Rapamycin combined with anti-CD45RB mAB and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Gagliani, Nicola ^a,b,c   Gregori, Silvia ^b   Jofra, Tatiana ^a   Valle, Andrea ^a,c   Stabilini, Angela ^a   Rothstein, David M ^d   Atkinson, Mark ^e   Roncarolo, Maria Grazia ^b,c   Battaglia, Manuela ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^e UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45RB MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY; MYELOSTIM; RAPAMYCIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; CD4 ANTIGEN; CD45 ANTIGEN; EPITOPE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BIOACCUMULATION; CD4+ T LYMPHOCYTE; CELL TRANSPLANTATION; CELLULAR DISTRIBUTION; CLINICAL PROTOCOL; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PANCREAS ISLET; REGULATORY T LYMPHOCYTE; ALLOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; DRUG COMBINATION; DRUG EFFECT; HUMAN; IMMUNOLOGY; METABOLISM; PANCREAS ISLET TRANSPLANTATION; SPLEEN; TIME;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; ANTIGENS, CD45; DRUG THERAPY, COMBINATION; EPITOPES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-10; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, ANIMAL; SIROLIMUS; SPLEEN; T-LYMPHOCYTES, REGULATORY; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 83055173312     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028434     Document Type: Article

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