The genus Cordyceps: A chemical and pharmacological review

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 4, 2013, Pages 474-493

  Yue, Kai ^a   Ye, Meng ^a   Zhou, Zuji ^a   Sun, Wen ^a   Lin, Xiao ^a  

^a SICHUAN AGRICULTURAL UNIVERSITY   (China)

Author keywords

ascomycetes; Cordyceps militaris; Cordyceps sinensis; mushroom

Indexed keywords

BALANOL; BIOPOLYMER; CORDYCEPIC ACID; CORDYCEPIN; CORDYCEPS CICADAE EXTRACT; CORDYCEPS EXTRACT; CORDYCEPS MILITARIS EXTRACT; CORDYCEPS OPHIOGLOSSOIDES EXTRACT; CORDYCEPS SINENSIS EXTRACT; CORDYHEPTAPETIDE A; CORDYMIN; CS F30; ERGOSTEROL; ERGOSTEROL PEROXIDE; EXOPOLYSACCHARIDE; FATTY ACID; FUNGAL EXTRACT; FUNGAL POLYSACCHARIDE; FUNGAL PROTEIN; GALACTOMANNAN; GALACTOSAMINOGLYCAN; LAMIVUDINE; METHOTREXATE; NUCLEOTIDE; NUCLEOTIDE DERIVATIVE; PAECILOMYCES JAPONICA EXTRACT; PEPTIDE; QUINIC ACID; STEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ADJUVANT THERAPY; ANTIBACTERIAL ACTIVITY; ANTIDIABETIC ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; AORTA ATHEROSCLEROSIS; AORTA THROMBOSIS; APOPTOSIS; BIOLOGICAL ACTIVITY; CHEMICAL COMPOSITION; CORDYCEPS; CORDYCEPS CICADAE; CORDYCEPS OPHIOGLOSSOIDES; DIABETES MELLITUS; DRUG ACTIVITY; FIBROSIS; GEOGRAPHIC DISTRIBUTION; GROUP A STREPTOCOCCAL INFECTION; HEPATITIS B; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOMODULATION; INSECTICIDAL ACTIVITY; LIVER FIBROSIS; LIVER METASTASIS; LIVER PROTECTION; MELANOMA; METASTASIS INHIBITION; NEUROPROTECTION; NONHUMAN; OPHIOCORDYCEPS; PAECILOMYCES JAPONICA; RENAL PROTECTION; REVIEW; SARCOMA; SKIN ANAPHYLAXIS; SOLID TUMOR; TAXONOMY;

EID: 84995317098     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01601.x     Document Type: Review

References (150)

1. Kobayasi Y,. The genus Cordyceps and its allies. Sci Rep Tokyo Bunrika Daiguku (Section B) 1941; 84: 53-260.
2. Mains EB,. North American entomogenous species of Cordyceps. Mycologia 1958; 50: 169-222.
3. Rogeron C,. The hypocrealean fungi (Ascomycetes, Hypocreales). Mycologia 1970; 62: 865-910.
4. Sung GH, et al,. Phylogenetic classification of Cordyceps and the clavicipitaceous fungi. Stud Mycol 2007; 57: 5-59.
5. Kobaysi Y, Shimizu D,. Monograph of the genus Torrubiella. Bull Nat Sci Museum Ser B 1982; 8: 43-78.
6. Negi CS, et al,. Yar tsa Gumba (Cordyceps sinensis): a call for its sustainable exploitation. Int J Sustain Dev World Ecol 2006; 13: 165-172.
7. Cunningham KG, et al,. Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link. Nature 1950; 166: 949-949.
8. Chen SZ, Chu JZ,. NMR and IR studies on the characterization of cordycepin and 2'-deoxyadenosine. Zhongguo Kang Sheng Su Za Shi 1996; 21: 9-12.
9. Gong YX, et al,. Simultaneous determination of six main nucleosides and bases in natural and cultured Cordyceps by capillary electrophoresis. J Chromatogr A 2004; 1055: 215-221.
10. Yang FQ, et al,. Determination of nucleotides, nucleosides and their transformation products in Cordyceps by ion-pairing reversed-phase liquid chromatography-mass spectrometry. J Chromatogr A 2010; 1217: 5501-5510.
11. Liu J, et al,. Chemical constituents of Cordyceps militaris (L.) Link. Zhongguo Zhong Yao Za Zhi 1989; 14: 608-609.
12. Guarino AJ, Kredich NM,. Isolation and identification of 3'-amino-3'-deoxyadenosine from Cordyceps militaris. Biochim Biophys Acta 1963; 68: 317-319.
13. Kredich NM, Guarino AJ,. Homocitrullyl aminoadenosine, a nucleoside isolated from Cordyceps militaris. J Biol Chem 1961; 236: 3300-3302.
14. Yu RM, et al,. Structural characterization and antioxidant activity of a polysaccharide from the fruiting bodies of cultured Cordyceps militaris. Carbohydr Polym 2007; 70: 430-436.
15. Wu YL, et al,. Studies on isolation and structural features of a polysaccharide from the mycelium of an Chinese edible fungus (Cordyceps sinensis). Carbohydr Polym 2006; 63: 251-256.
16. Yuan JG, et al,. Studies on the components and pharmacological action of polysaccharide from Cordyceps sinensis. Food Drug 2005; 7: 45-48.
17. Yu RM, et al,. Isolation and biological properties of polysaccharide CPS-1 from cultured Cordyceps militaris. Fitoterapia 2004; 75: 465-472.
18. Wang Y, et al,. Protection of chronic renal failure by a polysaccharide from Cordyceps sinensis. Fitoterapia 2010; 81: 397-402.
19. Wang Y, et al,. Purification and properties of polysaccharide Ck1-A from cultured mycelia of Cordyceps kyushuensis. Mycosystema 2003; 22: 452-456.
20. Wang Y, Zhang C,. Isolation, purification and properties of a polysaccharide Ck3-A from Cordyceps kyushuensis cultured mycelium. Food Ferment Ind 2003; 29: 25-27.
21. Wang BJ, et al,. Studies on structure and properties of water soluble polysaccharide from fruiting body of Cordyceps militaris (L.) Link. Chem Res Chin Univ 2003; 19: 37-40.
22. Kiho T, et al,. Structural features and hypoglycemic activity of a polysaccharide (CS-F10) from the cultured mycelium of Cordyceps sinensis. Biol Pharm Bull 1999; 22: 966-970.
23. Kiho T, et al,. Polysaccharides in fungi. XXXII. Hypoglycemic activity and chemical properties of a polysaccharide from the cultural mycelium of Cordyceps sinensis. Biol Pharm Bull 1993; 16: 1291-1293.
24. Gai X, Zhang Y,. Study of extracellular polysaccharide from Cordyceps militaris (L.) Link I. Mycosystema 1992; 11: 300-307.
25. Kiho T, et al,. Minor, protein-containing galactomannans from the insect-body portion of the fungal preparation Chan hua (Cordyceps cicadae). Carbohydr Res 1998; 181: 207-215.
26. Kiho T, et al,. A minor, protein-containing galactomannan from a sodium carbonate extract of Cordyceps sinensis. Carbohydr Res 1986; 156: 189-197.
27. Yamada H, et al,. Structure and antitumor activity of an alkalisoluble polysaccharide from Cordyceps ophioglossoides. Carbohydr Res 1984; 125: 107-115.
28. Ukai S, et al,. Structure of a new galactomannan from the ascocarps of Cordyceps cicadae shing. Carbohydr Res 1982; 101: 109-116.
29. Miyazaki T, et al,. Studies on fungal polysaccharides. XX. Galactomannan of Cordyceps sinensis. Chem Pharm Bull 1977; 25: 3324-3328.
30. Zhang WY, et al,. Effects of the exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis on immunocytes of H22 tumor bearing mice. Fitoterapia 2008; 79: 168-173.
31. Kim SW, et al,. Optimization of submerged culture process for the production of mycelial biomass and exo-polysaccharides by Cordyceps militaris C738. J Appl Microbiol 2003; 94: 120-126.
32. Xiao J-H, et al,. Nutritional requirements for the hyperproduction of bioactive exopolysaccharides by submerged fermentation of the edible medicinal fungus Cordyceps taii. Biochem Eng J 2010; 49: 241-249.
33. Ikeda M, et al,. Co-N reaction-a new serological activity index-on Wegener's granulomatosis. J Laryngol Otol 1993; 107: 607-610.
34. Lee JS, et al,. Study on macrophage activation and structural characteristics of purified polysaccharide from the liquid culture broth of Cordyceps militaris. Carbohydr Polym 2010; 82: 982-988.
35. Yu R, et al,. Structural elucidation and biological activity of a novel polysaccharide by alkaline extraction from cultured Cordyceps militaris. Carbohydr Polym 2009; 75: 166-171.
36. Zhu Z-Y, et al,. Structure and anti-tumor activity of a high-molecular-weight polysaccharide from cultured mycelium of Cordyceps gunnii. Carbohydr Polym 2012; 88: 1072-1076.
37. Yan JK, et al,. Structural elucidation of an exopolysaccharide from mycelial fermentation of a Tolypocladium sp fungus isolated from wild Cordyceps sinensis. Carbohydr Polym 2010; 79: 125-130.
38. Yan J-K, et al,. Physiochemical properties and antitumor activities of two α-glucans isolated from hot water and alkaline extracts of Cordyceps (Cs-HK1) fungal mycelia. Carbohydr Polym 2010; 85: 753-758.
39. Cheung JKH, et al,. Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: signaling cascade and induction of cytokines. J Ethnopharmacol 2009; 124: 61-68.
40. Wang Z-M, et al,. Structural characterisation and immunomodulatory property of an acidic polysaccharide from mycelial culture of Cordyceps sinensis fungus Cs-HK1. Food Chem 2011; 125: 637-643.
41. Kim SD,. Isolation, structure and cholesterol esterase inhibitory activity of a polysaccharide, PS-A, from Cordyceps sinensis. J Korean Soc Appl Biol Chem 2010; 53: 784-789.
42. Bok JW, et al,. Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochemistry 1999; 51: 891-898.
43. Li SP, et al,. Simultaneous determination of ergosterol, nucleosides and their bases from natural and cultured Cordyceps by pressurised liquid extraction and high-performance liquid chromatography. J Chromatogr A 2004; 1036: 239-243.
44. Kuo YC, et al,. Activation and proliferation signals in primary human T lymphocytes inhibited by ergosterol peroxide isolated from Cordyceps cicadae. Br J Pharmacol 2003; 140: 895-906.
45. Zhu JS, et al,. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis-Part II. J Altern Complement Med 1998; 4: 429-457.
46. Yang FQ, et al,. Analysis of sterols and fatty acids in natural and cultured Cordyceps by one-step derivatization followed with gas chromatography-mass spectrometry. J Pharm Biomed Anal 2009; 49: 1172-1178.
47. Kaczka E, et al,. Identification of cordycepin, a metabolite of Cordyceps militaris, as 3'-deoxyadenosine. Biochem Biophys Res Commun 1964; 14: 456-457.
48. Chatterjee R, et al,. Cordyceps sinensis (Berkeley) saccardo: structure of cordycepic acid. J Am Pharm Assoc 1957; 46: 114-118.
49. Krasnoff SB, et al,. Cicadapeptins I and II: new Aib-containing peptides from the entomopathogenic fungus Cordyceps heteropoda. J Nat Prod 2005; 68: 50-55.
50. Fujita T, et al,. A novel immunosuppressant, ISP-I, of Isaria sinclairii. J Pharm-Dynam 1990; 13: s-48.
51. Chen Y, et al,. Genetic diversity and taxonomic implication of Cordyceps sinensis as revealed by RAPD markers. Biochem Genet 1999; 37: 201-213.
52. Isaka M, et al,. Structures of cordypyridones A-D, antimalarial N-hydroxy- and N-methoxy-2-pyridones from the insect pathogenic fungus Cordyceps nipponica. J Org Chem 2001; 66: 4803-4808.
53. Kneifel H, et al,. Ophiocordin, an antifungal antibiotic of Cordyceps ophioglossoides. Arch Microbiol 1977; 113: 121-130.
54. Boros C, et al,. Comparison of balanol from Verticillium balanoides and ophiocordin from Cordyceps ophioglossoides. J Antibiot 1994; 47: 1010-1016.
55. Isaka M, et al,. Bioxanthracenes from the insect pathogenic fungus Cordyceps pseudomilitaris BCC 1620. II. Structure elucidation. J Antibiot 2001; 54: 36-43.
56. Jaturapat A, et al,. Bioxanthracenes from the insect pathogenic fungus Cordyceps pseudomilitaris BCC 1620. I. Taxonomy, fermentation, isolation and antimalarial activity. J Antibiot 2001; 54: 29-35.
57. Rukachaisirikul V, et al,. 10-membered macrolides from the insect pathogenic fungus Cordyceps militaris BCC 2816. J Nat Prod 2004; 67: 1953-1955.
58. Watanabe N, et al,. Entomogenous fungi that produce 2,6-pyridine dicarboxylic acid (dipicolinic acid). J Biosci Bioeng 2006; 102: 365-368.
59. Kawaguchi N, et al,. Occurrence of Gal beta (1-3) GalNAc-Ser/Thr in the linkage region of polygalactosamine containing fungal glycoprotein from Cordyceps ophioglossoides. Biochem Biophys Res Commun 1986; 140: 350-356.
60. Jung EC, et al,. A mushroom lectin from ascomycete Cordyceps militaris. Biochim Biophys Acta-Gen Subj 2007; 1770: 833-838.
61. Huang LF, et al,. Simultaneous separation and determination of active components in Cordyceps sinensis and Cordyceps militarris by LC/ESI-MS. J Pharm Biomed Anal 2003; 33: 1155-1162.
62. Sprecher M, Sprinson DB,. A reinvestigation of the structure of 'cordycepic acid'1a. J Org Chem 1963; 28: 2490-2491.
63. Jiang P,. Pharmacology constituent and function of Cordyceps sinensis. J Westnorthern Med 1987; 2: 43-44.
64. Li S, et al,. The nucleosides contents and their variation in natural Cordyceps sinensis and cultured Cordyceps mycelia. J Chin Pharm Sci 2001; 10: 175-179.
65. Li SP, et al,. Anti-oxidation activity of different types of natural Cordyceps sinensis and cultured Cordyceps mycelia. Phytomedicine 2001; 8: 207-212.
66. Li SP, et al,. The fruiting body and its caterpillar host of Cordyceps sinensis show close resemblance in main constituents and anti-oxidation activity. Phytomedicine 2002; 9: 319-324.
67. Yuan JP, et al,. Simultaneous determination of free ergosterol and ergosteryl esters in Cordyceps sinensis by HPLC. Food Chem 2007; 105: 1755-1759.
68. Li S, et al,. RP-HPLC determination of ergosterol in natural and cultured Cordyceps. Chin J Mod Appl Pharm 2011; 18: 297-299.
69. Zhou XW, et al,. Cordyceps fungi: natural products, pharmacological functions and developmental products. J Pharm Pharmacol 2009; 61: 279-291.
70. Xu RH, et al,. Effects of Cordyceps sinensis on natural killer activity and colony formation of B16 melanoma. Chin Med J 1992; 105: 97-101.
71. Sone Y, et al,. Structures and antitumor activities of the polysaccharides isolated from fruiting body and the growing culture of mycelium of Ganoderma lucidum. Agric Biol Chem 1985; 49: 2641-2653.
72. Kuo CF, et al,. Cordyceps sinensis mycelium protects mice from group A streptococcal infection. J Med Microbiol 2005; 54: 795-802.
73. Lin XX, et al,. Effects of fermented Cordyceps powder on pulmonary function in sensitized guinea pigs and airway inflammation in sensitized rats. Zhongguo Zhong Yao Za Zhi 2001; 26: 622-625.
74. Liu Z, et al,. Anti-inflammation effects of Cordyceps sinensis mycelium in focal cerebral ischemic injury rats. Inflammation 2011; 34: 639-644.
75. Rao YK, et al,. Constituents isolated from Cordyceps militaris suppress enhanced inflammatory mediator's production and human cancer cell proliferation. J Ethnopharmacol 2010; 131: 363-367.
76. Liu P, et al,. Influence of Cordyceps sinensis (Berk.) Sacc. and rat serum containing same medicine on IL-1, IFN and TNF produced by rat Kupffer cells. Chin J Chin Mater Med 1996; 21: 367-369.
77. Lin YW, Chiang BH,. Anti-tumor activity of the fermentation broth of Cordyceps militaris cultured in the medium of Radix astragali. Process Biochem 2008; 43: 244-250.
78. Huang YL, et al,. In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse. Life Sci 2004; 75: 1051-1062.
79. Zhao X, Li L,. Cordyceps sinensis in protection of the kidney from cyclosporine A nephrotoxicity. Zhonghua Yi Xue Za Zhi 1993; 73: 410-412.
80. Wu ZL, et al,. Inhibitory effect or Cordyceps sinensis and Cordyceps militaris on human glomerular mesangial cell proliferation induced by native LDL. Cell Biochem Funct 2000; 18: 93-97.
81. Gong H, et al,. Effects of Cordyceps sinensis on T lymphocyte subsets and hepatofibrosis in patients with chronic hepatitis B. Hunan Yi Ke Da Xue Xue Bao 2000; 25: 248-250.
82. Jung K, et al,. Effect of medicinal plant extracts on forced swimming capacity in mice. J Ethnopharmacol 2004; 93: 75-81.
83. Liu YK, Shen W,. Inhibitive effect of Cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism. World J Gastroenterol 2003; 9: 529-533.
84. Lo HC, et al,. Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin. Am J Chin Med 2006; 34: 819-832.
85. Leung PH, et al,. Chemical properties and antioxidant activity of exopolysaccharides from mycelial culture of Cordyceps sinensis fungus Cs-HK1. Food Chem 2009; 114: 1251-1256.
86. Lee B, et al,. Cordyceps militaris improves neurite outgrowth in Neuro2A cells and reverses memory impairment in rats. Food Sci Biotechnol 2011; 20: 1599-1608.
87. Wong JH, et al,. Cordymin, an antifungal peptide from the medicinal fungus Cordyceps militaris. Phytomedicine 2011; 18: 387-392.
88. de Julián-Ortiz JV, et al,. Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds. J Med Chem 1999; 42: 3308-3314.
89. Ahn YJ, et al,. Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp. J Agric Food Chem 2000; 48: 2744-2748.
90. Kim J-R, et al,. Larvicidal activity against Plutella xylostella of cordycepin from the fruiting body of Cordyceps militaris. Pest Manag Sci 2002; 58: 713-717.
91. Zhang XL, et al,. Cordyceps sinensis decreases TGF-β1 dependent epithelial to mesenchymal transdifferentiation and attenuates renal fibrosis. Food Hydrocolloids 2012; 28: 200-212.
92. Nan JX, et al,. Antifibrotic effect of extracellular biopolymer from submerged mycelial cultures of Cordyceps militaris on liver fibrosis induced by bile duct ligation and scission in rats. Arch Pharm Res 2001; 24: 327-332.
93. Choi SB, et al,. Improvement of insulin resistance and insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized rats. Biosci Biotechnol Biochem 2004; 68: 2257-2264.
94. Mueller WEG, et al,. Cordycepin analogs of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Biochemistry 1991; 30: 2027-2033.
95. Kubo E, et al,. Effect of Cordyceps sinensis on TIMP-1 secretion from mouse melanoma cell. Cent Eur J Biol 2012; 7: 167-171.
96. Ng TB, Wang HX,. Pharmacological actions of Cordyceps, a prized folk medicine. J Pharm Pharmacol 2005; 57: 1509-1519.
97. Zhou XX, et al,. Cordycepin is an immunoregulatory active ingredient of Cordyceps sinensis. Am J Chin Med 2008; 36: 967-980.
98. Kuo CF, et al,. Abrogation of streptococcal pyrogenic exotoxin B-mediated suppression of phagocytosis in U937 cells by Cordyceps sinensis mycelium via production of cytokines. Food Chem Toxicol 2007; 45: 278-285.
99. Shin KH, et al,. Anti-tumor and immuno-stimulating activities of the fruiting bodies of Paecilomyces japonica, a new type of Cordyceps spp. Phytother Res 2003; 17: 830-833.
100. Shin KH, et al,. Antioxidant and immunostimulating activities of the fruiting bodies of Paecilomyces japonica, a new type of Cordyceps sp., Ann N Y Acad Sci 2001; 928: 261-273.
101. Won SY, Park EH,. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. J Ethnopharmacol 2005; 96: 555-561.
102. Li Y, et al,. Clinical application of Cordyceps sinensis on immunosuppressive therapy in renal transplantation. Transplant Proc 2009; 41: 1565-1569.
103. Li SP, et al,. A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury. Life Sci 2003; 73: 2503-2513.
104. Chen JP, et al,. Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H22 tumor-bearing mice. Life Sci 2006; 78: 2742-2748.
105. Yamaguchi Y, et al,. Antioxidant activity of the extracts from fruiting bodies of cultured Cordyceps sinensis. Phytother Res 2000; 14: 647-649.
106. Yoshikawa N, et al,. Cordycepin and Cordyceps sinensis reduce the growth of human promyelocytic leukaemia cells through the Wnt signalling pathway. Clin Exp Pharmacol Physiol 2007; 34: S61-S63.
107. Yoshikawa N, et al,. Antitumour activity of Cordycepin in mice. Clin Exp Pharmacol Physiol 2004; 31: S51-S53.
108. Chen Y, et al,. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997; 60: 2349-2359.
109. Zhang WY, et al,. Immunomodulatory and anti-tumor effects of an exopolysaccharide fraction from cultivated Cordyceps sinensis (Chinese caterpillar fungus) on tumour-bearing mice. Biotechnol Appl Biochem 2005; 42: 9-15.
110. Ohmori T, et al,. Isolation of galactosaminoglycan moiety (CO-N) from protein-bound polysaccharide of Cordyceps ophioglossoides and its effects against murine tumors. Chem Pharm Bull 1989; 37: 1019-1022.
111. Ohmori T, et al,. The correlation between molecular weight and antitumor activity of galactosaminoglycan (CO-N) from Cordyceps ophioglossoides. Chem Pharm Bull 1989; 37: 1337-1340.
112. Yoshida J, et al,. Anti-tumor activity of an extract of Cordyceps sinensis (Berk.) Sacc. against murine tumor cell lines. Jpn J Exp Med 1989; 59: 157-161.
113. Nakamura K, et al,. Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice. Jpn J Pharmacol 1999; 79: 335-341.
114. Nakamura K, et al,. Combined effects of Cordyceps sinensis and methotrexate on hematogenic lung metastasis in mice. Recept Channels 2003; 9: 329-334.
115. Nakamura K, et al,. Activation of in vivo Kupffer cell function by oral administration of Cordyceps sinensis in rats. Jpn J Pharmacol 1999; 79: 505-508.
116. Lim HW, et al,. Antitumor activity of Cordyceps militaris on human cancer cell line. Korean J Pharmacognosy 2004; 25: 364-367.
117. Kuo YC, et al,. Growth inhibitors against tumor cells in Cordyceps sinensis other than corydcepin and polysaccharides. Cancer Invest 1994; 12: 611-615.
118. Kuo YC, et al,. Cordyceps sinensis as an immunomodulatory agent. Am J Chin Med 1996; 24: 111-125.
119. Yoo HS, et al,. Effects of Cordyceps militaris extract on angiogenesis and tumor growth. Acta Pharmacol Sin 2004; 25: 657-665.
120. Park C, et al,. Growth inhibition of U937 leukemia cells by aqueous extract of Cordyceps militaris through induction of apoptosis. Oncol Rep 2005; 13: 1211-1216.
121. Buenz EJ, et al,. The traditional Chinese medicine Cordyceps sinensis and its effects on apoptotic homeostasis. J Ethnopharmacol 2005; 96: 19-29.
122. Wang R, et al,. Clinical Trial Report on Chronic Hepatitis Treatment Using Immune-assist Brand Mushroom Extract Mixture in Conjunction with the Drug LAMIVUDINE [Epivirtm]. [online] 2002; Available from: http://www. alohamedicinals.com/Hep-B-Study2.pdf.
123. Yang LY, et al,. H1-A extracted from Cordyceps sinensis suppresses the proliferation of human mesangial cells and promotes apoptosis, probably by inhibiting the tyrosine phosphorylation of Bcl-2 and Bcl-XL. J Lab Clin Med 2003; 141: 74-80.
124. Lin CY, et al,. Inhibition of activated human mesangial cell proliferation by the natural product of Cordyceps sinensis (H1-A): an implication for treatment of IgA mesangial nephropathy. J Lab Clin Med 1999; 133: 55-63.
125. Yang LY, et al,. Efficacy of a pure compound H1-A extracted from Cordyceps sinensis on autoimmune disease of MRL lpr/lpr mice. J Lab Clin Med 1999; 134: 492-500.
126. Kiho T, et al,. Polysaccharides in fungi.36. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver. Biol Pharm Bull 1996; 19: 294-296.
127. Yamaguchi Y, et al,. Inhibitory effects of water extracts from fruiting bodies of cultured Cordyceps sinensis on raised serum lipid peroxide levels and aortic cholesterol deposition in atherosclerotic mice. Phytother Res 2000; 14: 650-652.
128. Koh JH, et al,. Hypocholesterolemic effect of hot-water extract from mycelia of Cordyceps sinensis. Biol Pharm Bull 2003; 26: 84-87.
129. Cho H-J, et al,. Cordycepin (3'- deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP- and cyclic GMP-dependent manner. Eur J Pharmacol 2007; 558: 43-51.
130. Rukachaisirikul V, et al,. A cyclopeptide from the insect pathogenic fungus Cordyceps sp. BCC 1788. J Nat Prod 2006; 69: 305-307.
131. Isaka M, et al,. A xanthocillin-like alkaloid from the insect pathogenic fungus Cordyceps brunnearubra BCC 1395. J Nat Prod 2007; 70: 656-658.
132. Chiou WF, et al,. Protein constituent contributes to the hypotensive and vasorelaxant activities of Cordyceps sinensis. Life Sci 2000; 66: 1369-1376.
133. Jin DQ, et al,. Mycelial extract of Cordyceps ophioglossoides prevents neuronal cell death and ameliorates beta-amyloid peptide-induced memory deficits in rats. Biol Pharm Bull 2004; 27: 1126-1129.
134. Kuo YC, et al,. Regulation of bronchoalveolar lavage fluids cell function by the immunomodulatory agents from Cordyceps sinensis. Life Sci 2001; 68: 1067-1082.
135. Oh JY, et al,. The ethyl acetate extract of Cordyceps militaris inhibits IgE-mediated allergic responses in mast cells and passive cutaneous anaphylaxis reaction in mice. J Ethnopharmacol 2011; 135: 422-429.
136. Zhao Y,. Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits. Zhonghua Yi Xue Za Zhi 1991; 71: 612-615.
137. Hsu CC, et al,. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 2003; 73: 2127-2136.
138. Yamaguchi N, et al,. Augmentation of various immune reactivities of tumor-bearing hosts with an extract of Cordyceps sinensis. Biotherapy 1990; 2: 199-205.
139. Brown KS, Trigo JR,. Multi-level complexity in the use of plant allelochemicals by aposematic insects. Chemoecology 1994; 5: 119-126.
140. Zhao M, et al,. Investigation on distribution and habitat of Blaps rynchopetera Fairmaire (Coleoptera:Tenebrionidae) in Yunnan. Forest Res 2007; 20: 356-362.
141. Kiho T, et al,. Polysaccharides in fungi. XXV. Biological activities of two galactomannans from the insect-body portion of Chan hua (fungus: Cordyceps cicadae). Yakugaku Zasshi J Pharm Soc Jpn 1990; 110: 286-288.
142. Weng SC, et al,. Immunomodulatory functions of extracts from the Chinese medicinal fungus Cordyceps cicadae. J Ethnopharmacol 2002; 83: 79-85.
143. Lee K-H,. Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine. Public Health Nutr 2000; 3 (4A): 515-522.
144. Inamdar N, et al,. Herbal drugs in milieu of modern drugs. Int J Green Pharm 2008; 2: 2-8.
145. Paterson RRM,. Cordyceps-a traditional Chinese medicine and another fungal therapeutic biofactory? Phytochemistry 2008; 69: 1469-1495.
146. Bateman J, et al,. Possible toxicity of herbal remedies. Scott Med J 1998; 43: 7-15.
147. Jane MM,. Preoperative considerations with herbal medicines. AORN J 1999; 69: 173-183.
148. Holliday J, Cleaver M,. Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) Link (Ascomycetes). A review. Int J Med Mushrooms 2008; 10: 219-234.
149. Yang JY, et al,. Effects of exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis fungus on c-Myc, c-Fos, and VEGF expression in B16 melanoma-bearing mice. Pathol Res Pract 2008; 201: 745-750.
150. Das SK, et al,. A new approach for improving cordycepin productivity in surface liquid culture of Cordyceps militaris using high-energy ion beam irradiation. Lett Appl Microbiol 2008; 47: 534-538.