메뉴 건너뛰기




Volumn 40, Issue , 2016, Pages 47-59

How to rule the nucleus: divide et impera

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIFFERENTIATION; CELL MATURATION; CHROMOSOME SEGREGATION; EUCHROMATIN; GENE REARRANGEMENT; GENOME; GENOME ANALYSIS; HETEROCHROMATIN; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; CELL NUCLEUS; GENETICS; TRANSCRIPTION INITIATION;

EID: 84971428467     PISSN: 09550674     EISSN: 18790410     Source Type: Journal    
DOI: 10.1016/j.ceb.2016.02.014     Document Type: Review
Times cited : (132)

References (119)
  • 3
    • 84919949716 scopus 로고    scopus 로고
    • A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping
    • The authors introduce a modification of the Hi-C method with much higher resolution. The new approach allows further subdivision of A and B compartments into six subcompartments and identification of about 10,000 loop domains (apparently corresponding to subTADs) with a median size of 185 kb, which are conserved between cell types and species. Loop formation is highly correlated with presence of convergent CTCF-binding sites at the base of the loops.
    • 3•• Rao, S.S., Huntley, M.H., Durand, N.C., Stamenova, E.K., Bochkov, I.D., Robinson, J.T., Sanborn, A.L., Machol, I., Omer, A.D., Lander, E.S., et al. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell 159 (2014), 1665–1680 The authors introduce a modification of the Hi-C method with much higher resolution. The new approach allows further subdivision of A and B compartments into six subcompartments and identification of about 10,000 loop domains (apparently corresponding to subTADs) with a median size of 185 kb, which are conserved between cell types and species. Loop formation is highly correlated with presence of convergent CTCF-binding sites at the base of the loops.
    • (2014) Cell , vol.159 , pp. 1665-1680
    • Rao, S.S.1    Huntley, M.H.2    Durand, N.C.3    Stamenova, E.K.4    Bochkov, I.D.5    Robinson, J.T.6    Sanborn, A.L.7    Machol, I.8    Omer, A.D.9    Lander, E.S.10
  • 4
    • 84861095603 scopus 로고    scopus 로고
    • Topological domains in mammalian genomes identified by analysis of chromatin interactions
    • 4 Dixon, J.R., Selvaraj, S., Yue, F., Kim, A., Li, Y., Shen, Y., Hu, M., Liu, J.S., Ren, B., Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature 485 (2012), 376–380.
    • (2012) Nature , vol.485 , pp. 376-380
    • Dixon, J.R.1    Selvaraj, S.2    Yue, F.3    Kim, A.4    Li, Y.5    Shen, Y.6    Hu, M.7    Liu, J.S.8    Ren, B.9
  • 8
    • 84893155560 scopus 로고    scopus 로고
    • Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming
    • 8 Zhang, H., Jiao, W., Sun, L., Fan, J., Chen, M., Wang, H., Xu, X., Shen, A., Li, T., Niu, B., et al. Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming. Cell Stem Cell 13 (2013), 30–35.
    • (2013) Cell Stem Cell , vol.13 , pp. 30-35
    • Zhang, H.1    Jiao, W.2    Sun, L.3    Fan, J.4    Chen, M.5    Wang, H.6    Xu, X.7    Shen, A.8    Li, T.9    Niu, B.10
  • 10
    • 84948587544 scopus 로고    scopus 로고
    • Genome-wide maps of nuclear lamina interactions in single human cells
    • The authors use a modified DamID-methodology to map nuclear lamina interactions in single human cells. Some LADs are highly consistent between cells while a portion of LADs exhibit cell-to-cell variability. Detachment of LADs from the periphery occurs in a coordinated manner dependent on spatial proximity by a mechanism reminiscent of unzipping.
    • 10•• Kind, J., Pagie, L., de Vries, S.S., Nahidiazar, L., Dey, S.S., Bienko, M., Zhan, Y., Lajoie, B., de Graaf, C.A., Amendola, M., et al. Genome-wide maps of nuclear lamina interactions in single human cells. Cell 163 (2015), 134–147 The authors use a modified DamID-methodology to map nuclear lamina interactions in single human cells. Some LADs are highly consistent between cells while a portion of LADs exhibit cell-to-cell variability. Detachment of LADs from the periphery occurs in a coordinated manner dependent on spatial proximity by a mechanism reminiscent of unzipping.
    • (2015) Cell , vol.163 , pp. 134-147
    • Kind, J.1    Pagie, L.2    de Vries, S.S.3    Nahidiazar, L.4    Dey, S.S.5    Bienko, M.6    Zhan, Y.7    Lajoie, B.8    de Graaf, C.A.9    Amendola, M.10
  • 13
    • 84937042919 scopus 로고    scopus 로고
    • Characterization and dynamics of pericentromere-associated domains in mice
    • One of few studies on the role of pericentromeric satellite repeats in the organization of the mammalian genome. PADs represent silenced chromatin which is scarcely assembled around chromocenters in ESC; in differentiated cells, PADs progressively increase and consolidate in larger blocks closely overlapping with constitutive LADs.
    • 13• Wijchers, P.J., Geeven, G., Eyres, M., Bergsma, A.J., Janssen, M., Verstegen, M., Zhu, Y., Schell, Y., Vermeulen, C., de Wit, E., et al. Characterization and dynamics of pericentromere-associated domains in mice. Genome Res 25 (2015), 958–969 One of few studies on the role of pericentromeric satellite repeats in the organization of the mammalian genome. PADs represent silenced chromatin which is scarcely assembled around chromocenters in ESC; in differentiated cells, PADs progressively increase and consolidate in larger blocks closely overlapping with constitutive LADs.
    • (2015) Genome Res , vol.25 , pp. 958-969
    • Wijchers, P.J.1    Geeven, G.2    Eyres, M.3    Bergsma, A.J.4    Janssen, M.5    Verstegen, M.6    Zhu, Y.7    Schell, Y.8    Vermeulen, C.9    de Wit, E.10
  • 17
    • 84978655886 scopus 로고    scopus 로고
    • Large-scale chromatin structure–function relationships during the cell cycle and development: insights from replication timing
    • 17 Dileep, V., Rivera-Mulia, J.C., Sima, J., Gilbert, D.M., Large-scale chromatin structure–function relationships during the cell cycle and development: insights from replication timing. Cold Spring Harb Symp Quant Biol, 2015.
    • (2015) Cold Spring Harb Symp Quant Biol
    • Dileep, V.1    Rivera-Mulia, J.C.2    Sima, J.3    Gilbert, D.M.4
  • 19
    • 84943358548 scopus 로고    scopus 로고
    • Architectural hallmarks of the pluripotent genome
    • 19 Bouwman, B.A., de Laat, W., Architectural hallmarks of the pluripotent genome. FEBS Lett 589 (2015), 2905–2913.
    • (2015) FEBS Lett , vol.589 , pp. 2905-2913
    • Bouwman, B.A.1    de Laat, W.2
  • 20
    • 84925636391 scopus 로고    scopus 로고
    • Chromatin-driven behavior of topologically associating domains
    • 20 Ciabrelli, F., Cavalli, G., Chromatin-driven behavior of topologically associating domains. J Mol Biol 427 (2015), 608–625.
    • (2015) J Mol Biol , vol.427 , pp. 608-625
    • Ciabrelli, F.1    Cavalli, G.2
  • 21
    • 84943358862 scopus 로고    scopus 로고
    • Structural and functional diversity of topologically associating domains
    • 21 Dekker, J., Heard, E., Structural and functional diversity of topologically associating domains. FEBS Lett 589 (2015), 2877–2884.
    • (2015) FEBS Lett , vol.589 , pp. 2877-2884
    • Dekker, J.1    Heard, E.2
  • 22
    • 84902212007 scopus 로고    scopus 로고
    • The 3D genome in transcriptional regulation and pluripotency
    • 22 Gorkin, D.U., Leung, D., Ren, B., The 3D genome in transcriptional regulation and pluripotency. Cell Stem Cell 14 (2014), 762–775.
    • (2014) Cell Stem Cell , vol.14 , pp. 762-775
    • Gorkin, D.U.1    Leung, D.2    Ren, B.3
  • 23
    • 84943348158 scopus 로고    scopus 로고
    • Structure, function and evolution of topologically associating domains (TADs) at HOX loci
    • 23 Lonfat, N., Duboule, D., Structure, function and evolution of topologically associating domains (TADs) at HOX loci. FEBS Lett 589 (2015), 2869–2876.
    • (2015) FEBS Lett , vol.589 , pp. 2869-2876
    • Lonfat, N.1    Duboule, D.2
  • 24
    • 84924875394 scopus 로고    scopus 로고
    • The role of chromosome domains in shaping the functional genome
    • 24 Sexton, T., Cavalli, G., The role of chromosome domains in shaping the functional genome. Cell 160 (2015), 1049–1059.
    • (2015) Cell , vol.160 , pp. 1049-1059
    • Sexton, T.1    Cavalli, G.2
  • 25
    • 84860879005 scopus 로고    scopus 로고
    • Human transposon tectonics
    • 25 Burns, K.H., Boeke, J.D., Human transposon tectonics. Cell 149 (2012), 740–752.
    • (2012) Cell , vol.149 , pp. 740-752
    • Burns, K.H.1    Boeke, J.D.2
  • 27
    • 84897020434 scopus 로고    scopus 로고
    • Recollections of a scientific journey published in human genetics: from chromosome territories to interphase cytogenetics and comparative genome hybridization
    • 27 Cremer, T., Cremer, C., Lichter, P., Recollections of a scientific journey published in human genetics: from chromosome territories to interphase cytogenetics and comparative genome hybridization. Hum Genet 133 (2014), 403–416.
    • (2014) Hum Genet , vol.133 , pp. 403-416
    • Cremer, T.1    Cremer, C.2    Lichter, P.3
  • 28
    • 64249139170 scopus 로고    scopus 로고
    • Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution
    • 28 Solovei, I., Kreysing, M., Lanctot, C., Kosem, S., Peichl, L., Cremer, T., Guck, J., Joffe, B., Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution. Cell 137 (2009), 356–368.
    • (2009) Cell , vol.137 , pp. 356-368
    • Solovei, I.1    Kreysing, M.2    Lanctot, C.3    Kosem, S.4    Peichl, L.5    Cremer, T.6    Guck, J.7    Joffe, B.8
  • 30
    • 52249097416 scopus 로고    scopus 로고
    • Gene associations: true romance or chance meeting in a nuclear neighborhood?
    • 30 Lawrence, J.B., Clemson, C.M., Gene associations: true romance or chance meeting in a nuclear neighborhood?. Cell Biol 182 (2008), 1035–1038.
    • (2008) Cell Biol , vol.182 , pp. 1035-1038
    • Lawrence, J.B.1    Clemson, C.M.2
  • 31
    • 84889005653 scopus 로고    scopus 로고
    • Transcription factories: genome organization and gene regulation
    • 31 Papantonis, A., Cook, P.R., Transcription factories: genome organization and gene regulation. Chem Rev 113 (2013), 8683–8705.
    • (2013) Chem Rev , vol.113 , pp. 8683-8705
    • Papantonis, A.1    Cook, P.R.2
  • 32
    • 84940895347 scopus 로고    scopus 로고
    • Why the activity of a gene depends on its neighbors
    • 32 Feuerborn, A., Cook, P.R., Why the activity of a gene depends on its neighbors. Trends Genet 31 (2015), 483–490.
    • (2015) Trends Genet , vol.31 , pp. 483-490
    • Feuerborn, A.1    Cook, P.R.2
  • 34
    • 84892474589 scopus 로고    scopus 로고
    • Polycomb silencing: from linear chromatin domains to 3D chromosome folding
    • 34 Cheutin, T., Cavalli, G., Polycomb silencing: from linear chromatin domains to 3D chromosome folding. Curr Opin Genet Dev 25 (2014), 30–37.
    • (2014) Curr Opin Genet Dev , vol.25 , pp. 30-37
    • Cheutin, T.1    Cavalli, G.2
  • 35
    • 84892659829 scopus 로고    scopus 로고
    • When untethered, something silent inside comes
    • 35 Politz, J.C., Ragoczy, T., Groudine, M., When untethered, something silent inside comes. Nucleus 4 (2013), 153–155.
    • (2013) Nucleus , vol.4 , pp. 153-155
    • Politz, J.C.1    Ragoczy, T.2    Groudine, M.3
  • 36
    • 84885774880 scopus 로고    scopus 로고
    • Something silent this way forms: the functional organization of the repressive nuclear compartment
    • 36 Politz, J.C., Scalzo, D., Groudine, M., Something silent this way forms: the functional organization of the repressive nuclear compartment. Annu Rev Cell Dev Biol 29 (2013), 241–270.
    • (2013) Annu Rev Cell Dev Biol , vol.29 , pp. 241-270
    • Politz, J.C.1    Scalzo, D.2    Groudine, M.3
  • 37
    • 84876871047 scopus 로고    scopus 로고
    • Occupying chromatin: polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put
    • 37 Simon, J.A., Kingston, R.E., Occupying chromatin: polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol Cell 49 (2013), 808–824.
    • (2013) Mol Cell , vol.49 , pp. 808-824
    • Simon, J.A.1    Kingston, R.E.2
  • 38
    • 84922621952 scopus 로고    scopus 로고
    • Function and information content of DNA methylation
    • 38 Schubeler, D., Function and information content of DNA methylation. Nature 517 (2015), 321–326.
    • (2015) Nature , vol.517 , pp. 321-326
    • Schubeler, D.1
  • 39
    • 84874194072 scopus 로고    scopus 로고
    • DNA methylation: roles in mammalian development
    • 39 Smith, Z.D., Meissner, A., DNA methylation: roles in mammalian development. Nat Rev Genet 14 (2013), 204–220.
    • (2013) Nat Rev Genet , vol.14 , pp. 204-220
    • Smith, Z.D.1    Meissner, A.2
  • 40
    • 84949529403 scopus 로고    scopus 로고
    • Perinuclear anchoring of H3K9-methylated chromatin stabilizes induced cell fate in C. elegans embryos
    • The authors identified new chromodomain protein CEC-4 associated with the nuclear envelope and binding methylated H3K9-enriched chromatin. A mutant form of CEC-4 fails to anchor HC to the nuclear periphery during embryo's development, which leads to changes in ability of differentiating cells to maintain their developmental program.
    • 40•• Gonzalez-Sandoval, A., Towbin, B.D., Kalck, V., Cabianca, D.S., Gaidatzis, D., Hauer, M.H., Geng, L., Wang, L., Yang, T., Wang, X., et al. Perinuclear anchoring of H3K9-methylated chromatin stabilizes induced cell fate in C. elegans embryos. Cell, 2015 The authors identified new chromodomain protein CEC-4 associated with the nuclear envelope and binding methylated H3K9-enriched chromatin. A mutant form of CEC-4 fails to anchor HC to the nuclear periphery during embryo's development, which leads to changes in ability of differentiating cells to maintain their developmental program.
    • (2015) Cell
    • Gonzalez-Sandoval, A.1    Towbin, B.D.2    Kalck, V.3    Cabianca, D.S.4    Gaidatzis, D.5    Hauer, M.H.6    Geng, L.7    Wang, L.8    Yang, T.9    Wang, X.10
  • 43
    • 0035141289 scopus 로고    scopus 로고
    • Two-color fluorescence labeling of early and mid-to-late replicating chromatin in living cells
    • 43 Schermelleh, L., Solovei, I., Zink, D., Cremer, T., Two-color fluorescence labeling of early and mid-to-late replicating chromatin in living cells. Chromosome Res 9 (2001), 77–80.
    • (2001) Chromosome Res , vol.9 , pp. 77-80
    • Schermelleh, L.1    Solovei, I.2    Zink, D.3    Cremer, T.4
  • 44
    • 10644221120 scopus 로고    scopus 로고
    • Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome
    • 44 Chadwick, B.P., Willard, H.F., Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome. Proc Natl Acad Sci U S A 101 (2004), 17450–17455.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 17450-17455
    • Chadwick, B.P.1    Willard, H.F.2
  • 47
    • 84877795624 scopus 로고    scopus 로고
    • Identical cells with different 3D genomes; cause and consequences?
    • 47 Krijger, P.H., de Laat, W., Identical cells with different 3D genomes; cause and consequences?. Curr Opin Genet Dev 23 (2013), 191–196.
    • (2013) Curr Opin Genet Dev , vol.23 , pp. 191-196
    • Krijger, P.H.1    de Laat, W.2
  • 48
    • 84939802036 scopus 로고    scopus 로고
    • Getting the genome in shape: the formation of loops, domains and compartments
    • 48 Bouwman, B.A., de Laat, W., Getting the genome in shape: the formation of loops, domains and compartments. Genome Biol, 16, 2015, 154.
    • (2015) Genome Biol , vol.16 , pp. 154
    • Bouwman, B.A.1    de Laat, W.2
  • 49
    • 84876838711 scopus 로고    scopus 로고
    • The hierarchy of the 3D genome
    • 49 Gibcus, J.H., Dekker, J., The hierarchy of the 3D genome. Mol Cell 49 (2013), 773–782.
    • (2013) Mol Cell , vol.49 , pp. 773-782
    • Gibcus, J.H.1    Dekker, J.2
  • 51
    • 84875703872 scopus 로고    scopus 로고
    • Single-cell dynamics of genome–nuclear lamina interactions
    • The authors use an elegant approach to trace LADs in living cells. The study shows that contacts between LADs and the nuclear lamina are highly dynamic and that LADs are stochastically reshuffled after mitosis with some mother LADs ending up in the nuclear interior often at the nucleolar periphery. The H3K9 methyltransferase, setting up the H3K9me2 repressive mark, is identified as the major regulator of LAD attachment to the nuclear lamina.
    • 51•• Kind, J., Pagie, L., Ortabozkoyun, H., Boyle, S., de Vries, S.S., Janssen, H., Amendola, M., Nolen, L.D., Bickmore, W.A., van Steensel, B., Single-cell dynamics of genome–nuclear lamina interactions. Cell 153 (2013), 178–192 The authors use an elegant approach to trace LADs in living cells. The study shows that contacts between LADs and the nuclear lamina are highly dynamic and that LADs are stochastically reshuffled after mitosis with some mother LADs ending up in the nuclear interior often at the nucleolar periphery. The H3K9 methyltransferase, setting up the H3K9me2 repressive mark, is identified as the major regulator of LAD attachment to the nuclear lamina.
    • (2013) Cell , vol.153 , pp. 178-192
    • Kind, J.1    Pagie, L.2    Ortabozkoyun, H.3    Boyle, S.4    de Vries, S.S.5    Janssen, H.6    Amendola, M.7    Nolen, L.D.8    Bickmore, W.A.9    van Steensel, B.10
  • 52
    • 84873375779 scopus 로고    scopus 로고
    • Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence
    • The authors state that the genome can be subdivided into LADs and inter-LADs (iLADs) and further divide them into constitutive and facultative LADs/iLADs. Constitutive LADs are characterized by high A/T content and conservation in evolution pointing to their functional significance in genome scaffolding.
    • 52• Meuleman, W., Peric-Hupkes, D., Kind, J., Beaudry, J.B., Pagie, L., Kellis, M., Reinders, M., Wessels, L., van Steensel, B., Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence. Genome Res 23 (2013), 270–280 The authors state that the genome can be subdivided into LADs and inter-LADs (iLADs) and further divide them into constitutive and facultative LADs/iLADs. Constitutive LADs are characterized by high A/T content and conservation in evolution pointing to their functional significance in genome scaffolding.
    • (2013) Genome Res , vol.23 , pp. 270-280
    • Meuleman, W.1    Peric-Hupkes, D.2    Kind, J.3    Beaudry, J.B.4    Pagie, L.5    Kellis, M.6    Reinders, M.7    Wessels, L.8    van Steensel, B.9
  • 53
    • 84928165183 scopus 로고    scopus 로고
    • Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain
    • This study reports on intra-chromosomal and inter-chromosomal interactions of H3K27me3-marked repressed loci, including the Hox genes. The authors discuss the role of Polycomb proteins in silencing genes residing within gene-rich chromosomal regions of the euchromatic A compartment.
    • 53• Vieux-Rochas, M., Fabre, P.J., Leleu, M., Duboule, D., Noordermeer, D., Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain. Proc Natl Acad Sci U S A 112 (2015), 4672–4677 This study reports on intra-chromosomal and inter-chromosomal interactions of H3K27me3-marked repressed loci, including the Hox genes. The authors discuss the role of Polycomb proteins in silencing genes residing within gene-rich chromosomal regions of the euchromatic A compartment.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 4672-4677
    • Vieux-Rochas, M.1    Fabre, P.J.2    Leleu, M.3    Duboule, D.4    Noordermeer, D.5
  • 54
    • 84920871341 scopus 로고    scopus 로고
    • Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins
    • 54 Harr, J.C., Luperchio, T.R., Wong, X., Cohen, E., Wheelan, S.J., Reddy, K.L., Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins. J Cell Biol 208 (2015), 33–52.
    • (2015) J Cell Biol , vol.208 , pp. 33-52
    • Harr, J.C.1    Luperchio, T.R.2    Wong, X.3    Cohen, E.4    Wheelan, S.J.5    Reddy, K.L.6
  • 57
    • 84957442426 scopus 로고    scopus 로고
    • Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man
    • 57 Harr, J.C., Gonzalez-Sandoval, A., Gasser, S.M., Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man. EMBO Rep, 2016.
    • (2016) EMBO Rep
    • Harr, J.C.1    Gonzalez-Sandoval, A.2    Gasser, S.M.3
  • 58
    • 84873302358 scopus 로고    scopus 로고
    • LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation
    • Lamin B receptor (LBR) and lamin A/C (LA/C) are identified as major components of two peripheral HC tethers. During cellular differentiation both tethers are sequentially expressed, with LBR preceding LA/C. Absence of both proteins results in loss of peripheral HC and nuclear inversion. Expression of LA/C promotes cellular differentiation, whereas the LBR-tether delays it.
    • 58•• Solovei, I., Wang, A.S., Thanisch, K., Schmidt, C.S., Krebs, S., Zwerger, M., Cohen, T.V., Devys, D., Foisner, R., Peichl, L., et al. LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. Cell 152 (2013), 584–598 Lamin B receptor (LBR) and lamin A/C (LA/C) are identified as major components of two peripheral HC tethers. During cellular differentiation both tethers are sequentially expressed, with LBR preceding LA/C. Absence of both proteins results in loss of peripheral HC and nuclear inversion. Expression of LA/C promotes cellular differentiation, whereas the LBR-tether delays it.
    • (2013) Cell , vol.152 , pp. 584-598
    • Solovei, I.1    Wang, A.S.2    Thanisch, K.3    Schmidt, C.S.4    Krebs, S.5    Zwerger, M.6    Cohen, T.V.7    Devys, D.8    Foisner, R.9    Peichl, L.10
  • 59
    • 0033553877 scopus 로고    scopus 로고
    • Differences in the localization and morphology of chromosomes in the human nucleus
    • 59 Croft, J.A., Bridger, J.M., Boyle, S., Perry, P., Teague, P., Bickmore, W.A., Differences in the localization and morphology of chromosomes in the human nucleus. J Cell Biol 145 (1999), 1119–1131.
    • (1999) J Cell Biol , vol.145 , pp. 1119-1131
    • Croft, J.A.1    Bridger, J.M.2    Boyle, S.3    Perry, P.4    Teague, P.5    Bickmore, W.A.6
  • 62
    • 0043180471 scopus 로고    scopus 로고
    • Three-dimensional arrangements of centromeres and telomeres in nuclei of human and murine lymphocytes
    • 62 Weierich, C., Brero, A., Stein, S., von Hase, J., Cremer, C., Cremer, T., Solovei, I., Three-dimensional arrangements of centromeres and telomeres in nuclei of human and murine lymphocytes. Chromosome Res 11 (2003), 485–502.
    • (2003) Chromosome Res , vol.11 , pp. 485-502
    • Weierich, C.1    Brero, A.2    Stein, S.3    von Hase, J.4    Cremer, C.5    Cremer, T.6    Solovei, I.7
  • 64
    • 84896414509 scopus 로고    scopus 로고
    • Chromatin looping and organization at developmentally regulated gene loci
    • 64 Noordermeer, D., Duboule, D., Chromatin looping and organization at developmentally regulated gene loci. Wiley Interdiscip Rev Dev Biol 2 (2013), 615–630.
    • (2013) Wiley Interdiscip Rev Dev Biol , vol.2 , pp. 615-630
    • Noordermeer, D.1    Duboule, D.2
  • 65
    • 84894589713 scopus 로고    scopus 로고
    • Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation
    • 65 Kieffer-Kwon, K.R., Tang, Z., Mathe, E., Qian, J., Sung, M.H., Li, G., Resch, W., Baek, S., Pruett, N., Grontved, L., et al. Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation. Cell 155 (2013), 1507–1520.
    • (2013) Cell , vol.155 , pp. 1507-1520
    • Kieffer-Kwon, K.R.1    Tang, Z.2    Mathe, E.3    Qian, J.4    Sung, M.H.5    Li, G.6    Resch, W.7    Baek, S.8    Pruett, N.9    Grontved, L.10
  • 67
    • 84911478490 scopus 로고    scopus 로고
    • Topologically associating domains are stable units of replication-timing regulation
    • Genome-wide analysis of replication timing in 18 human and 13 mouse cell lines reveals that TAD boundaries coincide with boundaries of replication domains. The study confirms the matching of TADs with microscopically observed replication foci.
    • 67• Pope, B.D., Ryba, T., Dileep, V., Yue, F., Wu, W., Denas, O., Vera, D.L., Wang, Y., Hansen, R.S., Canfield, T.K., et al. Topologically associating domains are stable units of replication-timing regulation. Nature 515 (2014), 402–405 Genome-wide analysis of replication timing in 18 human and 13 mouse cell lines reveals that TAD boundaries coincide with boundaries of replication domains. The study confirms the matching of TADs with microscopically observed replication foci.
    • (2014) Nature , vol.515 , pp. 402-405
    • Pope, B.D.1    Ryba, T.2    Dileep, V.3    Yue, F.4    Wu, W.5    Denas, O.6    Vera, D.L.7    Wang, Y.8    Hansen, R.S.9    Canfield, T.K.10
  • 68
    • 84938893979 scopus 로고    scopus 로고
    • Topologically associating domains and their long-range contacts are established during early G1 coincident with the establishment of the replication-timing program
    • 68 Dileep, V., Ay, F., Sima, J., Vera, D.L., Noble, W.S., Gilbert, D.M., Topologically associating domains and their long-range contacts are established during early G1 coincident with the establishment of the replication-timing program. Genome Res 25 (2015), 1104–1113.
    • (2015) Genome Res , vol.25 , pp. 1104-1113
    • Dileep, V.1    Ay, F.2    Sima, J.3    Vera, D.L.4    Noble, W.S.5    Gilbert, D.M.6
  • 69
    • 84888018217 scopus 로고    scopus 로고
    • Organization of the mitotic chromosome
    • This scrupulous work shows that in striking difference to interphase, mitotic chromosomes lack TAD structure, implying that chromatin arrangement in the nucleus is established de novo after each division. Polymer simulation proposes a model of the mitotic chromosome as a compressed array of consecutive loops.
    • 69•• Naumova, N., Imakaev, M., Fudenberg, G., Zhan, Y., Lajoie, B.R., Mirny, L.A., Dekker, J., Organization of the mitotic chromosome. Science 342 (2013), 948–953 This scrupulous work shows that in striking difference to interphase, mitotic chromosomes lack TAD structure, implying that chromatin arrangement in the nucleus is established de novo after each division. Polymer simulation proposes a model of the mitotic chromosome as a compressed array of consecutive loops.
    • (2013) Science , vol.342 , pp. 948-953
    • Naumova, N.1    Imakaev, M.2    Fudenberg, G.3    Zhan, Y.4    Lajoie, B.R.5    Mirny, L.A.6    Dekker, J.7
  • 74
    • 84947765898 scopus 로고    scopus 로고
    • CTCF binding polarity determines chromatin looping
    • The authors employ high-resolution 4C-seq technique to show convergent orientation of CTCF-binding sites at the base of chromatin loops. Mutations in CTCF sites, induced by CRISPR/Cas genome editing, cause destabilization or disruption of chromatin loops.
    • 74• de Wit, E., Vos, E.S., Holwerda, S.J., Valdes-Quezada, C., Verstegen, M.J., Teunissen, H., Splinter, E., Wijchers, P.J., Krijger, P.H., de Laat, W., CTCF binding polarity determines chromatin looping. Mol Cell 60 (2015), 676–684 The authors employ high-resolution 4C-seq technique to show convergent orientation of CTCF-binding sites at the base of chromatin loops. Mutations in CTCF sites, induced by CRISPR/Cas genome editing, cause destabilization or disruption of chromatin loops.
    • (2015) Mol Cell , vol.60 , pp. 676-684
    • de Wit, E.1    Vos, E.S.2    Holwerda, S.J.3    Valdes-Quezada, C.4    Verstegen, M.J.5    Teunissen, H.6    Splinter, E.7    Wijchers, P.J.8    Krijger, P.H.9    de Laat, W.10
  • 76
    • 84939246295 scopus 로고    scopus 로고
    • CRISPR inversion of CTCF sites alters genome topology and enhancer/promoter function
    • The authors demonstrate that altering of chromatin loop configurations disrupts enhancer-promoter interactions and thus gene-expression. Convergent or divergent orientation of neighboring CTCF sites promotes or blocks chromatin loop formation, respectively.
    • 76• Guo, Y., Xu, Q., Canzio, D., Shou, J., Li, J., Gorkin, D.U., Jung, I., Wu, H., Zhai, Y., Tang, Y., et al. CRISPR inversion of CTCF sites alters genome topology and enhancer/promoter function. Cell 162 (2015), 900–910 The authors demonstrate that altering of chromatin loop configurations disrupts enhancer-promoter interactions and thus gene-expression. Convergent or divergent orientation of neighboring CTCF sites promotes or blocks chromatin loop formation, respectively.
    • (2015) Cell , vol.162 , pp. 900-910
    • Guo, Y.1    Xu, Q.2    Canzio, D.3    Shou, J.4    Li, J.5    Gorkin, D.U.6    Jung, I.7    Wu, H.8    Zhai, Y.9    Tang, Y.10
  • 80
    • 84930091577 scopus 로고    scopus 로고
    • Disruptions of topological chromatin domains cause pathogenic rewiring of gene–enhancer interactions
    • An excellent study on the role of TADs in maintaining genome function conducted in both patient-derived cells and mutant mice generated by CRISPR/Cas genome editing. Disruption of CTCF-associated boundaries, as a result of deletions, duplications and inversions, causes changes in enhancer–promoter interactions, which in turn result in altered gene expression and thus pathogenic phenotypes.
    • 80•• Lupianez, D.G., Kraft, K., Heinrich, V., Krawitz, P., Brancati, F., Klopocki, E., Horn, D., Kayserili, H., Opitz, J.M., Laxova, R., et al. Disruptions of topological chromatin domains cause pathogenic rewiring of gene–enhancer interactions. Cell 161 (2015), 1012–1025 An excellent study on the role of TADs in maintaining genome function conducted in both patient-derived cells and mutant mice generated by CRISPR/Cas genome editing. Disruption of CTCF-associated boundaries, as a result of deletions, duplications and inversions, causes changes in enhancer–promoter interactions, which in turn result in altered gene expression and thus pathogenic phenotypes.
    • (2015) Cell , vol.161 , pp. 1012-1025
    • Lupianez, D.G.1    Kraft, K.2    Heinrich, V.3    Krawitz, P.4    Brancati, F.5    Klopocki, E.6    Horn, D.7    Kayserili, H.8    Opitz, J.M.9    Laxova, R.10
  • 81
    • 84924533047 scopus 로고    scopus 로고
    • Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture
    • 81 Vietri Rudan, M., Barrington, C., Henderson, S., Ernst, C., Odom, D.T., Tanay, A., Hadjur, S., Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture. Cell Rep 10 (2015), 1297–1309.
    • (2015) Cell Rep , vol.10 , pp. 1297-1309
    • Vietri Rudan, M.1    Barrington, C.2    Henderson, S.3    Ernst, C.4    Odom, D.T.5    Tanay, A.6    Hadjur, S.7
  • 83
    • 85027929606 scopus 로고    scopus 로고
    • Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in genome organization
    • 83 Denholtz, M., Bonora, G., Chronis, C., Splinter, E., de Laat, W., Ernst, J., Pellegrini, M., Plath, K., Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in genome organization. Cell Stem Cell 13 (2013), 602–616.
    • (2013) Cell Stem Cell , vol.13 , pp. 602-616
    • Denholtz, M.1    Bonora, G.2    Chronis, C.3    Splinter, E.4    de Laat, W.5    Ernst, J.6    Pellegrini, M.7    Plath, K.8
  • 84
    • 84946811459 scopus 로고    scopus 로고
    • Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states
    • 84 Fabre, P.J., Benke, A., Joye, E., Nguyen Huynh, T.H., Manley, S., Duboule, D., Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states. Proc Natl Acad Sci U S A 112 (2015), 13964–13969.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 13964-13969
    • Fabre, P.J.1    Benke, A.2    Joye, E.3    Nguyen Huynh, T.H.4    Manley, S.5    Duboule, D.6
  • 85
    • 84900297485 scopus 로고    scopus 로고
    • Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription
    • 85 Giorgetti, L., Galupa, R., Nora, E.P., Piolot, T., Lam, F., Dekker, J., Tiana, G., Heard, E., Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription. Cell 157 (2014), 950–963.
    • (2014) Cell , vol.157 , pp. 950-963
    • Giorgetti, L.1    Galupa, R.2    Nora, E.P.3    Piolot, T.4    Lam, F.5    Dekker, J.6    Tiana, G.7    Heard, E.8
  • 86
    • 84907512608 scopus 로고    scopus 로고
    • Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation
    • The authors employ ChIP-seq and Hi-C to study changes in chromatin conformation upon progestin treatment of breast cancer cells. Significant structural modifications are observed in 20% of TADs, which demonstrate coordinated activation or silencing of their hormone-responsive genes.
    • 86• Le Dily, F., Bau, D., Pohl, A., Vicent, G.P., Serra, F., Soronellas, D., Castellano, G., Wright, R.H., Ballare, C., Filion, G., et al. Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation. Genes Dev 28 (2014), 2151–2162 The authors employ ChIP-seq and Hi-C to study changes in chromatin conformation upon progestin treatment of breast cancer cells. Significant structural modifications are observed in 20% of TADs, which demonstrate coordinated activation or silencing of their hormone-responsive genes.
    • (2014) Genes Dev , vol.28 , pp. 2151-2162
    • Le Dily, F.1    Bau, D.2    Pohl, A.3    Vicent, G.P.4    Serra, F.5    Soronellas, D.6    Castellano, G.7    Wright, R.H.8    Ballare, C.9    Filion, G.10
  • 87
    • 84923366733 scopus 로고    scopus 로고
    • Chromatin architecture reorganization during stem cell differentiation
    • The paper describes extensive switching of chromatin between the A and B compartments, which occurs during ESC differentiation with TADs being the units of the dynamic alterations. Intra-TAD interaction frequency tends to increase upon B-to-A switch and decrease upon A-to-B switch. Differentiation of ES cells is accompanied by large expansion of the B compartment, corroborating the knowledge about the permissive chromatin state in pluripotent cells.
    • 87•• Dixon, J.R., Jung, I., Selvaraj, S., Shen, Y., Antosiewicz-Bourget, J.E., Lee, A.Y., Ye, Z., Kim, A., Rajagopal, N., Xie, W., et al. Chromatin architecture reorganization during stem cell differentiation. Nature 518 (2015), 331–336 The paper describes extensive switching of chromatin between the A and B compartments, which occurs during ESC differentiation with TADs being the units of the dynamic alterations. Intra-TAD interaction frequency tends to increase upon B-to-A switch and decrease upon A-to-B switch. Differentiation of ES cells is accompanied by large expansion of the B compartment, corroborating the knowledge about the permissive chromatin state in pluripotent cells.
    • (2015) Nature , vol.518 , pp. 331-336
    • Dixon, J.R.1    Jung, I.2    Selvaraj, S.3    Shen, Y.4    Antosiewicz-Bourget, J.E.5    Lee, A.Y.6    Ye, Z.7    Kim, A.8    Rajagopal, N.9    Xie, W.10
  • 89
    • 77956272401 scopus 로고    scopus 로고
    • Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo
    • 89 Ahmed, K., Dehghani, H., Rugg-Gunn, P., Fussner, E., Rossant, J., Bazett-Jones, D.P., Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One, 5, 2010, e10531.
    • (2010) PLoS One , vol.5 , pp. e10531
    • Ahmed, K.1    Dehghani, H.2    Rugg-Gunn, P.3    Fussner, E.4    Rossant, J.5    Bazett-Jones, D.P.6
  • 90
    • 33745865934 scopus 로고    scopus 로고
    • Chromatin in pluripotent embryonic stem cells and differentiation
    • 90 Meshorer, E., Misteli, T., Chromatin in pluripotent embryonic stem cells and differentiation. Nat Rev Mol Cell Biol 7 (2006), 540–546.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 540-546
    • Meshorer, E.1    Misteli, T.2
  • 92
    • 84928744349 scopus 로고    scopus 로고
    • How cells build totipotency and pluripotency: nuclear, chromatin and transcriptional architecture
    • 92 Dang-Nguyen, T.Q., Torres-Padilla, M.E., How cells build totipotency and pluripotency: nuclear, chromatin and transcriptional architecture. Curr Opin Cell Biol 34 (2015), 9–15.
    • (2015) Curr Opin Cell Biol , vol.34 , pp. 9-15
    • Dang-Nguyen, T.Q.1    Torres-Padilla, M.E.2
  • 94
    • 77952994784 scopus 로고    scopus 로고
    • Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types
    • 94 Ryba, T., Hiratani, I., Lu, J., Itoh, M., Kulik, M., Zhang, J., Schulz, T.C., Robins, A.J., Dalton, S., Gilbert, D.M., Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types. Genome Res 20 (2010), 761–770.
    • (2010) Genome Res , vol.20 , pp. 761-770
    • Ryba, T.1    Hiratani, I.2    Lu, J.3    Itoh, M.4    Kulik, M.5    Zhang, J.6    Schulz, T.C.7    Robins, A.J.8    Dalton, S.9    Gilbert, D.M.10
  • 96
    • 84947245019 scopus 로고    scopus 로고
    • Remodeling of nuclear landscapes during human myelopoietic cell differentiation maintains co-aligned active and inactive nuclear compartments
    • 96 Hubner, B., Lomiento, M., Mammoli, F., Illner, D., Markaki, Y., Ferrari, S., Cremer, M., Cremer, T., Remodeling of nuclear landscapes during human myelopoietic cell differentiation maintains co-aligned active and inactive nuclear compartments. Epigenetics Chromatin, 8, 2015, 47.
    • (2015) Epigenetics Chromatin , vol.8 , pp. 47
    • Hubner, B.1    Lomiento, M.2    Mammoli, F.3    Illner, D.4    Markaki, Y.5    Ferrari, S.6    Cremer, M.7    Cremer, T.8
  • 97
    • 84946780209 scopus 로고    scopus 로고
    • Progressive chromatin condensation and H3K9 methylation regulate the differentiation of embryonic and hematopoietic stem cells
    • 97 Ugarte, F., Sousae, R., Cinquin, B., Martin, E.W., Krietsch, J., Sanchez, G., Inman, M., Tsang, H., Warr, M., Passegue, E., et al. Progressive chromatin condensation and H3K9 methylation regulate the differentiation of embryonic and hematopoietic stem cells. Stem Cell Rep 5 (2015), 728–740.
    • (2015) Stem Cell Rep , vol.5 , pp. 728-740
    • Ugarte, F.1    Sousae, R.2    Cinquin, B.3    Martin, E.W.4    Krietsch, J.5    Sanchez, G.6    Inman, M.7    Tsang, H.8    Warr, M.9    Passegue, E.10
  • 98
    • 77956651480 scopus 로고    scopus 로고
    • Differentiation and large scale spatial organization of the genome
    • 98 Joffe, B., Leonhardt, H., Solovei, I., Differentiation and large scale spatial organization of the genome. Curr Opin Genet Dev 20 (2010), 562–569.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 562-569
    • Joffe, B.1    Leonhardt, H.2    Solovei, I.3
  • 99
    • 84954195126 scopus 로고    scopus 로고
    • The redundancy of the mammalian heterochromatic compartment
    • 99 Politz, J.C., Scalzo, D., Groudine, M., The redundancy of the mammalian heterochromatic compartment. Curr Opin Genet Dev 37 (2015), 1–8.
    • (2015) Curr Opin Genet Dev , vol.37 , pp. 1-8
    • Politz, J.C.1    Scalzo, D.2    Groudine, M.3
  • 100
    • 77950920142 scopus 로고    scopus 로고
    • The spatial dynamics of tissue-specific promoters during C. elegans development
    • 100 Meister, P., Towbin, B.D., Pike, B.L., Ponti, A., Gasser, S.M., The spatial dynamics of tissue-specific promoters during C. elegans development. Genes Dev 24 (2010), 766–782.
    • (2010) Genes Dev , vol.24 , pp. 766-782
    • Meister, P.1    Towbin, B.D.2    Pike, B.L.3    Ponti, A.4    Gasser, S.M.5
  • 101
    • 84918539650 scopus 로고    scopus 로고
    • Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells
    • An elegant study demonstrating that induction of both transcription or chromatin decondensation of genes causes their repositioning into the nuclear interior. However, a shift to early replication is observed only in case of gene expression activation. This work reveals the causative relations between chromatin remodeling and gene topology.
    • 101•• Therizols, P., Illingworth, R.S., Courilleau, C., Boyle, S., Wood, A.J., Bickmore, W.A., Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells. Science 346 (2014), 1238–1242 An elegant study demonstrating that induction of both transcription or chromatin decondensation of genes causes their repositioning into the nuclear interior. However, a shift to early replication is observed only in case of gene expression activation. This work reveals the causative relations between chromatin remodeling and gene topology.
    • (2014) Science , vol.346 , pp. 1238-1242
    • Therizols, P.1    Illingworth, R.S.2    Courilleau, C.3    Boyle, S.4    Wood, A.J.5    Bickmore, W.A.6
  • 102
    • 0036006293 scopus 로고    scopus 로고
    • Chromatin motion is constrained by association with nuclear compartments in human cells
    • 102 Chubb, J.R., Boyle, S., Perry, P., Bickmore, W.A., Chromatin motion is constrained by association with nuclear compartments in human cells. Curr Biol 12 (2002), 439–445.
    • (2002) Curr Biol , vol.12 , pp. 439-445
    • Chubb, J.R.1    Boyle, S.2    Perry, P.3    Bickmore, W.A.4
  • 103
    • 0037416135 scopus 로고    scopus 로고
    • Chromosome order in HeLa cells changes during mitosis and early G1, but is stably maintained during subsequent interphase stages
    • 103 Walter, J., Schermelleh, L., Cremer, M., Tashiro, S., Cremer, T., Chromosome order in HeLa cells changes during mitosis and early G1, but is stably maintained during subsequent interphase stages. J Cell Biol 160 (2003), 685–697.
    • (2003) J Cell Biol , vol.160 , pp. 685-697
    • Walter, J.1    Schermelleh, L.2    Cremer, M.3    Tashiro, S.4    Cremer, T.5
  • 105
    • 38349043904 scopus 로고    scopus 로고
    • A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence
    • 105 Kumaran, R.I., Spector, D.L., A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence. J Cell Biol 180 (2008), 51–65.
    • (2008) J Cell Biol , vol.180 , pp. 51-65
    • Kumaran, R.I.1    Spector, D.L.2
  • 106
    • 40749122641 scopus 로고    scopus 로고
    • Transcriptional repression mediated by repositioning of genes to the nuclear lamina
    • 106 Reddy, K.L., Zullo, J.M., Bertolino, E., Singh, H., Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 452 (2008), 243–247.
    • (2008) Nature , vol.452 , pp. 243-247
    • Reddy, K.L.1    Zullo, J.M.2    Bertolino, E.3    Singh, H.4
  • 108
    • 0037023361 scopus 로고    scopus 로고
    • Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development
    • 108 Kosak, S.T., Skok, J.A., Medina, K.L., Riblet, R., Le Beau, M.M., Fisher, A.G., Singh, H., Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science 296 (2002), 158–162.
    • (2002) Science , vol.296 , pp. 158-162
    • Kosak, S.T.1    Skok, J.A.2    Medina, K.L.3    Riblet, R.4    Le Beau, M.M.5    Fisher, A.G.6    Singh, H.7
  • 110
    • 19744379789 scopus 로고    scopus 로고
    • Nuclear re-organisation of the Hoxb complex during mouse embryonic development
    • 110 Chambeyron, S., Da Silva, N.R., Lawson, K.A., Bickmore, W.A., Nuclear re-organisation of the Hoxb complex during mouse embryonic development. Development 132 (2005), 2215–2223.
    • (2005) Development , vol.132 , pp. 2215-2223
    • Chambeyron, S.1    Da Silva, N.R.2    Lawson, K.A.3    Bickmore, W.A.4
  • 111
    • 84899894562 scopus 로고    scopus 로고
    • Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci
    • 111 Noordermeer, D., Leleu, M., Schorderet, P., Joye, E., Chabaud, F., Duboule, D., Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci. Elife, 3, 2014, e02557.
    • (2014) Elife , vol.3 , pp. e02557
    • Noordermeer, D.1    Leleu, M.2    Schorderet, P.3    Joye, E.4    Chabaud, F.5    Duboule, D.6
  • 113
    • 84872572800 scopus 로고    scopus 로고
    • Developmentally regulated subnuclear genome reorganization restricts neural progenitor competence in Drosophila
    • 113 Kohwi, M., Lupton, J.R., Lai, S.L., Miller, M.R., Doe, C.Q., Developmentally regulated subnuclear genome reorganization restricts neural progenitor competence in Drosophila. Cell 152 (2013), 97–108.
    • (2013) Cell , vol.152 , pp. 97-108
    • Kohwi, M.1    Lupton, J.R.2    Lai, S.L.3    Miller, M.R.4    Doe, C.Q.5
  • 114
    • 84978481696 scopus 로고    scopus 로고
    • p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells
    • 114 Mardaryev, A.N., Gdula, M.R., Yarker, J.L., Emelianov, V.U., Poterlowicz, K., Sharov, A.A., Sharova, T.Y., Scarpa, J.A., Joffe, B., Solovei, I., et al. p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Development, 141, 2013, 3437.
    • (2013) Development , vol.141 , pp. 3437
    • Mardaryev, A.N.1    Gdula, M.R.2    Yarker, J.L.3    Emelianov, V.U.4    Poterlowicz, K.5    Sharov, A.A.6    Sharova, T.Y.7    Scarpa, J.A.8    Joffe, B.9    Solovei, I.10
  • 116
    • 84928914693 scopus 로고    scopus 로고
    • Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments
    • 116 Yoon, K.H., Ragoczy, T., Lu, Z., Kondoh, K., Kuang, D., Groudine, M., Buck, L.B., Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments. Proc Natl Acad Sci U S A 112 (2015), E2403–E2409.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. E2403-E2409
    • Yoon, K.H.1    Ragoczy, T.2    Lu, Z.3    Kondoh, K.4    Kuang, D.5    Groudine, M.6    Buck, L.B.7
  • 117
    • 3242748982 scopus 로고    scopus 로고
    • Positional changes of pericentromeric heterochromatin and nucleoli in postmitotic Purkinje cells during murine cerebellum development
    • 117 Solovei, I., Grandi, N., Knoth, R., Volk, B., Cremer, T., Positional changes of pericentromeric heterochromatin and nucleoli in postmitotic Purkinje cells during murine cerebellum development. Cytogenet Genome Res 105 (2004), 302–310.
    • (2004) Cytogenet Genome Res , vol.105 , pp. 302-310
    • Solovei, I.1    Grandi, N.2    Knoth, R.3    Volk, B.4    Cremer, T.5
  • 118
    • 84879065123 scopus 로고    scopus 로고
    • Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina
    • 118 Popova, E.Y., Grigoryev, S.A., Fan, Y., Skoultchi, A.I., Zhang, S.S., Barnstable, C.J., Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina. J Biol Chem 288 (2013), 17895–17907.
    • (2013) J Biol Chem , vol.288 , pp. 17895-17907
    • Popova, E.Y.1    Grigoryev, S.A.2    Fan, Y.3    Skoultchi, A.I.4    Zhang, S.S.5    Barnstable, C.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.