Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation

Journal of Medicinal Chemistry

Volumn 53, Issue 10, 2010, Pages 4002-4008

  Carletti, Eugénie ^a,b   Colletier, Jacques Philippe ^a   Dupeux, Florine ^c   Trovaslet, Marie ^b   Masson, Patrick ^a,b   Nachon, Florian ^b  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b CENTRE DE RECHERCHES   (France)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; FASCICULIN; TABUN;

ANIMAL EXPERIMENT; ARTICLE; CATALYST; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DEALKYLATION; DEAMINATION; DRUG INHIBITION; DRUG STRUCTURE; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MELTING POINT; MOUSE; NONHUMAN; PROTEIN INTERACTION; STEREOCHEMISTRY; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY;

ACETYLCHOLINESTERASE; CATALYTIC DOMAIN; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DEALKYLATION; ELAPID VENOMS; ENZYME STABILITY; HUMANS; MODELS, MOLECULAR; PHOSPHORIC ACID ESTERS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; SOLUTIONS;

EID: 77952718967     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901853b     Document Type: Article

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