No evidence for caspase-dependent apoptosis in acetaminophen hepatotoxicity

Hepatology

Volumn 53, Issue 2, 2011, Pages 718-719

  Jaeschke, Hartmut ^a   Williams, C David ^a   Farhood, Anwar ^b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b Brackenridge Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; PARACETAMOL;

APOPTOSIS; DNA DAMAGE; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME ACTIVATION; LETTER; LIVER TOXICITY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL;

ACETAMINOPHEN; ANIMALS; APOPTOSIS; CASPASES; CYTOCHROME P-450 ENZYME SYSTEM; DIMETHYL SULFOXIDE; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; LIVER; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; SOLVENTS;

EID: 79251486638     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.23940     Document Type: Letter

References (6)

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3. Gujral JS, Knight TR, Farhood A, Bajt ML, Jaeschke H. Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? Toxicol Sci 2002; 67: 322-328.
4. Cover C, Mansouri A, Knight TR, Bajt ML, Lemasters JJ, Pessayre D, et al. Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther 2005; 315: 879-887.
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6. Bajt ML, Cover C, Lemasters JJ, Jaeschke H. Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci 2006; 94: 217-225.