C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis

Journal of Clinical Investigation

Volumn 106, Issue 3, 2000, Pages 361-371

  Youssef, Sawsan ^a   Maor, Gila ^a   Wildbaum, Gizi ^a   Grabie, Nir ^a   Gour Lavie, Alumit ^a   Karin, Nathan ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE; DNA VACCINE; FRACTALKINE; FREUND ADJUVANT; GENE PRODUCT; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; RANTES; TUBERCULIN;

ADJUVANT ARTHRITIS; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; FEMALE; IMMUNOLOGICAL MEMORY; IMMUNOLOGICAL TOLERANCE; NONHUMAN; PRIORITY JOURNAL; RAT; VACCINATION;

EID: 0033846366     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9109     Document Type: Article

References (31)

1. Rheumatoid arthritis. Pathophysiology and implications for therapy
2. Development of arthritis, periarthritis and periostitis in rats given adjuvants
3. Role of cytokines in rheumatoid arthritis
4. Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids
5. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis
6. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis
7. Anti tumor necrosis factor-alpha therapy of rheumatoid arthritis
8. Recombinant soluble tumor necrosis factor receptor (p80) fusion protein: Toxicity and dose finding trial in refractory rheumatoid arthritis
9. Biologic agents for treating rheumatoid arthritis. Concepts and progress
10. Chemokines
11. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
12. Chemokines and T lymphocytes: More than an attraction
13. An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis
14. An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model
15. Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model
16. Augmentation of natural immunity to a pro-inflammatory cytokine (TNF-a) by targeted DNA vaccine confers long lasting resistance to experimental autoimmune encephalomyelitis
17. Long lasting protective immunity to experimental autoimmune encephalomyelitis following vaccination with naked DNA encoding C-C chemokines
18. Therapeutic vaccination against adjuvant arthritis using autoimmune T-cells treated with hydrostatic pressure
19. Myelin-liposome protection against experimental autoimmune encephalomyelitis is associated with reduced neuroantigen-specific T-cell-mediated responses
20. Antiarthritic effects demonstrated by an interleukin-2 receptor-targeted cytotoxin (DAB486IL-2) in rat adjuvant arthritis
21. Heterologons protection against influenza by injection of DNA encoding a viral protein
22. Genetic immunization is a simple method for eliciting an immune response
23. DNA vaccines
24. DNA vaccines
25. Priming of cytotoxic T lymphocytes by DNA vaccines: Requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes
26. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
27. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization
28. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
29. Prevention of experimental autoimmune encephalomyelitis by MIP-1alpha and MCP-1 naked DNA vaccines
30. The role of an epithelial neutrophil-activating peptide-78-like protein in rat adjuvant-induced arthritis
31. Streptococcal ceil wall-induced arthritis: Requirements for IL-4, IL-10, IFN-gamma, and monocyte chemoattracrant protein-1