Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells

Bioscience, Biotechnology and Biochemistry

Volumn 79, Issue 6, 2015, Pages 1021-1025

  Imamura, Kenta ^a   Asai, Momoko ^a   Sugamoto, Kazuhiro ^a   Matsumoto, Tomoko ^a   Yamasaki, Yumi ^a   Kamei, Ichiro ^a   Hattori, Takahiro ^b   Kishimoto, Masaoki ^b   Niisaka, Seiji ^b   Kubo, Masaomi ^b   Nishiyama, Kazuo ^a   Yamasaki, Masao ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b Shinseikosan Co   (Japan)

Author keywords

Adenosine kinase; Adenosine receptor; Cordycepin; Nitric oxide; RAW 264.7 cells

Indexed keywords

ENZYMES;

ADENOSINE KINASE; ADENOSINE RECEPTOR; ANTI-INFLAMMATORY EFFECTS; CORDYCEPIN; INTRACELLULAR METABOLISM; NUCLEOSIDE TRANSPORTERS; RAW 264.7 CELLS; SUPPRESSING EFFECTS;

NITRIC OXIDE;

ANTIINFLAMMATORY AGENT; CORDYCEPIN; DEOXYADENOSINE DERIVATIVE; LIPOPOLYSACCHARIDE; NITRIC OXIDE;

ANIMAL; BIOSYNTHESIS; CELL LINE RAW 264.7; DRUG EFFECTS; MACROPHAGE; METABOLISM; MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DEOXYADENOSINES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; RAW 264.7 CELLS;

EID: 84940094637     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1080/09168451.2015.1008977     Document Type: Article

References (28)

1. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987; 327:524-526.
2. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992; 6:3051-3064.
3. Lind L. Circulating markers of inflammation and atherosclerosis. Atherosclerosis. 2003; 169:203-214.
4. Baumann H, Gauldie J. Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation. Mol. Biol. Med. 1990; 7:147-159.
5. Kwak HJ, Song JS, Heo J.Y., Yang SD, Nam JY, Cheon HG. Roflumilast inhibits lipopolysaccharide-induced inflammatory mediators via suppression of nuclear factor-kappaB, p38 mito-gen-activated protein kinase, and c-Jun NH2-terminal kinase activation. J. Pharmacol. Exp. Ther. 2005; 315:1188-1195.
6. Yoo HS, Shin JW, Cho J.H., Son CG, Lee YW, Park SY, Cho CK. Effects of Cordyceps militaris extract on angiogenesis and tumor growth. Acta Pharmacol. Sin. 2004; 25:657-665.
7. Shin S, Lee S, Kwon J., Moon S, Lee S, Lee C-K, Cho K, Ha N-J, Kim K. Cordycepin suppresses expression of diabetes regulating genes by inhibition of lipopolysaccharide-induced inflammation in macrophages. Immune Netw. 2009; 9:98-105.
8. Choi SB, Park CH, Choi M.K., Jun DW, Park S. Improvement of insulin resistance and insulin secretion by water extracts of cordyceps militaris, phellinus linteus, and paecilomyces tenuipes in 90% pancreatectomized rats. Biosci. Biotechnol. Biochem. 2004; 68:2257-2264.
9. Kim HG, Shrestha B, Lim S.Y., Yoon DH, Chang WC, Shin DJ, Han S.K., Park SM, Park JH, Park HI, Sung JM, Jang Y, Chung N, Hwang KC, Kim TW. Cordycepin inhibits lipopolysaccha-ride-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur. J. Pharmacol. 2006; 545:192-199.
10. Haskó G, Cronstein B. Regulation of inflammation by adeno-sine. Front. Immunol. 2013; 4:1-8.
11. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009; 111:904-915.
12. Kreckler LM, Wan TC, Ge Z.D., Auchampach JA. Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor. J. Pharmacol. Exp. Ther. 2006; 317:172-180.
13. Yang J, Zheng X, Haugen F., Darè E, Lövdahl C, Schulte G, Fredholm BB, Valen G. Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors. Acta Physiol. (Oxford). 2014; 210: 590-599.
14. Németh ZH, Lutz CS, Csóka B, Deitch E.A., Leibovich SJ, Gause WC, Tone M, Pacher P., Vizi ES, Haskó G. Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism. J. Immunol. 2005; 175:8260-8270.
15. Wong YY, Moon A, Duffin R., Barthet-Barateig A, Meijer HA, Clemens M.J., de Moor CH. Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. J. Biol. Chem. 2010; 285:2610-2621.
16. Chang SY, Kim DB, Ryu G.R., Ko SH, Jeong IK, Ahn YB, Jo Y.H., Kim MJ. Exendin-4 inhibits iNOS expression at the protein level in LPS-stimulated Raw 264.7 macrophage by the activation of cAMP/PKA pathway. J. Cell. Biochem. 2013; 114:844-853.
17. Han ES, Oh JY, Park HJ. Cordyceps militaris extract suppresses dextran sodium sulfate-induced acute colitis in mice and production of inflammatory mediators from macrophages and mast cells. J. Ethnopharmacol. 2011; 134:703-710.
18. Jeong JW, Jin CY, Kim G.Y., Lee JD, Park C, Kim GD, Kim W.J., Jung WK, Seo SK, Choi IW, Choi YH. Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells. Int. Immunopharmacol. 2010; 10:1580-1586.
19. Huang LF, Liang YZ, Guo F.Q., Zhou ZF, Cheng BM. Simultaneous separation and determination of active components in Cordyceps sinensis and Cordyceps militarris by LC/ESI-MS. J. Pharm. Biomed. Anal. 2003; 33:1155-1162.
20. Haskó G, Cronstein BN. Adenosine: an endogenous regulator of innate immunity. Trends Immunol. 2004; 25:33-39.
21. Haskó G, Szabó C, Németh ZH, Kvetan V, Pastores SM, Vizi ES. Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J. Immunol. 1996; 15:4634-4640.
22. Chen Y, Yang SH, Hueng D.Y., Syu JP, Liao CC, Wu YC. Cordycepin induces apoptosis of C6 glioma cells through the adeno-sine 2A receptor-p53-caspase-7-PARP pathway. Chem. Biol. Interact. 2014; 216:17-25.
23. Nakamura K, Yoshikawa N, Yamaguchi Y., Kagota S, Shinozuka K, Kunitomo M. Antitumor effect of cordycepin (3'-deoxyadeno-sine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation. Anticancer Res. 2006; 26:43-47.
24. Wong YY, Moon A, Duffin R., Barthet-Barateig A, Meijer HA, Clemens M.J., de Moor CH. Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. J. Biol. Chem. 2010; 285:2610-2621.
25. Kadomatsu M, Nakajima S, Kato H., Gu L, Chi Y, Yao J., Kitamura M. Cordycepin as a sensitizer to tumour necrosis factor (TNF)-α-induced apoptosis through eukaryotic translation initiation factor 2α (eIF2α)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-κB. Clin. Exp. Immunol. 2012; 168:325-332.
26. Seldon PM, Barnes PJ, Meja K, Giembycz MA. Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase. Mol. Pharmacol. 1995; 48:747-757.
27. Hurme M. Modulation of interleukin-1 beta production by cyclic AMP in human monocytes. FEBS Lett. 1990; 263:35-37.
28. Chen CC1, Chiu KT, Sun YT, Chen WC. Role of the cyclic AMP-protein kinase A pathway in lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages. Involvement of cyclooxygenase-2. J. Biol. Chem. 1999; 274: 31559-31564.