Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors

European Journal of Medicinal Chemistry

Volumn 114, Issue , 2016, Pages 162-169

  Hammuda, Arwa ^a   Shalaby, Raed ^a   Rovida, Stefano ^b   Edmondson, Dale E ^c   Binda, Claudia ^b   Khalil, Ashraf ^a  

^a Qatar University ^*  (Qatar)

^b UNIVERSITY OF PAVIA   (Italy)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chalcones; Drug design; Enzyme; Monoamine oxidase; Neuroprotection; Synthesis

Indexed keywords

3 (2,3 DIMETHOXYPHENYL) 1 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 3 (2,3 DIMETHOXYPHENYL) 1 [3 (TRIFLUOROMETHOXY)PHENYL]PROP 2 EN 1 ONE; 3 (2,3 DIMETHOXYPHENYL) 1 [3 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 3 (2,3 DIMETHOXYPHENYL) 1 [4 (METHYLSULFONYL)PHENYL]PROP 2 EN 1 ONE; 3 (2,3 DIMETHOXYPHENYL) 1 [4 (METHYLTHIO)PHENYL)PROP 2 EN 1 ONE; 3 (BENZO[D][1,3]DIOXOL 4 YL) 1 [2 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 3 (BENZO[D][1,3]DIOXOL 4 YL) 1 [3 (TRIFLUOROMETHOXY)PHENYL]PROP 2 EN 1 ONE; 3 (BENZO[D][1,3]DIOXOL 4 YL) 1 [3 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 3 (BENZO[D][1,3]DIOXOL 4 YL) 1 [4 (METHYLSULFONYL)PHENYL]PROP 2 EN 1 ONE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AROMATIC COMPOUND; CHALCONE DERIVATIVE; KETONE; MONOAMINE OXIDASE B INHIBITOR; UNCLASSIFIED DRUG; AMINE OXIDASE (FLAVIN CONTAINING); MONOAMINE OXIDASE INHIBITOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; IC50; INSECT CELL; NONHUMAN; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84964194148     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.02.038     Document Type: Article

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