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Volumn 29, Issue 17, 2011, Pages 3356-3362

Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines

Author keywords

Adjuvant; Experimental Autoimmune Encephalomyelitis; Vaccination

Indexed keywords

FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; MONTANIDE ISA 51; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PLASMID DNA; PROTEOLIPID PROTEIN; VACCINE; VIRUS DNA;

EID: 79954575661     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.08.103     Document Type: Review
Times cited : (32)

References (62)
  • 1
    • 0029888979 scopus 로고    scopus 로고
    • Two models for multiple sclerosis: experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis virus
    • Tsunoda I., Fujinami R.S. Two models for multiple sclerosis: experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis virus. J Neuropathol Exp Neurol 1996, 55:673-686.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 673-686
    • Tsunoda, I.1    Fujinami, R.S.2
  • 2
    • 84954971084 scopus 로고
    • Sensitization to horse serum by means of adjuvants
    • Freund J., McDermott K. Sensitization to horse serum by means of adjuvants. Proc Soc Exp Biol Med 1942, 49:548-553.
    • (1942) Proc Soc Exp Biol Med , vol.49 , pp. 548-553
    • Freund, J.1    McDermott, K.2
  • 3
    • 53249140904 scopus 로고    scopus 로고
    • Myelin sheaths and autoimmune response induced by myelin proteins and alphaviruses. I. Physicochemical background
    • Sedzik J. Myelin sheaths and autoimmune response induced by myelin proteins and alphaviruses. I. Physicochemical background. Curr Med Chem 2008, 15:1899-1910.
    • (2008) Curr Med Chem , vol.15 , pp. 1899-1910
    • Sedzik, J.1
  • 4
    • 0020700751 scopus 로고
    • Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein
    • Fritz R.B., Chou C-H.J., McFarlin D.E. Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein. J Immunol 1983, 130:1024-1026.
    • (1983) J Immunol , vol.130 , pp. 1024-1026
    • Fritz, R.B.1    Chou, C.-H.J.2    McFarlin, D.E.3
  • 5
    • 0023272841 scopus 로고
    • Experimental allergic encephalomyelitis mediated by murine encephalitogenic T cell lines specific for myelin proteolipid apoprotein
    • Satoh J., Sakai K., Endoh M., Koike F., Kunishita T., Namikawa T., et al. Experimental allergic encephalomyelitis mediated by murine encephalitogenic T cell lines specific for myelin proteolipid apoprotein. J Immunol 1987, 138:179-184.
    • (1987) J Immunol , vol.138 , pp. 179-184
    • Satoh, J.1    Sakai, K.2    Endoh, M.3    Koike, F.4    Kunishita, T.5    Namikawa, T.6
  • 7
    • 28244459495 scopus 로고    scopus 로고
    • Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis
    • Tsunoda I., Libbey J.E., Kuang L.-Q., Terry E.J., Fujinami R.S. Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis. Am J Pathol 2005, 167:1631-1646.
    • (2005) Am J Pathol , vol.167 , pp. 1631-1646
    • Tsunoda, I.1    Libbey, J.E.2    Kuang, L.-Q.3    Terry, E.J.4    Fujinami, R.S.5
  • 8
    • 0032476701 scopus 로고    scopus 로고
    • Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis
    • Pohl-Koppe A., Burchett S.K., Thiele E.A., Hafler D.A. Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis. J Neuroimmunol 1998, 91:19-27.
    • (1998) J Neuroimmunol , vol.91 , pp. 19-27
    • Pohl-Koppe, A.1    Burchett, S.K.2    Thiele, E.A.3    Hafler, D.A.4
  • 9
    • 0034983697 scopus 로고    scopus 로고
    • Can virus infections trigger autoimmune disease?
    • Fujinami R.S. Can virus infections trigger autoimmune disease?. J Autoimmun 2001, 16:229-234.
    • (2001) J Autoimmun , vol.16 , pp. 229-234
    • Fujinami, R.S.1
  • 11
    • 77956080330 scopus 로고    scopus 로고
    • Animal models of multiple sclerosis-potentials and limitations
    • epub ahead of print
    • Mix E., Meyer-Rienecker H., Hartung H.P., Zettl U.K. Animal models of multiple sclerosis-potentials and limitations. Prog Neurobiol 2010, epub ahead of print.
    • (2010) Prog Neurobiol
    • Mix, E.1    Meyer-Rienecker, H.2    Hartung, H.P.3    Zettl, U.K.4
  • 12
    • 34248659946 scopus 로고    scopus 로고
    • The CD8 T cell in multiple sclerosis: suppressor cell or mediator of neuropathology?
    • Johnson A.J., Suidan G.L., McDole J., Pirko I. The CD8 T cell in multiple sclerosis: suppressor cell or mediator of neuropathology?. Int Rev Neurobiol 2007, 79:73-97.
    • (2007) Int Rev Neurobiol , vol.79 , pp. 73-97
    • Johnson, A.J.1    Suidan, G.L.2    McDole, J.3    Pirko, I.4
  • 16
    • 33947535936 scopus 로고    scopus 로고
    • Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis
    • Rodriguez M. Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis. Brain Pathol 2007, 17:219-229.
    • (2007) Brain Pathol , vol.17 , pp. 219-229
    • Rodriguez, M.1
  • 18
    • 67449116625 scopus 로고    scopus 로고
    • Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells
    • Pöllinger B., Krishnamoorthy G., Berer K., Lassmann H., Bösl M.R., Dunn R., et al. Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med 2009, 206:1303-1316.
    • (2009) J Exp Med , vol.206 , pp. 1303-1316
    • Pöllinger, B.1    Krishnamoorthy, G.2    Berer, K.3    Lassmann, H.4    Bösl, M.R.5    Dunn, R.6
  • 19
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran B., Zhang G.-X., Yu S., Li J., Chen X.-H., Ventura E.S., et al. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol 2002, 169:7104-7110.
    • (2002) J Immunol , vol.169 , pp. 7104-7110
    • Gran, B.1    Zhang, G.-X.2    Yu, S.3    Li, J.4    Chen, X.-H.5    Ventura, E.S.6
  • 21
    • 46049093364 scopus 로고    scopus 로고
    • Th17 Cells and autoimmune encephalomyelitis (EAE/MS)
    • Aranami T., Yamamura T. Th17 Cells and autoimmune encephalomyelitis (EAE/MS). Allergol Int 2008, 57:115-120.
    • (2008) Allergol Int , vol.57 , pp. 115-120
    • Aranami, T.1    Yamamura, T.2
  • 23
    • 33750142276 scopus 로고    scopus 로고
    • Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
    • Veldhoen M., Hocking R.J., Flavell R.A., Stockinger B. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol 2006, 7:1151-1156.
    • (2006) Nat Immunol , vol.7 , pp. 1151-1156
    • Veldhoen, M.1    Hocking, R.J.2    Flavell, R.A.3    Stockinger, B.4
  • 25
    • 33846558558 scopus 로고    scopus 로고
    • Kinetics and organ distribution of IL-17-producing CD4 cells in proteolipid protein 139-151 peptide-induced experimental autoimmune encephalomyelitis of SJL mice
    • Hofstetter H.H., Toyka K.V., Tary-Lehmann M., Lehmann P.V. Kinetics and organ distribution of IL-17-producing CD4 cells in proteolipid protein 139-151 peptide-induced experimental autoimmune encephalomyelitis of SJL mice. J Immunol 2007, 178:1372-1378.
    • (2007) J Immunol , vol.178 , pp. 1372-1378
    • Hofstetter, H.H.1    Toyka, K.V.2    Tary-Lehmann, M.3    Lehmann, P.V.4
  • 26
    • 63549122337 scopus 로고    scopus 로고
    • Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production
    • Xie L., Li X.-K., Funeshima-Fuji N., Kimura H., Matsumoto Y., Isaka Y., et al. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. Int Immunopharmacol 2009, 9:575-581.
    • (2009) Int Immunopharmacol , vol.9 , pp. 575-581
    • Xie, L.1    Li, X.-K.2    Funeshima-Fuji, N.3    Kimura, H.4    Matsumoto, Y.5    Isaka, Y.6
  • 27
    • 0027274058 scopus 로고
    • Enhancement of autoimmune disease using recombinant vaccinia virus encoding myelin proteolipid protein [published erratum appears in J Neuroimmunol 48:120, 1993]
    • Barnett L.A., Whitton J.L., Wada Y., Fujinami R.S. Enhancement of autoimmune disease using recombinant vaccinia virus encoding myelin proteolipid protein [published erratum appears in J Neuroimmunol 48:120, 1993]. J Neuroimmunol 1993, 44:15-25.
    • (1993) J Neuroimmunol , vol.44 , pp. 15-25
    • Barnett, L.A.1    Whitton, J.L.2    Wada, Y.3    Fujinami, R.S.4
  • 28
    • 77956938380 scopus 로고    scopus 로고
    • Potential triggers of MS in: R Martin and A Lutterotti (Eds.), Molecular Basis of Multiple Sclerosis. The Immune System, in: Results and Problems in Cell Differentiation, , Springer, New York, Berlin & Heidelberg
    • Libbey JE, Fujinami RS. Potential triggers of MS in: R Martin and A Lutterotti (Eds.), Molecular Basis of Multiple Sclerosis. The Immune System, in: Results and Problems in Cell Differentiation, vol. 51, Springer, New York, Berlin & Heidelberg, 2010, pp. 21-42.
    • (2010) , vol.51 , pp. 21-42
    • Libbey, J.E.1    Fujinami, R.S.2
  • 29
    • 0029912167 scopus 로고    scopus 로고
    • Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis
    • Barnett L.A., Whitton J.L., Wang L.Y., Fujinami R.S. Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis. J Neuroimmunol 1996, 64:163-173.
    • (1996) J Neuroimmunol , vol.64 , pp. 163-173
    • Barnett, L.A.1    Whitton, J.L.2    Wang, L.Y.3    Fujinami, R.S.4
  • 30
    • 0030781981 scopus 로고    scopus 로고
    • Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein
    • Genain C.P., Gritz L., Joshi N., Panicali D., Davis R.L., Whitaker J.N., et al. Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein. J Neuroimmunol 1997, 79:119-128.
    • (1997) J Neuroimmunol , vol.79 , pp. 119-128
    • Genain, C.P.1    Gritz, L.2    Joshi, N.3    Panicali, D.4    Davis, R.L.5    Whitaker, J.N.6
  • 31
    • 0022974996 scopus 로고
    • T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis
    • Zamvil S.S., Mitchell D.J., Moore A.C., Kitamura K., Steinman L., Rothbard J.B. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 1986, 324:258-260.
    • (1986) Nature , vol.324 , pp. 258-260
    • Zamvil, S.S.1    Mitchell, D.J.2    Moore, A.C.3    Kitamura, K.4    Steinman, L.5    Rothbard, J.B.6
  • 32
    • 0024840204 scopus 로고
    • Encephalitogenic epitopes of myelin basic protein
    • Fritz R.B., McFarlin D.E. Encephalitogenic epitopes of myelin basic protein. Chem Immunol 1989, 46:101-125.
    • (1989) Chem Immunol , vol.46 , pp. 101-125
    • Fritz, R.B.1    McFarlin, D.E.2
  • 33
    • 0027979005 scopus 로고
    • Minireview: autoimmune responses to myelin proteolipid protein
    • Sobel R.A., Greer J.M., Kuchroo V.K. Minireview: autoimmune responses to myelin proteolipid protein. Neurochem Res 1994, 19:915-921.
    • (1994) Neurochem Res , vol.19 , pp. 915-921
    • Sobel, R.A.1    Greer, J.M.2    Kuchroo, V.K.3
  • 34
    • 0028070413 scopus 로고
    • Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: a review
    • Tuohy V.K. Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: a review. Neurochem Res 1994, 19:935-944.
    • (1994) Neurochem Res , vol.19 , pp. 935-944
    • Tuohy, V.K.1
  • 35
    • 0030941033 scopus 로고    scopus 로고
    • Enhancement of EAE and induction of autoantibodies to T-cell epitopes in mice infected with a recombinant vaccinia virus encoding myelin proteolipid protein
    • Wang L.-Y., Fujinami R.S. Enhancement of EAE and induction of autoantibodies to T-cell epitopes in mice infected with a recombinant vaccinia virus encoding myelin proteolipid protein. J Neuroimmunol 1997, 75:75-83.
    • (1997) J Neuroimmunol , vol.75 , pp. 75-83
    • Wang, L.-Y.1    Fujinami, R.S.2
  • 36
    • 0033519264 scopus 로고    scopus 로고
    • Infection with a recombinant vaccinia virus encoding myelin proteolipid protein causes suppression of chronic relapsing-remitting experimental allergic encephalomyelitis
    • Wang L.-Y., Theil D.J., Whitton J.L., Fujinami R.S. Infection with a recombinant vaccinia virus encoding myelin proteolipid protein causes suppression of chronic relapsing-remitting experimental allergic encephalomyelitis. J Neuroimmunol 1999, 96:148-157.
    • (1999) J Neuroimmunol , vol.96 , pp. 148-157
    • Wang, L.-Y.1    Theil, D.J.2    Whitton, J.L.3    Fujinami, R.S.4
  • 37
    • 0034917817 scopus 로고    scopus 로고
    • Viruses can silently prime for and trigger central nervous system autoimmune disease
    • Theil D.J., Tsunoda I., Rodriguez F., Whitton J.L., Fujinami R.S. Viruses can silently prime for and trigger central nervous system autoimmune disease. J NeuroVirol 2001, 7:220-227.
    • (2001) J NeuroVirol , vol.7 , pp. 220-227
    • Theil, D.J.1    Tsunoda, I.2    Rodriguez, F.3    Whitton, J.L.4    Fujinami, R.S.5
  • 38
    • 34547107306 scopus 로고    scopus 로고
    • Sequential polymicrobial infections lead to CNS inflammatory disease: possible involvement of bystander activation in heterologous immunity
    • Tsunoda I., Libbey J.E., Fujinami R.S. Sequential polymicrobial infections lead to CNS inflammatory disease: possible involvement of bystander activation in heterologous immunity. J Neuroimmunol 2007, 188:22-33.
    • (2007) J Neuroimmunol , vol.188 , pp. 22-33
    • Tsunoda, I.1    Libbey, J.E.2    Fujinami, R.S.3
  • 39
    • 33745070952 scopus 로고    scopus 로고
    • Multiple sclerosis and virus induced immune responses: autoimmunity can be primed by molecular mimicry and augmented by bystander activation
    • McCoy L., Tsunoda I., Fujinami R.S. Multiple sclerosis and virus induced immune responses: autoimmunity can be primed by molecular mimicry and augmented by bystander activation. Autoimmunity 2006, 39:9-19.
    • (2006) Autoimmunity , vol.39 , pp. 9-19
    • McCoy, L.1    Tsunoda, I.2    Fujinami, R.S.3
  • 40
    • 0028960035 scopus 로고
    • Cytokines and murine autoimmune encephalomyelitis: inhibition or enhancement of disease with antibodies to select cytokines, or by delivery of exogenous cytokines using a recombinant vaccinia virus system
    • Willenborg D.O., Fordham S.A., Cowden W.B., Ramshaw I.A. Cytokines and murine autoimmune encephalomyelitis: inhibition or enhancement of disease with antibodies to select cytokines, or by delivery of exogenous cytokines using a recombinant vaccinia virus system. Scand J Immunol 1995, 41:31-41.
    • (1995) Scand J Immunol , vol.41 , pp. 31-41
    • Willenborg, D.O.1    Fordham, S.A.2    Cowden, W.B.3    Ramshaw, I.A.4
  • 41
    • 0031870767 scopus 로고    scopus 로고
    • Enhancement of experimental allergic encephalomyelitis (EAE) by DNA immunization with myelin proteolipid protein (PLP) plasmid DNA
    • Tsunoda I., Kuang L.-Q., Tolley N.D., Whitton J.L., Fujinami R.S. Enhancement of experimental allergic encephalomyelitis (EAE) by DNA immunization with myelin proteolipid protein (PLP) plasmid DNA. J Neuropathol Exp Neurol 1998, 57:758-767.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 758-767
    • Tsunoda, I.1    Kuang, L.-Q.2    Tolley, N.D.3    Whitton, J.L.4    Fujinami, R.S.5
  • 42
    • 0033559521 scopus 로고    scopus 로고
    • Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimulation
    • Ruiz P.J., Garren H., Ruiz I.U., Hirschberg D.L., Nguyen L-VT, Karpuj M.V., et al. Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimulation. J Immunol 1999, 162:3336-3341.
    • (1999) J Immunol , vol.162 , pp. 3336-3341
    • Ruiz, P.J.1    Garren, H.2    Ruiz, I.U.3    Hirschberg, D.L.4    Nguyen, L.-V.T.5    Karpuj, M.V.6
  • 43
    • 0034897403 scopus 로고    scopus 로고
    • Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway
    • Garren H., Ruiz P.J., Watkins T.A., Fontoura P., Nguyen L-VT, Estline E.R., et al. Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway. Immunity 2001, 15:15-22.
    • (2001) Immunity , vol.15 , pp. 15-22
    • Garren, H.1    Ruiz, P.J.2    Watkins, T.A.3    Fontoura, P.4    Nguyen, L.-V.T.5    Estline, E.R.6
  • 44
    • 14244261236 scopus 로고    scopus 로고
    • Private specificities of CD8 T cell responses control patterns of heterologous immunity
    • Kim S.-K., Cornberg M., Wang X.Z., Chen H.D., Selin L.K., Welsh R.M. Private specificities of CD8 T cell responses control patterns of heterologous immunity. J Exp Med 2005, 201:523-533.
    • (2005) J Exp Med , vol.201 , pp. 523-533
    • Kim, S.-K.1    Cornberg, M.2    Wang, X.Z.3    Chen, H.D.4    Selin, L.K.5    Welsh, R.M.6
  • 48
    • 54849415440 scopus 로고    scopus 로고
    • Targeting myelin proteolipid protein to the MHC class I pathway by ubiquitination modulates the course of experimental autoimmune encephalomyelitis
    • Theil D.J., Libbey J.E., Rodriguez F., Whitton J.L., Tsunoda I., Derfuss T.J., et al. Targeting myelin proteolipid protein to the MHC class I pathway by ubiquitination modulates the course of experimental autoimmune encephalomyelitis. J Neuroimmunol 2008, 204:92-100.
    • (2008) J Neuroimmunol , vol.204 , pp. 92-100
    • Theil, D.J.1    Libbey, J.E.2    Rodriguez, F.3    Whitton, J.L.4    Tsunoda, I.5    Derfuss, T.J.6
  • 49
    • 70349404047 scopus 로고    scopus 로고
    • Pertussis toxin stimulates IL-17 production in response to Bordetella pertussis infection in mice
    • Andreasen C., Powell D.A., Carbonetti N.H. Pertussis toxin stimulates IL-17 production in response to Bordetella pertussis infection in mice. PLoS ONE 2009, 4:e7079.
    • (2009) PLoS ONE , vol.4
    • Andreasen, C.1    Powell, D.A.2    Carbonetti, N.H.3
  • 50
    • 33751579426 scopus 로고    scopus 로고
    • TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells
    • Higgins S.C., Jarnicki A.G., Lavelle E.C., Mills K.H.G. TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells. J Immunol 2006, 177:7980-7989.
    • (2006) J Immunol , vol.177 , pp. 7980-7989
    • Higgins, S.C.1    Jarnicki, A.G.2    Lavelle, E.C.3    Mills, K.H.G.4
  • 53
    • 77954170923 scopus 로고    scopus 로고
    • Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells
    • Tigno-Aranjuez J.T., Jaini R., Tuohy V.K., Lehmann P.V., Tary-Lehmann M. Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells. J Immunol 2009, 183:5654-5661.
    • (2009) J Immunol , vol.183 , pp. 5654-5661
    • Tigno-Aranjuez, J.T.1    Jaini, R.2    Tuohy, V.K.3    Lehmann, P.V.4    Tary-Lehmann, M.5
  • 54
    • 0033179015 scopus 로고    scopus 로고
    • Viruses as triggers of autoimmunity: facts and fantasies
    • Whitton J.L., Fujinami R.S. Viruses as triggers of autoimmunity: facts and fantasies. Curr Opin Microbiol 1999, 2:392-397.
    • (1999) Curr Opin Microbiol , vol.2 , pp. 392-397
    • Whitton, J.L.1    Fujinami, R.S.2
  • 55
    • 1842613450 scopus 로고    scopus 로고
    • Microorganisms and autoimmunity: making the barren field fertile?
    • von Herrath M.G., Fujinami R.S., Whitton J.L. Microorganisms and autoimmunity: making the barren field fertile?. Nat Rev Microbiol 2003, 1:151-157.
    • (2003) Nat Rev Microbiol , vol.1 , pp. 151-157
    • von Herrath, M.G.1    Fujinami, R.S.2    Whitton, J.L.3
  • 56
    • 0032490610 scopus 로고    scopus 로고
    • Aluminum compounds as vaccine adjuvants
    • Gupta R.K. Aluminum compounds as vaccine adjuvants. Adv Drug Deliv Rev 1998, 32:155-172.
    • (1998) Adv Drug Deliv Rev , vol.32 , pp. 155-172
    • Gupta, R.K.1
  • 57
    • 54949138806 scopus 로고    scopus 로고
    • Vaccine adjuvants. The dream becomes real
    • Tagliabue A., Rappuoli R. Vaccine adjuvants. The dream becomes real. Hum Vaccin 2008, 4:347-349.
    • (2008) Hum Vaccin , vol.4 , pp. 347-349
    • Tagliabue, A.1    Rappuoli, R.2
  • 58
    • 33845905223 scopus 로고    scopus 로고
    • Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling
    • Gavin A.L., Hoebe K., Duong B., Ota T., Martin C., Beutler B., et al. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science 2006, 314:1936-1938.
    • (2006) Science , vol.314 , pp. 1936-1938
    • Gavin, A.L.1    Hoebe, K.2    Duong, B.3    Ota, T.4    Martin, C.5    Beutler, B.6
  • 59
    • 34250206008 scopus 로고    scopus 로고
    • Toll or toll-free adjuvant path toward the optimal vaccine development
    • Ishii K.J., Akira S. Toll or toll-free adjuvant path toward the optimal vaccine development. J Clin Immunol 2007, 27:363-371.
    • (2007) J Clin Immunol , vol.27 , pp. 363-371
    • Ishii, K.J.1    Akira, S.2
  • 60
    • 33745851536 scopus 로고    scopus 로고
    • Adjuvant activity of CpG oligodeoxynucleotides
    • Klinman D.M. Adjuvant activity of CpG oligodeoxynucleotides. Int Rev Immunol 2006, 25:135-154.
    • (2006) Int Rev Immunol , vol.25 , pp. 135-154
    • Klinman, D.M.1
  • 61
    • 0142058176 scopus 로고    scopus 로고
    • Recent advances in the discovery and delivery of vaccine adjuvants
    • O'Hagan D.T., Valiante N.M. Recent advances in the discovery and delivery of vaccine adjuvants. Nat Rev Drug Discov 2003, 2:727-735.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 727-735
    • O'Hagan, D.T.1    Valiante, N.M.2
  • 62
    • 33645225168 scopus 로고    scopus 로고
    • The use of oil adjuvants in therapeutic vaccines
    • Aucouturier J., Ascarateil S., Dupuis L. The use of oil adjuvants in therapeutic vaccines. Vaccine 2006, 24(Suppl. 2):S2-S5.
    • (2006) Vaccine , vol.24 , Issue.SUPPL. 2
    • Aucouturier, J.1    Ascarateil, S.2    Dupuis, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.