Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration

Spine Journal

Volumn 13, Issue 3, 2013, Pages 331-341

  Vo, Nam V ^a   Hartman, Robert A ^a   Yurube, Takashi ^a,b   Jacobs, Lloydine J ^a   Sowa, Gwendolyn A ^a   Kang, James D ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

ADAMTS; Aging; Extracellular matrix; Intervertebral disc degeneration; MMPs

Indexed keywords

ADAMTS1 PROTEIN; AGGRECANASE 1; AGGRECANASE 2; COLLAGENASE; COLLAGENASE 3; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 15; MATRIX METALLOPROTEINASE 16; MATRIX METALLOPROTEINASE 17; MATRIX METALLOPROTEINASE 19; MATRIX METALLOPROTEINASE 20; MATRIX METALLOPROTEINASE 26; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUTROPHIL COLLAGENASE; STROMELYSIN; STROMELYSIN 2; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

CELLULAR DISTRIBUTION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; EXTRACELLULAR MATRIX; GENE CONTROL; GENE DUPLICATION; GENE EXPRESSION; GENETIC PREDISPOSITION; HUMAN; INTERVERTEBRAL DISK DEGENERATION; INTRACELLULAR SIGNALING; NUCLEUS PULPOSUS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE; REVIEW; UPREGULATION;

AGING; EXTRACELLULAR MATRIX; HUMANS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MATRIX METALLOPROTEINASES; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASES; UP-REGULATION;

EID: 84875552081     PISSN: 15299430     EISSN: 18781632     Source Type: Journal    
DOI: 10.1016/j.spinee.2012.02.027     Document Type: Review

References (100)

1. National Center for Health Statistics Spine: low back and neck pain. The burden of musculoskeletal diseases in the United States 2011 National Center for Health Statistics Hyattsville, MD: National Health and Nutrition Examination Survey Data, 1998-2004
2. A. Soni Back problems: use and expenditures for the U.S. adult population, 2007. Statistical brief #289 2010 Agency for Healthcare research and Quality Rockville, MD
3. J.O. Galante Tensile properties of the human lumbar annulus fibrosus Acta Orthop Scand Suppl 100 1967 1 91
4. D.R. Eyre, and H. Muir Types I and II collagens in intervertebral disc. Interchanging radial distributions in annulus fibrosus Biochem J 157 1976 267 270
5. J.C. Iatridis, and I.A. Stokes Biomechanics of the spine V.C. Mow, R. Huiskes, Basic orthopaedic biomechanics and mechano-biology 2005 Lippincott Williams & Wilkins Philadelphia, PA 529 561
6. N. Boos, S. Weissbach, and H. Rohrbach Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science Spine 27 2002 2631 2644
7. C.L. Le Maitre, A. Pockert, and D.J. Buttle Matrix synthesis and degradation in human intervertebral disc degeneration Biochem Soc Trans 35 2007 652 655
8. P.J. Roughley Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix Spine 29 2004 2691 2699
9. V.K. Podichetty The aging spine: the role of inflammatory mediators in intervertebral disc degeneration Cell Mol Biol (Noisy-le-grand) 53 2007 4 18
10. E.J. Blain Mechanical regulation of matrix metalloproteinases Front Biosci 12 2007 507 527
11. R. Visse, and H. Nagase Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry Circ Res 92 2003 827 839
12. T. Cawston, S. Carrere, and J. Catterall Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronic obstructive pulmonary disease Novartis Found Symp 234 2001 205 218 discussion 218-28
13. H. Nagase, R. Visse, and G. Murphy Structure and function of matrix metalloproteinases and TIMPs Cardiovasc Res 69 2006 562 573
14. H.L. Fillmore, T.E. VanMeter, and W.C. Broaddus Membrane-type matrix metalloproteinases (MT-MMPs): expression and function during glioma invasion J Neurooncol 53 2001 187 202
15. L.J. McCawley, and L.M. Matrisian Matrix metalloproteinases: they're not just for matrix anymore! Curr Opin Cell Biol 13 2001 534 540
16. S. Porter, I.M. Clark, and L. Kevorkian The ADAMTS metalloproteinases Biochem J 386 2005 15 27
17. G. Murphy, and H. Nagase Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair? Nat Clin Pract Rheumatol 4 2008 128 135
18. B. Pasternak, and P. Aspenberg Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics Acta Orthop 80 2009 693 703
19. C. Gendron, M. Kashiwagi, and N.H. Lim Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4 J Biol Chem 282 2007 18294 18306
20. M.D. Tortorella, T.C. Burn, and M.A. Pratta Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins Science 284 1999 1664 1666
21. E.C. Arner, M.A. Pratta, and J.M. Trzaskos Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity J Biol Chem 274 1999 6594 6601
22. J.C. Rodriguez-Manzaneque, J. Westling, and S.N. Thai ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors Biochem Biophys Res Commun 293 2002 501 508
23. G. Hashimoto, H. Nakamura, and K. Tanzawa Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4) FEBS Lett 494 2001 192 195
24. M. Kashiwagi, M. Tortorella, and H. Nagase TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5) J Biol Chem 276 2001 12501 12504
25. C. Weiler, A.G. Nerlich, and J. Zipperer 2002 SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption Eur Spine J 11 2002 308 320
26. H.E. Gruber, J.A. Ingram, and E.N. Hanley Jr. Immunolocalization of MMP-19 in the human intervertebral disc: implications for disc aging and degeneration Biotech Histochem 80 2005 157 162
27. C.L. Le Maitre, A.J. Freemont, and J.A. Hoyland Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc J Pathol 204 2004 47 54
28. S.M. Richardson, P. Doyle, and B.M. Minogue Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc Arthritis Res Ther 11 2009 R126
29. S. Roberts, B. Caterson, and J. Menage Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc Spine 25 2000 3005 3013
30. B.E. Bachmeier, A. Nerlich, and N. Mittermaier Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration Eur Spine J 18 2009 1573 1586
31. J.K. Crean, S. Roberts, and D.C. Jaffray Matrix metalloproteinases in the human intervertebral disc: role in disc degeneration and scoliosis Spine 22 1997 2877 2884
32. C.L. Le Maitre, A.J. Freemont, and J.A. Hoyland Human disc degeneration is associated with increased MMP 7 expression Biotech Histochem 81 2006 125 131
33. H.E. Gruber, J.A. Ingram, and G.L. Hoelscher Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs Arthritis Res Ther 11 2009 R184
34. M. Klawitter, L. Quero, and A. Bertolo Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration J Negat Results Biomed 10 2011 9
35. G. Lyons, S.M. Eisenstein, and M.B. Sweet Biochemical changes in intervertebral disc degeneration Biochim Biophys Acta 673 1981 443 453
36. R.H. Pearce, and B.J. Grimmer Target tissue models: the proteoglycans and degeneration of the human intervertebral disc J Rheumatol Suppl 11 1983 108 110
37. J.D. Sandy A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis Osteoarthritis Cartilage 14 2006 95 100
38. C.B. Little, C.R. Flannery, and C.E. Hughes Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro Biochem J 344 1999 61 68
39. J.C. Iatridis, K. Godburn, and K. Wuertz Region-dependent aggrecan degradation patterns in the rat intervertberal disc are affected by mechanical loading in vivo Spine 36 2011 203 209
40. A.J. Pockert, S.M. Richardson, and C.L. Le Maitre Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration Arthritis Rheum 60 2009 482 491
41. C.Q. Zhao, Y.H. Zhang, and S.D. Jiang ADAMTS-5 and intervertebral disc degeneration: the results of tissue immunohistochemistry and in vitro cell culture J Orthop Res 29 2011 718 725
42. K.P. Patel, J.D. Sandy, and K. Akeda Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration Spine 32 2007 2596 2603
43. S.S. Glasson, R. Askew, and B. Sheppard Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis Nature 434 2005 644 648
44. H. Stanton, F.M. Rogerson, and C.J. East ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro Nature 434 2005 648 652
45. R. Sztrolovics, M. Alini, and P.J. Roughley Aggrecan degradation in human intervertebral disc and articular cartilage Biochem J 326 1997 235 241
46. G. Sowa, G. Vadalà, and R. Studer Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression Spine 33 2008 1821 1828
47. I.M. Clark, T.E. Swingler, and C.L. Sampieri The regulation of matrix metalloproteinases and their inhibitors Int J Biochem Cell Biol 40 2008 1362 1378
48. J.A. Ulrich, E.C. Liebenberg, and D.U. Thuillier ISSLS prize winner: repeated disc injury causes persistent inflammation Spine 32 2007 2812 2819
49. G.A. Sowa, J.P. Coelho, and K.M. Bell Alterations in gene expression in response to compression of nucleus pulposus cells Spine J 11 2011 36 43
50. C.L. Korecki, J.J. MacLean, and J.C. Iatridis Dynamic compression effects on intervertebral disc mechanics and biology Spine 33 2008 1403 1409
51. J.J. MacLean, C.R. Lee, and M. Alini Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression J Orthop Res 22 2004 1193 1200
52. J.J. MacLean, C.R. Lee, and M. Alini The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc J Orthop Res 23 2005 1120 1127
53. A.H. Hsieh, and J.C. Lotz Prolonged spinal loading induces matrix metalloproteinase-2 activation in intervertebral discs Spine 28 2003 1781 1788
54. T. Yurube, K. Nishida, and T. Suzuki Matrix metalloproteinase (MMP)-3 gene up-regulation in a rat tail compression loading-induced disc degeneration model J Orthop Res 28 2010 1026 1032
55. K. Wuertz, K. Godburn, and J.J. MacLean In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression J Orthop Res 27 2009 1235 1242
56. S.C. Chan, S.J. Ferguson, and B. Gantenbein-Ritter The effects of dynamic loading on the intervertebral disc Eur Spine J 20 2011 1796 1812
57. G. Sowa, P. Coelho, and N. Vo Determination of annulus fibrosus cell response to tensile strain as a function of duration, magnitude, and frequency J Orthop Res 29 2011 1275 1283
58. B.A. Walter, C.L. Korecki, and D. Purmessur Complex loading affects intervertebral disc mechanics and biology Osteoarthritis Cartilage 19 2011 1011 1018
59. A. Barbir, E.K. Godburn, and A.J. Michalek Effects of torsion on intervertebral disc gene expression and biomechanics, using a rat tail model Spine 36 2011 607 614
60. S.C. Chan, S.J. Ferguson, and K. Wuertz Biological response of the intervertebral disc to repetitive short term cyclic torsion Spine 30 2011 44 53
61. C. Weiler, A.G. Nerlich, and B.E. Bachmeier Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls Spine 30 2005 44 53 discussion 54
62. C.L. Le Maitre, J.A. Hoyland, and A.J. Freemont Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile Arthritis Res Ther 9 2007 R77
63. C.L. Le Maitre, A.J. Freemont, and J.A. Hoyland The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration Arthritis Res Ther 7 2005 R732 R745
64. M.A. Rousseau, J.A. Ulrich, and E.C. Bass Stab incision for inducing intervertebral disc degeneration in the rat Spine 32 2007 17 24
65. S. Sobajima, A.L. Shimer, and R.C. Chadderdon Quantitative analysis of gene expression in a rabbit model of intervertebral disc degeneration by real-time polymerase chain reaction Spine J 5 2005 14 23
66. D.G. Anderson, M.W. Izzo, and D.J. Hall Comparative gene expression profiling of normal and degenerative discs: analysis of a rabbit annular laceration model Spine 27 2002 1291 1296
67. C.L. Le Maitre, J.A. Hoyland, and A.J. Freemont Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study Arthritis Res Ther 9 2007 R83
68. R.K. Studer, A.M. Aboka, and L.G. Gilbertson p.38 MAPK inhibition in nucleus pulposus cells: a potential target for treating intervertebral disc degeneration Spine 32 2007 2827 2833
69. R.K. Studer, L.G. Gilbertson, and H. Georgescu p.38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1 J Orthop Res 26 2008 991 998
70. A.G. Nerlich, B.E. Bachmeier, and E. Schleicher Immunomorphological analysis of RAGE receptor expression and NF-kappaB activation in tissue samples from normal and degenerated intervertebral discs of various ages Ann N Y Acad Sci 1096 2007 239 248
71. Y.Y. Lo, and T.F. Cruz Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes J Biol Chem 270 1995 11727 11730
72. N. Jallali, H. Ridha, and C. Thrasivoulou Modulation of intracellular reactive oxygen species level in chondrocytes by IGF-1, FGF, and TGF-beta1 Connect Tissue Res 48 2007 149 158
73. M. Del Carlo, D. Schwartz, and E.A. Erickson Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments Free Radic Biol Med 42 2007 1350 1358
74. C.M. Davies, F. Guilak, and J.B. Weinberg Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis Osteoarthritis Cartilage 16 2008 624 630
75. D.M. Soukane, A. Shirazi-Adl, and J.P. Urban Computation of coupled diffusion of oxygen, glucose and lactic acid in an intervertebral disc J Biomech 40 2007 2645 2654
76. N. Vo, D. Wang, and G. Sowa Differential effects of nicotine and tobacco smoke condensate on human annulus fibrosus cell metabolism J Orthop Res 29 2011 1585 1591
77. D. Chan, Y. Song, and P. Sham Genetics of disc degeneration Eur Spine J 15 2006 S317 S325
78. M.C. Battie, and T. Videman Lumbar disc degeneration: epidemiology and genetics J Bone Joint Surg Am 88 2006 3 9
79. T. Videman, L.E. Gibbons, and M.C. Battié The relative roles of intragenic polymorphisms of the vitamin d receptor gene in lumbar spine degeneration and bone density Spine 26 2001 E7 E12
80. S. Annunen, J. Ott, and D.J. Prockop An allele of COL9A2 associated with intervertebral disc disease Science 285 1999 409 412
81. L. Ala-Kokko Genetic risk factors for lumbar disc disease Ann Med 34 2002 42 47
82. K.J. Doege, S.N. Coulter, and L.M. Meek A human-specific polymorphism in the coding region of the aggrecan gene. Variable number of tandem repeats produce a range of core protein sizes in the general population J Biol Chem 272 1997 13974 13979
83. M. Takahashi, H. Haro, and Y. Wakabayashi The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene J Bone Joint Surg Br 83 2001 491 495
84. D.M. Dong, M. Yao, and B. Liu Association between the -1306C/T polymorphism of matrix metalloproteinase-2 gene and lumbar disc disease in Chinese young adults Eur Spine J 16 2007 1958 1961
85. Y.Q. Song, D.W. Ho, and J. Karppinen Association between promoter -1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese BMC Med Genet 9 2008 38
86. Z.M. Sun, L. Miao, and Y.G. Zhang Association between the -1562 C/T polymorphism of matrix metalloproteinase-9 gene and lumbar disc disease in the young adult population in North China Connect Tissue Res 50 2009 181 185
87. K. Nishida, T. Suzuki, and K. Kakutani Gene therapy approach for disc degeneration and associated spinal disorders Eur Spine J 17 2008 459 466
88. J.P. Urban, and S. Roberts Degeneration of the intervertebral disc Arthritis Res Ther 5 2003 120 130
89. J.P. Urban, S. Smith, and J.C. Fairbank Nutrition of the intervertebral disc Spine 29 2004 2700 2709
90. A.M. Gilbert, M.G. Bursavich, and S. Lombardi 5-((1H-pyrazol-4-yl) methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5 Bioorg Med Chem Lett 17 2007 1189 1192
91. A.J. Fosang, and C.B. Little Drug insight: aggrecanases as therapeutic targets for osteoarthritis Nat Clin Pract Rheumatol 4 2008 420 427
92. K. Huang, C. Zhang, and X.W. Zhang Effect of dehydroepiandrosterone on aggrecanase expression in articular cartilage in a rabbit model of osteoarthritis Mol Biol Rep 38 2011 3569 3572
93. D.M. Elliott, C.S. Yerramalli, and J.C. Beckstein The effect of relative needle diameter in puncture and sham injection animal models of degeneration Spine 33 2008 588 596
94. A.J. Michalek, K.L. Funabashi, and J.C. Iatridis Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently Eur Spine J 19 2010 2110 2116
95. E.A. Lin, and C.J. Liu The role of ADAMTSs in arthritis Protein Cell 1 2010 33 47
96. D. Bourboulia, and W.G. Stetler-Stevenson Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): positive and negative regulators in tumor cell adhesion Semin Cancer Biol 20 2010 161 168
97. K. Brew, D. Dinakarpandian, and H. Nagase Tissue inhibitors of metalloproteinases: evolution, structure and function Biochim Biophys Acta 1477 2000 267 283
98. R.A. Black TIMP3 checks inflammation Nat Genet 36 2004 934 935
99. T. Handa, H. Ishihara, and H. Ohshima Effects of hydrostatic pressure on matrix synthesis and matrix metalloproteinase production in the human lumbar intervertebral disc Spine 22 1997 1085 1091
100. C. Neidlinger-Wilke, K. Würtz, and J.P. Urban Regulation of gene expression in intervertebral disc cells by low and high hydrostatic pressure Eur Spine J 15 2006 S372 S378