Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury

Oncotarget

Volumn 7, Issue 14, 2016, Pages 17681-17698

  Wang, Shaogui ^a,b   Ni, Hong Min ^b   Dorko, Kenneth ^b   Kumer, Sean C ^c   Schmitt, Timothy M ^c   Nawabi, Atta ^c   Komatsu, Masaaki ^d   Huang, Heqing ^a   Ding, Wen Xing ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^d NIIGATA UNIVERSITY   (Japan)

Author keywords

Alcohol; Liver injury; Necroptosis; RIP3; Steatosis

Indexed keywords

ALANINE AMINOTRANSFERASE; LIVER PROTEIN; MESSENGER RNA; PROTEASOME; PROTEASOME 26S SUBUNIT ADENOSINE TRIPHOSPHATASE 1; PROTEASOME SUBUNIT ALPHA TYPE 2; RECEPTOR INTERACTING PROTEIN KINASE 3; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; AGFG1 PROTEIN, HUMAN; ALCOHOL; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; NUCLEOPORIN; RALBP1 PROTEIN, MOUSE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, HUMAN; RIPK3 PROTEIN, MOUSE; RNA BINDING PROTEIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL LIVER CIRRHOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FATTY LIVER; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NECROPTOSIS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RIP3 GENE; TRANSLATION REGULATION; UPREGULATION; ALCOHOL LIVER DISEASE; ANIMAL; BINGE DRINKING; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; ENZYMOLOGY; KNOCKOUT MOUSE; LIVER; METABOLISM; PATHOLOGY;

ANIMALS; BINGE DRINKING; ETHANOL; FATTY LIVER; GTPASE-ACTIVATING PROTEINS; HUMANS; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR PORE COMPLEX PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RNA-BINDING PROTEINS;

EID: 84971399681     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6893     Document Type: Article

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