메뉴 건너뛰기




Volumn 40, Issue 13, 2015, Pages 955-963

Inflammatory kinetics and efficacy of anti-inflammatory treatments on human nucleus pulposus cells

Author keywords

alginate beads; atlizumab; IL 1Ra; infliximab; intervertebral disc degeneration; nucleus pulposus cells; pentosan polysulfate; TNF

Indexed keywords

ALGINIC ACID; ANTIINFLAMMATORY AGENT; CYTOKINE; CYTOKINE RECEPTOR ANTAGONIST; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PENTOSAN POLYSULFATE; PROTEIN; TOCILIZUMAB; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; TUMOR NECROSIS FACTOR;

EID: 84938220900     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0000000000000932     Document Type: Article
Times cited : (42)

References (56)
  • 1
    • 33751099828 scopus 로고    scopus 로고
    • The treatment of disc-herniation-induced sciatica with infliximab: One-year follow-up results of first II, a randomized controlled trial
    • Korhonen T, Karppinen J, Paimela L, The treatment of disc-herniation-induced sciatica with infliximab: one-year follow-up results of FIRST II, a randomized controlled trial. Spine (Phila Pa 1976) 2006; 31: 2759-66
    • (2006) Spine (Phila Pa 1976 , vol.31 , pp. 2759-2766
    • Korhonen, T.1    Karppinen, J.2    Paimela, L.3
  • 2
    • 29444448264 scopus 로고    scopus 로고
    • The treatment of disc herniation-induced sciatica with infliximab: Results of a randomized, controlled, 3-month follow-up study
    • Korhonen T, Karppinen J, Paimela L, The treatment of disc herniation-induced sciatica with infliximab: results of a randomized, controlled, 3-month follow-up study. Spine (Phila Pa 1976) 2005; 30: 2724-8
    • (2005) Spine (Phila Pa 1976 , vol.30 , pp. 2724-2728
    • Korhonen, T.1    Karppinen, J.2    Paimela, L.3
  • 3
    • 84871051576 scopus 로고    scopus 로고
    • Years lived with disability (ylds) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the global burden of disease study 2010
    • Vos T, Flaxman AD, Naghavi M, Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2163-96
    • (2012) Lancet , vol.380 , pp. 2163-2196
    • Vos, T.1    Flaxman, A.D.2    Naghavi, M.3
  • 4
    • 13444268945 scopus 로고    scopus 로고
    • Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: A study in surgical specimen and autopsy controls
    • discussion 4
    • Weiler C, Nerlich AG, Bachmeier BE, Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine 2005; 30: 44-53; discussion 4
    • (2005) Spine , vol.30 , pp. 44-53
    • Weiler, C.1    Nerlich, A.G.2    Bachmeier, B.E.3
  • 5
    • 34548790240 scopus 로고    scopus 로고
    • Catabolic cytokine expression in degenerate and herniated human intervertebral discs: Il-1beta and tnfalpha expression profile
    • Le Maitre CL, Hoyland JA, Freemont AJ,. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res Ther 2007; 9: R77
    • (2007) Arthritis Res Ther , vol.9 , pp. R77
    • Le Maitre, C.L.1    Hoyland, J.A.2    Freemont, A.J.3
  • 6
    • 34247250302 scopus 로고    scopus 로고
    • Analysis of tissue distribution of TNF-Alpha, TNF-Alpha-receptors, and the activating TNF-Alpha-converting enzyme suggests activation of the TNF-Alpha system in the aging intervertebral disc
    • Bachmeier BE, Nerlich AG, Weiler C, Analysis of tissue distribution of TNF-Alpha, TNF-Alpha-receptors, and the activating TNF-Alpha-converting enzyme suggests activation of the TNF-Alpha system in the aging intervertebral disc. Ann N Y Acad Sci 2007; 1096: 44-54
    • (2007) Ann N y Acad Sci , vol.1096 , pp. 44-54
    • Bachmeier, B.E.1    Nerlich, A.G.2    Weiler, C.3
  • 7
    • 84896697934 scopus 로고    scopus 로고
    • A combinatorial relative mass value evaluation of endogenous bioactive proteins in three-dimensional cultured nucleus pulposus cells of herniated intervertebral discs: Identification of potential target proteins for gene therapeutic approaches
    • Mern DS, Fontana J, Beierfuss A, A combinatorial relative mass value evaluation of endogenous bioactive proteins in three-dimensional cultured nucleus pulposus cells of herniated intervertebral discs: identification of potential target proteins for gene therapeutic approaches. PLoS One 2013; 8: e81467
    • (2013) PLoS One , vol.8 , pp. e81467
    • Mern, D.S.1    Fontana, J.2    Beierfuss, A.3
  • 8
    • 84891163628 scopus 로고    scopus 로고
    • Role of cytokines in intervertebral disc degeneration: Pain and disc content
    • Risbud MV, Shapiro IM,. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol 2014; 10: 44-56
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 44-56
    • Risbud, M.V.1    Shapiro, I.M.2
  • 9
    • 84875803486 scopus 로고    scopus 로고
    • A role for tnfalpha in intervertebral disc degeneration: A non-recoverable catabolic shift
    • Purmessur D, Walter BA, Roughley PJ, A role for TNFalpha in intervertebral disc degeneration: a non-recoverable catabolic shift. Biochem Biophys Res Commun 2013; 433: 151-6
    • (2013) Biochem Biophys Res Commun , vol.433 , pp. 151-156
    • Purmessur, D.1    Walter, B.A.2    Roughley, P.J.3
  • 10
    • 84897517099 scopus 로고    scopus 로고
    • Inflammatory mediators in intervertebral disk degeneration and discogenic pain
    • Wuertz K, Haglund L,. Inflammatory mediators in intervertebral disk degeneration and discogenic pain. Global Spine J 2013; 03: 175-84
    • (2013) Global Spine J , vol.3 , pp. 175-184
    • Wuertz, K.1    Haglund, L.2
  • 11
    • 77957688083 scopus 로고    scopus 로고
    • Enhancement of intervertebral disc cell senescence by wnt/beta-catenin signaling-induced matrix metalloproteinase expression
    • Hiyama A, Sakai D, Risbud MV, Enhancement of intervertebral disc cell senescence by WNT/beta-catenin signaling-induced matrix metalloproteinase expression. Arthritis Rheum 2010; 62: 3036-47
    • (2010) Arthritis Rheum , vol.62 , pp. 3036-3047
    • Hiyama, A.1    Sakai, D.2    Risbud, M.V.3
  • 12
    • 84887345656 scopus 로고    scopus 로고
    • A complex interaction between wnt signaling and TNF-Alpha in nucleus pulposus cells
    • Hiyama A, Yokoyama K, Nukaga T, A complex interaction between Wnt signaling and TNF-Alpha in nucleus pulposus cells. Arthritis Res Ther 2013; 15: R189
    • (2013) Arthritis Res Ther , vol.15 , pp. R189
    • Hiyama, A.1    Yokoyama, K.2    Nukaga, T.3
  • 13
    • 44849136816 scopus 로고    scopus 로고
    • Investigation of the role of il-1 and TNF in matrix degradation in the intervertebral disc
    • Hoyland JA, Le Maitre C, Freemont AJ,. Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology (Oxford) 2008; 47: 809-14
    • (2008) Rheumatology (Oxford , vol.47 , pp. 809-814
    • Hoyland, J.A.1    Le Maitre, C.2    Freemont, A.J.3
  • 14
    • 33749445416 scopus 로고    scopus 로고
    • Differential regulation of matrix degrading enzymes in a tnfalpha-induced model of nucleus pulposus tissue degeneration
    • Seguin CA, Bojarski M, Pilliar RM, Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration. Matrix Biol 2006; 25: 409-18
    • (2006) Matrix Biol , vol.25 , pp. 409-418
    • Seguin, C.A.1    Bojarski, M.2    Pilliar, R.M.3
  • 15
    • 24744443292 scopus 로고    scopus 로고
    • Tumor necrosis factor-Alpha modulates matrix production and catabolism in nucleus pulposus tissue
    • Seguin CA, Pilliar RM, Roughley PJ, Tumor necrosis factor-Alpha modulates matrix production and catabolism in nucleus pulposus tissue. Spine 2005; 30: 1940-8
    • (2005) Spine , vol.30 , pp. 1940-1948
    • Seguin, C.A.1    Pilliar, R.M.2    Roughley, P.J.3
  • 16
    • 37249020868 scopus 로고    scopus 로고
    • Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: Lessons from the osteoarthritic experience
    • Goupille P, Mulleman D, Chevalier X,. Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience. Arthritis Res Ther 2007; 9: 110
    • (2007) Arthritis Res Ther , vol.9 , pp. 110
    • Goupille, P.1    Mulleman, D.2    Chevalier, X.3
  • 17
    • 78650180893 scopus 로고    scopus 로고
    • Healing of a painful intervertebral disc should not be confused with reversing disc degeneration: Implications for physical therapies for discogenic back pain
    • Adams MA, Stefanakis M, Dolan P,. Healing of a painful intervertebral disc should not be confused with reversing disc degeneration: implications for physical therapies for discogenic back pain. Clin Biomech (Bristol, Avon) 2010; 25: 961-71
    • (2010) Clin Biomech (Bristol, Avon , vol.25 , pp. 961-971
    • Adams, M.A.1    Stefanakis, M.2    Dolan, P.3
  • 18
    • 76649092954 scopus 로고    scopus 로고
    • Tumor necrosis alpha-blocking agent (etanercept): A triple blind randomized controlled trial of its use in treatment of sciatica
    • Okoro T, Tafazal SI, Longworth S, Tumor necrosis alpha-blocking agent (etanercept): a triple blind randomized controlled trial of its use in treatment of sciatica. J Spinal Disord Tech 2010; 23: 74-7
    • (2010) J Spinal Disord Tech , vol.23 , pp. 74-77
    • Okoro, T.1    Tafazal, S.I.2    Longworth, S.3
  • 19
    • 33750567990 scopus 로고    scopus 로고
    • The effect of infliximab, a monoclonal antibody against TNF-Alpha, on disc herniation resorption: A randomized controlled study
    • Autio RA, Karppinen J, Niinimaki J, The effect of infliximab, a monoclonal antibody against TNF-Alpha, on disc herniation resorption: a randomized controlled study. Spine (Phila Pa 1976) 2006; 31: 2641-5
    • (2006) Spine (Phila Pa 1976 , vol.31 , pp. 2641-2645
    • Autio, R.A.1    Karppinen, J.2    Niinimaki, J.3
  • 20
    • 66249114334 scopus 로고    scopus 로고
    • Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: Implications for the pathogenesis of intervertebral disc degeneration
    • Millward-Sadler SJ, Costello PW, Freemont AJ, Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther 2009; 11: R65
    • (2009) Arthritis Res Ther , vol.11 , pp. R65
    • Millward-Sadler, S.J.1    Costello, P.W.2    Freemont, A.J.3
  • 21
    • 20444482444 scopus 로고    scopus 로고
    • Positive feedback loop of interleukin-1beta upregulating production of inflammatory mediators in human intervertebral disc cells in vitro
    • Jimbo K, Park JS, Yokosuka K, Positive feedback loop of interleukin-1beta upregulating production of inflammatory mediators in human intervertebral disc cells in vitro. J Neurosurg Spine 2005; 2: 589-95
    • (2005) J Neurosurg Spine , vol.2 , pp. 589-595
    • Jimbo, K.1    Park, J.S.2    Yokosuka, K.3
  • 22
    • 79955060109 scopus 로고    scopus 로고
    • Human nucleus pulposus cells react to il-6: Independent actions and amplification of response to il-1 and TNF-Alpha
    • Studer RK, Vo N, Sowa G, Human nucleus pulposus cells react to IL-6: independent actions and amplification of response to IL-1 and TNF-Alpha. Spine (Phila Pa 1976) 2011; 36: 593-9
    • (2011) Spine (Phila Pa 1976 , vol.36 , pp. 593-599
    • Studer, R.K.1    Vo, N.2    Sowa, G.3
  • 23
    • 79959855332 scopus 로고    scopus 로고
    • Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist
    • Sinclair SM, Shamji MF, Chen J, Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist. Spine (Phila Pa 1976) 2011; 36: 1190-6
    • (2011) Spine (Phila Pa 1976 , vol.36 , pp. 1190-1196
    • Sinclair, S.M.1    Shamji, M.F.2    Chen, J.3
  • 24
    • 84864499507 scopus 로고    scopus 로고
    • Il-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates il-1beta-mediated degradation of nucleus pulposus in vitro
    • Gorth DJ, Mauck RL, Chiaro JA, IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1beta-mediated degradation of nucleus pulposus in vitro. Arthritis Res Ther 2012; 14: R179
    • (2012) Arthritis Res Ther , vol.14 , pp. R179
    • Gorth, D.J.1    Mauck, R.L.2    Chiaro, J.A.3
  • 25
    • 84865104998 scopus 로고    scopus 로고
    • Curcuma dmso extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing tlr2 expression and jnk activity
    • Klawitter M, Quero L, Klasen J, Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity. J Inflamm (Lond) 2012; 9: 29
    • (2012) J Inflamm (Lond , vol.9 , pp. 29
    • Klawitter, M.1    Quero, L.2    Klasen, J.3
  • 26
    • 80053343083 scopus 로고    scopus 로고
    • The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo
    • Wuertz K, Quero L, Sekiguchi M, The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo. Spine (Phila Pa 1976) 2011; 36: E1373-84
    • (2011) Spine (Phila Pa 1976 , vol.36 , pp. E1373-E1384
    • Wuertz, K.1    Quero, L.2    Sekiguchi, M.3
  • 27
    • 77954239098 scopus 로고    scopus 로고
    • Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues
    • Shamji MF, Setton LA, Jarvis W, Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum 2010; 62: 1974-82
    • (2010) Arthritis Rheum , vol.62 , pp. 1974-1982
    • Shamji, M.F.1    Setton, L.A.2    Jarvis, W.3
  • 28
    • 0025332891 scopus 로고
    • Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc
    • Thompson JP, Pearce RH, Schechter MT, Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine 1990; 15: 411-5
    • (1990) Spine , vol.15 , pp. 411-415
    • Thompson, J.P.1    Pearce, R.H.2    Schechter, M.T.3
  • 29
    • 84871090952 scopus 로고    scopus 로고
    • Regenerative potential of tgfbeta3 +dex and notochordal cell conditioned media on degenerated human intervertebral disc cells
    • Abbott RD, Purmessur D, Monsey RD, Regenerative potential of TGFbeta3 +Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells. J Orthop Res 2012; 30: 482-8
    • (2012) J Orthop Res , vol.30 , pp. 482-488
    • Abbott, R.D.1    Purmessur, D.2    Monsey, R.D.3
  • 30
    • 77952468837 scopus 로고    scopus 로고
    • Influence of cytokine inhibitors on concentration and activity of mmp-1 and mmp-3 in disc herniation
    • Genevay S, Finckh A, Mezin F, Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation. Arthritis Res Ther 2009; 11: R169
    • (2009) Arthritis Res Ther , vol.11 , pp. R169
    • Genevay, S.1    Finckh, A.2    Mezin, F.3
  • 31
    • 79251547039 scopus 로고    scopus 로고
    • The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: An altered mechanotransduction pathway with degeneration
    • Gilbert HT, Hoyland JA, Freemont AJ, The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration. Arthritis Res Ther 2011; 13: R8
    • (2011) Arthritis Res Ther , vol.13 , pp. R8
    • Gilbert, H.T.1    Hoyland, J.A.2    Freemont, A.J.3
  • 32
    • 34848893110 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: An in situ zymographic and gene therapy study
    • Le Maitre CL, Hoyland JA, Freemont AJ,. Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study. Arthritis Res Ther 2007; 9: R83
    • (2007) Arthritis Res Ther , vol.9 , pp. R83
    • Le Maitre, C.L.1    Hoyland, J.A.2    Freemont, A.J.3
  • 33
    • 80053349369 scopus 로고    scopus 로고
    • Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging c57b6 mice
    • Wu J, Guan TJ, Zheng S, Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice. Lab Invest 2011; 91: 1459-71
    • (2011) Lab Invest , vol.91 , pp. 1459-1471
    • Wu, J.1    Guan, T.J.2    Zheng, S.3
  • 34
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-Time quantitative PCR and the 2(-delta delta c(t)) method
    • Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-Time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-8
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 35
    • 84882954359 scopus 로고    scopus 로고
    • Elevated il-1beta and il-6 levels in lumbar herniated discs in patients with sciatic pain
    • Andrade P, Hoogland G, Garcia MA, Elevated IL-1beta and IL-6 levels in lumbar herniated discs in patients with sciatic pain. Eur Spine J 2013; 22: 714-20
    • (2013) Eur Spine J , vol.22 , pp. 714-720
    • Andrade, P.1    Hoogland, G.2    Garcia, M.A.3
  • 36
    • 50849093185 scopus 로고    scopus 로고
    • Is the interleukin-6 haplotype a prognostic factor for sciatica
    • Karppinen J, Daavittila I, Noponen N, Is the interleukin-6 haplotype a prognostic factor for sciatica. ? Eur J Pain 2008; 12: 1018-25
    • (2008) Eur J Pain , vol.12 , pp. 1018-1025
    • Karppinen, J.1    Daavittila, I.2    Noponen, N.3
  • 37
    • 84875967410 scopus 로고    scopus 로고
    • Cxcl8 (il-8) mediates neutrophil recruitment and behavior in the zebrafish inflammatory response
    • de Oliveira S, Reyes-Aldasoro CC, Candel S, Cxcl8 (IL-8) mediates neutrophil recruitment and behavior in the zebrafish inflammatory response. J Immunol 2013; 190: 4349-59
    • (2013) J Immunol , vol.190 , pp. 4349-4359
    • De Oliveira, S.1    Reyes-Aldasoro, C.C.2    Candel, S.3
  • 38
    • 0033594416 scopus 로고    scopus 로고
    • Mcp-1 and il-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
    • Gerszten RE, Garcia-Zepeda EA, Lim YC, MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 1999; 398: 718-23
    • (1999) Nature , vol.398 , pp. 718-723
    • Gerszten, R.E.1    Garcia-Zepeda, E.A.2    Lim, Y.C.3
  • 39
    • 0016355478 scopus 로고
    • A new look at the statistical model identification
    • Akaike H, A new look at the statistical model identification. IEEE Trans Automatic Control 1974; AC-19: 716-23
    • (1974) IEEE Trans Automatic Control , vol.19 , pp. 716-723
    • Akaike, H.1
  • 40
    • 84864484260 scopus 로고    scopus 로고
    • Intervertebral disc and macrophage interaction induces mechanical hyperalgesia and cytokine production in a herniated disc model in rats
    • Takada T, Nishida K, Maeno K, Intervertebral disc and macrophage interaction induces mechanical hyperalgesia and cytokine production in a herniated disc model in rats. Arthritis Rheum 2012; 64: 2601-10
    • (2012) Arthritis Rheum , vol.64 , pp. 2601-2610
    • Takada, T.1    Nishida, K.2    Maeno, K.3
  • 41
    • 84893781652 scopus 로고    scopus 로고
    • Effects of secreted factors in culture medium of annulus fibrosus cells on microvascular endothelial cells: Elucidating the possible pathomechanisms of matrix degradation and nerve in-growth in disc degeneration
    • Moon HJ, Yurube T, Lozito TP, Effects of secreted factors in culture medium of annulus fibrosus cells on microvascular endothelial cells: elucidating the possible pathomechanisms of matrix degradation and nerve in-growth in disc degeneration. Osteoarthritis Cartilage 2014; 22: 344-54
    • (2014) Osteoarthritis Cartilage , vol.22 , pp. 344-354
    • Moon, H.J.1    Yurube, T.2    Lozito, T.P.3
  • 42
    • 84889802479 scopus 로고    scopus 로고
    • The cytokine and chemokine expression profile of nucleus pulposus cells: Implications for degeneration and regeneration of the intervertebral disc
    • Phillips KL, Chiverton N, Michael AL, The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc. Arthritis Res Ther 2013; 15: R213
    • (2013) Arthritis Res Ther , vol.15 , pp. R213
    • Phillips, K.L.1    Chiverton, N.2    Michael, A.L.3
  • 43
    • 33645523979 scopus 로고    scopus 로고
    • Possible pathogenesis of painful intervertebral disc degeneration
    • Peng B, Hao J, Hou S, Possible pathogenesis of painful intervertebral disc degeneration. Spine (Phila Pa 1976) 2006; 31: 560-6
    • (2006) Spine (Phila Pa 1976 , vol.31 , pp. 560-566
    • Peng, B.1    Hao, J.2    Hou, S.3
  • 44
    • 0036062994 scopus 로고    scopus 로고
    • Mast cells in the pathogenesis of chronic back pain: A hypothesis
    • Freemont AJ, Jeziorska M, Hoyland JA, Mast cells in the pathogenesis of chronic back pain: a hypothesis. J Pathol 2002; 197: 281-5
    • (2002) J Pathol , vol.197 , pp. 281-285
    • Freemont, A.J.1    Jeziorska, M.2    Hoyland, J.A.3
  • 45
    • 29744447597 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration
    • Le Maitre CL, Freemont AJ, Hoyland JA,. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 2005; 7: R732-45
    • (2005) Arthritis Res Ther , vol.7 , pp. R732-R745
    • Le Maitre, C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 46
    • 84928969481 scopus 로고    scopus 로고
    • Tnfa transport induced by dynamic loading alters biomechanics of intact intervertebral discs
    • In Press
    • Walter BA, Likhitpanichkul M, Illien-Junger S, TNFa Transport Induced by Dynamic Loading Alters Biomechanics of Intact Intervertebral Discs. PLoS One 2015; In Press
    • (2015) PLoS One
    • Walter, B.A.1    Likhitpanichkul, M.2    Illien-Junger, S.3
  • 47
    • 84869755800 scopus 로고    scopus 로고
    • Targeting interleukin-6: All the way to treat autoimmune and inflammatory diseases
    • Tanaka T, Kishimoto T,. Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases. Int J Biol Sci 2012; 8: 1227-36
    • (2012) Int J Biol Sci , vol.8 , pp. 1227-1236
    • Tanaka, T.1    Kishimoto, T.2
  • 48
    • 33748121115 scopus 로고    scopus 로고
    • Interleukin-6 and chronic inflammation
    • Gabay C,. Interleukin-6 and chronic inflammation. Arthritis Res Ther 2006; 8 (Suppl 2): S3
    • (2006) Arthritis Res Ther , vol.8 , pp. S3
    • Gabay, C.1
  • 49
    • 70349777471 scopus 로고    scopus 로고
    • Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage
    • Sui Y, Lee JH, DiMicco MA, Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage. Arthritis Rheum 2009; 60: 2985-96
    • (2009) Arthritis Rheum , vol.60 , pp. 2985-2996
    • Sui, Y.1    Lee, J.H.2    DiMicco, M.A.3
  • 50
    • 79960340632 scopus 로고    scopus 로고
    • Complex loading affects intervertebral disc mechanics and biology
    • Walter BA, Korecki CL, Purmessur D, Complex loading affects intervertebral disc mechanics and biology. Osteoarthritis Cartilage 2011; 19: 1011-8
    • (2011) Osteoarthritis Cartilage , vol.19 , pp. 1011-1018
    • Walter, B.A.1    Korecki, C.L.2    Purmessur, D.3
  • 51
    • 84866941876 scopus 로고    scopus 로고
    • Issls prize winner: Disc dynamic compression in rats produces long-lasting increases in inflammatory mediators in discs and induces long-lasting nerve injury and regeneration of the afferent fibers innervating discs: A pathomechanism for chronic discogenic low back pain
    • Miyagi M, Ishikawa T, Kamoda H, ISSLS prize winner: disc dynamic compression in rats produces long-lasting increases in inflammatory mediators in discs and induces long-lasting nerve injury and regeneration of the afferent fibers innervating discs: a pathomechanism for chronic discogenic low back pain. Spine (Phila Pa 1976) 2012; 37: 1810-8
    • (2012) Spine (Phila Pa 1976 , vol.37 , pp. 1810-1818
    • Miyagi, M.1    Ishikawa, T.2    Kamoda, H.3
  • 52
    • 0346120078 scopus 로고    scopus 로고
    • Human nucleus pulposis can respond to a pro-inflammatory stimulus
    • Burke JG, Watson RW GW, Conhyea D, Human nucleus pulposis can respond to a pro-inflammatory stimulus. Spine 2003; 28: 2685-93
    • (2003) Spine , vol.28 , pp. 2685-2693
    • Burke, J.G.1    Watson, R.W.G.2    Conhyea, D.3
  • 53
    • 84903289154 scopus 로고    scopus 로고
    • Inflammation induces irreversible biophysical changes in isolated nucleus pulposus cells
    • Maidhof R, Jacobsen T, Papatheodorou A, Inflammation induces irreversible biophysical changes in isolated nucleus pulposus cells. PLoS One 2014; 9: e99621
    • (2014) PLoS One , vol.9 , pp. e99621
    • Maidhof, R.1    Jacobsen, T.2    Papatheodorou, A.3
  • 54
    • 39049144760 scopus 로고    scopus 로고
    • Issls prize winner: Repeated disc injury causes persistent inflammation
    • Ulrich JA, Liebenberg EC, Thuillier DU, ISSLS prize winner: repeated disc injury causes persistent inflammation. Spine (Phila Pa 1976) 2007; 32: 2812-9
    • (2007) Spine (Phila Pa 1976 , vol.32 , pp. 2812-2819
    • Ulrich, J.A.1    Liebenberg, E.C.2    Thuillier, D.U.3
  • 55
    • 84892715888 scopus 로고    scopus 로고
    • High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain
    • Gawri R, Rosenzweig DH, Krock E, High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain. Arthritis Res Ther 2014; 16: R21
    • (2014) Arthritis Res Ther , vol.16 , pp. R21
    • Gawri, R.1    Rosenzweig, D.H.2    Krock, E.3
  • 56
    • 0032167851 scopus 로고    scopus 로고
    • A new culture system to study the metabolism of the intervertebral disc in vitro
    • discussion 8
    • Chiba K, Andersson GB, Masuda K, A new culture system to study the metabolism of the intervertebral disc in vitro. Spine (Phila Pa 1976) 1998; 23: 1821-7; discussion 8
    • (1998) Spine (Phila Pa 1976 , vol.23 , pp. 1821-1827
    • Chiba, K.1    Andersson, G.B.2    Masuda, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.