Mice with IFN-γ receptor deficiency are less susceptible to experimental autoimmune myasthenia gravis

Journal of Immunology

Volumn 162, Issue 7, 1999, Pages 3775-3781

  Zhang, Guang Xian ^a,d   Xiao, Bao Guo ^a   Bai, Xue Feng ^a   Van Der Meide, Peter H ^b   Örn, Anders ^c   Link, Hans ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR; GAMMA INTERFERON RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ARTICLE; DISEASE PREDISPOSITION; FEEDBACK SYSTEM; HUMORAL IMMUNITY; IMMUNOREGULATION; MOUSE; MYASTHENIA GRAVIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; TORPEDO;

ANIMALS; ANTIBODY AFFINITY; CELLS, CULTURED; CYTOKINES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; IMMUNE SERA; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MUSCLE WEAKNESS; MYASTHENIA GRAVIS; RECEPTORS, CHOLINERGIC; RECEPTORS, INTERFERON; RNA, MESSENGER;

EID: 0033120962     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Lindstrom, J., D. Shelton, and Y. Fujii. 1988. Myasthenia gravis. Adv. Immunol. 42:233.
2. Drachman, D. 1994. Myasthenia gravis. N. Engl. J. Med. 330:1797.
3. Asthana, D., Y. Fujii, G Huston, and J. Lindstrom. 1993. Regulation of antibody production by helper T cell clones in experimental autoimmune myasthenia gravis is mediated by IL-4 and antigen-specific T cell factors. Clin. Immunol. Immunopathol. 67:240.
4. Link, H., O. Olsson, J. B. Sun, W. Z. Wang, G. Andersson, H. P. Ekre, T. Brenner, O. Abramsky, and T. Olsson. 1991. Acetylcholine receptor reactive T and B cells in myasthenia gravis and controls. J. Clin. Invest. 87:2191.
5. Emilie, D., M. C. Crevon, S. Cohen-Kaminsky, M. Peuchmaur, O. Devergne, S. Berrih-Aknin, and P. Galanaud. 1991. In situ production of interleukins in hyperplastic thymus from myasthenia gravis patients. Hum. Pathol. 22:461.
6. Link, J., M. Söderström, A. Ljungdahl, B. Höjebere, T. Olsson, Z. Xu, S. Fredrikson, Z. Y. Wang, and H. Link. 1994. Organ-specific autoantigens induce IFN-γ and IL-4 mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis. Neurology 44:728.
7. + T cells are essential to induce experimental autoimmune myasthenia gravis. J. Exp. Med. 184:349.
8. Cohen-Kaminsky, S., O. Devergne, R. M. Delattre, I. Klingel-Schmitt, D. Emilie, P. Galanaud, and S. Berrih-Aknin. 1993. Interleukin-6 overproduction by cultured thymic epithelial cells from patients with myasthenia gravis is potentially involved in thymic hyperplasia. Eur. Cytokine Network 4:121.
9. Zhang, G. X., L. Y. Yu, B. G. Xiao, and H. Link. 1996. Enhancement of experimental autoimmune myasthenia gravis by rhIL-10 is associated with B cell hyperreactivity. Fourth International Conference on Cytokines. Florence, Italy, p. 111 (Abstr.).
10. Link, J., B. He, V. Navikas, S. Fredrikson, and H. Link. 1995. Transforming growth factor-β1 suppresses autoantigen-induced expression of pro-inflammatory cytokines but not interleukin-10 in multiple sclerosis and myasthenia gravis. J. Neuroimmunol. 58:21.
11. Deng, C., E. Goluszko, S. Baron, B. Wu, and P. Christadoss. 1996. IFN-α therapy is effective in suppressing the clinical experimental myasthenia gravis. J Immunol. 157:5675.
12. Billiau, A. 1996. Interferon-γ in autoimmunity. Cytokine Growth Factor Rev. 7:25.
13. Ferber, I. A., S. Brocke, C. Taylor-Edwards, W. Ridgway, C. Dinisco, L. Steinman, D. Dalton, and C. G. Fathman. 1996. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental allergic encephalomyelitis (EAE). J. Immunol. 156:5.
14. Huang, S., W. Hendriks, A. Althage, S., Hemmi, H. Bluethmann, R. Kamijo. J. Vilcek, R. M. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-γ receptor. Science 259:1742.
15. Lindstrom, J., B. Einarson, and S. Tzartos. 1981. Production and assay of antibodies to acetylcholine receptors. Methods Enzymol. 74:432.
16. Berman, P. W., and J. Patrick. 1980. Experimental myasthenia gravis: a murine system. J. Exp. Med. 151:204.
17. Pullen, G. R., M. G. Fitzgerald, and C. S. Hosking. 1986. Antibody avidity determination by ELISA using thiocyanate elution. J. Immunol. Methods 86:83.
18. Bai, X. F., J. Zhu, G. X. Zhang, G. Kaponides, B. Höjeberg, P. H. van de Meide, and H. Link. 1997. IL-10 suppresses experimental autoimmune neuritis and down-regulates Th1-type immune response. Clin. Immunol. Immunopathol. 83: 117.
19. Wolf, E., R. Wanke, E. Schenck, W. Hermanns, and G. Brem. 1995. Effects of growth hormone overproduction on grip strength of transgenic mice. Eur. J. Endocrinol. 133:735.
20. Marzo, A. L., M. J. Garlepp, M. Schon-Hegrad, and R. L. Dawkins, 1986. Susceptibility to murine experimental autoallergic myasthenia gravis: the role of antibody specificity. Clin. Exp. Immunol. 64:101.
21. Lindstrom, J. M., A. G. Angel, M. E. Seybold, V. Lenon, and E. H. Lambert 1976. Pathological mechanisms in experimental autoimmune myasthenia gravis. II. Passive transfer of experimental autoimmune myasthenia gravis in rats with anti-acetylcholine receptor antibodies. J. Exp. Med. 144:739.
22. Dijkema, R., P. H. van der Meide, M. Dubbeld, J. Wubben, and H. Schellekens, 1986. Cloning, expression and purification of rat IFN-γ. Methods Enzymol. 119: 453.
23. Shirai, T., N. Shimizu, S. Horiguchi, and H. Ito. 1989. Rat TNF alpha. Agric. Biol. Chem. 53:1733.
24. + T cells. Eur. J. Immunol. 21:1187.
25. Moore, K. W., P. Vieia, D. F. Fiorentino, M. L. Trounsteine, T. A. Khan, and T. R. Mosmann. 1990. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science 248:1230.
26. Derynck, R., J. A. Jarret, E. Y. Chen, D. H. Eaton, I. R. Bell, R. K. Assoian, A. B. Roberts, M. B. Spon, and D. V. Goeddel. 1985. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature 316:701.
27. Toyka, K. V., D. B. Drachman, A. Pestronk, and I. Kao. 1975. Myasthenia gravis: passive transfer from man to mouse. Science 190:397.
28. Schattner, A. 1994. Lymphokines in autoimmunity: a critical review. Clin. Immunol. Immunopathol. 70:177.
29. Wang, Z. Y., H. Link, and W. X. Huang. 1993. T-cell immunity to acetylcholine receptor and its subunits in Lewis rats over the course of experimental autoimmune myasthenia gravis. Scand. J. Immunol. 37:615.
30. Hohlfeld, R., K. V. Toyko, S. J. Tzartos, W. Carson, and B. M. Conti-Tronconi. 1987. Human T helper lymphocytes in myasthenia gravis recognize the nicotinic receptor subunit. Proc. Natl. Acad. Sci. USA 84:5379.
31. Ma, C. G., G. X. Zhang, B. G. Xiao, and H. Link. 1996. Cellular mRNA expression of IFN-γ, IL-4 and TGF-β in rats nasally tolerized against experimental autoimmune myasthenia gravis (EAMG). Clin. Exp. Immunol. 104:509.
32. von Herrath, M. G., and M. B. A. Oldstone, 1997. Interferon-γ is essential for destruction of β cells and development of insulin-dependent diabetes mellitus. J. Exp. Med. 185:531.
33. Kageyama, Y., Y. Koide, A. Yoshida, M. Uchijima, T. Arai, S. Miyamoto, T. Ozeki, M. Hiyoshi, K. Kushida, and T. Inoue. 1998. Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-γ receptor. J. Immunol. 161: 1542.
34. Brown, R. M., and K. A. Krolick. 1988. Clonotypic analysis of the antibody response to the acetylcholine receptor in experimental autoimmune myasthenia gravis. J. Neuroimmunol. 19:205.
35. Sidman, C. L., J. D. Marshall, L. D. Shultz, P. W. Gray, and H. M. Johnson. 1984. γ-Interferon is one of several direct B cell-maturing lymphokines. Nature 309: 801.
36. Snapper, C. M., and J. J. Mond. 1993. Towards a comprehensive view of immunoglobulin class switching. Immunol. Today 14:15.
37. Gu, D., L. Wogensen, N. A. Calcutt, C. Xia, S. Zhu, J. P. Merlie, H. S. Fox, J. Lindstrom, H. C. Powell, and N. Sarvetnick. 1995. Myasthenia gravis-like syndrome induced by expression of interferon-γ in the neuromuscular junction. J. Exp. Med. 181:547.
38. Rizzo, L. V., R. H. DeKruyff, and D. T. Umetsu 1992. Generation of B cell memory and affinity maturation: induction with Th1 and Th2 T cell clones. J. Immunol. 148:3733.
39. Coyle, A. J., S. Tsuyuki, C. Bertrand, S. Huang, M. Aguet, S. S. Alkan, and G. P. Anderson. 1996. Mice lacking the IFN-γ receptor have an impaired ability to resolve a lung cosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile. J. Immunol. 156:2680.
40. Mosmann, T. R. and S. Sad. 1996. The expanding universe of T cell subsets: Th1, Th2 and more. Immunol. Today 17:138.
41. Skoskiewicz, M. H., R. B. Callin, E. E. Sternberger, and P. S. Russel. 1985. Widespread and selective induction of major histocompatibility complex determined antigens in vivo by interferon. J. Exp. Med. 162:1645.
42. Adams, D. O., and T. A. Hamilton. 1987. Molecular transductional mechanisms by which IFN-γ and other signals regulate macrophage development. Immunol. Rev. 97:5.
43. Collart, M. A., J. Belin, D. Vassalli, S. de Kossodo, and P. Vassalli. 1986. γ-Interferon enhances macrophage transcription of the tumor necrosis factor/cachetin, interleukin-1, and urokinase genes, which are controlled by short-lived repressors. J. Exp. Med. 164:2113.
44. Marfaing-Koka, A., O. Devergne, G. Gorgone, A. Portier, T. J. Schall, P. Galanaud, and D. Emilie. 1995. Regulation of the production of the RANTES chemokine by endothelial cells. J. Immunol. 154:1870.
45. Engel, A. G., M. Tsujihata, J. Lindstrom, and V. A. Lennon. 1976. The motor end plates in myasthenia gravis and experimental autoimmune myasthenia gravis: a quantitative ultrastructure study. Ann. NY Acad. Sci. 274:60.
46. Aime, C., S. Cohen-Kaminsky, and S. Berrih-Aknin. 1991. In vitro interleukin-1 production in thymic hyperplasia and thymoma from patients with myasthenia gravis. J. Clin. Immunol. 11:268.
47. Ahlberg, R. E., R. Pirskanen, and A. K. Lefvert. 1991. Defective T lymphocyte function in nonthymectomized patients with myasthenia gravis. Clin. Immunol. Immunopathol. 60:93.
48. Zhang, G. X., L. Y. Yu, F. D. Shi, B. G. Xiao, J. Bjȯrk, G. Hedlund, and H. Link. 1997. Linomide suppresses both Th1 and Th2 cytokines in experimental autoimmune myasthenia gravis. J. Neuroimmunol. 73:175.
49. Jelinek, D. F., and P. E. Lipsky. 1987. Enhancement of human B cell proliferation and differentiation by tumor necrosis factor α and interleukin 1. J. Immunol. 139:2970.
50. Lanzavecchia, A. 1985. Antigen-specific interaction between T and B cells. Naure 309:801.
51. Balasa, B., C. Deng, J. Lee, L. M. Bradley, D. K. Dalton, P. Christadoss, and N. Sarvetnick. 1997. Interferon γ (IFN-γ) is necessary for the genesis of acetylcholine-induced clinical experimental autoimmune myasthenia gravis in mice. J. Exp. Med. 186:385.
52. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon γ gene. Science 259:1739.