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Volumn 99, Issue 6, 2016, Pages 857-862

Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets

Author keywords

Chemokines; CXCL12; Immunotherapy; Regulatory T cells; Tolerance

Indexed keywords

CCL25 CHEMOKINE; CD4 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR CXCR3; CXCL11 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; BIOLOGICAL FACTOR;

EID: 84971373567     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.2MR0915-441R     Document Type: Review
Times cited : (71)

References (103)
  • 1
    • 0034144269 scopus 로고    scopus 로고
    • Chemokines: A new classification system and their role in immunity
    • Zlotnik, A., Yoshie, O. (2000) Chemokines: a new classification system and their role in immunity. Immunity 12, 121-127.
    • (2000) Immunity , vol.12 , pp. 121-127
    • Zlotnik, A.1    Yoshie, O.2
  • 2
    • 0036485214 scopus 로고    scopus 로고
    • Chemokine receptors: Multifaceted therapeutic targets
    • Proudfoot, A. E. (2002) Chemokine receptors: multifaceted therapeutic targets. Nat. Rev. Immunol. 2, 106-115.
    • (2002) Nat.Rev. Immunol , vol.2 , pp. 106-115
    • Proudfoot, A.E.1
  • 3
    • 0032509889 scopus 로고    scopus 로고
    • Chemokines—chemotactic cytokines that mediate inflammation
    • Luster, A. D. (1998) Chemokines—chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338, 436-445.
    • (1998) N. Engl. J. Med , vol.338 , pp. 436-445
    • Luster, A.D.1
  • 4
    • 0024519822 scopus 로고
    • Adhesion molecules controlling lymphocyte migration
    • Stoolman, L. M. (1989) Adhesion molecules controlling lymphocyte migration. Cell 56, 907-910.
    • (1989) Cell , vol.56 , pp. 907-910
    • Stoolman, L.M.1
  • 5
    • 0025161990 scopus 로고
    • VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
    • Elices, M. J., Osborn, L., Takada, Y., Crouse, C., Luhowskyj, S., Hemler, M. E., Lobb, R. R. (1990) VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60, 577-584.
    • (1990) Cell , vol.60 , pp. 577-584
    • Elices, M.J.1    Osborn, L.2    Takada, Y.3    Crouse, C.4    Luhowskyj, S.5    Hemler, M.E.6    Lobb, R.R.7
  • 6
    • 0025283118 scopus 로고
    • Leukocyte adhesion to endothelium in inflammation
    • Osborn, L. (1990) Leukocyte adhesion to endothelium in inflammation. Cell 62, 3-6.
    • (1990) Cell , vol.62 , pp. 3-6
    • Osborn, L.1
  • 7
    • 0025182959 scopus 로고
    • Adhesion receptors of the immune system
    • Springer, T. A. (1990) Adhesion receptors of the immune system. Nature 346, 425-434.
    • (1990) Nature , vol.346 , pp. 425-434
    • Springer, T.A.1
  • 8
    • 0026429124 scopus 로고
    • Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin
    • Spertini, O., Kansas, G. S., Munro, J. M., Griffin, J. D., Tedder, T. F. (1991) Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin. Nature 349, 691-694.
    • (1991) Nature , vol.349 , pp. 691-694
    • Spertini, O.1    Kansas, G.S.2    Munro, J.M.3    Griffin, J.D.4    Tedder, T.F.5
  • 9
    • 0035900753 scopus 로고    scopus 로고
    • The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b
    • Martinelli, R., Sabroe, I., LaRosa, G., Williams, T. J., Pease, J. E. (2001) The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b. J. Biol. Chem. 276, 42957-42964.
    • (2001) J. Biol. Chem , vol.276 , pp. 42957-42964
    • Martinelli, R.1    Sabroe, I.2    Larosa, G.3    Williams, T.J.4    Pease, J.E.5
  • 10
    • 77956923012 scopus 로고    scopus 로고
    • A fusion protein encoding the second extracellular domain of CCR5 arrests chemokine-induced cosignaling and effectively suppresses ongoing experimental autoimmune encephalomyelitis
    • Sapir, Y., Vitenshtein, A., Barsheshet, Y., Zohar, Y., Wildbaum, G., Karin, N. (2010) A fusion protein encoding the second extracellular domain of CCR5 arrests chemokine-induced cosignaling and effectively suppresses ongoing experimental autoimmune encephalomyelitis. J. Immunol. 185, 2589-2599.
    • (2010) J. Immunol , vol.185 , pp. 2589-2599
    • Sapir, Y.1    Vitenshtein, A.2    Barsheshet, Y.3    Zohar, Y.4    Wildbaum, G.5    Karin, N.6
  • 11
    • 68949117973 scopus 로고    scopus 로고
    • A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2
    • Izhak, L., Wildbaum, G., Zohar, Y., Anunu, R., Klapper, L., Elkeles, A., Seagal, J., Yefenof, E., Ayalon-Soffer, M., Karin, N. (2009) A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2. J. Immunol. 183, 732-739.
    • (2009) J. Immunol , vol.183 , pp. 732-739
    • Izhak, L.1    Wildbaum, G.2    Zohar, Y.3    Anunu, R.4    Klapper, L.5    Elkeles, A.6    Seagal, J.7    Yefenof, E.8    Ayalon-Soffer, M.9    Karin, N.10
  • 12
    • 0036604393 scopus 로고    scopus 로고
    • Plasmid DNA encoding IFNgamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis
    • Wildbaum, G., Netzer, N., Karin, N. (2002) Plasmid DNA encoding IFNgamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis. J. Immunol. 168, 5885-5892.
    • (2002) J. Immunol , vol.168 , pp. 5885-5892
    • Wildbaum, G.1    Netzer, N.2    Karin, N.3
  • 13
    • 0036721708 scopus 로고    scopus 로고
    • Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis
    • Salomon, I., Netzer, N., Wildbaum, G., Schif-Zuck, S., Maor, G., Karin, N. (2002) Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis. J. Immunol. 169, 2685-2693.
    • (2002) J. Immunol , vol.169 , pp. 2685-2693
    • Salomon, I.1    Netzer, N.2    Wildbaum, G.3    Schif-Zuck, S.4    Maor, G.5    Karin, N.6
  • 14
    • 0033846366 scopus 로고    scopus 로고
    • C-C Chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis
    • Youssef, S., Maor, G., Wildbaum, G., Grabie, N., Gour-Lavie, A., Karin, N. (2000) C-C Chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis. J. Clin. Invest. 106, 361-371.
    • (2000) J. Clin. Invest , vol.106 , pp. 361-371
    • Youssef, S.1    Maor, G.2    Wildbaum, G.3    Grabie, N.4    Gour-Lavie, A.5    Karin, N.6
  • 15
    • 0032794139 scopus 로고    scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by MIP-1alpha and MCP-1 naked DNA vaccines
    • Youssef, S., Wildbaum, G., Karin, N. (1999) Prevention of experimental autoimmune encephalomyelitis by MIP-1alpha and MCP-1 naked DNA vaccines. J. Autoimmun. 13, 21-29.
    • (1999) J. Autoimmun , vol.13 , pp. 21-29
    • Youssef, S.1    Wildbaum, G.2    Karin, N.3
  • 16
    • 33645902493 scopus 로고    scopus 로고
    • Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat
    • Serbina, N. V., Pamer, E. G. (2006) Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 7, 311-317.
    • (2006) Immunol , vol.7 , pp. 311-317
    • Serbina, N.V.1    Pamer, E.G.2
  • 17
    • 0034596949 scopus 로고    scopus 로고
    • Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2
    • Izikson, L., Klein, R. S., Charo, I. F., Weiner, H. L., Luster, A. D. (2000) Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J. Exp. Med. 192, 1075-1080.
    • (2000) J. Exp. Med , vol.192 , pp. 1075-1080
    • Izikson, L.1    Klein, R.S.2    Charo, I.F.3    Weiner, H.L.4    Luster, A.D.5
  • 18
    • 0032473406 scopus 로고    scopus 로고
    • Monocyte chemotactic protein 1 regulates oral tolerance induction by inhibition of T helper cell 1-related cytokines
    • Karpus, W. J., Kennedy, K. J., Kunkel, S. L., Lukacs, N. W. (1998) Monocyte chemotactic protein 1 regulates oral tolerance induction by inhibition of T helper cell 1-related cytokines. J. Exp. Med. 187, 733-741.
    • (1998) J. Exp. Med , vol.187 , pp. 733-741
    • Karpus, W.J.1    Kennedy, K.J.2    Kunkel, S.L.3    Lukacs, N.W.4
  • 19
    • 32144454172 scopus 로고    scopus 로고
    • The many roles of chemokines and chemokine receptors in inflammation
    • Charo, I. F., Ransohoff, R. M. (2006) The many roles of chemokines and chemokine receptors in inflammation. N. Engl. J. Med. 354, 610-621.
    • (2006) N. Engl. J. Med , vol.354 , pp. 610-621
    • Charo, I.F.1    Ransohoff, R.M.2
  • 20
    • 79955476625 scopus 로고    scopus 로고
    • Overcoming hurdles in developing successful drugs targeting chemokine receptors
    • Schall, T. J., Proudfoot, A. E. (2011) Overcoming hurdles in developing successful drugs targeting chemokine receptors. Nat. Rev. Immunol. 11, 355-363.
    • (2011) Nat. Rev. Immunol , vol.11 , pp. 355-363
    • Schall, T.J.1    Proudfoot, A.E.2
  • 23
    • 84905658091 scopus 로고    scopus 로고
    • Biased and G protein-independent signaling of chemokine receptors. Front
    • Steen, A., Larsen, O., Thiele, S., Rosenkilde, M. M. (2014) Biased and G protein-independent signaling of chemokine receptors. Front. Immunol. 5, 277.
    • (2014) Immunol , vol.5 , pp. 277
    • Steen, A.1    Larsen, O.2    Thiele, S.3    Rosenkilde, M.M.4
  • 24
    • 84877131386 scopus 로고    scopus 로고
    • Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7
    • Steen, A., Thiele, S., Guo, D., Hansen, L. S., Frimurer, T. M., Rosenkilde, M. M. (2013) Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7. J. Biol. Chem. 288, 12511-12521.
    • (2013) J. Biol. Chem , vol.288 , pp. 12511-12521
    • Steen, A.1    Thiele, S.2    Guo, D.3    Hansen, L.S.4    Frimurer, T.M.5    Rosenkilde, M.M.6
  • 25
    • 84860253205 scopus 로고    scopus 로고
    • Differential b-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs
    • Zimmerman, B., Beautrait, A., Aguila, B., Charles, R., Escher, E., Claing, A., Bouvier, M., Laporte, S. A. (2012) Differential b-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs. Sci. Signal. 5, ra33.
    • (2012) Sci. Signal , vol.5 , pp. 33
    • Zimmerman, B.1    Beautrait, A.2    Aguila, B.3    Charles, R.4    Escher, E.5    Claing, A.6    Bouvier, M.7    Laporte, S.A.8
  • 26
    • 84862776738 scopus 로고    scopus 로고
    • Biased signaling pathways in b2-adrenergic receptor characterized by 19F-NMR
    • Liu, J. J., Horst, R., Katritch, V., Stevens, R. C., Wüthrich, K. (2012) Biased signaling pathways in b2-adrenergic receptor characterized by 19F-NMR. Science 335, 1106-1110.
    • (2012) Science , vol.335 , pp. 1106-1110
    • Liu, J.J.1    Horst, R.2    Katritch, V.3    Stevens, R.C.4    Wüthrich, K.5
  • 27
    • 0035189876 scopus 로고    scopus 로고
    • The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC
    • Bardi, G., Lipp, M., Baggiolini, M., Loetscher, P. (2001) The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC. Eur. J. Immunol. 31, 3291-3297.
    • (2001) Eur. J. Immunol , vol.31 , pp. 3291-3297
    • Bardi, G.1    Lipp, M.2    Baggiolini, M.3    Loetscher, P.4
  • 28
    • 79953047378 scopus 로고    scopus 로고
    • Combinatorial guidance by CCR7 ligands for T lymphocytes migration in co-existing chemokine fields
    • Nandagopal, S., Wu, D., Lin, F. (2011) Combinatorial guidance by CCR7 ligands for T lymphocytes migration in co-existing chemokine fields. PLoS One 6, e18183.
    • (2011) Plos One , vol.6
    • Nandagopal, S.1    Wu, D.2    Lin, F.3
  • 29
    • 78751585802 scopus 로고    scopus 로고
    • Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4
    • Ricart, B. G., John, B., Lee, D., Hunter, C. A., Hammer, D. A. (2011) Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4. J. Immunol. 186, 53-61.
    • (2011) J. Immunol , vol.186 , pp. 53-61
    • Ricart, B.G.1    John, B.2    Lee, D.3    Hunter, C.A.4    Hammer, D.A.5
  • 30
    • 0033384911 scopus 로고    scopus 로고
    • Differential modes of regulation of CXC chemokine-induced internalization and recycling of human CXCR1 and CXCR2
    • Feniger-Barish, R., Ran, M., Zaslaver, A., Ben-Baruch, A. (1999) Differential modes of regulation of CXC chemokine-induced internalization and recycling of human CXCR1 and CXCR2. Cytokine 11, 996-1009.
    • (1999) Cytokine , vol.11 , pp. 996-1009
    • Feniger-Barish, R.1    Ran, M.2    Zaslaver, A.3    Ben-Baruch, A.4
  • 31
    • 0029900788 scopus 로고    scopus 로고
    • Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2
    • Jones, S. A., Wolf, M., Qin, S., Mackay, C. R., Baggiolini, M. (1996) Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2. Proc. Natl. Acad. Sci. USA 93, 6682-6686.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6682-6686
    • Jones, S.A.1    Wolf, M.2    Qin, S.3    Mackay, C.R.4    Baggiolini, M.5
  • 33
    • 0035892915 scopus 로고    scopus 로고
    • CXCR3 internalization following T cell-endothelial cell contact: Preferential role of IFN-inducible T cell alpha chemoattractant (CXCL11)
    • Sauty, A., Colvin, R. A., Wagner, L., Rochat, S., Spertini, F., Luster, A. D. (2001) CXCR3 internalization following T cell-endothelial cell contact: preferential role of IFN-inducible T cell alpha chemoattractant (CXCL11). J. Immunol. 167, 7084-7093.
    • (2001) J. Immunol , vol.167 , pp. 7084-7093
    • Sauty, A.1    Colvin, R.A.2    Wagner, L.3    Rochat, S.4    Spertini, F.5    Luster, A.D.6
  • 34
    • 3142774174 scopus 로고    scopus 로고
    • Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function
    • Colvin, R. A., Campanella, G. S., Sun, J., Luster, A. D. (2004) Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function. J. Biol. Chem. 279, 30219-30227.
    • (2004) J. Biol. Chem , vol.279 , pp. 30219-30227
    • Colvin, R.A.1    Campanella, G.S.2    Sun, J.3    Luster, A.D.4
  • 35
    • 33746505443 scopus 로고    scopus 로고
    • CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis
    • Colvin, R. A., Campanella, G. S., Manice, L. A., Luster, A. D. (2006) CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. Mol. Cell. Biol. 26, 5838-5849.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 5838-5849
    • Colvin, R.A.1    Campanella, G.S.2    Manice, L.A.3    Luster, A.D.4
  • 36
    • 0035057215 scopus 로고    scopus 로고
    • Human interferon-inducible 10-kDa protein and human interferon-inducible T cell alpha chemoattractant are allotopic ligands for human CXCR3: Differential binding to receptor states. Mol
    • Cox, M. A., Jenh, C. H., Gonsiorek, W., Fine, J., Narula, S. K., Zavodny, P. J., Hipkin, R. W. (2001) Human interferon-inducible 10-kDa protein and human interferon-inducible T cell alpha chemoattractant are allotopic ligands for human CXCR3: differential binding to receptor states. Mol. Pharmacol. 59, 707-715.
    • (2001) Pharmacol , vol.59 , pp. 707-715
    • Cox, M.A.1    Jenh, C.H.2    Gonsiorek, W.3    Fine, J.4    Narula, S.K.5    Zavodny, P.J.6    Hipkin, R.W.7
  • 38
    • 58149149835 scopus 로고    scopus 로고
    • CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells
    • Meiron, M., Zohar, Y., Anunu, R., Wildbaum, G., Karin, N. (2008) CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells. J. Exp. Med. 205, 2643-2655.
    • (2008) J. Exp. Med , vol.205 , pp. 2643-2655
    • Meiron, M.1    Zohar, Y.2    Anunu, R.3    Wildbaum, G.4    Karin, N.5
  • 41
    • 34047275761 scopus 로고    scopus 로고
    • Control of cell migration in the development of the posterior lateral line: Antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1
    • Dambly-Chaudière, C., Cubedo, N., Ghysen, A. (2007) Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1. BMC Dev. Biol. 7, 23.
    • (2007) BMC Dev. Biol , vol.7 , pp. 23
    • Dambly-Chaudière, C.1    Cubedo, N.2    Ghysen, A.3
  • 43
    • 84886784063 scopus 로고    scopus 로고
    • Generation and dynamics of an endogenous, selfgenerated signaling gradient across a migrating tissue
    • Venkiteswaran, G., Lewellis, S. W., Wang, J., Reynolds, E., Nicholson, C., Knaut, H. (2013) Generation and dynamics of an endogenous, selfgenerated signaling gradient across a migrating tissue. Cell 155, 674-687.
    • (2013) Cell , vol.155 , pp. 674-687
    • Venkiteswaran, G.1    Lewellis, S.W.2    Wang, J.3    Reynolds, E.4    Nicholson, C.5    Knaut, H.6
  • 44
    • 84899658199 scopus 로고    scopus 로고
    • CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons
    • Abe, P., Mueller, W., Schütz, D., MacKay, F., Thelen, M., Zhang, P., Stumm, R. (2014) CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons. Development 141, 1857-1863.
    • (2014) Development , vol.141 , pp. 1857-1863
    • Abe, P.1    Mueller, W.2    Schütz, D.3    Mackay, F.4    Thelen, M.5    Zhang, P.6    Stumm, R.7
  • 46
    • 84896046811 scopus 로고    scopus 로고
    • CXCR7 influences the migration of B cells during maturation
    • Humpert, M. L., Pinto, D., Jarrossay, D., Thelen, M. (2014) CXCR7 influences the migration of B cells during maturation. Eur. J. Immunol. 44, 694-705.
    • (2014) Eur. J. Immunol , vol.44 , pp. 694-705
    • Humpert, M.L.1    Pinto, D.2    Jarrossay, D.3    Thelen, M.4
  • 48
    • 38449092560 scopus 로고    scopus 로고
    • Recruitment and activation of macrophages by pathogenic CD4 T cells in type 1 diabetes: Evidence for involvement of CCR8 and CCL1
    • Cantor, J., Haskins, K. (2007) Recruitment and activation of macrophages by pathogenic CD4 T cells in type 1 diabetes: evidence for involvement of CCR8 and CCL1. J. Immunol. 179, 5760-5767.
    • (2007) J. Immunol , vol.179 , pp. 5760-5767
    • Cantor, J.1    Haskins, K.2
  • 49
    • 38449102676 scopus 로고    scopus 로고
    • Macrophage activation and polarization. Front
    • Martinez, F. O., Sica, A., Mantovani, A., Locati, M. (2008) Macrophage activation and polarization. Front. Biosci. 13, 453-461.
    • (2008) Biosci , vol.13 , pp. 453-461
    • Martinez, F.O.1    Sica, A.2    Mantovani, A.3    Locati, M.4
  • 50
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A., Coffman, R. L. (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357.
    • (1986) J. Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 51
    • 0031573611 scopus 로고    scopus 로고
    • In vivo effects of T helper cell type 2 cytokines on macrophage antigen-presenting cell induction of T helper subsets
    • Cua, D. J., Stohlman, S. A. (1997) In vivo effects of T helper cell type 2 cytokines on macrophage antigen-presenting cell induction of T helper subsets. J. Immunol. 159, 5834-5840.
    • (1997) J. Immunol , vol.159 , pp. 5834-5840
    • Cua, D.J.1    Stohlman, S.A.2
  • 52
    • 0036366462 scopus 로고    scopus 로고
    • T(H)1 and T(H)2 cells: A historical perspective. Nat
    • Liew, F. Y. (2002) T(H)1 and T(H)2 cells: a historical perspective. Nat. Rev. Immunol. 2, 55-60.
    • (2002) Rev. Immunol , vol.2 , pp. 55-60
    • Liew, F.Y.1
  • 53
    • 0032400918 scopus 로고    scopus 로고
    • Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis
    • Wildbaum, G., Youssef, S., Grabie, N., Karin, N. (1998) Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis. J. Immunol. 161, 6368-6374.
    • (1998) J. Immunol , vol.161 , pp. 6368-6374
    • Wildbaum, G.1    Youssef, S.2    Grabie, N.3    Karin, N.4
  • 54
    • 15444380345 scopus 로고    scopus 로고
    • Targeted overexpression of IL-18 binding protein at the central nervous system overrides flexibility in functional polarization of antigen-specific Th2 cells
    • Schif-Zuck, S., Westermann, J., Netzer, N., Zohar, Y., Meiron, M., Wildbaum, G., Karin, N. (2005) Targeted overexpression of IL-18 binding protein at the central nervous system overrides flexibility in functional polarization of antigen-specific Th2 cells. J. Immunol. 174, 4307-4315.
    • (2005) J. Immunol , vol.174 , pp. 4307-4315
    • Schif-Zuck, S.1    Westermann, J.2    Netzer, N.3    Zohar, Y.4    Meiron, M.5    Wildbaum, G.6    Karin, N.7
  • 55
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
    • Leonard, J. P., Waldburger, K. E., Goldman, S. J. (1995) Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181, 381-386.
    • (1995) J. Exp. Med , vol.181 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 56
    • 33646001437 scopus 로고    scopus 로고
    • Targeting cytokines of the interleukin-12 family in autoimmunity
    • Kang, B. Y., Kim, T. S. (2006) Targeting cytokines of the interleukin-12 family in autoimmunity. Curr. Med. Chem. 13, 1149-1156.
    • (2006) Curr. Med. Chem , vol.13 , pp. 1149-1156
    • Kang, B.Y.1    Kim, T.S.2
  • 57
    • 0033041866 scopus 로고    scopus 로고
    • Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis
    • Butler, D. M., Malfait, A. M., Maini, R. N., Brennan, F. M., Feldmann, M. (1999) Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis. Eur. J. Immunol. 29, 2205-2212.
    • (1999) Eur. J. Immunol , vol.29 , pp. 2205-2212
    • Butler, D.M.1    Malfait, A.M.2    Maini, R.N.3    Brennan, F.M.4    Feldmann, M.5
  • 58
    • 0036103112 scopus 로고    scopus 로고
    • Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: Blocking interleukin 18 attenuates intestinal damage
    • Sivakumar, P. V., Westrich, G. M., Kanaly, S., Garka, K., Born, T. L., Derry, J. M., Viney, J. L. (2002) Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Gut 50, 812-820.
    • (2002) Gut , vol.50 , pp. 812-820
    • Sivakumar, P.V.1    Westrich, G.M.2    Kanaly, S.3    Garka, K.4    Born, T.L.5    Derry, J.M.6    Viney, J.L.7
  • 59
    • 0029010646 scopus 로고
    • In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice
    • Healey, D., Ozegbe, P., Arden, S., Chandler, P., Hutton, J., Cooke, A. (1995) In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J. Clin. Invest. 95, 2979-2985.
    • (1995) J. Clin. Invest , vol.95 , pp. 2979-2985
    • Healey, D.1    Ozegbe, P.2    Arden, S.3    Chandler, P.4    Hutton, J.5    Cooke, A.6
  • 60
    • 0031452948 scopus 로고    scopus 로고
    • Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens
    • Tian, J., Lehmann, P. V., Kaufman, D. L. (1997) Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. J. Exp. Med. 186, 2039-2043.
    • (1997) J. Exp. Med , vol.186 , pp. 2039-2043
    • Tian, J.1    Lehmann, P.V.2    Kaufman, D.L.3
  • 61
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat
    • Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., Weaver, C. T. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123-1132.
    • (2005) Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 63
    • 37549030879 scopus 로고    scopus 로고
    • Interleukin-17 as an effector molecule of innate and acquired immunity against infections
    • Matsuzaki, G., Umemura, M. (2007) Interleukin-17 as an effector molecule of innate and acquired immunity against infections. Microbiol. Immunol. 51, 1139-1147.
    • (2007) Microbiol. Immunol , vol.51 , pp. 1139-1147
    • Matsuzaki, G.1    Umemura, M.2
  • 65
    • 84883238238 scopus 로고    scopus 로고
    • Continuous G-CSF therapy for isolated chronic mucocutaneous candidiasis: Complete clinical remission with restoration of IL-17 secretion
    • Wildbaum, G., Shahar, E., Katz, R., Karin, N., Etzioni, A., Pollack, S. (2013) Continuous G-CSF therapy for isolated chronic mucocutaneous candidiasis: complete clinical remission with restoration of IL-17 secretion. J. Allergy Clin. Immunol. 132, 761-764.
    • (2013) J. Allergy Clin. Immunol , vol.132 , pp. 761-764
    • Wildbaum, G.1    Shahar, E.2    Katz, R.3    Karin, N.4    Etzioni, A.5    Pollack, S.6
  • 67
    • 84864334183 scopus 로고    scopus 로고
    • Mucosal immunology: IL-22 keeps commensals in their place
    • Bird, L. (2012) Mucosal immunology: IL-22 keeps commensals in their place. Nat. Rev. Immunol. 12, 550-551.
    • (2012) Nat. Rev. Immunol , vol.12 , pp. 550-551
    • Bird, L.1
  • 69
    • 45749101727 scopus 로고    scopus 로고
    • Induction and effector functions of T(H)17 cells
    • Bettelli, E., Korn, T., Oukka, M., Kuchroo, V. K. (2008) Induction and effector functions of T(H)17 cells. Nature 453, 1051-1057.
    • (2008) Nature , vol.453 , pp. 1051-1057
    • Bettelli, E.1    Korn, T.2    Oukka, M.3    Kuchroo, V.K.4
  • 70
    • 84856296021 scopus 로고    scopus 로고
    • Briakinumab versus methotrexate for psoriasis
    • author reply 380
    • Malgarini, R. B., Pimpinella, G. (2012) Briakinumab versus methotrexate for psoriasis. N. Engl. J. Med. 366, 379, author reply 380.
    • (2012) N. Engl. J. Med , vol.366 , pp. 379
    • Malgarini, R.B.1    Pimpinella, G.2
  • 72
    • 84859079527 scopus 로고    scopus 로고
    • To be 17 again—anti-interleukin-17 treatment for psoriasis
    • Waisman, A. (2012) To be 17 again—anti-interleukin-17 treatment for psoriasis. N. Engl. J. Med. 366, 1251-1252.
    • (2012) N. Engl. J. Med , vol.366 , pp. 1251-1252
    • Waisman, A.1
  • 74
    • 33746342994 scopus 로고    scopus 로고
    • Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol
    • Sakaguchi, S., Ono, M., Setoguchi, R., Yagi, H., Hori, S., Fehervari, Z., Shimizu, J., Takahashi, T., Nomura, T. (2006) Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212, 8-27.
    • (2006) Rev , vol.212 , pp. 8-27
    • Sakaguchi, S.1    Ono, M.2    Setoguchi, R.3    Yagi, H.4    Hori, S.5    Fehervari, Z.6    Shimizu, J.7    Takahashi, T.8    Nomura, T.9
  • 75
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat
    • Sakaguchi, S. (2005) Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6, 345-352.
    • (2005) Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 76
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing, K., Sakaguchi, S. (2010) Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat. Immunol. 11, 7-13.
    • (2010) Nat. Immunol , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 77
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • Shevach, E. M. (2009) Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30, 636-645.
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 78
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD252 naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen, W., Jin, W., Hardegen, N., Lei, K. J., Li, L., Marinos, N., McGrady, G., Wahl, S. M. (2003) Conversion of peripheral CD4+CD252 naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886.
    • (2003) J. Exp. Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 80
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh, L., Quintana, F. J., Pot, C., Joller, N., Xiao, S., Kumar, D., Burns, E. J., Sherr, D. H., Weiner, H. L., Kuchroo, V. K. (2010) The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat. Immunol. 11, 854-861.
    • (2010) Nat. Immunol , vol.11 , pp. 854-861
    • Apetoh, L.1    Quintana, F.J.2    Pot, C.3    Joller, N.4    Xiao, S.5    Kumar, D.6    Burns, E.J.7    Sherr, D.H.8    Weiner, H.L.9    Kuchroo, V.K.10
  • 81
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen, Y., Kuchroo, V. K., Inobe, J., Hafler, D. A., Weiner, H. L. (1994) Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265, 1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 82
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
    • Yednock, T. A., Cannon, C., Fritz, L. C., Sanchez-Madrid, F., Steinman, L., Karin, N. (1992) Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 356, 63-66.
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3    Sanchez-Madrid, F.4    Steinman, L.5    Karin, N.6
  • 84
    • 0034210221 scopus 로고    scopus 로고
    • The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: Role in transendothelial/stromal migration and engraftment of NOD/SCID mice
    • Peled, A., Kollet, O., Ponomaryov, T., Petit, I., Franitza, S., Grabovsky, V., Slav, M. M., Nagler, A., Lider, O., Alon, R., Zipori, D., Lapidot, T. (2000) The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood 95, 3289-3296.
    • (2000) Blood , vol.95 , pp. 3289-3296
    • Peled, A.1    Kollet, O.2    Ponomaryov, T.3    Petit, I.4    Franitza, S.5    Grabovsky, V.6    Slav, M.M.7    Nagler, A.8    Lider, O.9    Alon, R.10    Zipori, D.11    Lapidot, T.12
  • 85
    • 77957157551 scopus 로고    scopus 로고
    • The multiple faces of CXCL12 (SDF-1alpha) in the regulation of immunity during health and disease
    • Karin, N. (2010) The multiple faces of CXCL12 (SDF-1alpha) in the regulation of immunity during health and disease. J. Leukoc. Biol. 88, 463-473.
    • (2010) J. Leukoc. Biol , vol.88 , pp. 463-473
    • Karin, N.1
  • 86
    • 84871998834 scopus 로고    scopus 로고
    • The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications
    • Shachar, I., Karin, N. (2013) The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications. J. Leukoc. Biol. 93, 51-61.
    • (2013) J. Leukoc. Biol , vol.93 , pp. 51-61
    • Shachar, I.1    Karin, N.2
  • 87
    • 0036913215 scopus 로고    scopus 로고
    • Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis
    • Frigerio, S., Junt, T., Lu, B., Gerard, C., Zumsteg, U., Holländer, G. A., Piali, L. (2002) Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat. Med. 8, 1414-1420.
    • (2002) Nat. Med , vol.8 , pp. 1414-1420
    • Frigerio, S.1    Junt, T.2    Lu, B.3    Gerard, C.4    Zumsteg, U.5    Holländer, G.A.6    Piali, L.7
  • 88
    • 33646029748 scopus 로고    scopus 로고
    • Severe disease, unaltered leukocyte migration, and reduced IFN-gamma production in CXCR32/2 mice with experimental autoimmune encephalomyelitis
    • Liu, L., Huang, D., Matsui, M., He, T. T., Hu, T., Demartino, J., Lu, B., Gerard, C., Ransohoff, R. M. (2006) Severe disease, unaltered leukocyte migration, and reduced IFN-gamma production in CXCR32/2 mice with experimental autoimmune encephalomyelitis. J. Immunol. 176, 4399-4409.
    • (2006) J. Immunol , vol.176 , pp. 4399-4409
    • Liu, L.1    Huang, D.2    Matsui, M.3    He, T.T.4    Hu, T.5    Demartino, J.6    Lu, B.7    Gerard, C.8    Ransohoff, R.M.9
  • 90
    • 84855901533 scopus 로고    scopus 로고
    • Molecular mechanism of b-arrestin-biased agonism at seven-transmembrane receptors
    • Reiter, E., Ahn, S., Shukla, A. K., Lefkowitz, R. J. (2012) Molecular mechanism of b-arrestin-biased agonism at seven-transmembrane receptors. Annu. Rev. Pharmacol. Toxicol. 52, 179-197.
    • (2012) Annu. Rev. Pharmacol. Toxicol , vol.52 , pp. 179-197
    • Reiter, E.1    Ahn, S.2    Shukla, A.K.3    Lefkowitz, R.J.4
  • 92
    • 0027513982 scopus 로고
    • A mutationinduced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model
    • Samama, P., Cotecchia, S., Costa, T., Lefkowitz, R. J. (1993) A mutationinduced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J. Biol. Chem. 268, 4625-4636.
    • (1993) J. Biol. Chem , vol.268 , pp. 4625-4636
    • Samama, P.1    Cotecchia, S.2    Costa, T.3    Lefkowitz, R.J.4
  • 95
    • 3142519564 scopus 로고    scopus 로고
    • In vitro-expanded human CD4(+) CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures
    • Godfrey, W. R., Ge, Y. G., Spoden, D. J., Levine, B. L., June, C. H., Blazar, B. R., Porter, S. B. (2004) In vitro-expanded human CD4(+) CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 104, 453-461.
    • (2004) Blood , vol.104 , pp. 453-461
    • Godfrey, W.R.1    Ge, Y.G.2    Spoden, D.J.3    Levine, B.L.4    June, C.H.5    Blazar, B.R.6    Porter, S.B.7
  • 96
    • 36549015611 scopus 로고    scopus 로고
    • Isolation, expansion, and characterization of human natural and adaptive regulatory T cells. Methods Mol
    • Gregori, S., Bacchetta, R., Passerini, L., Levings, M. K., Roncarolo, M. G. (2007) Isolation, expansion, and characterization of human natural and adaptive regulatory T cells. Methods Mol. Biol. 380, 83-105.
    • (2007) Biol , vol.380 , pp. 83-105
    • Gregori, S.1    Bacchetta, R.2    Passerini, L.3    Levings, M.K.4    Roncarolo, M.G.5
  • 97
    • 77956538422 scopus 로고    scopus 로고
    • Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10- dependent ILT4/HLA-G pathway
    • Gregori, S., Tomasoni, D., Pacciani, V., Scirpoli, M., Battaglia, M., Magnani, C. F., Hauben, E., Roncarolo, M. G. (2010) Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10- dependent ILT4/HLA-G pathway. Blood 116, 935-944.
    • (2010) Blood , vol.116 , pp. 935-944
    • Gregori, S.1    Tomasoni, D.2    Pacciani, V.3    Scirpoli, M.4    Battaglia, M.5    Magnani, C.F.6    Hauben, E.7    Roncarolo, M.G.8
  • 98
    • 83055173312 scopus 로고    scopus 로고
    • Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation
    • Gagliani, N., Gregori, S., Jofra, T., Valle, A., Stabilini, A., Rothstein, D. M., Atkinson, M., Roncarolo, M. G., Battaglia, M. (2011) Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation. PLoS One 6, e28434.
    • (2011) Plos One , vol.434 , pp. 6
    • Gagliani, N.1    Gregori, S.2    Jofra, T.3    Valle, A.4    Stabilini, A.5    Rothstein, D.M.6    Atkinson, M.7    Roncarolo, M.G.8    Battaglia, M.9
  • 99
    • 79952202516 scopus 로고    scopus 로고
    • Methods for in vitro generation of human type 1 regulatory T cells
    • Gregori, S., Roncarolo, M. G., Bacchetta, R. (2011) Methods for in vitro generation of human type 1 regulatory T cells. Methods Mol. Biol. 677, 31-46.
    • (2011) Methods Mol. Biol , vol.677 , pp. 31-46
    • Gregori, S.1    Roncarolo, M.G.2    Bacchetta, R.3
  • 103
    • 82555192217 scopus 로고    scopus 로고
    • The yin and yang of interleukin-2-mediated immunotherapy
    • Bluestone, J. A. (2011) The yin and yang of interleukin-2-mediated immunotherapy. N. Engl. J. Med. 365, 2129-2131.
    • (2011) N. Engl. J. Med , vol.365 , pp. 2129-2131
    • Bluestone, J.A.1


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