Homoisoflavonoids: Natural scaffolds with potent and selective monoamine oxidase-B inhibition properties

Journal of Medicinal Chemistry

Volumn 54, Issue 7, 2011, Pages 2155-2164

  Desideri, Nicoletta ^a   Bolasco, Adriana ^a   Fioravanti, Rossella ^a   Proietti Monaco, Luca ^a   Orallo, Francisco ^b   Yáñez, Matilde ^b   Ortuso, Francesco ^c   Alcaro, Stefano ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 [4 (DIMETHYLAMINO)BENZYLIDENE]CHROMAN 4 ONE; 3 BENZYL 4H CHROMEN 4 ONE DERIVATIVE; 3 BENZYLCHROMAN 4 ONE DERIVATIVE; 3 BENZYLIDENE 4 CHROMANONE DERIVATIVE; 5,7 DIHYDROXY 3 (4 HYDROXYBENZYLIDENE)CHROMAN 4 ONE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CLORGYLINE; HOMOISOFLAVONOID DERIVATIVE; IPRONIAZID; MOCLOBEMIDE; MOLECULAR SCAFFOLD; MONOAMINE OXIDASE INHIBITOR; SELEGILINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

DRUG DISCOVERY; FLAVONOIDS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 79953769169     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1013709     Document Type: Article

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