Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface

Proteins: Structure, Function and Bioinformatics

Volumn 84, Issue 9, 2016, Pages 1246-1256

  Franklin, Matthew C ^a,b   Rudolph, Michael J ^a   Ginter, Christopher ^a   Cassidy, Michael S ^a   Cheung, Jonah ^a  

^a NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

acetylcholinesterase; acyl pocket loop; crystal structure; insecticide; nerve agent; organophosphate; oxime; paraoxon

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; DIMER; PARAOXON; PRALIDOXIME; ACHE PROTEIN, HUMAN; ANTIDOTE; CHOLINESTERASE INHIBITOR; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; INSECTICIDE; PROTEIN BINDING; RECOMBINANT PROTEIN;

AGING; ARTICLE; BINDING AFFINITY; CHOLINESTERASE INHIBITION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; COVALENT BOND; DEALKYLATION; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; HYDROGEN BOND; ORGANOPHOSPHATE POISONING; PRIORITY JOURNAL; STATIC ELECTRICITY; BINDING SITE; CELL LINE; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ACETYLCHOLINESTERASE; AMINO ACID MOTIFS; ANTIDOTES; BINDING SITES; CELL LINE; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; EPITHELIAL CELLS; GENE EXPRESSION; GPI-LINKED PROTEINS; HUMANS; INSECTICIDES; PARAOXON; PRALIDOXIME COMPOUNDS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS;

EID: 84973375290     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.25073     Document Type: Article

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