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Volumn 52, Issue , 2014, Pages 74-89

Innate immunity in myasthenia gravis thymus: Pathogenic effects of Toll-like receptor 4 signaling on autoimmunity

Author keywords

Chemokines; Dendritic cells; Myasthenia gravis; Regulatory T cells; Thymus; TLR4

Indexed keywords

CHEMOKINE RECEPTOR CCR4; CHOLINERGIC RECEPTOR; CHOLINESTERASE INHIBITOR; CORTICOSTEROID; CYTOKINE; IMMUNOSUPPRESSIVE AGENT; MACROPHAGE DERIVED CHEMOKINE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TOLL LIKE RECEPTOR 4;

EID: 84904339949     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2013.12.013     Document Type: Article
Times cited : (60)

References (68)
  • 2
    • 84879188812 scopus 로고    scopus 로고
    • The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes
    • Marx A., Pfister F., Schalke B., Saruhan-Direskeneli G., Melms A., Strobel P. The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes. Autoimmun Rev 2013, 12:875-884.
    • (2013) Autoimmun Rev , vol.12 , pp. 875-884
    • Marx, A.1    Pfister, F.2    Schalke, B.3    Saruhan-Direskeneli, G.4    Melms, A.5    Strobel, P.6
  • 4
    • 21244469489 scopus 로고    scopus 로고
    • Increased toll-like receptor 4 expression in thymus of myasthenic patients with thymitis and thymic involution
    • Bernasconi P., Barberis M., Baggi F., Passerini L., Cannone M., Arnoldi E., et al. Increased toll-like receptor 4 expression in thymus of myasthenic patients with thymitis and thymic involution. Am J Pathol 2005, 167:129-139.
    • (2005) Am J Pathol , vol.167 , pp. 129-139
    • Bernasconi, P.1    Barberis, M.2    Baggi, F.3    Passerini, L.4    Cannone, M.5    Arnoldi, E.6
  • 5
    • 84884211312 scopus 로고    scopus 로고
    • Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis
    • Cufi P., Dragin N., Weiss J.M., Martinez-Martinez P., De Baets M.H., Roussin R., et al. Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis. Ann Neurol 2013, 73:281-293.
    • (2013) Ann Neurol , vol.73 , pp. 281-293
    • Cufi, P.1    Dragin, N.2    Weiss, J.M.3    Martinez-Martinez, P.4    De Baets, M.H.5    Roussin, R.6
  • 7
    • 5944261457 scopus 로고    scopus 로고
    • Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
    • Kurt-Jones E.A., Popova L., Kwinn L., Haynes L.M., Jones L.P., Tripp R.A., et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000, 1:398-401.
    • (2000) Nat Immunol , vol.1 , pp. 398-401
    • Kurt-Jones, E.A.1    Popova, L.2    Kwinn, L.3    Haynes, L.M.4    Jones, L.P.5    Tripp, R.A.6
  • 8
    • 77950988479 scopus 로고    scopus 로고
    • Detection of poliovirus-infected macrophages in thymus of patients with myasthenia gravis
    • Cavalcante P., Barberis M., Cannone M., Baggi F., Antozzi C., Maggi L., et al. Detection of poliovirus-infected macrophages in thymus of patients with myasthenia gravis. Neurology 2010, 74:1118-1126.
    • (2010) Neurology , vol.74 , pp. 1118-1126
    • Cavalcante, P.1    Barberis, M.2    Cannone, M.3    Baggi, F.4    Antozzi, C.5    Maggi, L.6
  • 10
    • 0031764104 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
    • Sallusto F., Lanzavecchia A., Mackay C.R. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today 1998, 19:568-574.
    • (1998) Immunol Today , vol.19 , pp. 568-574
    • Sallusto, F.1    Lanzavecchia, A.2    Mackay, C.R.3
  • 11
    • 0032908743 scopus 로고    scopus 로고
    • Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine
    • Imai T., Nagira M., Takagi S., Kakizaki M., Nishimura M., Wang J., et al. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol 1999, 11:81-88.
    • (1999) Int Immunol , vol.11 , pp. 81-88
    • Imai, T.1    Nagira, M.2    Takagi, S.3    Kakizaki, M.4    Nishimura, M.5    Wang, J.6
  • 12
    • 0035086113 scopus 로고    scopus 로고
    • Dendritic cells as a major source of macrophage-derived chemokine/CCL22 invitro and invivo
    • Vulcano M., Albanesi C., Stoppacciaro A., Bagnati R., D'Amico G., Struyf S., et al. Dendritic cells as a major source of macrophage-derived chemokine/CCL22 invitro and invivo. Eur J Immunol 2001, 31:812-822.
    • (2001) Eur J Immunol , vol.31 , pp. 812-822
    • Vulcano, M.1    Albanesi, C.2    Stoppacciaro, A.3    Bagnati, R.4    D'Amico, G.5    Struyf, S.6
  • 13
    • 0036927106 scopus 로고    scopus 로고
    • Differential migration behavior and chemokine production by myeloid and plasmacytoid dendritic cells
    • Penna G., Vulcano M., Sozzani S., Adorini L. Differential migration behavior and chemokine production by myeloid and plasmacytoid dendritic cells. Hum Immunol 2002, 63:1164-1171.
    • (2002) Hum Immunol , vol.63 , pp. 1164-1171
    • Penna, G.1    Vulcano, M.2    Sozzani, S.3    Adorini, L.4
  • 14
    • 0030987778 scopus 로고    scopus 로고
    • The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4
    • Imai T., Baba M., Nishimura M., Kakizaki M., Takagi S., Yoshie O. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. JBiol Chem 1997, 272:15036-15042.
    • (1997) JBiol Chem , vol.272 , pp. 15036-15042
    • Imai, T.1    Baba, M.2    Nishimura, M.3    Kakizaki, M.4    Takagi, S.5    Yoshie, O.6
  • 15
    • 0031893264 scopus 로고    scopus 로고
    • Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4
    • Imai T., Chantry D., Raport C.J., Wood C.L., Nishimura M., Godiska R., et al. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. JBiol Chem 1998, 273:1764-1768.
    • (1998) JBiol Chem , vol.273 , pp. 1764-1768
    • Imai, T.1    Chantry, D.2    Raport, C.J.3    Wood, C.L.4    Nishimura, M.5    Godiska, R.6
  • 16
    • 34250321683 scopus 로고    scopus 로고
    • CCR4-dependent regulatory T cell function in inflammatory bowel disease
    • Yuan Q., Bromley S.K., Means T.K., Jones K.J., Hayashi F., Bhan A.K., et al. CCR4-dependent regulatory T cell function in inflammatory bowel disease. JExp Med 2007, 204:1327-1334.
    • (2007) JExp Med , vol.204 , pp. 1327-1334
    • Yuan, Q.1    Bromley, S.K.2    Means, T.K.3    Jones, K.J.4    Hayashi, F.5    Bhan, A.K.6
  • 18
    • 33644833492 scopus 로고    scopus 로고
    • Roles of chemokines in thymopoiesis: redundancy and regulation
    • Fu W., Chen W. Roles of chemokines in thymopoiesis: redundancy and regulation. Cell Mol Immunol 2004, 1:266-273.
    • (2004) Cell Mol Immunol , vol.1 , pp. 266-273
    • Fu, W.1    Chen, W.2
  • 19
    • 84864833865 scopus 로고    scopus 로고
    • Th17 response and inflammatory autoimmune diseases
    • Waite J.C., Skokos D. Th17 response and inflammatory autoimmune diseases. Int J Inflam 2012, 2012:819467.
    • (2012) Int J Inflam , vol.2012 , pp. 819467
    • Waite, J.C.1    Skokos, D.2
  • 20
    • 84858800607 scopus 로고    scopus 로고
    • Acetylcholine receptor-induced experimental myasthenia gravis: what have we learned from animal models after three decades?
    • Baggi F., Antozzi C., Toscani C., Cordiglieri C. Acetylcholine receptor-induced experimental myasthenia gravis: what have we learned from animal models after three decades?. Arch Immunol Ther Exp (Warsz) 2012, 60:19-30.
    • (2012) Arch Immunol Ther Exp (Warsz) , vol.60 , pp. 19-30
    • Baggi, F.1    Antozzi, C.2    Toscani, C.3    Cordiglieri, C.4
  • 21
    • 0842300349 scopus 로고    scopus 로고
    • Breakdown of tolerance to a self-peptide of acetylcholine receptor alpha-subunit induces experimental myasthenia gravis in rats
    • Baggi F., Annoni A., Ubiali F., Milani M., Longhi R., Scaioli W., et al. Breakdown of tolerance to a self-peptide of acetylcholine receptor alpha-subunit induces experimental myasthenia gravis in rats. JImmunol 2004, 172:2697-2703.
    • (2004) JImmunol , vol.172 , pp. 2697-2703
    • Baggi, F.1    Annoni, A.2    Ubiali, F.3    Milani, M.4    Longhi, R.5    Scaioli, W.6
  • 23
    • 33745041451 scopus 로고    scopus 로고
    • Acyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
    • Macagno A., Molteni M., Rinaldi A., Bertoni F., Lanzavecchia A., Rossetti C., et al. Acyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. JExp Med 2006, 203:1481-1492.
    • (2006) JExp Med , vol.203 , pp. 1481-1492
    • Macagno, A.1    Molteni, M.2    Rinaldi, A.3    Bertoni, F.4    Lanzavecchia, A.5    Rossetti, C.6
  • 24
  • 25
    • 0344780200 scopus 로고    scopus 로고
    • Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses
    • Flugel A., Willem M., Berkowicz T., Wekerle H. Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nat Med 1999, 5:843-847.
    • (1999) Nat Med , vol.5 , pp. 843-847
    • Flugel, A.1    Willem, M.2    Berkowicz, T.3    Wekerle, H.4
  • 26
    • 22344453196 scopus 로고    scopus 로고
    • Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion
    • Kawakami N., Nagerl U.V., Odoardi F., Bonhoeffer T., Wekerle H., Flugel A. Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. JExp Med 2005, 201:1805-1814.
    • (2005) JExp Med , vol.201 , pp. 1805-1814
    • Kawakami, N.1    Nagerl, U.V.2    Odoardi, F.3    Bonhoeffer, T.4    Wekerle, H.5    Flugel, A.6
  • 27
    • 77954382081 scopus 로고    scopus 로고
    • Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system
    • Cordiglieri C., Odoardi F., Zhang B., Nebel M., Kawakami N., Klinkert W.E., et al. Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain 2010, 133:1930-1943.
    • (2010) Brain , vol.133 , pp. 1930-1943
    • Cordiglieri, C.1    Odoardi, F.2    Zhang, B.3    Nebel, M.4    Kawakami, N.5    Klinkert, W.E.6
  • 28
    • 1842581667 scopus 로고    scopus 로고
    • Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells
    • Parker L.C., Whyte M.K., Vogel S.N., Dower S.K., Sabroe I. Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells. JImmunol 2004, 172:4977-4986.
    • (2004) JImmunol , vol.172 , pp. 4977-4986
    • Parker, L.C.1    Whyte, M.K.2    Vogel, S.N.3    Dower, S.K.4    Sabroe, I.5
  • 29
    • 0742323358 scopus 로고    scopus 로고
    • Tcell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node
    • Miller M.J., Hejazi A.S., Wei S.H., Cahalan M.D., Parker I. Tcell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc Natl Acad Sci U S A 2004, 101:998-1003.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 998-1003
    • Miller, M.J.1    Hejazi, A.S.2    Wei, S.H.3    Cahalan, M.D.4    Parker, I.5
  • 30
    • 5444229324 scopus 로고    scopus 로고
    • Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes
    • Miller M.J., Safrina O., Parker I., Cahalan M.D. Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. JExp Med 2004, 200:847-856.
    • (2004) JExp Med , vol.200 , pp. 847-856
    • Miller, M.J.1    Safrina, O.2    Parker, I.3    Cahalan, M.D.4
  • 31
    • 33645067654 scopus 로고    scopus 로고
    • Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells invivo
    • Tadokoro C.E., Shakhar G., Shen S., Ding Y., Lino A.C., Maraver A., et al. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells invivo. JExp Med 2006, 203:505-511.
    • (2006) JExp Med , vol.203 , pp. 505-511
    • Tadokoro, C.E.1    Shakhar, G.2    Shen, S.3    Ding, Y.4    Lino, A.C.5    Maraver, A.6
  • 32
    • 84883639103 scopus 로고    scopus 로고
    • Antigen-specific suppression and immunological synapse formation by regulatory T cells require the mst1 kinase
    • Tomiyama T., Ueda Y., Katakai T., Kondo N., Okazaki K., Kinashi T. Antigen-specific suppression and immunological synapse formation by regulatory T cells require the mst1 kinase. PLoS One 2013, 8:e73874.
    • (2013) PLoS One , vol.8
    • Tomiyama, T.1    Ueda, Y.2    Katakai, T.3    Kondo, N.4    Okazaki, K.5    Kinashi, T.6
  • 33
    • 0035005143 scopus 로고    scopus 로고
    • Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis
    • Flugel A., Berkowicz T., Ritter T., Labeur M., Jenne D.E., Li Z., et al. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Immunity 2001, 14:547-560.
    • (2001) Immunity , vol.14 , pp. 547-560
    • Flugel, A.1    Berkowicz, T.2    Ritter, T.3    Labeur, M.4    Jenne, D.E.5    Li, Z.6
  • 34
    • 84883804068 scopus 로고    scopus 로고
    • Autoimmune myasthenia gravis: autoantibody mechanisms and new developments on immune regulation
    • Le Panse R., Berrih-Aknin S. Autoimmune myasthenia gravis: autoantibody mechanisms and new developments on immune regulation. Curr Opin Neurol 2013, 26:569-576.
    • (2013) Curr Opin Neurol , vol.26 , pp. 569-576
    • Le Panse, R.1    Berrih-Aknin, S.2
  • 36
    • 84873196393 scopus 로고    scopus 로고
    • SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients
    • Weiss J.M., Cufi P., Bismuth J., Eymard B., Fadel E., Berrih-Aknin S., et al. SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients. Immunobiology 2013, 218:373-381.
    • (2013) Immunobiology , vol.218 , pp. 373-381
    • Weiss, J.M.1    Cufi, P.2    Bismuth, J.3    Eymard, B.4    Fadel, E.5    Berrih-Aknin, S.6
  • 37
    • 40449111457 scopus 로고    scopus 로고
    • Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells
    • Lim H.W., Lee J., Hillsamer P., Kim C.H. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. JImmunol 2008, 180:122-129.
    • (2008) JImmunol , vol.180 , pp. 122-129
    • Lim, H.W.1    Lee, J.2    Hillsamer, P.3    Kim, C.H.4
  • 38
    • 84857938454 scopus 로고    scopus 로고
    • CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells
    • Poppensieker K., Otte D.M., Schurmann B., Limmer A., Dresing P., Drews E., et al. CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells. Proc Natl Acad Sci U S A 2012, 109:3897-3902.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3897-3902
    • Poppensieker, K.1    Otte, D.M.2    Schurmann, B.3    Limmer, A.4    Dresing, P.5    Drews, E.6
  • 40
    • 71649111435 scopus 로고    scopus 로고
    • Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis
    • Flytlie H.A., Hvid M., Lindgreen E., Kofod-Olsen E., Petersen E.L., Jorgensen A., et al. Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis. Cytokine 2010, 49:24-29.
    • (2010) Cytokine , vol.49 , pp. 24-29
    • Flytlie, H.A.1    Hvid, M.2    Lindgreen, E.3    Kofod-Olsen, E.4    Petersen, E.L.5    Jorgensen, A.6
  • 42
    • 24144480562 scopus 로고    scopus 로고
    • Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
    • Watanabe N., Wang Y.H., Lee H.K., Ito T., Wang Y.H., Cao W., et al. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature 2005, 436:1181-1185.
    • (2005) Nature , vol.436 , pp. 1181-1185
    • Watanabe, N.1    Wang, Y.H.2    Lee, H.K.3    Ito, T.4    Wang, Y.H.5    Cao, W.6
  • 43
    • 0035500756 scopus 로고    scopus 로고
    • Cutting edge: CCR4 mediates antigen-primed T cell binding to activated dendritic cells
    • Wu M., Fang H., Hwang S.T. Cutting edge: CCR4 mediates antigen-primed T cell binding to activated dendritic cells. JImmunol 2001, 167:4791-4795.
    • (2001) JImmunol , vol.167 , pp. 4791-4795
    • Wu, M.1    Fang, H.2    Hwang, S.T.3
  • 44
    • 58849163200 scopus 로고    scopus 로고
    • IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17
    • Henry C.J., Ornelles D.A., Mitchell L.M., Brzoza-Lewis K.L., Hiltbold E.M. IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. JImmunol 2008, 181:8576-8584.
    • (2008) JImmunol , vol.181 , pp. 8576-8584
    • Henry, C.J.1    Ornelles, D.A.2    Mitchell, L.M.3    Brzoza-Lewis, K.L.4    Hiltbold, E.M.5
  • 45
    • 77949388453 scopus 로고    scopus 로고
    • Undiminished regulatory T cells in the thymus of patients with myasthenia gravis
    • Matsui N., Nakane S., Saito F., Ohigashi I., Nakagawa Y., Kurobe H., et al. Undiminished regulatory T cells in the thymus of patients with myasthenia gravis. Neurology 2010, 74:816-820.
    • (2010) Neurology , vol.74 , pp. 816-820
    • Matsui, N.1    Nakane, S.2    Saito, F.3    Ohigashi, I.4    Nakagawa, Y.5    Kurobe, H.6
  • 46
  • 48
    • 77954143695 scopus 로고    scopus 로고
    • Innate IL-17-producing cells: the sentinels of the immune system
    • Cua D.J., Tato C.M. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 2010, 10:479-489.
    • (2010) Nat Rev Immunol , vol.10 , pp. 479-489
    • Cua, D.J.1    Tato, C.M.2
  • 50
    • 0030587964 scopus 로고    scopus 로고
    • Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis
    • Wakkach A., Guyon T., Bruand C., Tzartos S., Cohen-Kaminsky S., Berrih-Aknin S. Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis. JImmunol 1996, 157:3752-3760.
    • (1996) JImmunol , vol.157 , pp. 3752-3760
    • Wakkach, A.1    Guyon, T.2    Bruand, C.3    Tzartos, S.4    Cohen-Kaminsky, S.5    Berrih-Aknin, S.6
  • 51
    • 0023189057 scopus 로고
    • Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study
    • Schluep M., Willcox N., Vincent A., Dhoot G.K., Newsom-Davis J. Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study. Ann Neurol 1987, 22:212-222.
    • (1987) Ann Neurol , vol.22 , pp. 212-222
    • Schluep, M.1    Willcox, N.2    Vincent, A.3    Dhoot, G.K.4    Newsom-Davis, J.5
  • 52
    • 51649116293 scopus 로고    scopus 로고
    • The myasthenia gravis thymus: a rare source of human autoantibody-secreting plasma cells for testing potential therapeutics
    • Hill M.E., Shiono H., Newsom-Davis J., Willcox N. The myasthenia gravis thymus: a rare source of human autoantibody-secreting plasma cells for testing potential therapeutics. JNeuroimmunol 2008, 201-202:50-56.
    • (2008) JNeuroimmunol , pp. 50-56
    • Hill, M.E.1    Shiono, H.2    Newsom-Davis, J.3    Willcox, N.4
  • 53
    • 0023841883 scopus 로고
    • Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients
    • Melms A., Schalke B.C., Kirchner T., Muller-Hermelink H.K., Albert E., Wekerle H. Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients. JClin Invest 1988, 81:902-908.
    • (1988) JClin Invest , vol.81 , pp. 902-908
    • Melms, A.1    Schalke, B.C.2    Kirchner, T.3    Muller-Hermelink, H.K.4    Albert, E.5    Wekerle, H.6
  • 54
    • 2442606191 scopus 로고    scopus 로고
    • Lymphocyte trafficking across high endothelial venules: dogmas and enigmas
    • Miyasaka M., Tanaka T. Lymphocyte trafficking across high endothelial venules: dogmas and enigmas. Nat Rev Immunol 2004, 4:360-370.
    • (2004) Nat Rev Immunol , vol.4 , pp. 360-370
    • Miyasaka, M.1    Tanaka, T.2
  • 55
    • 84862976472 scopus 로고    scopus 로고
    • Adecade of imaging cellular motility and interaction dynamics in the immune system
    • Germain R.N., Robey E.A., Cahalan M.D. Adecade of imaging cellular motility and interaction dynamics in the immune system. Science 2012, 336:1676-1681.
    • (2012) Science , vol.336 , pp. 1676-1681
    • Germain, R.N.1    Robey, E.A.2    Cahalan, M.D.3
  • 56
    • 0037036142 scopus 로고    scopus 로고
    • Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
    • Miller M.J., Wei S.H., Parker I., Cahalan M.D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 2002, 296:1869-1873.
    • (2002) Science , vol.296 , pp. 1869-1873
    • Miller, M.J.1    Wei, S.H.2    Parker, I.3    Cahalan, M.D.4
  • 57
    • 0037036114 scopus 로고    scopus 로고
    • Dynamic imaging of T cell-dendritic cell interactions in lymph nodes
    • Stoll S., Delon J., Brotz T.M., Germain R.N. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 2002, 296:1873-1876.
    • (2002) Science , vol.296 , pp. 1873-1876
    • Stoll, S.1    Delon, J.2    Brotz, T.M.3    Germain, R.N.4
  • 58
    • 33745133006 scopus 로고    scopus 로고
    • Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells
    • Qi H., Egen J.G., Huang A.Y., Germain R.N. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 2006, 312:1672-1676.
    • (2006) Science , vol.312 , pp. 1672-1676
    • Qi, H.1    Egen, J.G.2    Huang, A.Y.3    Germain, R.N.4
  • 59
    • 68649115555 scopus 로고    scopus 로고
    • Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node
    • Chtanova T., Han S.J., Schaeffer M., van Dooren G.G., Herzmark P., Striepen B., et al. Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node. Immunity 2009, 31:342-355.
    • (2009) Immunity , vol.31 , pp. 342-355
    • Chtanova, T.1    Han, S.J.2    Schaeffer, M.3    van Dooren, G.G.4    Herzmark, P.5    Striepen, B.6
  • 60
    • 70449106029 scopus 로고    scopus 로고
    • Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
    • Bartholomaus I., Kawakami N., Odoardi F., Schlager C., Miljkovic D., Ellwart J.W., et al. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 2009, 462:94-98.
    • (2009) Nature , vol.462 , pp. 94-98
    • Bartholomaus, I.1    Kawakami, N.2    Odoardi, F.3    Schlager, C.4    Miljkovic, D.5    Ellwart, J.W.6
  • 61
    • 84880284892 scopus 로고    scopus 로고
    • Acombination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity
    • Lodygin D., Odoardi F., Schlager C., Korner H., Kitz A., Nosov M., et al. Acombination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity. Nat Med 2013, 19:784-790.
    • (2013) Nat Med , vol.19 , pp. 784-790
    • Lodygin, D.1    Odoardi, F.2    Schlager, C.3    Korner, H.4    Kitz, A.5    Nosov, M.6
  • 62
    • 84891338087 scopus 로고    scopus 로고
    • Co-activation through TLR4 and TLR9 but not TLR2 skews Treg-mediated modulation of Igs and induces IL-17 secretion in Treg:B cell co-cultures
    • [Epub 2013 Mar 25]
    • Adjobimey T., Satoguina J., Oldenburg J., Hoerauf A., Layland L.E. Co-activation through TLR4 and TLR9 but not TLR2 skews Treg-mediated modulation of Igs and induces IL-17 secretion in Treg:B cell co-cultures. Innate Immun 2014, 20(1):12-23. [Epub 2013 Mar 25].
    • (2014) Innate Immun , vol.20 , Issue.1 , pp. 12-23
    • Adjobimey, T.1    Satoguina, J.2    Oldenburg, J.3    Hoerauf, A.4    Layland, L.E.5
  • 63
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
    • Eisenbarth S.C., Piggott D.A., Huleatt J.W., Visintin I., Herrick C.A., Bottomly K. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. JExp Med 2002, 196:1645-1651.
    • (2002) JExp Med , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1    Piggott, D.A.2    Huleatt, J.W.3    Visintin, I.4    Herrick, C.A.5    Bottomly, K.6
  • 64
    • 46749134328 scopus 로고    scopus 로고
    • Dendritic cell behaviour invivo: lessons learned from intravital two-photon microscopy
    • Cavanagh L.L., Weninger W. Dendritic cell behaviour invivo: lessons learned from intravital two-photon microscopy. Immunol Cell Biol 2008, 86:428-438.
    • (2008) Immunol Cell Biol , vol.86 , pp. 428-438
    • Cavanagh, L.L.1    Weninger, W.2
  • 65
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C., Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003, 299:1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 67
    • 84875368702 scopus 로고    scopus 로고
    • Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis
    • Luo C., Li Y., Liu W., Feng H., Wang H., Huang X., et al. Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis. JNeuroimmunol 2013, 256:55-61.
    • (2013) JNeuroimmunol , vol.256 , pp. 55-61
    • Luo, C.1    Li, Y.2    Liu, W.3    Feng, H.4    Wang, H.5    Huang, X.6
  • 68
    • 84879323599 scopus 로고    scopus 로고
    • ATRA alters humoral responses associated with amelioration of EAMG symptoms by balancing Tfh/Tfr helper cell profiles
    • Xie X., Mu L., Yao X., Li N., Sun B., Li Y., et al. ATRA alters humoral responses associated with amelioration of EAMG symptoms by balancing Tfh/Tfr helper cell profiles. Clin Immunol 2013, 148:162-176.
    • (2013) Clin Immunol , vol.148 , pp. 162-176
    • Xie, X.1    Mu, L.2    Yao, X.3    Li, N.4    Sun, B.5    Li, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.