Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc

PeerJ

Volumn 2016, Issue 5, 2016, Pages

  Li, Yan ^a   Li, Kang ^a   Mao, Lu ^b   Han, Xiuguo ^a   Zhang, Kai ^a   Zhao, Changqing ^a   Zhao, Jie ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Cordycepin; Degeneration; Inflammation; Intervertebral disc; Nucleus pulposus cells

Indexed keywords

AGGRECAN; AGGRECANASE 1; AGGRECANASE 2; BETA ACTIN; COLLAGEN TYPE 2; COLLAGENASE 3; CORDYCEPIN; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; STROMELYSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; CELL MIGRATION; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERVERTEBRAL DISK DEGENERATION; LUCIFERASE ASSAY; MALE; NONHUMAN; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; UPREGULATION; WESTERN BLOTTING;

EID: 84971572269     PISSN: None     EISSN: 21678359     Source Type: Journal    
DOI: 10.7717/peerj.1992     Document Type: Article

References (51)

1. Bachmeier BE, Nerlich A, Mittermaier N, Weiler C, Lumenta C, Wuertz K, Boos N. 2009. Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration. European Spine Journal 18:1573-1586 DOI 10.1007/s00586-009-1031-8.
2. Berenbaum F. 2004. Signaling transduction: target in osteoarthritis. Current Opinion in Rheumatology 16:616-622 DOI 10.1097/01.bor.0000133663.37352.4a.
3. Ellman MB, Kim JS, An HS, Chen D, KC R, An J, Dittakavi T, van Wijnen AJ, Cs-Szabo G, Li X, Xiao G, An S, Kim SG, Im HJ. 2012. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: in vitro, ex vivo studies. Gene 505:283-290 DOI 10.1016/j.gene.2012.06.004.
4. England S, Bevan S, Docherty RJ. 1996. PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. Journal of Physiology 495(Pt 2):429-440 DOI 10.1113/jphysiol.1996.sp021604.
5. Gawri R, Rosenzweig DH, Krock E, Ouellet JA, Stone LS, Quinn TM, Haglund L. 2014. High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain. Arthritis Research & Therapy 16: Article R21 DOI 10.1186/ar4449.
6. Gendron C, Kashiwagi M, Lim NH, Enghild JJ, Thøgersen IB, Hughes C, Caterson B, Nagase H. 2007. Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4. Journal of Biological Chemistry 282:18294-18306 DOI 10.1074/jbc. M701523200.
7. Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA. 2007. 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorganic & Medicinal Chemistry Letters 17:1189-1192 DOI 10.1016/j.bmcl.2006.12.020.
8. Gruber HE, Hoelscher GL, Ingram JA, Bethea S, Cox M, Hanley Jr EN. 2015. Proinflam-matory cytokines modulate the chemokine CCL2 (MCP-1) in human annulus cells in vitro: CCL2 expression and production. Experimental and Molecular Pathology 98(1):102-105 DOI 10.1016/j.yexmp.2014.12.002.
9. Haro H, Crawford HC, Fingleton B, MacDougall JR, Shinomiya K, Spengler DM, Matrisian LM. 2000. Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption. Journal of Clinical Investigation 105:133-141 DOI 10.1172/JCI7090.
10. Hart LG, Deyo RA, Cherkin DC. 1995. Physician office visits for low back pain. Frequency, clinical evaluation, and treatment patterns from a US national survey. Spine 20:11-19 DOI 10.1097/00007632-199501000-00003.
11. He W, Zhang MF, Ye J, Jiang TT, Fang X, Song Y. 2010. Cordycepin induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules. Journal of Zhejiang University Science B 11:654-660.
12. Hou G, Lu H, Chen M, Yao H, Zhao H. 2014. Oxidative stress participates in age-related changes in rat lumbar intervertebral discs. Archives of Gerontology and Geriatrics 59:665-669 DOI 10.1016/j.archger.2014.07.002.
13. Hu P, Chen W, Bao J, Jiang L, Wu L. 2014. Cordycepin modulates inflammatory and catabolic gene expression in interleukin-1beta-induced human chondrocytes from advanced-stage osteoarthritis: an in vitro study. International Journal of Clinical and Experimental Pathology 7:6575-6584.
14. Imamura K, Asai M, Sugamoto K, Matsumoto T, Yamasaki Y, Kamei I, Hattori T, Kishimoto M, Niisaka S, Kubo M, Nishiyama K, Yamasaki M. 2015. Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Bioscience, Biotechnology, and Biochemistry 79:1021-1025 DOI 10.1080/09168451.2015.1008977.
15. Iwata M, Ochi H, Asou Y, Haro H, Aikawa T, Harada Y, Nezu Y, Yogo T, Tagawa M, Hara Y. 2013. Variations in gene and protein expression in canine chondrodys-trophic nucleus pulposus cells following long-term three-dimensional culture. PLoS ONE 8:e63120 DOI 10.1371/journal.pone.0063120.
16. Jeong JW, Jin CY, Kim GY, Lee JD, Park C, Kim GD, Kim WJ, Jung WK, Seo SK, Choi IW, Choi YH. 2010. Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells. International Immunopharmacology 10:1580-1586 DOI 10.1016/j.intimp.2010.09.011.
17. Kepler CK, Ponnappan RK, Tannoury CA, Risbud MV, Anderson DG. 2013. The molecular basis of intervertebral disc degeneration. The Spine Journal 13:318-330 DOI 10.1016/j.spinee.2012.12.003.
18. Kim JS, Ellman MB, Yan D, An HS, Kc R, Li X, Chen D, Xiao G, Cs-Szabo G, Hoskin DW, Buechter DD, Van Wijnen AJ, Im HJ. 2013. Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. Journal of Cellular Physiology 228:1884-1896 DOI 10.1002/jcp.24350.
19. Kim H, Naura AS, Errami Y, Ju J, Boulares AH. 2011. Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP. Missouri Medicine 17:893-900.
20. Klawitter M, Hakozaki M, Kobayashi H, Krupkova O, Quero L, Ospelt C, Gay S, Hausmann O, Liebscher T, Meier U, Sekiguchi M, Konno S, Boos N, Ferguson SJ, Wuertz K. 2014. Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells. European Spine Journal 23:1878-1891 DOI 10.1007/s00586-014-3442-4.
21. Kozaci LD, Guner A, Oktay G, Guner G. 2006. Alterations in biochemical components of extracellular matrix in intervertebral disc herniation: role of MMP-2 and TIMP-2 in type II collagen loss. Cell Biochemistry and Function 24:431-436 DOI 10.1002/cbf.1250.
22. Kuslich SD, Ulstrom CL, Michael CJ. 1991. The tissue origin of low back pain and sciatica: a report of pain response to tissue stimulation during operations on the lumbar spine using local anesthesia. Orthopedic Clinics of North America 22:181-187.
23. Leckie SK, Bechara BP, Hartman RA, Sowa GA, Woods BI, Coelho JP, Witt WT, Dong QD, Bowman BW, Bell KM, Vo NV, Wang B, Kang JD. 2012. Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model. The Spine Journal 12:7-20 DOI 10.1016/j.spinee.2011.09.011.
24. Lee EJ, Kim WJ, Moon SK. 2010. Cordycepin suppresses TNF-alpha-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cells. Phytotherapy Research 24:1755-1761 DOI 10.1002/ptr.3132.
25. Lee SJ, Kim TU, Park JS, Ra JY. 2013. Inhibition of nitric oxide mediated protein nitration: therapeutic implications in experimental radiculopathy. Spine (Phila Pa 1976) 38(20):1749-1753 DOI 10.1097/BRS.0b013e3182a085d9.
26. Le Maitre CL, Freemont AJ, Hoyland JA. 2004. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. Journal of Pathology 204:47-54 DOI 10.1002/path.1608.
27. Li Y, Li K, Hu Y, Xu B, Zhao J. 2015. Piperine mediates LPS induced inflammatory and catabolic effects in rat intervertebral disc. International Journal of Clinical and Experimental Pathology 8:6203-6213.
28. Likhitpanichkul M, Kim Y, Torre OM, See E, Kazezian Z, Pandit A, Hecht AC, Iatridis JC. 2015. Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFalpha drug. The Spine Journal 15:2045-2054 DOI 10.1016/j.spinee.2015.04.026.
29. Lim TH, Ramakrishnan PS, Kurriger GL, Martin JA, Stevens JW, Kim J, Mendoza SA. 2006. Rat spinal motion segment in organ culture: a cell viability study. Spine 31:1291-1297 DOI 10.1097/01.brs.0000218455.28463.f0.
30. Nakamura K, Shinozuka K, Yoshikawa N. 2015. Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis. Journal of Pharmacological Sciences 127:53-56 DOI 10.1016/j.jphs.2014.09.001.
31. Patel KP, Sandy JD, Akeda K, Miyamoto K, Chujo T, An HS, Masuda K. 2007. Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration. Spine 32:2596-2603 DOI 10.1097/BRS.0b013e318158cb85.
32. Paterson RR. 2008. Cordyceps: a traditional Chinese medicine and another fungal therapeutic biofactory? Phytochemistry 69:1469-1495 DOI 10.1016/j.phytochem.2008.01.027.
33. Pockert AJ, Richardson SM, Le Maitre CL. 2009. Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration. Arthtitis and Rheumatism 60:482-491 DOI 10.1002/art.24291.
34. Rajan NE, Bloom O, Maidhof R, Stetson N, Sherry B, Levine M, Chahine NO. 2013. Toll-Like Receptor 4 (TLR4) expression and stimulation in a model of intervertebral disc inflammation and degeneration. Spine 38:1343-1351 DOI 10.1097/BRS.0b013e31826b71f4.
35. Ren Z, Cui J, Huo Z, Xue J, Cui H, Luo B, Jiang L, Yang R. 2012. Cordycepin sup-presses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting Iκ Bα phosphorylation, and blocking IKK ubiquitination. International Immunopharmacology 14:698-703 DOI 10.1016/j.intimp.2012.10.008.
36. Schmittgen TD, Livak KJ. 2008. Analyzing real-time PCR data by the comparative C(T) method. Nature Protocols 3:1101-1108 DOI 10.1038/nprot.2008.73.
37. Schwarzer AC, Aprill CN, Derby R, Fortin J, Kine G, Bogduk N. 1994. The relative contributions of the disc and zygapophyseal joint in chronic low back pain. Spine 19:801-806 DOI 10.1097/00007632-199404000-00013.
38. Shi Z, Gu T, Xin H, Wu J, Xu C, Zhang C, He Q, Ruan D. 2015. Intervention of rAAV-hTERT-transducted nucleus pulposus cells in early stage of intervertebral disc degeneration: a study in canine model. Tissue Engineering Part A 21:2186-2194 DOI 10.1089/ten.tea.2014.0408.
39. Tak PP, Firestein GS. 2001. NF-kappaB: a key role in inflammatory diseases. Journal of Clinical Investigation 107:7-11 DOI 10.1172/JCI11830.
40. Takada T, Nishida K, Maeno K, Kakutani K, Yurube T, Doita M, Kurosaka M. 2012. Intervertebral disc and macrophage interaction induces mechanical hyperalgesia and cytokine production in a herniated disc model in rats. Arthtitis and Rheumatism 64:2601-2610 DOI 10.1002/art.34456.
41. Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, Rosenfeld SA, Copeland RA, Decicco CP, Wynn R, Rockwell A, Yang F, Duke JL, Solomon K, George H, Bruckner R, Nagase H, Itoh Y, Ellis DM, Ross H, Wiswall BH, Murphy K, Hillman Jr MC, Hollis GF, Newton RC, Magolda RL, Trzaskos JM, Arner EC. 1999. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science 284:1664-1666 DOI 10.1126/science.284.5420.1664.
42. Vo NV, Hartman RA, Yurube T, Jacobs LJ, Sowa GA, Kang JD. 2013. Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration. The Spine Journal 13:331-341 DOI 10.1016/j.spinee.2012.02.027.
43. Walter BA, Purmessur D, Likhitpanichkul M, Weinberg A, Cho SK, Qureshi SA, Hecht AC, Iatridis JC. 2015. Inflammatory kinetics and efficacy of anti-inflammatory treatments on human nucleus pulposus cells. Spine 40:955-963 DOI 10.1097/BRS.0000000000000932.
44. Wang J, Tian Y, Phillips KL, Chiverton N, Haddock G, Bunning RA, Cross AK, Shapiro IM, Le Maitre CL, Risbud MV. 2013. Tumor necrosis factor alpha-and interleukin-1beta-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. Arthtitis and Rheumatism 65:832-842 DOI 10.1002/art.37819.
45. Wang IC, Ueng SW, Lin SS, Niu CC, Yuan LJ, Su CI, Chen CH, Chen WJ. 2011. Effect of hyperbaric oxygenation on intervertebral disc degeneration: an in vitro study with human lumbar nucleus pulposus. Spine 36:1925-1931 DOI 10.1097/BRS.0b013e3181feebde.
46. Weiler C, Nerlich AG, Zipperer J, Bachmeier BE, Boos N. 2002. SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption. European Spine Journal 11:308-320 DOI 10.1007/s00586-002-0472-0.
47. Wuertz K, Haglund L. 2013. Inflammatory mediators in intervertebral disk degeneration and discogenic pain. Global Spine Journal 3:175-184 DOI 10.1055/s-0033-1347299.
48. Yang H, Cao C, Wu C, Yuan C, Gu Q, Shi Q, Zou J. 2015. TGF-βl Suppresses Inflammation in Cell Therapy for Intervertebral Disc Degeneration. Scientific Reports 5: Article 13254 DOI 10.1038/srep13254.
49. Yoshida M, Nakamura T, Kikuchi T, Takagi K, Matsukawa A. 2002. Expression of monocyte chemoattractant protein-1 in primary cultures of rabbit intervertebral disc cells. Journal of Orthopaedic Research 20:1298-1304 DOI 10.1016/S0736-0266(02)00060-8.
50. You C, Zhu K, Liu X, Xi C, Zhang Z, Xu G, Yan J. 2013. Tumor necrosis factor-alpha-dependent infiltration of macrophages into the dorsal root ganglion in a rat disc herniation model. Spine 38:2003-2007 DOI 10.1097/BRS.0b013e3182a84701.
51. Yue K, Ye M, Zhou Z, Sun W, Lin X. 2013. The genus Cordyceps: a chemical and pharmacological review. Journal of Pharmacy and Pharmacology 65:474-493 DOI 10.1111/j.2042-7158.2012.01601.x.