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5
-
-
13044303121
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-
note
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DFP, diisopropylphosphorofluoridate; sarin, O-isopropylmethylphosphonofluoridate; soman, O-pinacolyl methylphosphonofluoridate.
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-
-
-
6
-
-
0033151759
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Millard, C. B.; Kryger, G.; Ordentlich, A.; Greenblatt, H. M.; Harel, M.; Raves, M. L.; Segall, Y.; Barak, D.; Shafferman, A.; Silman, I.; Sussman, J. Biochemistry 1999, 38, 7032-7039.
-
(1999)
Biochemistry
, vol.38
, pp. 7032-7039
-
-
Millard, C.B.1
Kryger, G.2
Ordentlich, A.3
Greenblatt, H.M.4
Harel, M.5
Raves, M.L.6
Segall, Y.7
Barak, D.8
Shafferman, A.9
Silman, I.10
Sussman, J.11
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8
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0025778840
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121 were prepared in PEG-200, pH 6.0, and data were collected at 100 K with synchrotron radiation at Elletra, Trieste (1vxr) or Broohaven National Laboratory, NY (1vxo). All crystals were isomorphous with native TcAChE (2ace); see ref 5 and Sussman, J. L.; Harel, M.; Frolow, F.; Oefner, C.; Goldman, A.; Toker, L.; and Silman, I. Science 1991, 253, 872-879. The final R-factors were 18.9% (1vxr) and 19.4% (1vxo), and the free-R-factors were 23.0% (1vxr) and 23.4% (1vxo).
-
(1991)
Science
, vol.253
, pp. 872-879
-
-
Sussman, J.L.1
Harel, M.2
Frolow, F.3
Oefner, C.4
Goldman, A.5
Toker, L.6
Silman, I.7
-
9
-
-
33644811612
-
-
The substrate was acetythiocholine and enzyme activity was measured by the method of Ellman, G. L.; Courtney, K. D.; Andres, V.; Featherstone, R. M. Biochem. Pharmacol. 1961, 7, 88-95.
-
(1961)
Biochem. Pharmacol.
, vol.7
, pp. 88-95
-
-
Ellman, G.L.1
Courtney, K.D.2
Andres, V.3
Featherstone, R.M.4
-
10
-
-
0027373839
-
-
(a) Ordentlich, A.; Kronman, C.; Barak, D.; Stein, D.; Ariel, N.; Marcus, D.; Velan, B.; Shafferman, A. FEBS Lett. 1993, 334, 215-220.
-
(1993)
FEBS Lett.
, vol.334
, pp. 215-220
-
-
Ordentlich, A.1
Kronman, C.2
Barak, D.3
Stein, D.4
Ariel, N.5
Marcus, D.6
Velan, B.7
Shafferman, A.8
-
11
-
-
0027495085
-
-
(b) Saxena, A.; Doctor, B. P.; Maxwell, D. M.; Lenz, D. E.; Radic, Z.; Taylor, P. Biochem. Biophys. Res. Commun. 1993, 197, 343-349.
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.197
, pp. 343-349
-
-
Saxena, A.1
Doctor, B.P.2
Maxwell, D.M.3
Lenz, D.E.4
Radic, Z.5
Taylor, P.6
-
12
-
-
0032573032
-
-
Saxena, A.; Viragh, C.; Frazier, D. S.; Kovach, I. M.; Maxwell, D. M.; Lockridge, O.; Doctor, B. P. Biochemistry 1998, 37, 15086-15096.
-
(1998)
Biochemistry
, vol.37
, pp. 15086-15096
-
-
Saxena, A.1
Viragh, C.2
Frazier, D.S.3
Kovach, I.M.4
Maxwell, D.M.5
Lockridge, O.6
Doctor, B.P.7
-
13
-
-
0029847276
-
-
(a) Bencsura, A.; Enyedy, I. Y.; Kovach, I. M. J. Am. Chem. Soc. 1996, 118, 8531-8541.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 8531-8541
-
-
Bencsura, A.1
Enyedy, I.Y.2
Kovach, I.M.3
-
14
-
-
0029742777
-
-
(b) Shafferman, A.; Ordentlich, A.; Barak, D.; Stein, D.; Ariel, N.; Velan, B. Biochem. J. 1996, 318, 833-840.
-
(1996)
Biochem. J.
, vol.318
, pp. 833-840
-
-
Shafferman, A.1
Ordentlich, A.2
Barak, D.3
Stein, D.4
Ariel, N.5
Velan, B.6
-
15
-
-
0030755235
-
-
Wlodek, S. T.; Antosiewicz, J.; Briggs, J. M. J. Am. Chem. Soc. 1997, 119, 8159-8165.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 8159-8165
-
-
Wlodek, S.T.1
Antosiewicz, J.2
Briggs, J.M.3
-
16
-
-
0001471822
-
-
Selwood, T.; Feaster, S. R.; States, M. J.; Pryor, A. N.; Quinn, D. M. J. Am. Chem. Soc. 1993, 115, 10477-10482.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 10477-10482
-
-
Selwood, T.1
Feaster, S.R.2
States, M.J.3
Pryor, A.N.4
Quinn, D.M.5
-
17
-
-
0026093195
-
-
Bone, R.; Sampson, N. S.; Bartlett, P. A.; Agard, D. A. Biochemistry 1991, 30, 2263-2272.
-
(1991)
Biochemistry
, vol.30
, pp. 2263-2272
-
-
Bone, R.1
Sampson, N.S.2
Bartlett, P.A.3
Agard, D.A.4
-
18
-
-
0025953442
-
-
Harel, M.; Su, C.-T.; Frolow, F.; Ashani, Y.; Silman, I.; Sussman, J. L. J. Mol. Biol. 1991, 221, 909-918.
-
(1991)
J. Mol. Biol.
, vol.221
, pp. 909-918
-
-
Harel, M.1
Su, C.-T.2
Frolow, F.3
Ashani, Y.4
Silman, I.5
Sussman, J.L.6
-
19
-
-
0028168468
-
-
Derewenda, Z. S.; Derewenda, U.; Kobos, P. M. J. Mol. Biol. 1994, 241, 83-93.
-
(1994)
J. Mol. Biol.
, vol.241
, pp. 83-93
-
-
Derewenda, Z.S.1
Derewenda, U.2
Kobos, P.M.3
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