Cordycepin suppresses TNF-alpha-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cells

Phytotherapy Research

Volumn 24, Issue 12, 2010, Pages 1755-1761

  Lee, Eo Jin ^a,b   Kim, Wun Jae ^b,c   Moon, Sung Kwon ^a,b  

^a Chungju National University   (South Korea)

^b Chungbuk National University   (South Korea)

^c Chungbuk National University College of Medicine   (South Korea)

Author keywords

AP 1; bladder cancer cells; cordycepin; invasion; migration; MMP 9; NF B

Indexed keywords

CORDYCEPIN; GELATINASE A; GELATINASE B; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CORDYCEPS; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PROMOTER REGION; PROTEIN EXPRESSION; ZYMOGRAPHY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DEOXYADENOSINES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA; URINARY BLADDER NEOPLASMS;

CORDYCEPS MILITARIS;

EID: 78649264325     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3132     Document Type: Article

References (27)

1. Bond M, Rosalind P, Fabunmi P, Baker AH, Newby AC., 1998. Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B. FEBS Lett 435: 29-34.
2. Chang W, Lim S, Song H, et al,. 2008. Cordycepin inhibits vascular smooth muscle cell proliferation. Eur J Pharmacol 597: 64-69.
3. Davies B, Waxman J, Wasan H, et al,. 1993. Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion. Cancer Res 53: 5365-5369.
4. Ioannidis P, Courtis N, Havredaki M, Michailakis E, Tsiapalis CM, Trangas T., 1999. The polyadenylation inhibitor cordycepin (3′dA) causes a decline in c-MYC mRNA levels without affecting c-MYC protein levels. Oncogene 18: 117-125.
5. Kakizoe T, Tobisu K, Takai K, Tanaka Y, Kishi K, Teshima S., 1988. Relationship between papillary and nodular transitional cell carcinoma in the human urinary bladder. Cancer Res 48: 2299-2303.
6. Kim HG, Shrestha B, Lim SY, et al,. 2006. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol 545: 192-199.
7. Kim S, Kim Y, Kim JE, Cho KH, Chung JH., 2008. Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. Phytomedicine 15: 340-347.
8. Lee SJ, Park SS, Cho YH, et al,. 2008a. Activation of matrix metalloproteinase-9 by TNF-alpha in human urinary bladder cancer HT1376 cells: the role of MAP kinase signaling pathways. Oncol Rep 19: 1007-1013.
9. Lee SJ, Park SS, Lee US, Kim WJ, Moon SK., 2008b. Signaling pathway for TNF-alpha-induced MMP-9 expression: mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells. Int Immunopharmacol 8: 1821-1826.
10. Lin CW, Hou WC, Shen SC, et al,. 2008. Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. Carcinogenesis 29: 1807-1815.
11. Liotta LA., 1986. Tumor invasion and metastasis-role of extracellular matrix: Rhoads Memorial Award Lecture. Cancer Res 46: 1-7.
12. Maeda-Yamamoto M, Kawahara H, Tahara N, Tsuji K, Hara Y, Isemura M., 1999. Effects of tea polyphenols on the invasion and matrix metalloproteinases activities of human fibrosarcoma HT1080 cells. J Agric Food Chem 47: 2350-2354.
13. Matrisian LM., 1990. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 6: 121-125.
14. Moon SK, Cha BY, Kim CH., 2004a. ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1: Involvement of the ras dependent pathway. J Cell Physiol 198: 417-427.
15. Moon SK, Jung SY, Choi YH, Lee YC, Patterson C, Kim CH., 2004b. PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: involvement of p38 mitogen activated protein kinase. J Cell Physiol 198: 310-323.
16. Noh EM, Kim JS, Hur H, et al,. 2009. Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford) 48: 45-48.
17. Nutt JE, Durkan GC, Mellon JK, Lunec J., 2003. Matrix metalloproteinases (MMPs) in bladder cancer: the induction of MMP9 by epidermal growth factor and its detection in urine. BJU Int 91: 99-104.
18. Oak MH, El Bedoui J, Anglard P, Schini-Kerth VB., 2004. Red wine polyphenolic compounds strongly inhibit pro-matrix metalloproteinase-2 expression and its activation in response to thrombin via direct inhibition of membrane type 1-matrix metalloproteinase in vascular smooth muscle cells. Circulation 110: 1861-1867.
19. Prout G. J, r, Griffin PP, Shipley WU., 1979. Bladder carcinoma as a systemic disease. Cancer 43: 2532-2539.
20. Sato H, Kita M, Seiki M., 1993. v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines. J Biol Chem 268: 23460-23468.
21. Sato H, Seiki M., 1993. Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 8: 395-405.
22. Shin KY, Moon HS, Park HY, et al,. 2000. Effects of tumor necrosis factor-alpha and interferon-gamma on expressions of matrix metalloproteinase-2 and -9 in human bladder cancer cells. Cancer Lett 159: 127-134.
23. Sier CF, Casetta G, Verheijen JH, et al,. 2000. Enhanced urinary gelatinase activities (matrix metalloproteinases 2 and 9) are associated with early-stage bladder carcinoma: a comparison with clinically used tumor markers. Clin Cancer Res 6: 2333-2340.
24. Stein JP, Grossfeld GD, Ginsberg DA, et al,. 1998. Prognostic markers in bladder cancer: a contemporary review of the literature. J Urol 160: 645-659.
25. Tang FY, Su YC, Chen NC, Hsieh HS, Chen KS., 2008. Resveratrol inhibits migration and invasion of human breast-cancer cells. Mol Nutr Food Res 52: 683-691.
26. Wu WC, Hsiao JR, Lian YY, Lin CY, Huang BM., 2007. The apoptotic effect of cordycepin on human OEC-M1 oral cancer cell line. Cancer Chemother Pharmacol 60: 103-111.
27. Zeegers MP, Tan FE, Dorant E, van Den Brandt PA., 2000. The impact of characteristics of cigarette smoking on urinary tract cancer risk: a meta-analysis of epidemiologic studies. Cancer 89: 630-639.