evidence for two subunits and one FAD. Arch. Biochem. Biophys. 189:481-89
78. Mitoma J, Ito A. 1992. Mitochondrial targeting signal of rat liver monoamine oxidase B is located at its carboxy terminus. J. Biochem. 111(1):20-24
79. Mitra C, Guha SR. 1980. Serotonin oxidation by type B MAO of rat brain. Biochem. Pharmacol. 29:1213-16
80. Molina V, Ciesielski L, Gobaille S, Isel F, Mandel P. 1987. Inhibition of mouse-killing behavior by serotonin-mimetic drugs: effects of partial alterations of serotonin neurotransmission. Pharmacol. Biochem. Behav. 27:123-31
81. Nanko S, Ueki A, Hatton M. 1996. No association between Parkinson's disease and monoamine oxidase A and B gene polymorphism. Neurosci. Lett. 204:125-27
82. Neff NH, Yang HY. 1974. Another look at the monoamine oxidases and the monoamine oxidase inhibitor drugs. Life Sci. 14(11):2061-74
83. O'Carroll AM, Fowler CJ, Phillips JP, Tobbia I, Tipton KF. 1983. The deamination of dopamine by human brain monoamine oxidase. Specificity for the two enzyme forms in seven brain regions. Naunyn-Schmiedeberg's Arch. Pharmacol. 322(3):198-202
84. Olivier B, Mos J. 1992. Rodent models of aggressive behavior and serotonergic drugs. Prog. Neuro-Psychopharmacol. Biol. Psychiatr. 16:847-70
85. Oreland L, Fowler CJ, Schalling D. 1981. Low platelet monoamine oxidase activity in cigarette smokers. Life Sci. 29(24):2511-18
86. Parsian A, Suarez BK, Tabakoff B, Ovchinnikova L, Fisher L, et al. 1995. Monoamine oxidases and alcoholism. I. Studies in unrelated alcoholics and normal controls. Am. J. Med. Genet. Neuropsychiatr. Genet. 60:409-16
87. Paterson IA, Juorio AV, Boulton AA. 1990. Possible mechanism of action of deprenyl in Parkinsonism. Lancet 336(8708):183 (Letter)
88. Pintar JE, Barbosa J, Francke U, Castiglione CM, Hawkins M, et al. 1981. Gene for monoamine oxidase type A assigned to the human X chromosome. J. Neurosci. 1:166-75
89. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, et al. 1997. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276:2045-47
90. Popova NK, Kulikov AV, Avgustinovich DE, Shigantsov SN. 1996. The characteristics of the brain serotonin system and anxiety in the C57BL and CBA mouse strains. Zh. Vyss. Nerv. Deyat. im. I. P. Pavlova 46(2):348-54
91. Powell JF, Hsu YP, Weyler W, Chen SA, Salach J, et al. 1989. The primary structure of bovine monoamine oxidase type A. Comparison with peptide sequences of bovine monoamine oxidase type B and other flavoenzymes. J. Biochem. 259:407-13
92. Raddatz R, Lanier SM. 1997. Relationship between imidazoline/guanidinium receptive sites and monoamine oxidase A and B. Neurochem. Int. 30:109-17
93. Raddatz R, Parini A, Lanier SM. 1995. Imidazoline/guanidinium binding domains on monoamine oxidases. Relationship to subtypes of imidazoline-binding proteins and tissue-specific interaction of imidazoline ligands with monoamine oxidase B. J. Biol. Chem. 270:27961-68
94. Riederer P, Jellinger K. 1983. Neurochemical insights into monoamine oxidase inhibitors, with special reference to deprenyl (selegiline). Acta Neurol. Scand. Suppl. 95:43-55
95. Sanchez C, Arnt J, Hyttel J, Moltzen EK. 1993. The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice. Psychopharmacology 110:53-59
96. Sano M, Ernesto C, Ronald MS, Thomas RG, Klauber MR, et al. 1997. A controlled trial of selegiline or α-tocopherol, or both as treatment for Alzheimer's disease. N. Engl. J. Med. 336(17):1216-22
97. 1B receptor. Science 265:1875-78
98. Saura J, Bleuel Z, Ulrich J, Mendelowitsch A, Chen K, et al. 1996. Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization. Neuroscience 70(3):755-74
99. 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J. Neurosci. 12(5):1977-99
100. Saura J, Richards JG, Mahy N. 1994a. Age-related changes in MAO in B1/C57 mouse tissues: a quantitative radioautographic study. J. Neural Transm. 41:89-94
101. Saura J, Richards JG, Mahy N. 1994b. Differential age-related changes of MAO-A and MAO-B in mouse brain and peripheral organs. Neurobiol. Aging 15(4):399-408
102. Scarr E, Wingerchuk DM, Juorio AV, Paterson IA. 1994. The effects of monoamine oxidase B inhibition on dopamine metabolism in rats with nigro-striatal lesions. Neurol. Res. 19(2):153-59
103. Shih JC. 1991. Molecular basis of human MAO A and B. Neuropsychopharmacology 4(1):1-7
104. Shiloff BA, Behrens PQ, Kwan SW, Lee JH, Abell CW. 1996. Monoamine oxidase B isolated from bovine liver exists as large oligomeric complexes in vitro. Eur. J. Biochem. 242(1):41-50
105. Sims KB, de la Chapelle A, Norio R, Sankila E-M, Hsu Y-PP, et al. 1989. Monoamine oxidase deficiency in males with an X chromosome deletion. Neuron 2:1069-76
106. 2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J. Pharmacol. Exp. Ther 266(2):684-91
107. Suzuki O, Katsumata Y, Oya M. 1981. Oxidation of β-phenylethylamine by both types of monoamine oxidase: examination of enzymes in brain and liver mitochondria of eight species. J. Neurochem. 36(3):1298-301
108. Tatton WG, Chalmers-Redman RME. 1996. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology 47(Suppl. 3):S171-83
109. Thorpe LW, Westlund KN, Kochersperger LM, Abell CW, Denney RM. 1987. Immunocytochemical localization of monoamine oxidases A and B in human peripheral tissues and brain. J. Histochem. Cytochem. 35(1):23-32
110. Tipton KF, O'Carroll AM, McCrodden JM. 1987. The catalytic behavior of monoamine oxidase. J. Neural Transm. 23(Suppl.):25-35
111. Tsang D, Ho KP, Wen HL. 1986. Ontogenesis of multiple forms of monoamine oxidase in rat brain regions and liver. Dev. Neurosci. 8(4):243-50
112. Tsugeno Y, Hirashiki I, Ogata F, Ito A. 1995. Regions of the molecule responsible for substrate specificity of monoamine oxidase A and B: a chimeric enzyme analysis. J. Biochem. 118(5):974-80
113. Tsugeno Y, Ito A. 1997. A key amino acid responsible for substrate selectivity of monoamine oxidase A and B. J. Biol. Chem. 272(22):14033-36
114. 2 receptor linked inositol phospholipid hydrolysis. Biochem Pharmacol. 40(9):2111-16
115. Vanyukov MM, Moss HB, Yu LM, Tarter RE, Deka R. 1995. Preliminary evidence for an association of a dinucleotide repeat polymorphism at the MAO A gene with early onset alcoholism/substance abuse. Am. J. Med. Genet. Neuropsychiatr. Genet. 60:122-26
116. Westlund KN. 1994. The distribution of monoamine oxidases A and B in normal human brain. In Monoamine Oxidase Inhibitors in Neurological Diseases, ed. A Lieberman, CW Olanow, MBH Youdim, K Tipton, pp. 1-19. New York: Dekker
117. Westlund KN, Denney RM, Kochersperger LM, Rose RM, Abell CW. 1985. Distinct monoamine oxidase A and B populations in primate brain. Science 230(4722):181-83
118. Westlund KN, Denney RM, Rose RM, Abell CW. 1988. Localization of distinct monoamine oxidase A and monoamine oxidase B cell populations in human brainstem. Neuroscience 25(2):439-56
119. Westlund KN, Krakower TJ, Kwan SW, Abell CW. 1993. Intracellular distribution of monoamine oxidase A in selected regions of rat and monkey brain and spinal cord. Brain Res. 612(1-2):221-30
120. Weyler W. 1994. Functional expression of C-terminally truncated human monoamine oxidase type A in Saccharomyces cerevisiae. J. Neural Transm. 41(Suppl.):3-15
121. Weyler W, Salach JI. 1985. Purification and properties of mitochondrial monoamine oxidase type A from human placenta. J. Biol. Chem. 260:13199-207
122. Willoughby J, Glover V, Sandler M. 1988. Histochemical localization of monoamine oxidase A and B in rat brain. J. Neural Transm. 74(1):29-42
123. Wu HF, Chen K, Shih JC. 1993. Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines. Mol. Pharmacol. 43(6):888-93
124. Yu PH, Boulton AA. 1987. Irreversible inhibition of monoamine oxidase by some components of cigarette smoke. Life Sci. 41(6):675-82
125. Yu PH, Davis BA, Durden DA, Barber A, Terleckyj I, et al. 1994. Neurochemical and neuroprotective effects of some aliphatic propargylamines: new selective nonamphetamine-like monoamine oxidase B inhibitors. J. Neurochem. 62(2):697-704
126. Zhong B, Silverman RB. 1997. Identification of the active site cysteine in bovine liver monoamine oxidase B. J. Am. Chem. Soc. 119:6690-91
127. Zhou BP, Lewis DA, Kwan SW, Kirksey TJ, Abell CW. 1995. Mutagenesis at a highly conserved tyrosine monoamine oxidase B affects FAD incorporation and catalytic activity. Biochemistry 34(29):9526-33
128. Zhu QS, Chen K, Shih JC. 1994. Bidirectional promoter of human monoamine oxidase A (MAO A) controlled by transcription factor Sp1. J. Neurosci. 14(12):7393-403
129. Zhu QS, Grimsby J, Chen K, Shih JC. 1992. Promoter organization and activity of human monoamine oxidase (MAO) A and B genes. J. Neurosci. 12(11):4437-46
130. Zhu QS, Shih JC. 1997. An extensive repeat structure down-regulates human monoamine oxidase A promoter activity independent of an initiator-like sequence. J. Neurochem. 69:1368-73