메뉴 건너뛰기




Volumn 52, Issue 1, 2017, Pages 133-147

Review on Toll-Like Receptor Activation in Myasthenia Gravis: Application to the Development of New Experimental Models

Author keywords

Autoimmune diseases; Complete Freund s adjuvant; Inflammation; Innate immunity; Interferon type I; Mouse experimental models

Indexed keywords

BETA INTERFERON; CHEMOKINE; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR ANTIBODY; CXCL13 CHEMOKINE; FREUND ADJUVANT; IMMUNOGLOBULIN G1 ANTIBODY; LIPOPOLYSACCHARIDE; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST;

EID: 84969820299     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-016-8549-4     Document Type: Review
Times cited : (27)

References (143)
  • 1
    • 84904308431 scopus 로고    scopus 로고
    • Myasthenia gravis: a comprehensive review of immune dysregulation and etiological mechanisms
    • COI: 1:CAS:528:DC%2BC2cXislyrtQ%3D%3D, PID: 24389034
    • Berrih-Aknin S, Le Panse R (2014) Myasthenia gravis: a comprehensive review of immune dysregulation and etiological mechanisms. J Autoimmun 52:90–100
    • (2014) J Autoimmun , vol.52 , pp. 90-100
    • Berrih-Aknin, S.1    Le Panse, R.2
  • 2
    • 0035105784 scopus 로고    scopus 로고
    • Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies
    • COI: 1:CAS:528:DC%2BD3MXhvVOktLg%3D, PID: 11231638
    • Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A et al (2001) Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 7:365–368
    • (2001) Nat Med , vol.7 , pp. 365-368
    • Hoch, W.1    McConville, J.2    Helms, S.3    Newsom-Davis, J.4    Melms, A.5
  • 3
    • 79952513213 scopus 로고    scopus 로고
    • Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis
    • COI: 1:CAS:528:DC%2BC3MXktl2lsb8%3D, PID: 21387385
    • Higuchi O, Hamuro J, Motomura M, Yamanashi Y (2011) Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis. Ann Neurol 69:418–422
    • (2011) Ann Neurol , vol.69 , pp. 418-422
    • Higuchi, O.1    Hamuro, J.2    Motomura, M.3    Yamanashi, Y.4
  • 4
    • 84897981976 scopus 로고    scopus 로고
    • Autoantibodies to agrin in myasthenia gravis patients
    • PID: 24632822
    • Zhang B, Shen C, Bealmear B, Ragheb S, Xiong WC et al (2014) Autoantibodies to agrin in myasthenia gravis patients. PLoS One 9, e91816
    • (2014) PLoS One , vol.9
    • Zhang, B.1    Shen, C.2    Bealmear, B.3    Ragheb, S.4    Xiong, W.C.5
  • 5
    • 0036158217 scopus 로고    scopus 로고
    • Myasthenia gravis
    • PID: 12803656
    • Nicolle MW (2002) Myasthenia gravis. Neurologist 8:2–21
    • (2002) Neurologist , vol.8 , pp. 2-21
    • Nicolle, M.W.1
  • 6
    • 0023632437 scopus 로고
    • The role of the thymus in myasthenia gravis: immunohistological and immunological studies in 115 cases
    • COI: 1:STN:280:DyaL1c%2FnsFKitQ%3D%3D, PID: 3318621
    • Berrih-Aknin S, Morel E, Raimond F, Safar D, Gaud C et al (1987) The role of the thymus in myasthenia gravis: immunohistological and immunological studies in 115 cases. Ann N Y Acad Sci 505:50–70
    • (1987) Ann N Y Acad Sci , vol.505 , pp. 50-70
    • Berrih-Aknin, S.1    Morel, E.2    Raimond, F.3    Safar, D.4    Gaud, C.5
  • 7
    • 0029988314 scopus 로고    scopus 로고
    • The thymus and the pathogenesis of myasthenia gravis
    • COI: 1:STN:280:DyaK287ntlylsQ%3D%3D, PID: 8599878
    • Levinson AI, Wheatley LM (1996) The thymus and the pathogenesis of myasthenia gravis. Clin Immunol Immunopathol 78:1–5
    • (1996) Clin Immunol Immunopathol , vol.78 , pp. 1-5
    • Levinson, A.I.1    Wheatley, L.M.2
  • 8
    • 0242336467 scopus 로고    scopus 로고
    • Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis
    • PID: 12821509
    • Evoli A, Tonali PA, Padua L, Monaco ML, Scuderi F et al (2003) Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis. Brain 126:2304–2311
    • (2003) Brain , vol.126 , pp. 2304-2311
    • Evoli, A.1    Tonali, P.A.2    Padua, L.3    Monaco, M.L.4    Scuderi, F.5
  • 9
    • 58149389093 scopus 로고    scopus 로고
    • A comparison of long-term post-thymectomy outcome of anti-AChR-positive, anti-AChR-negative and anti-MuSK-positive patients with non-thymomatous myasthenia gravis
    • COI: 1:CAS:528:DC%2BD1cXhsVKrs7vP, PID: 19063688
    • Ponseti JM, Caritg N, Gamez J, Lopez-Cano M, Vilallonga R et al (2009) A comparison of long-term post-thymectomy outcome of anti-AChR-positive, anti-AChR-negative and anti-MuSK-positive patients with non-thymomatous myasthenia gravis. Expert Opin Biol Ther 9:1–8
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 1-8
    • Ponseti, J.M.1    Caritg, N.2    Gamez, J.3    Lopez-Cano, M.4    Vilallonga, R.5
  • 10
    • 84861656218 scopus 로고    scopus 로고
    • Thymic epithelial cells: working class heroes for T cell development and repertoire selection
    • COI: 1:CAS:528:DC%2BC38XmvFKgs78%3D, PID: 22591984
    • Anderson G, Takahama Y (2012) Thymic epithelial cells: working class heroes for T cell development and repertoire selection. Trends Immunol 33:256–263
    • (2012) Trends Immunol , vol.33 , pp. 256-263
    • Anderson, G.1    Takahama, Y.2
  • 11
    • 0034689058 scopus 로고    scopus 로고
    • An essential role for thymic mesenchyme in early T cell development
    • COI: 1:CAS:528:DC%2BD3cXitVehsL4%3D, PID: 10727466
    • Suniara RK, Jenkinson EJ, Owen JJ (2000) An essential role for thymic mesenchyme in early T cell development. J Exp Med 191:1051–1056
    • (2000) J Exp Med , vol.191 , pp. 1051-1056
    • Suniara, R.K.1    Jenkinson, E.J.2    Owen, J.J.3
  • 12
    • 22344449972 scopus 로고    scopus 로고
    • Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
    • COI: 1:CAS:528:DC%2BD2MXmtVaqsb8%3D, PID: 15983066
    • Derbinski J, Gabler J, Brors B, Tierling S, Jonnakuty S et al (2005) Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med 202:33–45
    • (2005) J Exp Med , vol.202 , pp. 33-45
    • Derbinski, J.1    Gabler, J.2    Brors, B.3    Tierling, S.4    Jonnakuty, S.5
  • 13
    • 70449371659 scopus 로고    scopus 로고
    • CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia
    • COI: 1:CAS:528:DC%2BD1MXhsVehtr3P, PID: 19847900
    • Berrih-Aknin S, Ruhlmann N, Bismuth J, Cizeron-Clairac G, Zelman E et al (2009) CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia. Ann Neurol 66:521–531
    • (2009) Ann Neurol , vol.66 , pp. 521-531
    • Berrih-Aknin, S.1    Ruhlmann, N.2    Bismuth, J.3    Cizeron-Clairac, G.4    Zelman, E.5
  • 15
    • 84873196393 scopus 로고    scopus 로고
    • SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients
    • COI: 1:CAS:528:DC%2BC38XoslGku74%3D, PID: 22704519
    • Weiss JM, Cufi P, Bismuth J, Eymard B, Fadel E et al (2013) SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients. Immunobiology 218:373–381
    • (2013) Immunobiology , vol.218 , pp. 373-381
    • Weiss, J.M.1    Cufi, P.2    Bismuth, J.3    Eymard, B.4    Fadel, E.5
  • 16
    • 84884586857 scopus 로고    scopus 로고
    • The thymus in autoimmune myasthenia gravis: paradigm for a tertiary lymphoid organ
    • Weiss JM, Cufi P, Le Panse R, Berrih-Aknin S (2013) The thymus in autoimmune myasthenia gravis: paradigm for a tertiary lymphoid organ. Rev Neurol (Paris) 169:640–649
    • (2013) Rev Neurol (Paris) , vol.169 , pp. 640-649
    • Weiss, J.M.1    Cufi, P.2    Le Panse, R.3    Berrih-Aknin, S.4
  • 17
    • 84896754346 scopus 로고    scopus 로고
    • Lymphatic vessels and tertiary lymphoid organs
    • COI: 1:CAS:528:DC%2BC2cXkt1WkurY%3D, PID: 24590281
    • Ruddle NH (2014) Lymphatic vessels and tertiary lymphoid organs. J Clin Invest 124:953–959
    • (2014) J Clin Invest , vol.124 , pp. 953-959
    • Ruddle, N.H.1
  • 18
    • 0030587964 scopus 로고    scopus 로고
    • Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis
    • COI: 1:CAS:528:DyaK28Xmtlakur8%3D, PID: 8871679
    • Wakkach A, Guyon T, Bruand C, Tzartos S, Cohen-Kaminsky S et al (1996) Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis. J Immunol 157:3752–3760
    • (1996) J Immunol , vol.157 , pp. 3752-3760
    • Wakkach, A.1    Guyon, T.2    Bruand, C.3    Tzartos, S.4    Cohen-Kaminsky, S.5
  • 19
    • 0023263064 scopus 로고
    • In vitro anti-acetylcholine receptor antibody synthesis by myasthenia gravis patient lymphocytes: correlations with thymic histology and thymic epithelial-cell interactions
    • COI: 1:STN:280:DyaL2s3ltFamsA%3D%3D, PID: 3496354
    • Safar D, Berrih-Aknin S, Morel E (1987) In vitro anti-acetylcholine receptor antibody synthesis by myasthenia gravis patient lymphocytes: correlations with thymic histology and thymic epithelial-cell interactions. J Clin Immunol 7:225–234
    • (1987) J Clin Immunol , vol.7 , pp. 225-234
    • Safar, D.1    Berrih-Aknin, S.2    Morel, E.3
  • 20
    • 0025029359 scopus 로고
    • Thymic B cells from myasthenia gravis patients are activated B cells phenotypic and functional analysis
    • COI: 1:STN:280:DyaK3cznsF2jtw%3D%3D, PID: 2144544
    • Leprince C, Cohen-Kaminsky S, Berrih-Aknin S, Vernet-Der Garabedian B, Treton D et al (1990) Thymic B cells from myasthenia gravis patients are activated B cells phenotypic and functional analysis. J Immunol 145:2115–2122
    • (1990) J Immunol , vol.145 , pp. 2115-2122
    • Leprince, C.1    Cohen-Kaminsky, S.2    Berrih-Aknin, S.3    Vernet-Der Garabedian, B.4    Treton, D.5
  • 21
    • 0023841883 scopus 로고
    • Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients
    • COI: 1:STN:280:DyaL1c7jvFOqtA%3D%3D, PID: 2449461
    • Melms A, Schalke BC, Kirchner T, Muller-Hermelink HK, Albert E et al (1988) Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients. J Clin Invest 81:902–908
    • (1988) J Clin Invest , vol.81 , pp. 902-908
    • Melms, A.1    Schalke, B.C.2    Kirchner, T.3    Muller-Hermelink, H.K.4    Albert, E.5
  • 22
    • 0025819525 scopus 로고
    • Anti-acetylcholine receptor antibodies decrease after thymectomy in patients with myasthenia gravis clinical correlations
    • COI: 1:STN:280:DyaK3MzlsVCntw%3D%3D, PID: 1883480
    • Kuks JB, Oosterhuis HJ, Limburg PC, The TH (1991) Anti-acetylcholine receptor antibodies decrease after thymectomy in patients with myasthenia gravis clinical correlations. J Autoimmun 4:197–211
    • (1991) J Autoimmun , vol.4 , pp. 197-211
    • Kuks, J.B.1    Oosterhuis, H.J.2    Limburg, P.C.3    The, T.H.4
  • 23
    • 0015045109 scopus 로고
    • Studies in myasthenia gravis: effects of thymectomy. Results on 185 patients with nonthymomatous and thymomatous myasthenia gravis, 1941–1969
    • COI: 1:STN:280:DyaE3M7nvFOqsA%3D%3D, PID: 5572596
    • Papatestas AE, Alpert LI, Osserman KE, Osserman RS, Kark AE (1971) Studies in myasthenia gravis: effects of thymectomy. Results on 185 patients with nonthymomatous and thymomatous myasthenia gravis, 1941–1969. Am J Med 50:465–474
    • (1971) Am J Med , vol.50 , pp. 465-474
    • Papatestas, A.E.1    Alpert, L.I.2    Osserman, K.E.3    Osserman, R.S.4    Kark, A.E.5
  • 24
    • 17944370017 scopus 로고    scopus 로고
    • Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis
    • COI: 1:CAS:528:DC%2BD2MXjsVert7k%3D, PID: 15843529
    • Feferman T, Maiti PK, Berrih-Aknin S, Bismuth J, Bidault J et al (2005) Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. J Immunol 174:5324–5331
    • (2005) J Immunol , vol.174 , pp. 5324-5331
    • Feferman, T.1    Maiti, P.K.2    Berrih-Aknin, S.3    Bismuth, J.4    Bidault, J.5
  • 25
    • 84904339949 scopus 로고    scopus 로고
    • Innate immunity in myasthenia gravis thymus: pathogenic effects of Toll-like receptor 4 signaling on autoimmunity
    • COI: 1:CAS:528:DC%2BC2cXivVOhtQ%3D%3D, PID: 24397961
    • Cordiglieri C, Marolda R, Franzi S, Cappelletti C, Giardina C et al (2014) Innate immunity in myasthenia gravis thymus: pathogenic effects of Toll-like receptor 4 signaling on autoimmunity. J Autoimmun 52:74–89
    • (2014) J Autoimmun , vol.52 , pp. 74-89
    • Cordiglieri, C.1    Marolda, R.2    Franzi, S.3    Cappelletti, C.4    Giardina, C.5
  • 26
    • 0032536373 scopus 로고    scopus 로고
    • B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    • COI: 1:CAS:528:DyaK1cXhtFCqurc%3D, PID: 9463416
    • Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M et al (1998) B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 187:655–660
    • (1998) J Exp Med , vol.187 , pp. 655-660
    • Legler, D.F.1    Loetscher, M.2    Roos, R.S.3    Clark-Lewis, I.4    Baggiolini, M.5
  • 27
    • 20744455989 scopus 로고    scopus 로고
    • Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjogren’s syndrome
    • COI: 1:CAS:528:DC%2BD2MXlvFChuro%3D, PID: 15934082
    • Barone F, Bombardieri M, Manzo A, Blades MC, Morgan PR et al (2005) Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjogren’s syndrome. Arthritis Rheum 52:1773–1784
    • (2005) Arthritis Rheum , vol.52 , pp. 1773-1784
    • Barone, F.1    Bombardieri, M.2    Manzo, A.3    Blades, M.C.4    Morgan, P.R.5
  • 28
    • 33745939483 scopus 로고    scopus 로고
    • The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis
    • PID: 16543475
    • Méraouna A, Cizeron-Clairac G, Le Panse R, Bismuth J, Truffault F et al (2006) The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis. Blood 108:432–440
    • (2006) Blood , vol.108 , pp. 432-440
    • Méraouna, A.1    Cizeron-Clairac, G.2    Le Panse, R.3    Bismuth, J.4    Truffault, F.5
  • 29
    • 33751558801 scopus 로고    scopus 로고
    • Microarrays reveal distinct gene signatures in the thymus of seropositive and seronegative myasthenia gravis patients and the role of CC chemokine ligand 21 in thymic hyperplasia
    • PID: 17114458
    • Le Panse R, Cizeron-Clairac G, Bismuth J, Berrih-Aknin S (2006) Microarrays reveal distinct gene signatures in the thymus of seropositive and seronegative myasthenia gravis patients and the role of CC chemokine ligand 21 in thymic hyperplasia. J Immunol 177:7868–7879
    • (2006) J Immunol , vol.177 , pp. 7868-7879
    • Le Panse, R.1    Cizeron-Clairac, G.2    Bismuth, J.3    Berrih-Aknin, S.4
  • 30
    • 77951228240 scopus 로고    scopus 로고
    • Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia
    • COI: 1:CAS:528:DC%2BC3cXksF2qurs%3D, PID: 20223524
    • Shiao YM, Lee CC, Hsu YH, Huang SF, Lin CY et al (2010) Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia. J Neuroimmunol 221:101–106
    • (2010) J Neuroimmunol , vol.221 , pp. 101-106
    • Shiao, Y.M.1    Lee, C.C.2    Hsu, Y.H.3    Huang, S.F.4    Lin, C.Y.5
  • 31
    • 84878255473 scopus 로고    scopus 로고
    • Expression of immune molecules CD25 and CXCL13 correlated with clinical severity of myasthenia gravis
    • COI: 1:CAS:528:DC%2BC3sXnsl2ksrs%3D, PID: 23397576
    • Zhang M, Guo J, Li H, Zhou Y, Tian F et al (2013) Expression of immune molecules CD25 and CXCL13 correlated with clinical severity of myasthenia gravis. J Mol Neurosci 50:317–323
    • (2013) J Mol Neurosci , vol.50 , pp. 317-323
    • Zhang, M.1    Guo, J.2    Li, H.3    Zhou, Y.4    Tian, F.5
  • 32
    • 60349093744 scopus 로고    scopus 로고
    • Interferon alpha and neuromuscular disorders
    • PID: 19171385
    • Stubgen JP (2009) Interferon alpha and neuromuscular disorders. J Neuroimmunol 207:3–17
    • (2009) J Neuroimmunol , vol.207 , pp. 3-17
    • Stubgen, J.P.1
  • 33
    • 0037387254 scopus 로고    scopus 로고
    • Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis
    • COI: 1:CAS:528:DC%2BD3sXjtlKrsLs%3D, PID: 12653847
    • Meager A, Wadhwa M, Dilger P, Bird C, Thorpe R et al (2003) Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis. Clin Exp Immunol 132:128–136
    • (2003) Clin Exp Immunol , vol.132 , pp. 128-136
    • Meager, A.1    Wadhwa, M.2    Dilger, P.3    Bird, C.4    Thorpe, R.5
  • 34
    • 57349083325 scopus 로고    scopus 로고
    • Autoantibodies against type I interferons as an additional diagnostic criterion for autoimmune polyendocrine syndrome type I
    • COI: 1:CAS:528:DC%2BD1cXhtlyqs7fM, PID: 18728167
    • Meloni A, Furcas M, Cetani F, Marcocci C, Falorni A et al (2008) Autoantibodies against type I interferons as an additional diagnostic criterion for autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 93:4389–4397
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4389-4397
    • Meloni, A.1    Furcas, M.2    Cetani, F.3    Marcocci, C.4    Falorni, A.5
  • 35
    • 18644367182 scopus 로고    scopus 로고
    • Effects of cytokines on acetylcholine receptor expression: implications for myasthenia gravis
    • COI: 1:CAS:528:DC%2BD2MXjvV2msbw%3D, PID: 15879086
    • Poea-Guyon S, Christadoss P, Le Panse R, Guyon T, De Baets M et al (2005) Effects of cytokines on acetylcholine receptor expression: implications for myasthenia gravis. J Immunol 174:5941–5949
    • (2005) J Immunol , vol.174 , pp. 5941-5949
    • Poea-Guyon, S.1    Christadoss, P.2    Le Panse, R.3    Guyon, T.4    De Baets, M.5
  • 37
    • 77955169480 scopus 로고    scopus 로고
    • Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses
    • COI: 1:CAS:528:DC%2BC3cXhtFSlurnO, PID: 20465564
    • Golding A, Rosen A, Petri M, Akhter E, Andrade F (2010) Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses. Immunology 131:107–117
    • (2010) Immunology , vol.131 , pp. 107-117
    • Golding, A.1    Rosen, A.2    Petri, M.3    Akhter, E.4    Andrade, F.5
  • 38
    • 84884211312 scopus 로고    scopus 로고
    • Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis
    • COI: 1:CAS:528:DC%2BC3sXks1CqsLw%3D, PID: 23280437
    • Cufi P, Dragin N, Weiss JM, Martinez-Martinez P, De Baets MH et al (2013) Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis. Ann Neurol 73:281–293
    • (2013) Ann Neurol , vol.73 , pp. 281-293
    • Cufi, P.1    Dragin, N.2    Weiss, J.M.3    Martinez-Martinez, P.4    De Baets, M.H.5
  • 39
    • 84904369154 scopus 로고    scopus 로고
    • Central role of interferon-beta in thymic events leading to myasthenia gravis
    • COI: 1:CAS:528:DC%2BC2cXivVGjsA%3D%3D, PID: 24393484
    • Cufi P, Dragin N, Ruhlmann N, Weiss JM, Fadel E et al (2014) Central role of interferon-beta in thymic events leading to myasthenia gravis. J Autoimmun 52:44–52
    • (2014) J Autoimmun , vol.52 , pp. 44-52
    • Cufi, P.1    Dragin, N.2    Ruhlmann, N.3    Weiss, J.M.4    Fadel, E.5
  • 40
    • 84958780772 scopus 로고    scopus 로고
    • Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis
    • Weiss JM, Robinet M, Aricha R, Cufi P, Villeret B et al (2016) Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis., Oncotarget
    • (2016) Oncotarget
    • Weiss, J.M.1    Robinet, M.2    Aricha, R.3    Cufi, P.4    Villeret, B.5
  • 41
    • 84904314341 scopus 로고    scopus 로고
    • Thymoma-associated myasthenia gravis: on the search for a pathogen signature
    • COI: 1:CAS:528:DC%2BC2cXhtFGlsb7F, PID: 24440286
    • Cufi P, Soussan P, Truffault F, Fetouchi R, Robinet M et al (2014) Thymoma-associated myasthenia gravis: on the search for a pathogen signature. J Autoimmun 52:29–35
    • (2014) J Autoimmun , vol.52 , pp. 29-35
    • Cufi, P.1    Soussan, P.2    Truffault, F.3    Fetouchi, R.4    Robinet, M.5
  • 42
    • 77949420644 scopus 로고    scopus 로고
    • The “hygiene hypothesis” for autoimmune and allergic diseases: an update
    • COI: 1:CAS:528:DC%2BC3cXltFGis70%3D, PID: 20415844
    • Okada H, Kuhn C, Feillet H, Bach JF (2010) The “hygiene hypothesis” for autoimmune and allergic diseases: an update. Clin Exp Immunol 160:1–9
    • (2010) Clin Exp Immunol , vol.160 , pp. 1-9
    • Okada, H.1    Kuhn, C.2    Feillet, H.3    Bach, J.F.4
  • 43
    • 63149158618 scopus 로고    scopus 로고
    • Antiviral immune responses: triggers of or triggered by autoimmunity?
    • PID: 19319143
    • Munz C, Lunemann JD, Getts MT, Miller SD (2009) Antiviral immune responses: triggers of or triggered by autoimmunity? Nat Rev Immunol 9:246–258
    • (2009) Nat Rev Immunol , vol.9 , pp. 246-258
    • Munz, C.1    Lunemann, J.D.2    Getts, M.T.3    Miller, S.D.4
  • 44
    • 33745712576 scopus 로고    scopus 로고
    • The thymus is a common target organ in infectious diseases
    • PID: 16846255
    • Savino W (2006) The thymus is a common target organ in infectious diseases. PLoS Pathog 2, e62
    • (2006) PLoS Pathog , vol.2
    • Savino, W.1
  • 45
    • 77950988479 scopus 로고    scopus 로고
    • Detection of poliovirus-infected macrophages in thymus of patients with myasthenia gravis
    • COI: 1:CAS:528:DC%2BC3cXksFSitb4%3D, PID: 20368632
    • Cavalcante P, Barberis M, Cannone M, Baggi F, Antozzi C et al (2010) Detection of poliovirus-infected macrophages in thymus of patients with myasthenia gravis. Neurology 74:1118–1126
    • (2010) Neurology , vol.74 , pp. 1118-1126
    • Cavalcante, P.1    Barberis, M.2    Cannone, M.3    Baggi, F.4    Antozzi, C.5
  • 46
    • 77952920585 scopus 로고    scopus 로고
    • Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus
    • PID: 20517934
    • Cavalcante P, Serafini B, Rosicarelli B, Maggi L, Barberis M et al (2010) Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus. Ann Neurol 67:726–738
    • (2010) Ann Neurol , vol.67 , pp. 726-738
    • Cavalcante, P.1    Serafini, B.2    Rosicarelli, B.3    Maggi, L.4    Barberis, M.5
  • 47
    • 79958247819 scopus 로고    scopus 로고
    • Epigenetic dysregulation of Epstein-Barr virus latency and development of autoimmune disease
    • COI: 1:CAS:528:DC%2BC38XhtVWjtr3L, PID: 21627044
    • Niller HH, Wolf H, Ay E, Minarovits J (2011) Epigenetic dysregulation of Epstein-Barr virus latency and development of autoimmune disease. Adv Exp Med Biol 711:82–102
    • (2011) Adv Exp Med Biol , vol.711 , pp. 82-102
    • Niller, H.H.1    Wolf, H.2    Ay, E.3    Minarovits, J.4
  • 48
    • 84858259176 scopus 로고    scopus 로고
    • Innate immune modulation in EBV infection
    • COI: 1:CAS:528:DC%2BC3MXitlSgt78%3D, PID: 21429244
    • Ning S (2011) Innate immune modulation in EBV infection. Herpesviridae 2:1
    • (2011) Herpesviridae , vol.2 , pp. 1
    • Ning, S.1
  • 49
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on toll-like receptors
    • COI: 1:CAS:528:DC%2BC3cXkvFSjsrc%3D, PID: 20404851
    • Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol 11:373–384
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 50
    • 84918564833 scopus 로고    scopus 로고
    • Toll-like receptor signaling pathways
    • PID: 25309543
    • Kawasaki T, Kawai T (2014) Toll-like receptor signaling pathways. Front Immunol 5:461
    • (2014) Front Immunol , vol.5 , pp. 461
    • Kawasaki, T.1    Kawai, T.2
  • 52
    • 84957442991 scopus 로고    scopus 로고
    • Toll-like receptor pathways in autoimmune diseases
    • COI: 1:CAS:528:DC%2BC2MXjtlSqsrg%3D, PID: 25687121
    • Chen JQ, Szodoray P, Zeher M (2016) Toll-like receptor pathways in autoimmune diseases. Clin Rev Allergy Immunol 50:1–17
    • (2016) Clin Rev Allergy Immunol , vol.50 , pp. 1-17
    • Chen, J.Q.1    Szodoray, P.2    Zeher, M.3
  • 53
    • 78549284013 scopus 로고    scopus 로고
    • TRIF mediates toll-like receptor 5-induced signaling in intestinal epithelial cells
    • COI: 1:CAS:528:DC%2BC3cXhsVCrt7zI, PID: 20855887
    • Choi YJ, Im E, Chung HK, Pothoulakis C, Rhee SH (2010) TRIF mediates toll-like receptor 5-induced signaling in intestinal epithelial cells. J Biol Chem 285:37570–37578
    • (2010) J Biol Chem , vol.285 , pp. 37570-37578
    • Choi, Y.J.1    Im, E.2    Chung, H.K.3    Pothoulakis, C.4    Rhee, S.H.5
  • 54
    • 84878707549 scopus 로고    scopus 로고
    • High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9-TRIF pathway
    • PID: 23673637
    • Volpi C, Fallarino F, Pallotta MT, Bianchi R, Vacca C et al (2013) High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9-TRIF pathway. Nat Commun 4:1852
    • (2013) Nat Commun , vol.4 , pp. 1852
    • Volpi, C.1    Fallarino, F.2    Pallotta, M.T.3    Bianchi, R.4    Vacca, C.5
  • 55
    • 84922311613 scopus 로고    scopus 로고
    • A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling
    • COI: 1:CAS:528:DC%2BC2MXitlOmtrk%3D, PID: 25505250
    • Nilsen NJ, Vladimer GI, Stenvik J, Orning MP, Zeid-Kilani MV et al (2015) A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling. J Biol Chem 290:3209–3222
    • (2015) J Biol Chem , vol.290 , pp. 3209-3222
    • Nilsen, N.J.1    Vladimer, G.I.2    Stenvik, J.3    Orning, M.P.4    Zeid-Kilani, M.V.5
  • 56
    • 84949624604 scopus 로고    scopus 로고
    • Space and time: new considerations about the relationship between toll-like receptors (TLRs) and type I interferons (IFNs)
    • COI: 1:CAS:528:DC%2BC2MXksF2hsL0%3D, PID: 25819430
    • Perkins DJ, Vogel SN (2015) Space and time: new considerations about the relationship between toll-like receptors (TLRs) and type I interferons (IFNs). Cytokine 74:171–174
    • (2015) Cytokine , vol.74 , pp. 171-174
    • Perkins, D.J.1    Vogel, S.N.2
  • 57
    • 84872077258 scopus 로고    scopus 로고
    • The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists
    • COI: 1:CAS:528:DC%2BC3sXjtlOnsg%3D%3D, PID: 23166319
    • Pohar J, Pirher N, Bencina M, Mancek-Keber M, Jerala R (2013) The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists. J Biol Chem 288:442–454
    • (2013) J Biol Chem , vol.288 , pp. 442-454
    • Pohar, J.1    Pirher, N.2    Bencina, M.3    Mancek-Keber, M.4    Jerala, R.5
  • 58
    • 84929640671 scopus 로고    scopus 로고
    • Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases
    • COI: 1:CAS:528:DC%2BC2MXotlGlur8%3D, PID: 25648980
    • Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y et al (2015) Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases. Nat Commun 6:6119
    • (2015) Nat Commun , vol.6 , pp. 6119
    • Kanno, A.1    Tanimura, N.2    Ishizaki, M.3    Ohko, K.4    Motoi, Y.5
  • 59
    • 82555187209 scopus 로고    scopus 로고
    • UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling
    • COI: 1:CAS:528:DC%2BC3MXhs1Grur%2FJ, PID: 22164301
    • Itoh H, Tatematsu M, Watanabe A, Iwano K, Funami K et al (2011) UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling. PLoS One 6, e28500
    • (2011) PLoS One , vol.6
    • Itoh, H.1    Tatematsu, M.2    Watanabe, A.3    Iwano, K.4    Funami, K.5
  • 60
    • 84901282752 scopus 로고    scopus 로고
    • TLR9 expressed on plasma membrane acts as a negative regulator of human B cell response
    • COI: 1:CAS:528:DC%2BC2cXjsF2gs70%3D, PID: 24582318
    • Guerrier T, Pochard P, Lahiri A, Youinou P, Pers JO et al (2014) TLR9 expressed on plasma membrane acts as a negative regulator of human B cell response. J Autoimmun 51:23–29
    • (2014) J Autoimmun , vol.51 , pp. 23-29
    • Guerrier, T.1    Pochard, P.2    Lahiri, A.3    Youinou, P.4    Pers, J.O.5
  • 61
    • 37649018614 scopus 로고    scopus 로고
    • Toll-like receptors and autoimmunity
    • COI: 1:CAS:528:DC%2BD1cXis1Wnsrg%3D, PID: 18190879
    • Hurst J, von Landenberg P (2008) Toll-like receptors and autoimmunity. Autoimmun Rev 7:204–208
    • (2008) Autoimmun Rev , vol.7 , pp. 204-208
    • Hurst, J.1    von Landenberg, P.2
  • 62
    • 78650576197 scopus 로고    scopus 로고
    • Use of defined TLR ligands as adjuvants within human vaccines
    • COI: 1:CAS:528:DC%2BC3MXhsVOgt7Y%3D, PID: 21198672
    • Duthie MS, Windish HP, Fox CB, Reed SG (2011) Use of defined TLR ligands as adjuvants within human vaccines. Immunol Rev 239:178–196
    • (2011) Immunol Rev , vol.239 , pp. 178-196
    • Duthie, M.S.1    Windish, H.P.2    Fox, C.B.3    Reed, S.G.4
  • 63
    • 84863690997 scopus 로고    scopus 로고
    • The effects of TLR activation on T-cell development and differentiation
    • PID: 22737174
    • Jin B, Sun T, Yu XH, Yang YX, Yeo AE (2012) The effects of TLR activation on T-cell development and differentiation. Clin Dev Immunol 2012:836485
    • (2012) Clin Dev Immunol , vol.2012 , pp. 836485
    • Jin, B.1    Sun, T.2    Yu, X.H.3    Yang, Y.X.4    Yeo, A.E.5
  • 64
    • 75749128201 scopus 로고    scopus 로고
    • Innate pathways to B-cell activation and tolerance
    • COI: 1:CAS:528:DC%2BC3cXisVehsrc%3D, PID: 20146708
    • Crampton SP, Voynova E, Bolland S (2010) Innate pathways to B-cell activation and tolerance. Ann N Y Acad Sci 1183:58–68
    • (2010) Ann N Y Acad Sci , vol.1183 , pp. 58-68
    • Crampton, S.P.1    Voynova, E.2    Bolland, S.3
  • 66
    • 39549105619 scopus 로고    scopus 로고
    • B cell autonomous TLR signaling and autoimmunity
    • COI: 1:CAS:528:DC%2BD1cXkslKhtbo%3D, PID: 18295736
    • Meyer-Bahlburg A, Rawlings DJ (2008) B cell autonomous TLR signaling and autoimmunity. Autoimmun Rev 7:313–316
    • (2008) Autoimmun Rev , vol.7 , pp. 313-316
    • Meyer-Bahlburg, A.1    Rawlings, D.J.2
  • 67
    • 79953162780 scopus 로고    scopus 로고
    • Toll-like receptor driven B cell activation in the induction of systemic autoimmunity
    • COI: 1:CAS:528:DC%2BC3MXkt1eitrk%3D, PID: 21306913
    • Green NM, Marshak-Rothstein A (2011) Toll-like receptor driven B cell activation in the induction of systemic autoimmunity. Semin Immunol 23:106–112
    • (2011) Semin Immunol , vol.23 , pp. 106-112
    • Green, N.M.1    Marshak-Rothstein, A.2
  • 68
    • 84872924539 scopus 로고    scopus 로고
    • Possible involvement of toll-like receptors in the pathogenesis of myasthenia gravis
    • COI: 1:CAS:528:DC%2BC3sXhs1Oiu7o%3D, PID: 22898741
    • Wang YZ, Yan M, Tian FF, Zhang JM, Liu Q et al (2013) Possible involvement of toll-like receptors in the pathogenesis of myasthenia gravis. Inflammation 36:121–130
    • (2013) Inflammation , vol.36 , pp. 121-130
    • Wang, Y.Z.1    Yan, M.2    Tian, F.F.3    Zhang, J.M.4    Liu, Q.5
  • 69
    • 84885102674 scopus 로고    scopus 로고
    • Altered expression of miR-146a in myasthenia gravis
    • COI: 1:CAS:528:DC%2BC3sXhslOjsLbE, PID: 24036458
    • Lu J, Yan M, Wang Y, Zhang J, Yang H et al (2013) Altered expression of miR-146a in myasthenia gravis. Neurosci Lett 555:85–90
    • (2013) Neurosci Lett , vol.555 , pp. 85-90
    • Lu, J.1    Yan, M.2    Wang, Y.3    Zhang, J.4    Yang, H.5
  • 70
    • 0037080024 scopus 로고    scopus 로고
    • Tissue expression of human toll-like receptors and differential regulation of toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
    • COI: 1:CAS:528:DC%2BD38XksFWntg%3D%3D, PID: 11777946
    • Zarember KA, Godowski PJ (2002) Tissue expression of human toll-like receptors and differential regulation of toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 168:554–561
    • (2002) J Immunol , vol.168 , pp. 554-561
    • Zarember, K.A.1    Godowski, P.J.2
  • 71
    • 21244469489 scopus 로고    scopus 로고
    • Increased toll-like receptor 4 expression in thymus of myasthenic patients with thymitis and thymic involution
    • COI: 1:CAS:528:DC%2BD2MXms1eitr0%3D, PID: 15972959
    • Bernasconi P, Barberis M, Baggi F, Passerini L, Cannone M et al (2005) Increased toll-like receptor 4 expression in thymus of myasthenic patients with thymitis and thymic involution. Am J Pathol 167:129–139
    • (2005) Am J Pathol , vol.167 , pp. 129-139
    • Bernasconi, P.1    Barberis, M.2    Baggi, F.3    Passerini, L.4    Cannone, M.5
  • 72
    • 84963705961 scopus 로고    scopus 로고
    • Increased expression of toll-like receptors 7 and 9 in myasthenia gravis thymus characterized by active Epstein-Barr virus infection
    • COI: 1:CAS:528:DC%2BC2MXitVyqsbjO, PID: 26723518
    • Cavalcante P, Galbardi B, Franzi S, Marcuzzo S, Barzago C et al (2016) Increased expression of toll-like receptors 7 and 9 in myasthenia gravis thymus characterized by active Epstein-Barr virus infection. Immunobiology 221:516–527
    • (2016) Immunobiology , vol.221 , pp. 516-527
    • Cavalcante, P.1    Galbardi, B.2    Franzi, S.3    Marcuzzo, S.4    Barzago, C.5
  • 73
    • 77952927095 scopus 로고    scopus 로고
    • Epstein-Barr virus promotes interferon-alpha production by plasmacytoid dendritic cells
    • COI: 1:CAS:528:DC%2BC3cXhtFGmsr7J, PID: 20178121
    • Quan TE, Roman RM, Rudenga BJ, Holers VM, Craft JE (2010) Epstein-Barr virus promotes interferon-alpha production by plasmacytoid dendritic cells. Arthritis Rheum 62:1693–1701
    • (2010) Arthritis Rheum , vol.62 , pp. 1693-1701
    • Quan, T.E.1    Roman, R.M.2    Rudenga, B.J.3    Holers, V.M.4    Craft, J.E.5
  • 74
    • 70350488070 scopus 로고    scopus 로고
    • Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3
    • COI: 1:CAS:528:DC%2BD1MXht1SrtbvF, PID: 19720839
    • Iwakiri D, Zhou L, Samanta M, Matsumoto M, Ebihara T et al (2009) Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3. J Exp Med 206:2091–2099
    • (2009) J Exp Med , vol.206 , pp. 2091-2099
    • Iwakiri, D.1    Zhou, L.2    Samanta, M.3    Matsumoto, M.4    Ebihara, T.5
  • 75
    • 34547102725 scopus 로고    scopus 로고
    • Epstein-Barr virus induces MCP-1 secretion by human monocytes via TLR2
    • COI: 1:CAS:528:DC%2BD2sXnvFyitro%3D, PID: 17522215
    • Gaudreault E, Fiola S, Olivier M, Gosselin J (2007) Epstein-Barr virus induces MCP-1 secretion by human monocytes via TLR2. J Virol 81:8016–8024
    • (2007) J Virol , vol.81 , pp. 8016-8024
    • Gaudreault, E.1    Fiola, S.2    Olivier, M.3    Gosselin, J.4
  • 76
    • 84865615098 scopus 로고    scopus 로고
    • Toll-like receptor 7 stimulates the expression of Epstein-Barr virus latent membrane protein 1
    • COI: 1:CAS:528:DC%2BC38XhtlSltrzK, PID: 22952664
    • Valente RM, Ehlers E, Xu D, Ahmad H, Steadman A et al (2012) Toll-like receptor 7 stimulates the expression of Epstein-Barr virus latent membrane protein 1. PLoS One 7, e43317
    • (2012) PLoS One , vol.7
    • Valente, R.M.1    Ehlers, E.2    Xu, D.3    Ahmad, H.4    Steadman, A.5
  • 77
    • 84908466794 scopus 로고    scopus 로고
    • Experimental autoimmune myasthenia gravis (EAMG): from immunochemical characterization to therapeutic approaches
    • COI: 1:CAS:528:DC%2BC2cXhvVWmsrbI, PID: 24970384
    • Fuchs S, Aricha R, Reuveni D, Souroujon MC (2014) Experimental autoimmune myasthenia gravis (EAMG): from immunochemical characterization to therapeutic approaches. J Autoimmun 54:51–59
    • (2014) J Autoimmun , vol.54 , pp. 51-59
    • Fuchs, S.1    Aricha, R.2    Reuveni, D.3    Souroujon, M.C.4
  • 78
    • 84939426065 scopus 로고    scopus 로고
    • Guidelines for standard preclinical experiments in the mouse model of myasthenia gravis induced by acetylcholine receptor immunization
    • Tuzun E, Berrih-Aknin S, Brenner T, Kusner LL, Le Panse R et al (2015) Guidelines for standard preclinical experiments in the mouse model of myasthenia gravis induced by acetylcholine receptor immunization., Exp Neurol
    • (2015) Exp Neurol
    • Tuzun, E.1    Berrih-Aknin, S.2    Brenner, T.3    Kusner, L.L.4    Le Panse, R.5
  • 80
    • 84952629810 scopus 로고    scopus 로고
    • Standardization of the experimental autoimmune myasthenia gravis (EAMG) model by immunization of rats with Torpedo californica acetylcholine receptors—recommendations for methods and experimental designs
    • COI: 1:CAS:528:DC%2BC2MXlt1agsb4%3D, PID: 25796590
    • Losen M, Martinez-Martinez P, Molenaar PC, Lazaridis K, Tzartos S et al (2015) Standardization of the experimental autoimmune myasthenia gravis (EAMG) model by immunization of rats with Torpedo californica acetylcholine receptors—recommendations for methods and experimental designs. Exp Neurol 270:18–28
    • (2015) Exp Neurol , vol.270 , pp. 18-28
    • Losen, M.1    Martinez-Martinez, P.2    Molenaar, P.C.3    Lazaridis, K.4    Tzartos, S.5
  • 81
    • 0035217962 scopus 로고    scopus 로고
    • Modes of action of Freund’s adjuvants in experimental models of autoimmune diseases
    • COI: 1:CAS:528:DC%2BD3MXpt1Sjt7g%3D, PID: 11739546
    • Billiau A, Matthys P (2001) Modes of action of Freund’s adjuvants in experimental models of autoimmune diseases. J Leukoc Biol 70:849–860
    • (2001) J Leukoc Biol , vol.70 , pp. 849-860
    • Billiau, A.1    Matthys, P.2
  • 82
    • 33748953709 scopus 로고    scopus 로고
    • CD4+ T and B cells cooperate in the immunoregulation of experimental autoimmune myasthenia gravis
    • COI: 1:CAS:528:DC%2BD28XhtVWqtrjE, PID: 16945426
    • Milani M, Ostlie N, Wu H, Wang W, Conti-Fine BM (2006) CD4+ T and B cells cooperate in the immunoregulation of experimental autoimmune myasthenia gravis. J Neuroimmunol 179:152–162
    • (2006) J Neuroimmunol , vol.179 , pp. 152-162
    • Milani, M.1    Ostlie, N.2    Wu, H.3    Wang, W.4    Conti-Fine, B.M.5
  • 83
    • 0036551108 scopus 로고    scopus 로고
    • Induction of skewed Th1/Th2 T-cell differentiation via subcutaneous immunization with Freund’s adjuvant
    • COI: 1:CAS:528:DC%2BD38XksFSqs7w%3D, PID: 11994139
    • Shibaki A, Katz SI (2002) Induction of skewed Th1/Th2 T-cell differentiation via subcutaneous immunization with Freund’s adjuvant. Exp Dermatol 11:126–134
    • (2002) Exp Dermatol , vol.11 , pp. 126-134
    • Shibaki, A.1    Katz, S.I.2
  • 84
    • 0030878993 scopus 로고    scopus 로고
    • Interferon gamma (IFN-gamma) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice
    • COI: 1:CAS:528:DyaK2sXlt1SnsL0%3D, PID: 9236190
    • Balasa B, Deng C, Lee J, Bradley LM, Dalton DK et al (1997) Interferon gamma (IFN-gamma) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice. J Exp Med 186:385–391
    • (1997) J Exp Med , vol.186 , pp. 385-391
    • Balasa, B.1    Deng, C.2    Lee, J.3    Bradley, L.M.4    Dalton, D.K.5
  • 85
    • 0033120962 scopus 로고    scopus 로고
    • Mice with IFN-gamma receptor deficiency are less susceptible to experimental autoimmune myasthenia gravis
    • COI: 1:CAS:528:DyaK1MXitFGqsLc%3D, PID: 10201893
    • Zhang GX, Xiao BG, Bai XF, van der Meide PH, Orn A et al (1999) Mice with IFN-gamma receptor deficiency are less susceptible to experimental autoimmune myasthenia gravis. J Immunol 162:3775–3781
    • (1999) J Immunol , vol.162 , pp. 3775-3781
    • Zhang, G.X.1    Xiao, B.G.2    Bai, X.F.3    van der Meide, P.H.4    Orn, A.5
  • 86
    • 84929029422 scopus 로고    scopus 로고
    • IL-17-producing CD4(+) T cells contribute to the loss of B-cell tolerance in experimental autoimmune myasthenia gravis
    • COI: 1:CAS:528:DC%2BC2MXks12hu7k%3D, PID: 25676041
    • Schaffert H, Pelz A, Saxena A, Losen M, Meisel A et al (2015) IL-17-producing CD4(+) T cells contribute to the loss of B-cell tolerance in experimental autoimmune myasthenia gravis. Eur J Immunol 45:1339–1347
    • (2015) Eur J Immunol , vol.45 , pp. 1339-1347
    • Schaffert, H.1    Pelz, A.2    Saxena, A.3    Losen, M.4    Meisel, A.5
  • 87
    • 33845905223 scopus 로고    scopus 로고
    • Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling
    • COI: 1:CAS:528:DC%2BD28Xhtlemt7fN, PID: 17185603
    • Gavin AL, Hoebe K, Duong B, Ota T, Martin C et al (2006) Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science 314:1936–1938
    • (2006) Science , vol.314 , pp. 1936-1938
    • Gavin, A.L.1    Hoebe, K.2    Duong, B.3    Ota, T.4    Martin, C.5
  • 88
    • 27744497439 scopus 로고    scopus 로고
    • Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity
    • COI: 1:CAS:528:DC%2BD2MXhtF2jur7P, PID: 16272281
    • Su SB, Silver PB, Grajewski RS, Agarwal RK, Tang J et al (2005) Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity. J Immunol 175:6303–6310
    • (2005) J Immunol , vol.175 , pp. 6303-6310
    • Su, S.B.1    Silver, P.B.2    Grajewski, R.S.3    Agarwal, R.K.4    Tang, J.5
  • 89
    • 33644991938 scopus 로고    scopus 로고
    • MyD88 signaling controls autoimmune myocarditis induction
    • COI: 1:CAS:528:DC%2BD28Xis1KjsA%3D%3D, PID: 16401773
    • Marty RR, Dirnhofer S, Mauermann N, Schweikert S, Akira S et al (2006) MyD88 signaling controls autoimmune myocarditis induction. Circulation 113:258–265
    • (2006) Circulation , vol.113 , pp. 258-265
    • Marty, R.R.1    Dirnhofer, S.2    Mauermann, N.3    Schweikert, S.4    Akira, S.5
  • 90
    • 34248512211 scopus 로고    scopus 로고
    • Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice
    • COI: 1:CAS:528:DC%2BD2sXmsFartLg%3D, PID: 17469144
    • Sadanaga A, Nakashima H, Akahoshi M, Masutani K, Miyake K et al (2007) Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice. Arthritis Rheum 56:1618–1628
    • (2007) Arthritis Rheum , vol.56 , pp. 1618-1628
    • Sadanaga, A.1    Nakashima, H.2    Akahoshi, M.3    Masutani, K.4    Miyake, K.5
  • 91
    • 77953246527 scopus 로고    scopus 로고
    • The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model
    • PID: 20107166
    • Fang J, Fang D, Silver PB, Wen F, Li B et al (2010) The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model. Invest Ophthalmol Vis Sci 51:3092–3099
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 3092-3099
    • Fang, J.1    Fang, D.2    Silver, P.B.3    Wen, F.4    Li, B.5
  • 92
    • 0022572186 scopus 로고
    • Anti-acetylcholine receptor antibodies induced in mice by syngeneic receptor without adjuvants
    • COI: 1:CAS:528:DyaL28XktVCqsrc%3D, PID: 3486818
    • Scadding GK, Calder L, Vincent A, Prior C, Wray D et al (1986) Anti-acetylcholine receptor antibodies induced in mice by syngeneic receptor without adjuvants. Immunology 58:151–155
    • (1986) Immunology , vol.58 , pp. 151-155
    • Scadding, G.K.1    Calder, L.2    Vincent, A.3    Prior, C.4    Wray, D.5
  • 93
    • 0027415254 scopus 로고
    • Pathogenic autoimmunity to affinity-purified mouse acetylcholine receptor induced without adjuvant in BALB/c mice
    • COI: 1:CAS:528:DyaK3sXisFeju7Y%3D, PID: 8458383
    • Jermy A, Beeson D, Vincent A (1993) Pathogenic autoimmunity to affinity-purified mouse acetylcholine receptor induced without adjuvant in BALB/c mice. Eur J Immunol 23:973–976
    • (1993) Eur J Immunol , vol.23 , pp. 973-976
    • Jermy, A.1    Beeson, D.2    Vincent, A.3
  • 94
    • 42249088234 scopus 로고    scopus 로고
    • Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
    • COI: 1:CAS:528:DC%2BD1cXkvVyrsrc%3D, PID: 18362170
    • Kool M, Soullie T, van Nimwegen M, Willart MA, Muskens F et al (2008) Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med 205:869–882
    • (2008) J Exp Med , vol.205 , pp. 869-882
    • Kool, M.1    Soullie, T.2    van Nimwegen, M.3    Willart, M.A.4    Muskens, F.5
  • 95
    • 29244482781 scopus 로고    scopus 로고
    • Vaccination with a MHC class II peptide in alum and inactive pertussis strongly ameliorates clinical MG in C57BL/6 mice
    • COI: 1:CAS:528:DC%2BD28Xkt12r, PID: 16271400
    • Oshima M, Maruta T, Ohtani M, Deitiker PR, Mosier D et al (2006) Vaccination with a MHC class II peptide in alum and inactive pertussis strongly ameliorates clinical MG in C57BL/6 mice. J Neuroimmunol 171:8–16
    • (2006) J Neuroimmunol , vol.171 , pp. 8-16
    • Oshima, M.1    Maruta, T.2    Ohtani, M.3    Deitiker, P.R.4    Mosier, D.5
  • 96
    • 0026730230 scopus 로고
    • A comparison of commercially available adjuvants for use in research
    • COI: 1:CAS:528:DyaK3sXksFGnug%3D%3D, PID: 1517600
    • Bennett B, Check IJ, Olsen MR, Hunter RL (1992) A comparison of commercially available adjuvants for use in research. J Immunol Methods 153:31–40
    • (1992) J Immunol Methods , vol.153 , pp. 31-40
    • Bennett, B.1    Check, I.J.2    Olsen, M.R.3    Hunter, R.L.4
  • 97
    • 0027160399 scopus 로고
    • Induction of experimental autoimmune myasthenia gravis with acetylcholine receptors using a nonionic block copolymer as adjuvant
    • COI: 1:CAS:528:DyaK3sXlslyqsrk%3D
    • Shenoy M, Christadoss P (1993) Induction of experimental autoimmune myasthenia gravis with acetylcholine receptors using a nonionic block copolymer as adjuvant. Immunol Investig 22:267–282
    • (1993) Immunol Investig , vol.22 , pp. 267-282
    • Shenoy, M.1    Christadoss, P.2
  • 98
    • 43049179999 scopus 로고    scopus 로고
    • LPS/TLR4 signal transduction pathway
    • COI: 1:CAS:528:DC%2BD1cXlslynt7c%3D, PID: 18304834
    • Lu YC, Yeh WC, Ohashi PS (2008) LPS/TLR4 signal transduction pathway. Cytokine 42:145–151
    • (2008) Cytokine , vol.42 , pp. 145-151
    • Lu, Y.C.1    Yeh, W.C.2    Ohashi, P.S.3
  • 99
    • 84919339026 scopus 로고    scopus 로고
    • Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria
    • COI: 1:CAS:528:DC%2BC2cXhvVems7bI, PID: 25458607
    • Demon D, Vande Walle L, Lamkanfi M (2014) Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria. Trends Biochem Sci 39:574–576
    • (2014) Trends Biochem Sci , vol.39 , pp. 574-576
    • Demon, D.1    Vande Walle, L.2    Lamkanfi, M.3
  • 100
    • 84891755468 scopus 로고    scopus 로고
    • TLR2 and TLR4 in autoimmune diseases: a comprehensive review
    • COI: 1:CAS:528:DC%2BC2cXhsFKrt7zL, PID: 24352680
    • Liu Y, Yin H, Zhao M, Lu Q (2014) TLR2 and TLR4 in autoimmune diseases: a comprehensive review. Clin Rev Allergy Immunol 47:136–147
    • (2014) Clin Rev Allergy Immunol , vol.47 , pp. 136-147
    • Liu, Y.1    Yin, H.2    Zhao, M.3    Lu, Q.4
  • 101
    • 84863463884 scopus 로고    scopus 로고
    • CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis
    • Allman W, Qi H, Saini SS, Li J, Tuzun E et al (2012) CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis. J Neuroimmunol 249:1–7
    • (2012) J Neuroimmunol , vol.249 , pp. 1-7
    • Allman, W.1    Qi, H.2    Saini, S.S.3    Li, J.4    Tuzun, E.5
  • 102
    • 49349117943 scopus 로고    scopus 로고
    • The adjuvant effect in infection and autoimmunity
    • COI: 1:CAS:528:DC%2BD1cXht12hsb%2FI, PID: 18175074
    • Rose NR (2008) The adjuvant effect in infection and autoimmunity. Clin Rev Allergy Immunol 34:279–282
    • (2008) Clin Rev Allergy Immunol , vol.34 , pp. 279-282
    • Rose, N.R.1
  • 103
    • 0038519234 scopus 로고    scopus 로고
    • LPS and Freund’s adjuvant initiate different inflammatory circuits in experimental autoimmune thyroiditis
    • COI: 1:CAS:528:DC%2BD3sXks1Gru7Y%3D, PID: 12799214
    • Damotte D, Goulvestre C, Charreire J, Carnaud C (2003) LPS and Freund’s adjuvant initiate different inflammatory circuits in experimental autoimmune thyroiditis. Eur Cytokine Netw 14:52–59
    • (2003) Eur Cytokine Netw , vol.14 , pp. 52-59
    • Damotte, D.1    Goulvestre, C.2    Charreire, J.3    Carnaud, C.4
  • 104
    • 33750795344 scopus 로고    scopus 로고
    • Nucleic acid-sensing TLRs as modifiers of autoimmunity
    • COI: 1:CAS:528:DC%2BD28XhtFGrsbfL, PID: 17082566
    • Deane JA, Bolland S (2006) Nucleic acid-sensing TLRs as modifiers of autoimmunity. J Immunol 177:6573–6578
    • (2006) J Immunol , vol.177 , pp. 6573-6578
    • Deane, J.A.1    Bolland, S.2
  • 105
    • 0018864218 scopus 로고
    • Experimental myasthenia gravis. A murine system
    • COI: 1:STN:280:DyaL3c%2FntlymtA%3D%3D, PID: 7350247
    • Berman PW, Patrick J (1980) Experimental myasthenia gravis. A murine system. J Exp Med 151:204–223
    • (1980) J Exp Med , vol.151 , pp. 204-223
    • Berman, P.W.1    Patrick, J.2
  • 106
    • 84886640605 scopus 로고
    • Acetylcholine receptor antibody-producing cells in thymus and lymph nodes in myasthenia gravis
    • COI: 1:STN:280:DyaL2M%2FnsFahtg%3D%3D, PID: 4038384
    • Fujii Y, Monden Y, Hashimoto J, Nakahara K, Kawashima Y (1985) Acetylcholine receptor antibody-producing cells in thymus and lymph nodes in myasthenia gravis. Clin Immunol Immunopathol 34:141–146
    • (1985) Clin Immunol Immunopathol , vol.34 , pp. 141-146
    • Fujii, Y.1    Monden, Y.2    Hashimoto, J.3    Nakahara, K.4    Kawashima, Y.5
  • 107
    • 2142646539 scopus 로고    scopus 로고
    • Arthritogenic properties of double-stranded (viral) RNA
    • COI: 1:CAS:528:DC%2BD2cXjt1Cktbs%3D, PID: 15100310
    • Zare F, Bokarewa M, Nenonen N, Bergstrom T, Alexopoulou L et al (2004) Arthritogenic properties of double-stranded (viral) RNA. J Immunol 172:5656–5663
    • (2004) J Immunol , vol.172 , pp. 5656-5663
    • Zare, F.1    Bokarewa, M.2    Nenonen, N.3    Bergstrom, T.4    Alexopoulou, L.5
  • 108
    • 20844439570 scopus 로고    scopus 로고
    • Early development of primary biliary cirrhosis in female C57BL/6 mice because of poly I:C administration
    • COI: 1:CAS:528:DC%2BD2MXlvFKqurs%3D, PID: 15910497
    • Okada C, Akbar SM, Horiike N, Onji M (2005) Early development of primary biliary cirrhosis in female C57BL/6 mice because of poly I:C administration. Liver Int 25:595–603
    • (2005) Liver Int , vol.25 , pp. 595-603
    • Okada, C.1    Akbar, S.M.2    Horiike, N.3    Onji, M.4
  • 109
    • 77649256624 scopus 로고    scopus 로고
    • Analysis of humoral immune response in experimental autoimmune pancreatitis in mice
    • COI: 1:CAS:528:DC%2BC3cXitlens7c%3D, PID: 19812526
    • Asada M, Nishio A, Akamatsu T, Tanaka J, Saga K et al (2010) Analysis of humoral immune response in experimental autoimmune pancreatitis in mice. Pancreas 39:224–231
    • (2010) Pancreas , vol.39 , pp. 224-231
    • Asada, M.1    Nishio, A.2    Akamatsu, T.3    Tanaka, J.4    Saga, K.5
  • 110
    • 23944497673 scopus 로고    scopus 로고
    • Viral double-stranded RNA aggravates lupus nephritis through toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells
    • COI: 1:CAS:528:DC%2BD2MXksF2gsL0%3D, PID: 15772251
    • Patole PS, Grone HJ, Segerer S, Ciubar R, Belemezova E et al (2005) Viral double-stranded RNA aggravates lupus nephritis through toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. J Am Soc Nephrol 16:1326–1338
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1326-1338
    • Patole, P.S.1    Grone, H.J.2    Segerer, S.3    Ciubar, R.4    Belemezova, E.5
  • 111
    • 33750380857 scopus 로고    scopus 로고
    • Genetic susceptibility to polyI:C-induced IFNalpha/beta-dependent accelerated disease in lupus-prone mice
    • COI: 1:CAS:528:DC%2BD28XhtFWns7nO, PID: 16900204
    • Jorgensen TN, Thurman J, Izui S, Falta MT, Metzger TE et al (2006) Genetic susceptibility to polyI:C-induced IFNalpha/beta-dependent accelerated disease in lupus-prone mice. Genes Immun 7:555–567
    • (2006) Genes Immun , vol.7 , pp. 555-567
    • Jorgensen, T.N.1    Thurman, J.2    Izui, S.3    Falta, M.T.4    Metzger, T.E.5
  • 112
    • 80054060025 scopus 로고    scopus 로고
    • Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjogren’s syndrome-like disease
    • PID: 21815968
    • Nandula SR, Scindia YM, Dey P, Bagavant H, Deshmukh US (2011) Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjogren’s syndrome-like disease. Oral Dis 17:801–807
    • (2011) Oral Dis , vol.17 , pp. 801-807
    • Nandula, S.R.1    Scindia, Y.M.2    Dey, P.3    Bagavant, H.4    Deshmukh, U.S.5
  • 113
    • 0037117454 scopus 로고    scopus 로고
    • Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide
    • COI: 1:CAS:528:DC%2BD38XjtFKlt74%3D, PID: 11943868
    • Moriyama H, Wen L, Abiru N, Liu E, Yu L et al (2002) Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc Natl Acad Sci U S A 99:5539–5544
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 5539-5544
    • Moriyama, H.1    Wen, L.2    Abiru, N.3    Liu, E.4    Yu, L.5
  • 114
    • 79955870871 scopus 로고    scopus 로고
    • Toll-like receptor 3 ligand polyinosinic:polycytidylic acid enhances autoimmune disease in a retinal autoimmunity model
    • COI: 1:CAS:528:DC%2BC3MXlvVCju78%3D, PID: 21296697
    • Ren X, Zhou H, Li B, Su SB (2011) Toll-like receptor 3 ligand polyinosinic:polycytidylic acid enhances autoimmune disease in a retinal autoimmunity model. Int Immunopharmacol 11:769–773
    • (2011) Int Immunopharmacol , vol.11 , pp. 769-773
    • Ren, X.1    Zhou, H.2    Li, B.3    Su, S.B.4
  • 115
    • 80052619577 scopus 로고    scopus 로고
    • The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis
    • COI: 1:CAS:528:DC%2BC3MXhtlSks7bE, PID: 21910728
    • Ambrosini YM, Yang GX, Zhang W, Tsuda M, Shu S et al (2011) The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis. Clin Exp Immunol 166:110–120
    • (2011) Clin Exp Immunol , vol.166 , pp. 110-120
    • Ambrosini, Y.M.1    Yang, G.X.2    Zhang, W.3    Tsuda, M.4    Shu, S.5
  • 116
    • 33751571417 scopus 로고    scopus 로고
    • Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta
    • COI: 1:CAS:528:DC%2BD28Xht1Wrs7fK, PID: 17114417
    • Touil T, Fitzgerald D, Zhang GX, Rostami A, Gran B (2006) Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta. J Immunol 177:7505–7509
    • (2006) J Immunol , vol.177 , pp. 7505-7509
    • Touil, T.1    Fitzgerald, D.2    Zhang, G.X.3    Rostami, A.4    Gran, B.5
  • 117
    • 84931264040 scopus 로고    scopus 로고
    • Induction of endogenous type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BC2MXmslOltLY%3D, PID: 25869642
    • Khorooshi R, Morch MT, Holm TH, Berg CT, Dieu RT et al (2015) Induction of endogenous type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis. Acta Neuropathol 130:107–118
    • (2015) Acta Neuropathol , vol.130 , pp. 107-118
    • Khorooshi, R.1    Morch, M.T.2    Holm, T.H.3    Berg, C.T.4    Dieu, R.T.5
  • 118
    • 77953454411 scopus 로고    scopus 로고
    • Injectable interferon beta-1b for the treatment of relapsing forms of multiple sclerosis
    • COI: 1:CAS:528:DC%2BC3cXjvFOlsrk%3D, PID: 22096354
    • Jankovic SM (2010) Injectable interferon beta-1b for the treatment of relapsing forms of multiple sclerosis. J Inflamm Res 3:25–31
    • (2010) J Inflamm Res , vol.3 , pp. 25-31
    • Jankovic, S.M.1
  • 119
    • 0016796265 scopus 로고
    • Experimental autoimmune myasthenia: a model of myasthenia gravis in rats and guinea pigs
    • COI: 1:STN:280:DyaE2M7lt1Krtg%3D%3D, PID: 1127382
    • Lennon VA, Lindstrom JM, Seybold ME (1975) Experimental autoimmune myasthenia: a model of myasthenia gravis in rats and guinea pigs. J Exp Med 141:1365–1375
    • (1975) J Exp Med , vol.141 , pp. 1365-1375
    • Lennon, V.A.1    Lindstrom, J.M.2    Seybold, M.E.3
  • 120
    • 0017145379 scopus 로고
    • Strain differences in the autoimmune response of mice to acetylcholine receptors
    • COI: 1:CAS:528:DyaE2sXltlGquw%3D%3D, PID: 1085423
    • Fuchs S, Nevo D, Tarrab-Hazdai R, Yaar I (1976) Strain differences in the autoimmune response of mice to acetylcholine receptors. Nature 263:329–330
    • (1976) Nature , vol.263 , pp. 329-330
    • Fuchs, S.1    Nevo, D.2    Tarrab-Hazdai, R.3    Yaar, I.4
  • 121
    • 0025992693 scopus 로고
    • The thymus in myasthenia gravis. Changes typical for the human disease are absent in experimental autoimmune myasthenia gravis of the Lewis rat
    • COI: 1:STN:280:DyaK38%2FlvFersw%3D%3D, PID: 1951638
    • Meinl E, Klinkert WE, Wekerle H (1991) The thymus in myasthenia gravis. Changes typical for the human disease are absent in experimental autoimmune myasthenia gravis of the Lewis rat. Am J Pathol 139:995–1008
    • (1991) Am J Pathol , vol.139 , pp. 995-1008
    • Meinl, E.1    Klinkert, W.E.2    Wekerle, H.3
  • 122
    • 0016904167 scopus 로고
    • Experimental autoimmune myasthenia gravis: cellular and humoral immune responses
    • COI: 1:CAS:528:DyaE28XkslKisLY%3D, PID: 1085587
    • Lennon VA, Lindstrom JM, Seybold ME (1976) Experimental autoimmune myasthenia gravis: cellular and humoral immune responses. Ann N Y Acad Sci 274:283–299
    • (1976) Ann N Y Acad Sci , vol.274 , pp. 283-299
    • Lennon, V.A.1    Lindstrom, J.M.2    Seybold, M.E.3
  • 123
    • 77649239326 scopus 로고    scopus 로고
    • IDO mediates TLR9-driven protection from experimental autoimmune diabetes
    • COI: 1:CAS:528:DC%2BD1MXhtlKhsbbM, PID: 19841163
    • Fallarino F, Volpi C, Zelante T, Vacca C, Calvitti M et al (2009) IDO mediates TLR9-driven protection from experimental autoimmune diabetes. J Immunol 183:6303–6312
    • (2009) J Immunol , vol.183 , pp. 6303-6312
    • Fallarino, F.1    Volpi, C.2    Zelante, T.3    Vacca, C.4    Calvitti, M.5
  • 124
    • 83055198367 scopus 로고    scopus 로고
    • Activation of the alternative NFkappaB pathway improves disease symptoms in a model of Sjogren’s syndrome
    • COI: 1:CAS:528:DC%2BC38XhtFWr, PID: 22174879
    • Gilboa-Geffen A, Wolf Y, Hanin G, Melamed-Book N, Pick M et al (2011) Activation of the alternative NFkappaB pathway improves disease symptoms in a model of Sjogren’s syndrome. PLoS One 6, e28727
    • (2011) PLoS One , vol.6
    • Gilboa-Geffen, A.1    Wolf, Y.2    Hanin, G.3    Melamed-Book, N.4    Pick, M.5
  • 125
    • 84904695842 scopus 로고    scopus 로고
    • In vivo administration of TLR9 agonist reduces the severity of experimental autoimmune encephalomyelitis. The role of plasmacytoid dendritic cells and B lymphocytes
    • COI: 1:CAS:528:DC%2BC2cXht1Smu7%2FL, PID: 24931054
    • Longhini AL, Santos MP, Pradella F, Moraes AS, Dionete AC et al (2014) In vivo administration of TLR9 agonist reduces the severity of experimental autoimmune encephalomyelitis. The role of plasmacytoid dendritic cells and B lymphocytes. CNS Neurosci Ther 20:787–790
    • (2014) CNS Neurosci Ther , vol.20 , pp. 787-790
    • Longhini, A.L.1    Santos, M.P.2    Pradella, F.3    Moraes, A.S.4    Dionete, A.C.5
  • 126
    • 43349087755 scopus 로고    scopus 로고
    • Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling
    • COI: 1:CAS:528:DC%2BD1cXjtVaqtLY%3D, PID: 18056480
    • Farhat K, Riekenberg S, Heine H, Debarry J, Lang R et al (2008) Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. J Leukoc Biol 83:692–701
    • (2008) J Leukoc Biol , vol.83 , pp. 692-701
    • Farhat, K.1    Riekenberg, S.2    Heine, H.3    Debarry, J.4    Lang, R.5
  • 128
    • 27744526784 scopus 로고    scopus 로고
    • TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements
    • COI: 1:CAS:528:DC%2BD2MXhtFKhtLrF, PID: 16105838
    • Nishiya T, Kajita E, Miwa S, Defranco AL (2005) TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J Biol Chem 280:37107–37117
    • (2005) J Biol Chem , vol.280 , pp. 37107-37117
    • Nishiya, T.1    Kajita, E.2    Miwa, S.3    Defranco, A.L.4
  • 129
    • 84894267102 scopus 로고    scopus 로고
    • Beyond dsRNA: toll-like receptor 3 signalling in RNA-induced immune responses
    • COI: 1:CAS:528:DC%2BC2cXisFSisrs%3D, PID: 24524192
    • Tatematsu M, Seya T, Matsumoto M (2014) Beyond dsRNA: toll-like receptor 3 signalling in RNA-induced immune responses. Biochem J 458:195–201
    • (2014) Biochem J , vol.458 , pp. 195-201
    • Tatematsu, M.1    Seya, T.2    Matsumoto, M.3
  • 130
    • 84918825891 scopus 로고    scopus 로고
    • Molecular and cellular regulation of toll-like receptor-4 activity induced by lipopolysaccharide ligands
    • PID: 25339952
    • Liaunardy-Jopeace A, Gay NJ (2014) Molecular and cellular regulation of toll-like receptor-4 activity induced by lipopolysaccharide ligands. Front Immunol 5:473
    • (2014) Front Immunol , vol.5 , pp. 473
    • Liaunardy-Jopeace, A.1    Gay, N.J.2
  • 131
    • 34548679608 scopus 로고    scopus 로고
    • TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system
    • COI: 1:CAS:528:DC%2BD2sXhtVChurrO, PID: 17690885
    • Miao EA, Andersen-Nissen E, Warren SE, Aderem A (2007) TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol 29:275–288
    • (2007) Semin Immunopathol , vol.29 , pp. 275-288
    • Miao, E.A.1    Andersen-Nissen, E.2    Warren, S.E.3    Aderem, A.4
  • 132
    • 84890840281 scopus 로고    scopus 로고
    • RNA recognition by human TLR8 can lead to autoimmune inflammation
    • COI: 1:CAS:528:DC%2BC3sXhvFynur3L, PID: 24277153
    • Guiducci C, Gong M, Cepika AM, Xu Z, Tripodo C et al (2013) RNA recognition by human TLR8 can lead to autoimmune inflammation. J Exp Med 210:2903–2919
    • (2013) J Exp Med , vol.210 , pp. 2903-2919
    • Guiducci, C.1    Gong, M.2    Cepika, A.M.3    Xu, Z.4    Tripodo, C.5
  • 133
    • 77954809558 scopus 로고    scopus 로고
    • Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses
    • COI: 1:CAS:528:DC%2BC3cXovVCgt7g%3D, PID: 20560798
    • Huang X, Yang Y (2010) Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses. Expert Opin Ther Targets 14:787–796
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 787-796
    • Huang, X.1    Yang, Y.2
  • 134
    • 20044368019 scopus 로고    scopus 로고
    • Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88
    • COI: 1:CAS:528:DC%2BD2MXhsFeqsbc%3D, PID: 15728506
    • Hasan U, Chaffois C, Gaillard C, Saulnier V, Merck E et al (2005) Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J Immunol 174:2942–2950
    • (2005) J Immunol , vol.174 , pp. 2942-2950
    • Hasan, U.1    Chaffois, C.2    Gaillard, C.3    Saulnier, V.4    Merck, E.5
  • 135
    • 84896277732 scopus 로고    scopus 로고
    • Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection
    • COI: 1:CAS:528:DC%2BC2cXjtlyruro%3D, PID: 24567377
    • Lee SM, Kok KH, Jaume M, Cheung TK, Yip TF et al (2014) Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection. Proc Natl Acad Sci U S A 111:3793–3798
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 3793-3798
    • Lee, S.M.1    Kok, K.H.2    Jaume, M.3    Cheung, T.K.4    Yip, T.F.5
  • 136
    • 84959237890 scopus 로고    scopus 로고
    • Toll-like receptor 11 (TLR11) interacts with flagellin and profilin through disparate mechanisms
    • PID: 26859749
    • Hatai H, Lepelley A, Zeng W, Hayden MS, Ghosh S (2016) Toll-like receptor 11 (TLR11) interacts with flagellin and profilin through disparate mechanisms. PLoS One 11, e0148987
    • (2016) PLoS One , vol.11
    • Hatai, H.1    Lepelley, A.2    Zeng, W.3    Hayden, M.S.4    Ghosh, S.5
  • 137
    • 35548929833 scopus 로고    scopus 로고
    • Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BD1cXitVWntg%3D%3D, PID: 17967728
    • Cho YG, Cho ML, Min SY, Kim HY (2007) Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis. Autoimmun Rev 7:65–70
    • (2007) Autoimmun Rev , vol.7 , pp. 65-70
    • Cho, Y.G.1    Cho, M.L.2    Min, S.Y.3    Kim, H.Y.4
  • 138
    • 79954575661 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines
    • COI: 1:CAS:528:DC%2BC3MXkvVWjsbo%3D, PID: 20850537
    • Libbey JE, Fujinami RS (2011) Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines. Vaccine 29:3356–3362
    • (2011) Vaccine , vol.29 , pp. 3356-3362
    • Libbey, J.E.1    Fujinami, R.S.2
  • 139
    • 62549120722 scopus 로고    scopus 로고
    • Role of regulatory T cells in a new mouse model of experimental autoimmune myositis
    • COI: 1:CAS:528:DC%2BD1MXjs1Wgs70%3D, PID: 19218348
    • Allenbach Y, Solly S, Gregoire S, Dubourg O, Salomon B et al (2009) Role of regulatory T cells in a new mouse model of experimental autoimmune myositis. Am J Pathol 174:989–998
    • (2009) Am J Pathol , vol.174 , pp. 989-998
    • Allenbach, Y.1    Solly, S.2    Gregoire, S.3    Dubourg, O.4    Salomon, B.5
  • 140
    • 0025014525 scopus 로고
    • Experimental autoimmune hepatitis: disease induction, time course and T-cell reactivity
    • COI: 1:STN:280:DyaK3c7gvFSguw%3D%3D, PID: 2271015
    • Lohse AW, Manns M, Dienes HP, Buschenfelde KH M z, Cohen IR (1990) Experimental autoimmune hepatitis: disease induction, time course and T-cell reactivity. Hepatology 11:24–30
    • (1990) Hepatology , vol.11 , pp. 24-30
    • Lohse, A.W.1    Manns, M.2    Dienes, H.P.3    Buschenfelde, M.4    Cohen, I.R.5
  • 141
    • 0033809989 scopus 로고    scopus 로고
    • Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy
    • COI: 1:STN:280:DC%2BD3M7js1Khsw%3D%3D, PID: 11092252
    • Jones DE, Palmer JM, Kirby JA, De Cruz DJ, McCaughan GW et al (2000) Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy. Liver 20:351–356
    • (2000) Liver , vol.20 , pp. 351-356
    • Jones, D.E.1    Palmer, J.M.2    Kirby, J.A.3    De Cruz, D.J.4    McCaughan, G.W.5
  • 142
    • 65349134088 scopus 로고    scopus 로고
    • Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis
    • COI: 1:CAS:528:DC%2BD1MXksVOktr4%3D, PID: 19264905
    • Little MA, Smyth L, Salama AD, Mukherjee S, Smith J et al (2009) Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis. Am J Pathol 174:1212–1220
    • (2009) Am J Pathol , vol.174 , pp. 1212-1220
    • Little, M.A.1    Smyth, L.2    Salama, A.D.3    Mukherjee, S.4    Smith, J.5
  • 143
    • 0036095703 scopus 로고    scopus 로고
    • Immunization of naive BALB/c mice with human beta2-glycoprotein I breaks tolerance to the murine molecule
    • COI: 1:CAS:528:DC%2BD38XksVynsLc%3D, PID: 12115248
    • Tincani A, Gilburd B, Abu-Shakra M, Blank M, Allegri F et al (2002) Immunization of naive BALB/c mice with human beta2-glycoprotein I breaks tolerance to the murine molecule. Arthritis Rheum 46:1399–1404
    • (2002) Arthritis Rheum , vol.46 , pp. 1399-1404
    • Tincani, A.1    Gilburd, B.2    Abu-Shakra, M.3    Blank, M.4    Allegri, F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.