Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis

Cell Reports

Volumn 15, Issue 10, 2016, Pages 2170-2184

  Pinzaru, Alexandra M ^a   Hom, Robert A ^b   Beal, Angela ^c   Phillips, Aaron F ^a   Ni, Eric ^a   Cardozo, Timothy ^a   Nair, Nidhi ^c   Choi, Jaehyuk ^d   Wuttke, Deborah S ^b   Sfeir, Agnel ^a   Denchi, Eros Lazzerini ^c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

ATR; Cutaneous T cell lymphoma; POT1; Replication stress; Telomere; Thymic lymphoma

Indexed keywords

ATR PROTEIN; ATM PROTEIN; ATR PROTEIN, MOUSE; DNA BINDING PROTEIN; MUTANT PROTEIN; POT1 PROTEIN, MOUSE; PROTEIN BINDING; PROTEIN P53;

ANIMAL CELL; ARTICLE; CANCER GROWTH; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHROMOSOME REPLICATION; CONTROLLED STUDY; CUTANEOUS T CELL LYMPHOMA; DISEASE SEVERITY; DNA DAMAGE; GENE; GENE INACTIVATION; GENETIC PREDISPOSITION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; LYMPHOID PROGENITOR CELL; MOUSE; NONHUMAN; POT1A GENE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOMATIC MUTATION; TELOMERE; TELOMERE HOMEOSTASIS; THYMUS LYMPHOMA; TUMOR SUPPRESSOR GENE; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DNA REPAIR; DNA REPLICATION; GENETICS; IMMUNOLOGY; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGICAL STRESS; THYMUS;

AMINO ACID SEQUENCE; ANIMALS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CARCINOGENESIS; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; GENETIC PREDISPOSITION TO DISEASE; GENOMIC INSTABILITY; LYMPHOID PROGENITOR CELLS; LYMPHOMA, T-CELL, CUTANEOUS; MICE; MUTANT PROTEINS; MUTATION; PROTEIN BINDING; STRESS, PHYSIOLOGICAL; TELOMERE; THYMUS GLAND; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84969780102     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.05.008     Document Type: Article

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