Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: Reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad

Biochemical Pharmacology

Volumn 79, Issue 3, 2010, Pages 507-515

  Hörnberg, Andreas ^a   Artursson, Elisabet ^a   Wärme, Rikard ^a   Pang, Yuan Ping ^b   Ekström, Fredrik ^a  

^a SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^b MAYO CLINIC   (United States)

Author keywords

Acetylcholinesterase; Crystallography; Histidine flip; Organophosphorus compound; Oxime

Indexed keywords

1 [(4 CARBAMOYLPYRIDIN 1 IUM 1 YL)METHOXYMETHYL]PYRIDIN 2 YLIDINE]METHYLOXOAZANIUM DICHLORIDE; 1,7 HEPTYLENE BIS N,N' 2 PYRIDINIUMALDOXIME DICHLORIDE; ACETYLCHOLINESTERASE; FENAMIPHOS; GLUTAMIC ACID; HISTIDINE; IMIDAZOLE; OXIME; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; CRYSTALLOGRAPHY; ENZYME INHIBITION; HYDROGEN BOND; KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; X RAY DIFFRACTION;

ACETYLCHOLINESTERASE; ANIMALS; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; HISTIDINE; HUMANS; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; PROTEIN BINDING;

EID: 70449637196     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.08.027     Document Type: Article

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