Chronic deletion and acute knockdown of Parkin have differential responses to acetaminophen-induced mitophagy and liver injury in mice

Journal of Biological Chemistry

Volumn 290, Issue 17, 2015, Pages 10934-10946

  Williams, Jessica A ^a   Ni, Hong Min ^a   Haynes, Anna ^a   Manley, Sharon ^a   Li, Yuan ^a   Jaeschke, Hartmut ^a   Ding, Wen Xing ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROPHORESIS; MITOCHONDRIA; PROTEINS;

C-JUN N-TERMINAL KINASE; DIFFERENTIAL RESPONSE; ELECTRON MICROSCOPY ANALYSIS; HEPATOCYTE PROLIFERATIONS; MITOCHONDRIAL PROTEIN; MYELOID LEUKEMIA; UBIQUITIN LIGASES; WESTERN-BLOT ANALYSIS;

MAMMALS;

CASPASE 3; GLUTATHIONE; GLUTATHIONE DISULFIDE; PARACETAMOL; PARKIN; PROTEASOME; PROTEIN MCL 1; STRESS ACTIVATED PROTEIN KINASE; ANALGESIC AGENT; MCL1 PROTEIN, MOUSE; MITOCHONDRIAL PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY PROTECTED AGAINST ACETAMINOPHEN INDUCED LIVER INJURY; CELL DIFFERENTIATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; LIVER CELL; LIVER INJURY; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRION; MITOPHAGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; DEFICIENCY; DRUG EFFECTS; GENE DELETION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; KNOCKOUT MOUSE; LIVER; METABOLISM; PATHOLOGY; TOXIC HEPATITIS; UBIQUITINATION;

ADENOVIRIDAE; MAMMALIA; MUS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CELL PROLIFERATION; DRUG-INDUCED LIVER INJURY; GENE DELETION; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HEPATOCYTES; LIVER; MICE; MICE, KNOCKOUT; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL PROTEINS; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 85047700403     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.602284     Document Type: Article

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