A step toward the reactivation of aged cholinesterases-Crystal structure of ligands binding to aged human butyrylcholinesterase

Chemico-Biological Interactions

Volumn 203, Issue 1, 2013, Pages 19-23

  Wandhammer, Marielle ^a,b   De Koning, Martijn ^c   Van Grol, Marco ^c   Loiodice, Mélanie ^a   Saurel, Laura ^a   Noort, Daan ^c   Goeldner, Maurice ^b   Nachon, Florian ^a  

^a INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c Department of CBRN Protection TNO Earth Environmental and Life Sciences   (Netherlands)

Author keywords

Acetylcholinesterase; Aging; Butyrylcholinesterase; Nerve agents; Reactivators; X ray structure

Indexed keywords

1 METHYL 2 (PERFLUOROPHENOXYIMINO)PYRIDINIUM; 4 TRICHLOROACETIMIDATE 1 BENZYLPYRIDINIUM; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; METHYL 2 (PENTAFLUOROBENZYLOXYIMINO)PYRIDINIUM IODIDE; RECOMBINANT ENZYME; SOMAN; UNCLASSIFIED DRUG;

ALKYLATION; CHOLINESTERASE INHIBITION; COMPETITIVE INHIBITION; COMPLEX FORMATION; CONFERENCE PAPER; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME REACTIVATION; ENZYME STRUCTURE; LIGAND BINDING;

ALKYLATION; BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; PHOSPHORYLATION; PRALIDOXIME COMPOUNDS; RECOMBINANT PROTEINS; SERINE; SOMAN;

EID: 84875805860     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.08.005     Document Type: Conference Paper

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