TH1 and TH2 cells: A historical perspective

Nature Reviews Immunology

Volumn 2, Issue 1, 2002, Pages 55-60

  Liew, Foo Y ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 4;

ALLERGY; ANIMAL CELL; AUTOIMMUNITY; B LYMPHOCYTE; BIOASSAY; CELL CLONING; CELL LINEAGE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; HISTORY; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; INFECTION; LEISHMANIASIS; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESEARCH; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE DIFFERENTIATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; TRANSCRIPTION REGULATION; ANIMAL; ARTICLE; AUTOIMMUNE DISEASE; BIOLOGICAL MODEL; CD4+ T LYMPHOCYTE; IMMUNOLOGY;

ALLERGY AND IMMUNOLOGY; ANIMALS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; HISTORY, 20TH CENTURY; HUMANS; INFECTION; MICE; MODELS, IMMUNOLOGICAL; TH1 CELLS; TH2 CELLS;

EID: 0036366462     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri705     Document Type: Review

References (81)

1. Dennert, G. Evidence for non-identity of T killer and T helper cells sensitised to allogeneic cell antigens. Nature 249, 358-360 (1974).
2. Cantor, H. & Boyse, E. A. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. J. Exp. Med. 141, 1376-1389 (1975).
3. Kisielow, P. et al. Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse. Nature 253, 219-220 (1975).
4. Ashman, R. B. & Mullbacher, A. A T helper cell for anti-viral cytotoxic T-cell responses. J. Exp. Med. 150, 1277-1282 (1979).
5. Gershon, R. K. & Kondo, K. Infectious immunological tolerance. Immunology 21, 903-914 (1971).
6. Liew, F. Y. & Parish, C. R. Lack of a correlation between cell-mediated immunity to the carrier and the carrier-hapten helper effect. J. Exp. Med. 139, 779-784 (1974).
7. Marrack, P. C. & Kappler, J. W. Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells. J. Immunol. 114, 1116-1125 (1975).
8. Janeway, C. A. Jr Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response. J. Immunol. 114, 1394-1401 (1975).
9. - helper T cells. J. Exp. Med. 147, 446-458 (1978).
10. Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. & Coffman, R. L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357 (1986).
11. + T lymphocytes in atopic patients. J. Immunol. 144, 4651-4656 (1990).
12. Parronchi, P. et al. Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc. Natl Acad. Sci. USA 88, 4538-4542 (1991).
13. Miller, J. F. & Mitchell, G. F. Thymus and antigen-reactive cells. Transplant. Rev. 1, 3-42 (1969).
14. Claman, H. N. & Chaperon, E. A. Immunologic complementation between thymus and marrow cells - a model for the two-cell theory of immunocompetence. Transplant. Rev. 1, 92-113 (1969).
15. Battisto, J. R. & Miller, J. Immunological unresponsiveness produced in adult guinea pigs by parenteral introduction of minute quantities of hapten or protein antigen. Proc. Soc. Exp. Bio. Med. 111, 111-115 (1962).
16. Asherson, G. L. & Stone, S. H. Selective and specific inhibition of 24 hour skin reactions in the guinea-pig. I. Immune deviation: description of the phenomenon and the effect of splenectomy. Immunology 9, 205-217 (1965).
17. Loewi, G., Holborow, E. J. & Temple, A. Inhibition of delayed hypersensitivity by pre-immunization without complete adjuvant. Immunology 10, 339-347 (1966).
18. Crowle, A. J. & Hu, C. C. Split tolerance affecting delayed hypersensitivity and induced in mice by pre-immunization with protein antigens in solution. Clin. Exp. Immunol. 1, 323-335 (1966).
19. Janicki, B. W. & Aron, S. A. Induction of tuberculin hypersensitivity and serologic unresponsiveness to tubercle bacilli in newborn and young guinea pigs. J. Immunol. 101, 121-127 (1968).
20. Parish, C. R. Immune response to chemically modified flagellin. II. Evidence for a fundamental relationship between humoral and cell-mediated immunity. J. Exp. Med. 134, 21-47 (1971).
21. Parish, C. R. & Liew, F. Y. Immune response to chemically modified flagellin. III. Enhanced cell-mediated immunity during high and low zone antibody tolerance to flagellin. J. Exp. Med. 135, 298-311 (1972).
22. Mitchison, N. A. Induction of immunological paralysis in two zones of dosage. Proc. R. Soc. Lond. B 161, 276-295 (1964).
23. Fathman, C. G. & Hengartner, H. Clones of alloreactive T cells. Nature 272, 617-618 (1978).
24. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63 (1983).
25. Stevens, T. L. et al. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334, 255-258 (1988).
26. Snapper C. M. & Paul, W. E. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236, 944-947 (1987).
27. + T cell clones. J. Immunol. 141, 849-855 (1988).
28. Kelso, A. & Gough, N. M. Coexpression of granulocyte-macrophage colony-stimulating factor, γ interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones. Proc. Natl Acad. Sci. USA 85, 9189-9193 (1988).
29. - T cell subset with an unrestricted cytokine profile. J. Immunol. 143, 518-525 (1989).
30. Del Prete, G. F. et al. Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J. Clin. Invest. 88, 346-350 (1991).
31. H2 subsets: doubt no more. Immunol. Today 12, 256-257 (1991).
32. H1 murine helper T lymphocyte clones. J. Immunol. 140, 4245-4252 (1988).
33. Fernandez-Botran, R., Sanders, V. M., Mosmann, T. R. & Vitetta, E. S. Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells. J. Exp. Med. 168, 543-558 (1988).
34. H2-like helper effectors. J. Immunol. 145, 3796-3806 (1990).
35. Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D. & Paul, W. E. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172, 921-929 (1990).
36. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260, 547-549 (1993).
37. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl Acad. Sci. USA 90, 10188-10192 (1993).
38. Hsieh, C. S., Heimberger, A. B., Gold, J. S., O'Garra, A. & Murphy, K. M. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system. Proc. Natl Acad. Sci. USA 89, 6065-6069 (1992).
39. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176, 1091-1098 (1992).
40. + T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Exp. Med. 182, 1579-1584 (1995).
41. + T cells. J. Exp. Med. 182, 1591-1596 (1995).
42. Rissoan, M. C. et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 283, 1183-1186 (1999).
43. H2 developmental pathways: application to autoimmune disease therapy. Cell 80, 707-718 (1995).
44. Coyle, A. J. et al. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 13, 95-105 (2000).
45. H2 human T cell clones. J. Immunol. 149, 2977-2983 (1992).
46. Lichtman, A. H. Chin, J., Schmidt, J. A. & Abbas, A. K. Role of interleukin 1 in the activation of T lymphocytes. Proc. Natl Acad. Sci. USA 85, 9699-9703 (1988).
47. H2 development and commitment. Immunity 12, 27-37 (2000).
48. Finkelman, F. D. et al. Stat6 regulation of in vivo IL-4 responses. J. Immunol. 164, 2303-2310 (2000).
49. Gazzinelli, R. T., Hieny, S., Wynn, T. A., Wolf, S. & Sher, A. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl Acad. Sci. USA 90, 6115-6119 (1993).
50. Scheicher, C., Mehlig, M., Dienes, H. R. & Reske, K. Uptake of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of interleukin-1 α and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation. Eur. J. Immunol. 25, 1566-1572 (1995).
51. + T cells. J. Immunol. 154, 5071-5079 (1995).
52. + T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179, 1285-1295 (1994).
53. Plaut, M. et al. Mast cell lines produce lymphokines in response to cross-linkage of Fcε RI or to calcium ionophores. Nature 339, 64-67 (1989).
54. Seder, R. A. et al. Mouse splenic and bone marrow cell populations that express high-affinity Fcε receptors and produce interleukin 4 are highly enriched in basophils. Proc. Natl Acad. Sci. USA 88, 2835-2839 (1991).
55. H cells. J. Exp. Med. 179, 1349-1353 (1994).
56. H2 development and susceptibility to Leishmania major in BALB/c mice. Immunity 6, 541-549 (1997).
57. H1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181, 1755-1762 (1995).
58. H1 lineage commitment. Cell 100, 655-669 (2000).
59. H2 cells. Immunity 4, 313-319 (1996).
60. Takeda, K. et al. Essential role of Stat6 in IL-4 signalling. Nature 380, 627-630 (1996).
61. H2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380, 630-633 (1996).
62. H2 cytokine gene expression in CD4 T cells. Cell 89, 587-596 (1997).
63. H2-specific expression of the interleukin-5 gene. J. Biol. Chem. 272, 21597-21603 (1997).
64. Ho, I. C., Hodge, M. R., Rooney, J. W. & Glimcher, L. H. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85, 973-983 (1996).
65. Howard, J. G., Hale, C. & Liew, F. Y. Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to Leishmania tropica. J. Exp. Med. 153, 557-568 (1981).
66. Scott, P., Natovitz, P., Coffman, R. L., Pearce, E. & Sher, A. Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med. 168, 1675-1684 (1988).
67. Heinzel, F. P., Sadick, M. D., Holaday B. J., Coffman, R. L. & Locksley, R. M. Reciprocal expression of interferon γ of interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169, 59-72 (1989).
68. Yamamura, M. et al. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254, 277-279 (1991).
69. Korenaga, M. et al. The role of interleukin-5 in protective immunity to Strongyloides venezuelensis infection in mice. Immunology 72, 502-507 (1991).
70. Urban, J. F. Jr, Katona, I. M., Paul, W. E. & Finkelman, F. D. Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc. Natl Acad. Sci. USA 88, 5513-5517 (1991).
71. H2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326, 298-304 (1992).
72. H-1 lymphokine subtype. Cell. Immunol. 124, 132-143 (1989).
73. Campbell, I. L., Kay, T. W., Oxbrow, L. & Harrison, L. C. Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 87, 739-742 (1991).
74. + T cells in leishmaniasis. Immunol. Today 10, 40-45 (1989).
75. H1 pattern of cytokines. J. Immunol. 144, 1744-1752 (1990).
76. H2-stimulating pathogens by γδ T cells in vivo. Nature 373, 255-257 (1995).
77. Peritt, D. et al. Differentiation of human NK cells into NK1 and NK2 subsets. J. Immunol. 161, 5821-5824 (1998).
78. + T cells produce large amounts of IL-4 and IFN-γ upon activation by anti-CD3 or CD1. J. Immunol. 159, 2240-2249 (1997).
79. Chen, Y., Kuchroo, V. K., Inobe, J., Hafler, D. A. & Weiner, H. L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265, 1237-1240 (1994).
80. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151-1164 (1995).
81. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737-742 (1997).