Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: Possible implications for the HI-6 antidote substrate specificity

Biochemical Pharmacology

Volumn 85, Issue 9, 2013, Pages 1389-1397

  Artursson, Elisabet ^a   Andersson, Per Ola ^a   Akfur, Christine ^a   Linusson, Anna ^b   Börjegren, Susanne ^a   Ekström, Fredrik ^a  

^a SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

Acetylcholinesterase; Crystal structure; Cyclosarin; Fluorescence decay spectroscopy; HI 6; Oxime; Reactivator; Russian VX; Structure activity relationship; Tabun; Time correlated single photon counting; Time resolved fluorescence

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; CYCLOSARIN; ORGANOPHOSPHORUS COMPOUND; PHOSPHORUS; RUSSIAN VX; TABUN; UNCLASSIFIED DRUG;

ARTICLE; CONJUGATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME REACTIVATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; FLUORESCENCE SPECTROSCOPY; HUMAN; IC 50; MOUSE; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; STEREOSPECIFICITY; X RAY CRYSTALLOGRAPHY;

ACETYLCHOLINESTERASE; ANIMALS; ANTIDOTES; CATALYTIC DOMAIN; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MICE; MODELS, MOLECULAR; ORGANOPHOSPHATES; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTHIOPHOSPHORUS COMPOUNDS; OXIMES; PROTEIN CONFORMATION; PYRIDINIUM COMPOUNDS; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY;

EID: 84875720255     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.01.016     Document Type: Article

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