Investigations on the 2-thiazolylhydrazyne scaffold: Synthesis and molecular modeling of selective human monoamine oxidase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 15, 2010, Pages 5715-5723

  Chimenti, Franco ^a   Bolasco, Adriana ^a   Secci, Daniela ^a   Chimenti, Paola ^a   Granese, Arianna ^a   Carradori, Simone ^a   Yáñez, Matilde ^b   Orallo, Francisco ^b   Ortuso, Francesco ^c   Alcaro, Stefano ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

2 Thiazolylhydrazyne; hMAO inhibitors; Molecular modeling

Indexed keywords

1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 ((1H INDOL 3 YL)METHYLENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (1 (COUMARIN 3 YL)ETHYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (1 (FURAN 2 YL)ETHYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (1 (NAPHTHALEN 2 YL)ETHYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (1 (PYRIDIN 2 YL)ETHYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (1 (PYRIDIN 3 YL)ETHYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (1 (PYRIDIN 4 YL)ETHYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (1 (THIOPHEN 2 YL)ETHYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (2 METHYLCYCLOHEXYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (2 METHYLCYCLOPENTYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (3 METHYLCYCLOHEXYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (3 METHYLCYCLOPMETHYLCYCLOPENTYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (4 METHYLCYCLOHEXYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (BENZODIOXOL 5 YLMETHYLENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (FURAN 2 YLMETHYLENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (HEPTAN 2 YLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (NAPHTHALEN 1 YLMETHYLENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (OCTAN 2 YLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (PENTAN 2 YLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (PENTAN 3 YLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (PROPAN 2 YLIYLIDENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (PYRIDIN 3 YLMETHYLENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (PYRIDIN 4 YLMETHYLENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 (THIOPHEN 2 YLMETHYLENE)HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 CYCLOHEPTYLIDENE HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 CYCLOHEXYLIDENE HYDRAZINE; 1 (4 (3 METHOXYPHENYL)THIAZOL 2 YL) 2 CYCLOPENTYLIDENE HYDRAZINE; MONOAMINE OXIDASE INHIBITOR; UNCLASSIFIED DRUG; AMINE OXIDASE (FLAVIN CONTAINING); HYDRAZINE DERIVATIVE; HYDROGEN PEROXIDE;

ARTICLE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM;

HUMANS; HYDRAZINES; HYDROGEN PEROXIDE; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955418391     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.007     Document Type: Article

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